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Lentinan and its Related Polysaccharides as Host Defence Potentiators: Their Application to Infectious Diseases and Cancer

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Immunotherapeutic Prospects of Infectious Diseases

Abstract

Cytotoxic anticancer chemotherapeutic agents generally accompany severe side effects to the hosts, and reduce the host resistance against cancer and infectious diseases, especially by destroying lymphoid cells and bone marrow cells. As a results, many cancer patients die of various kinds of pneumonitis, septicaemia, uremia or other secondary diseases. On the other hand, there is reliable clinical evidence to support the existence of intrinsic resistance against cancer and infectious diseases in the human body. An increase in this resistance may be one of the most important facets in the development of pharmaceutical therapy against such diseases. Based on this concept, we re-examined antitumour effects of many folk remedies which had been long believed to be effective to cancer patients, and then we isolated lentinan having marked antitumour activity from Lentinus edodes, an edible mushroom(Chihara et al. 1970).

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© 1990 Springer-Verlag Berlin Heidelberg

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Chihara, G. (1990). Lentinan and its Related Polysaccharides as Host Defence Potentiators: Their Application to Infectious Diseases and Cancer. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-76120-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76122-5

  • Online ISBN: 978-3-642-76120-1

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