Skip to main content
SpringerLink
Log in

The Significance for Human Health of Nitrate, Nitrite and N-Nitroso Compounds

  • Conference paper
Nitrate Contamination

Part of the book series: NATO ASI Series ((ASIG,volume 30))

Abstract

This lecture was to have been prepared by Phillip Issenberg, who was for many years my colleague at the Eppley Institute and recently passed away after a long fight with cancer. I dedicate this lecture to his memory. I valued enormously his warm friendship, his wise counsel, and our long and fruitful collaboration in research on N-nitroso compounds.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Autrup H, Stoner GD (1982) Metabolism of N-nitrosamines by cultured human and rat esophagus. Cancer Res 42:1307–1311

    CAS  Google Scholar 

  • Bartsch H, Ohshima H, Munoz N (1984) In vitro nitrosation, precancerous lesions and cancers of the gastrointestianal tract: On-going studies and preliminary results. In: O’Neill IK, Von Borstel RC, Miller CT, Long J, Bartsch H (eds.) N-Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer. IARC Sci Publ 57:957–964. Int. Agency Res. Cancer, Lyon

    Google Scholar 

  • Buchi G, Lee GCM, Yang D, Tannenbaum SR (1986) Direct acting, highly mutagenic α-hydroxynitrosamines from 4-chloroindoles. J Am Chem Soc 108:4115–4119

    Article  CAS  Google Scholar 

  • Conboy JJ, Hotchkiss JH (1989) A photolytic interface for HPLC: Chemiluminescence detection of nonvolatile N-nitroso compounds. Analyst 114:155–159

    Article  CAS  Google Scholar 

  • Day NE (1984) The geographic pathology of cancer of the oesophagus. Brit Med Bull 40:329–334

    CAS  Google Scholar 

  • Foreman D, Shuker DED (eds.) (1989) Nitrate, nitrite and nitroso compounds in human cancer. Cancer Surveys 8:205–487

    Google Scholar 

  • Harris CC, Autrup H, Stoner GD, Trump BF, Hillman E, Schafer PW, Jeffrey AM (1979) Metabolism of benzo(a)pyrene, N-nitrosodimethylamine, and N-nitrosopyrrolidine and identification of the major carcinogen-DNA adducts formed in cultured human esophagus. Cancer Res 39:4401–4406

    CAS  Google Scholar 

  • Hecht S, Hoffmann D (1989) The relavance of tobacco-specific nitrosamines to human cancer. Cancer Surveys 8:273–294

    CAS  Google Scholar 

  • Hoffmann D, Brunnemann KD (1983) Endogenous formation of N-nitrosoproline in cigarette smokers. Cancer Res 43:5570–5574

    CAS  Google Scholar 

  • Huang Q, Mirvish SS, Stoner G, Nickols J (1990) Metabolism of methyl-n-amylnitrosamine by human esophagus. Proc Am Ass Cancer Res 31:117

    Google Scholar 

  • Iqbal ZM, Epstein SS, Krull IS, Goff U, Mills K, Fine DH (1980) Kinetics of nitrosamine formation in mice following oral administration of trace-level precursors. In: Walker, EA, Gricuite L, Castegnaro M, Borzsonyi M (eds.) N-Nitroso Compounds: Formation and Occurrence. Sci Public Int Agency Res Cancer, Lyon, p 169

    Google Scholar 

  • Kamiyama S, Ohshima H, Shimada A, Saito N, Bourgade MC, Ziegler P, Bartsch H (1987) Urinazry excretion of N-nitrosamino acids and nitrate by inhabitants in high- and low-risk areas for stomach cancer in Northern Japan. In: Bartsch H, O’Neill I, Schulte-Hermann R (eds.) The Relevance of N-Nitroso Compunds to Human Cancer: Exposures and Mechanisms, IARC Sci Publ 84, Int Agency Res Cancer, Lyon, p 497

    Google Scholar 

  • Ladd KF, Newmark HL, Archer MC (1984) N-Nitrosation of proline in smokers and nonsmokers. J Natl Cancer Inst 73:83–87

    CAS  Google Scholar 

  • Licht RL, Tannenbaum SR, Dean WM (1988) Use of ascorbic acid to inhibt nitrosation: kinetic and mass transfer considerations for an in vitro system. Carcinogenesis 9:365–372

    Article  CAS  Google Scholar 

  • Licht RL, Dean WM (1988) Theoretical model for predicting rates of nitrosamine and nitrosamide formation in the human stomach. Carcinogenesis 9:2227–2237

    Article  CAS  Google Scholar 

  • Lu SH, Ohshima H, Fu HM, Tian Y, Li FM, Blettner M, Wahrendorf J, Bartsch H (1986) Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: Endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res 46:1485–1491

    CAS  Google Scholar 

  • Mirvish SS (1975) Formation of N-Nitroso compounds: Chemistry, kinetics and in vivo occurrence. Toxico Applied Pharmacol 31:325–351

    Article  CAS  Google Scholar 

  • Mirvish SS (1981) Inhibition of the formation of carcinogenic N-nitroso compounds by ascorbic acid and other compounds. In: Burchenal JH, Oettgen HP (eds.) Achievements, Challenges. Prospects for the 1980s. Grune and Stratton, New York, p 557

    Google Scholar 

  • Mirvish SS (1983) The etiology of gastric cancer: Intragastric nitrosamide formation and other theories. J Natl Cancer Inst 71:631–647

    Google Scholar 

  • Mirvish SS (1986) Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. Cancer 58:1842–1850

    Article  CAS  Google Scholar 

  • Mirvish SS, Wallcave L, Eagen M, Shubik P (1972) Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds. Science 177: 65–68.

    Article  CAS  Google Scholar 

  • Mirvish SS, Babcook DM, Deshpande AD, Nagel DL (1986) Identification of cholesterol as a mouse skin lipid that reacts with nitrogen dioxide to yield a nitrosating agent (NSA), and of cholesteryl nitrite as the NSA produced in a chemical system from cholesterol. Cancer Lett 31:97–104

    Article  CAS  Google Scholar 

  • Moller H, Landt J, Pedersen E, Jensen P, Autrup H, Jensen OM (1989) Endogenous nitrosation in relation to nitrate exposure from drinking water and diet in a Danish rural population. Cancer Res 49:3117–3121

    CAS  Google Scholar 

  • National Academy of Sciences (1981) The Health Effects of Nitrate, Nitrite and N-Nitroso Compounds. National Academy Press, Washington, D.C.

    Google Scholar 

  • Ning JP, Yu MC, Wang QS, Hendrson BE (1990) Consumption of salted fish and other risk factors for nasopharyngeal carcinoma (NPC) in Tianjin, a low-risk region for NPC in the People’s Republic of China. J Natl Cancer Inst 82:291–296

    Article  CAS  Google Scholar 

  • Ohshima H, Bartsch H (1981) Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine. Cancer Res 41:3658–3662

    CAS  Google Scholar 

  • Preussmann R, Stewart BW (1984) N-Nitroso carcinogens In: C.E. Searle (ed.) Chemical Carcinogens. Am Chem Soc 2:643–828.

    Google Scholar 

  • Sander J, Bürkle G (1969) Induktion maligner tumoren bei ratten durch gleichzeitige verfiitterung von nitrit und sekundären aminen. Z. Krebsforsch 73:54–66

    Article  CAS  Google Scholar 

  • Shephard S, Lutz W (1989) Nitrosation of dietary precursory. Cancer Surveys 8:401–421

    CAS  Google Scholar 

  • Umbenhauer D, Wild CP, Montesano R, Saffhill R, Boyle JM, Huh N, Kirstein U, Thomale J, Rajewsky MF, Lu SH (1985) 06-Methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int J Cancer 36:661–665

    Article  CAS  Google Scholar 

  • Wakabayashi K, Nagoo M, Singamura T (1989) Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite. Cancer Surveys 8:385–399

    CAS  Google Scholar 

  • Walton G (1951) Survey of literature relating to infant methemoglobinemia due to nitrate-contaminated water. Am J Public Health 41:988–996

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, 68198-6805, USA

    S. S. Mirvish

Authors
  1. S. S. Mirvish
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Civil Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588-0531, USA

    Istvan Bogárdi  & Wilma G. Ennenga  & 

  2. University of Nebraska Water Center, Lincoln, Nebraska, 68583-0844, USA

    Robert D. Kuzelka

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Mirvish, S.S. (1991). The Significance for Human Health of Nitrate, Nitrite and N-Nitroso Compounds. In: Bogárdi, I., Kuzelka, R.D., Ennenga, W.G. (eds) Nitrate Contamination. NATO ASI Series, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76040-2_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76040-2_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76042-6

  • Online ISBN: 978-3-642-76040-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation