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Pancreatic Enzymes in Health and Disease pp 103–112Cite as

Treatment of Pain in Chronic Pancreatitis with Pancreatic Enzymes: Another Point of View

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Abstract

Regulation of pancreatic enzyme secretion by the presence of pancreatic proteases in the duodenum via a negative feedback has been demonstrated in numerous studies in animals such as rats (Green and Lyman 1972; Ihse et al. 1979; Louie et al. 1986; Rausch et al. 1987; Shiratori et al. 1986), chicken (Chernick et al. 1948), and pig (Corring 1973). In rats this negative feedback control is mediated via cholecystokinin (CCK) (Louie et al. 1986; Fölsch et al. 1987; Lee et al. 1986). CCK is probably released by protease-sensitive proteins either from duodenal mucosa or pancreatic juice (Fukuoka et al. 1986; Lu et al. 1989). The findings in humans are controversial. Some groups have reported feedback inhibition of human pancreatic secretion by trypsin (Dlugosz et al. 1988; Ihse et al. 1977; Liener et al. 1988; Slaff et al. 1984) and mediation via CCK (Owyang et al. 1986a,b).

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Authors and Affiliations

  1. Outpatient Clinic, University of Würzburg, Klinikstr. 8, W-8700, Würzburg, Germany

    J. Mössner

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  1. J. Mössner
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Editors and Affiliations

  1. Department of Internal Medicine, Municipal Hospital Lüneburg, Bögelstr. 1, W-2120, Lüneburg, Germany

    Paul Georg Lankisch

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© 1991 Springer-Verlag Berlin Heidelberg

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Mössner, J. (1991). Treatment of Pain in Chronic Pancreatitis with Pancreatic Enzymes: Another Point of View. In: Lankisch, P.G. (eds) Pancreatic Enzymes in Health and Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76097-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-76097-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53187-6

  • Online ISBN: 978-3-642-76097-6

  • eBook Packages: Springer Book Archive

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