Skip to main content
SpringerLink
Log in

Serological Monitoring of Incidental Prostatic Carcinoma

  • Conference paper
Incidental Carcinoma of the Prostate

  • 46 Accesses

Abstract

About 11 years ago human prostate-specific antigen (PSA) was isolated in non-malignant prostatic tissue and characterized by M.C. Wang and associates [1], PSA is a single-chain glycoprotein enzyme containing 93% peptides and 7% carbohydrates with a molecular weight of 33000–34000 daltons [2] and an isoelectric point (iP) of 6.9 [3] or, rather, isomeric forms of iP 6.8–7.2. It is structurally and functionally similar to serine proteases [4] and, unlike prostatic acid phosphatase (PAP) is a useful and sensitive marker for screening in prostate cancer (PCA) [5, 6].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wang MC, Valenzuela LA, Murphy GP, Chu TM (1979) Purification of a human prostate specific antigen. Invest Urol 17:159–163

    PubMed  CAS  Google Scholar 

  2. Wang MC, Kuriyama M, Papsidero LD, Loor RM, Valenzuela LA, Murphy GP, Chu TM (1982) Prostate antigen of human cancer patients. In: Busch H, Yeoman LC (eds) Methods in cancer research, vol 19. Academic, New York, pp 179–197

    Google Scholar 

  3. Wang MC, Loor RM, Li SL, Chu TM (1983) Physico-chemical characterization of prostate antigen purified from human prostate gland and seminal plasma. ICRC Med Sci 11:327–328

    CAS  Google Scholar 

  4. Watt K, Lee P, M’Timkulu T, Chang W, Loor RM (1986) Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc Natl Acad Sci USA 83:3166

    Article  PubMed  CAS  Google Scholar 

  5. Daver A, Soret JY, Coblentz Y, Allain YM, Cellier P, Chauveau P (1988) The usefulness of prostate-specific antigen and prostatic acid phosphatase in clinical practice. Am J Clin Oncol (CCT) 11 (Suppl 2):S53–S60

    Article  Google Scholar 

  6. Caty A, Gosselin P, Cazin JL, Dehaut JM, Adenis L (1988) Significance of PSA and PAP in patients with or without prostatic cancer. Am J Clin Oncol (CCT) 11 (Suppl 2): S63–S64

    Article  Google Scholar 

  7. Nadji M et al (1981) Prostatic-specific antigen: an immunohistologic marker for prostatic neoplasms. Cancer 48:1229

    Article  PubMed  CAS  Google Scholar 

  8. Lange PH, Brawer MK (1989) Serum prostate-specific antigen: Its use in diagnosis and management of prostate cance. Urology (Suppl) 33(6):13–17

    Article  CAS  Google Scholar 

  9. Killian CS, Yang N, Kuriyama M, Vargas FP, Emmrich LJ, Slack NH, Wang MC, Papsidero LD, Murphy GP, Chu TM (1985) Prognostic importance of prostate-specific antigen for monitoring patients with localized prostate cancer. Cancer Res. 45:886

    PubMed  CAS  Google Scholar 

  10. Guinan P, Bhatti R, Ray P (1987) An evaluation of prostate specific antigen in prostatic cancer. J. Urol. 137:686–689

    PubMed  CAS  Google Scholar 

  11. Oesterling JE, Chan DW, Epstein JI, Kimball AW, Bruzek DJ, Rock RC, Brendler CB, Walsh PC (1988) Prostate specific antigen in the preoperative and postoperative evaluation of localized prostatic cancer treated with radical prostatectomy. J Urol 139:766–772

    CAS  Google Scholar 

  12. Delaere KPJ, Van Dieijen-Visser MP, Gijzen AHJ, Brombacher PJ (1988) Is prostate-specific antigen the most useful marker for screening in prostate cancer? Am J Clin Oncol (CCT) 11 (Suppl 2): S65-S67

    Article  Google Scholar 

  13. Brawer MD, Lange PH (1989) Prostate-specific antigen in managment of prostatic carcinoma. Urology (Suppl) 33 (5):11–16

    Article  CAS  Google Scholar 

  14. Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317:909–916

    Article  PubMed  CAS  Google Scholar 

  15. Stamey T, Kabalin JN (1989) Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. I. Untreated patients. J Urol 141:1070–1075

    PubMed  CAS  Google Scholar 

  16. Sheldon CA, Williams RD, Fraley EE (1980) Incidental carcinoma of the prostate: a review of the literature and critical reappraisal of classification. J Urol 124:626

    PubMed  CAS  Google Scholar 

  17. Mosteller F, Tukey JW (1977) Data analysis and regression: a second course in statistics. Addison-Wesley, Reading

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Urologische Klinik der Städtischen Kliniken Offenbach, Akademisches Lehrkrankenhaus der Johann Wolfgang Goethe-Universität, Frankfurt am Main, W-6050, Offenbach, Germany

    U. W. Tunn

Authors
  1. A. J. W. Goldschmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. M. Goldschmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. W. Tunn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Urologische Abteilung, Krankenhaus der Barmherzigen Brüder, Romanstraße 95, W-8000, München 19, Germany

    Jens E. Altwein  & Wolfgang Schneider  & 

  2. Urologische Abteilung, Stadtkrankenhaus Memmingen, W-8940, Memmingen, Germany

    Peter Faul

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Goldschmidt, A.J.W., Goldschmidt, S.M., Tunn, U.W. (1991). Serological Monitoring of Incidental Prostatic Carcinoma. In: Altwein, J.E., Faul, P., Schneider, W. (eds) Incidental Carcinoma of the Prostate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76129-4_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76129-4_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76131-7

  • Online ISBN: 978-3-642-76129-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation