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Polysaccharide Lentinan-Treatment Combined with Inflammatory Agent Augments Antitumor Activity of LAK Cells

  • A. Yamashita
  • E. Sumiyoshi
  • Z. Dai
  • M. Imada
  • T. Suga
  • A. Kosaka
Conference paper

Abstract

Lentinan(LNT) isolated from Lentinus edodes is a neutral ß(1–3) glucan type polysaccharide and possess no mitogenicity and toxicity for both normal and tumor cells. A number of previous studies undertaken mainly by Dr. Chihara’s group(Hamuro and Chihara 1985) has demonstrated that LNT possess in general two kinds of characteristics; one is immunological nature and the other is biological nature. Main immunological natures reside in the stimulation or potentiation of the T cell — macrophages — NK cell synergism in vivo, by which exert nonspecific immunoprophylaxis. Other noteworthy nature is the vascular dilatation and hemorrhage activity, indicating that LNT can exert direct or indirect action on the vascular system(Maeda et al. 1984). The present study aimed to define immunopotentiating action of LNT, focussing in particular on the synergistic action of LNT and lymphokine activated killer(LAK) cells on the suppression of autologous tumor-growth, in the context of LAK cell-extravasation into tumor tissues.

Keywords

Mammary Tumor Lymphokine Activate Killer Normal Lymphocyte Lymphokine Activate Killer Cell Vascular Dilatation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hamuro J, Chihara G (1985) Lentinan, a T-cell oriented immuno-potentiator: Its experimental and clinical applications and possible mechanism of immune modulation. In Fenichel RL, Chirigos MA, eds: Immune modulation agents and their mechanisms. Marcel Dekker, New York, p 409Google Scholar
  2. Maeda YY, Watanabe ST, Chihara G, Rokutanda M (1984) T cell mediated vascular dilatation and hemorrhage induced by antitumor polysaccharides. Int. J. Immunopharmacol. 6: 493CrossRefGoogle Scholar
  3. Kosaka A, Imaizumi A, Hattori Y, Yamashita A (1986) Nature of the antitumor action of lentinan-endocrine therapy on the mammary tumor. In Urushizaki I, Aoki T, Tsubura E, eds: Host defense mechanisms against cancer. Excerpta Medica, Tokyo, p 208Google Scholar
  4. Yamashita A, Masuda E, Hattori Y, Kosaka A (1989) Cellular and humoral factors in the antitumor action of lentinan on mammary tumors. Int. J. Immunother. V: 177Google Scholar
  5. Stoolman LM (1989) Adhesion molecules controlling lymphocyte migration. Cell, 56: 907PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. Yamashita
    • 1
  • E. Sumiyoshi
    • 1
  • Z. Dai
    • 1
  • M. Imada
    • 1
  • T. Suga
    • 1
  • A. Kosaka
    • 2
  1. 1.Department of AnatomyHamamatsu University School of MedicineHamamatsu, 431-31Japan
  2. 2.Division of SurgeryShimizu City HospitalShimizu, 424Japan

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