Abstract
Sodium diethyldithiocarbamate, ditiocarb, DTC, ImuthiolR, is a thiocarbamate compound, a class of chemical used as fungicides, bactericides and insecticides. The use of ditiocarb in immunocompromised patients was initiated in 1974. Various aspects of in vitro and in vivo effects of ditiocarb have been reported such as its effects on the immune system, on infectious agents or protection from oxygen radicals injury. Ditiocarb was shown to be an effective therapy of the mouse immunodeficiency syndrom induced by the LP-BM5 retrovirus (1).
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References
Hersh EM, Funk CY, Petersen EA, Mosier DE(1990). Effective therapy of the LP-BM5 murine retrovirus induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate. AID Res Hum Retroviruses (in press).
Lang JM, Oberling F, Aleksyevic A, et al. (1985). Immunomodulation with diethylditthiocarbamate in patients with AIDS-related complex. Lancet; 2: 1066.
Brewton GW, Hersh EM, Reuben JM, et al. (1986). Preliminary observations on Imuthiol therapy in symptomatic HTLV-III/1AV infection. In: International Conference on AIDS (Paris) Abstract book. p 601.
Lang JM, Touraine JL, Trepo C, et al. (1988). Randomized, double-blind, placebo-controlled study of ditiocarb sodium (Imuthiol) in human immunodeficiency virus infection. Lancet; 2: 702–6.
Dietrich M, Reisinger E, Ernst M, et al. (1990). Inhibition of HIV progression by ditiocarb. The Lancet, March 24, 1990, pp. 679–682.
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© 1990 Springer-Verlag Berlin Heidelberg
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Hersh, E.M., Caraux, J., Hessel, L., US Imuthiol AIDS Group. (1990). Effectiveness of Diethyldithiocarbamate (DTC, Imuthiol) in Reducing the Incidence of Opportunistic Infections in Patients with AIDS and ARC. A Randomized Placebo Controlled Multicenter Study. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_17
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DOI: https://doi.org/10.1007/978-3-642-76120-1_17
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