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Respiratory Mechanisms During Sleep that Might Be Responsible for Sudden Infant Death Syndrome

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Sleep and Health Risk

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Abstract

Sleep seems to play a role in the pathogenesis of the sudden infant death syndrome (SIDS) because of the close temporal relationship between the SIDS event and sleep. The demonstration of a disturbed respiratory pattern during sleep with excessive amounts of brief apnea in some ALTE infants (apparent life threatening event) was the basis for the sleep apnea hypothesis [10, 17, 29]. The concept of SIDS resulting from respiratory failure during sleep also was supported by pathologic findings in SIDS victims which indicate that a number of infants may have had chronic hypoxemia prior to death [22, 31]. In addition, differences in cardiorespiratory patterns during hypoxia and hypercapnia stress tests have been discussed for high-risk groups [1, 16, 28].

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References

  1. Ariagno R, Nagel L, Guilleminault C (1980) Waking and ventilatory responses during sleep in infants near-miss for sudden infant death syndrome. Sleep 3: 351–359

    PubMed  CAS  Google Scholar 

  2. Baba N, Quattrochi J, Reiner CB, Adrion W, McBride PT, Yates AJ (1983) Possible role of brain stem in sudden infant death syndrome. JAMA 249: 2789–2791

    Article  PubMed  CAS  Google Scholar 

  3. Bureau MA, Cote A, Blanchard PW, Hobbs S, Foulon P, Dalle D (1986) Exponential and diphasic ventilatory response to hypoxia in conscious lambs. J Appl Physiol 61: 836–842

    PubMed  CAS  Google Scholar 

  4. Carpenter RG, Gardner A, Harris J, Judd M, Lewry J, Maddock CR, Powell J, Taylor EM (1988) Prevention of unexpected infant death. Ann NY Acad Sci 533: 96–103

    Article  PubMed  CAS  Google Scholar 

  5. Carpenter RG, Gardner A, McWeeny PM, Emery JL (1977) Multistage scoring system for identifying infants at risk of unexpected death. Arch Dis Child 52: 606–612

    Article  PubMed  CAS  Google Scholar 

  6. Davi MJ, Sankaran K, Simons KJ, Simons FER, Seshia MM, Rigatto H (1978) Physiologic changes induced by theophylline in the treatment of apnea in preterm infants. J Pediatr 92: 91–95

    Article  PubMed  CAS  Google Scholar 

  7. Gabriel M, Witolla C, Albani M (1978) Sleep and aminophylline treatment of apnea in preterm infants. Eur J Pediatr 128: 145–149

    Article  PubMed  CAS  Google Scholar 

  8. Gerhardt T, McCarthy J, Bancalari E (1979) Effect of aminophylline on respiratory center activity and metabolic rate in premature infants with idiopathic apnea. Pediatrics 63: 537–542

    PubMed  CAS  Google Scholar 

  9. Guilleminault C, Ariagno RL, Forno LS, Nagel L, Baldwin R, Owen M (1979) Obstructive sleep apnea and near-miss SIDS: report of an infant with sudden death. Pediatrics 63: 837–843

    PubMed  CAS  Google Scholar 

  10. Guilleminault C, Peraita R, Souquet M, Dement WC (1975) Apneas during sleep in infants: possible relationship with sudden infant death syndrome. Science 190: 677–679

    Article  PubMed  CAS  Google Scholar 

  11. Gunby P (1978) Brain stem abnormalities may characterize S.I.D.S. victims. JAMA 240: 2138–2144

    Article  PubMed  CAS  Google Scholar 

  12. Haidmayer R, Kenner T (1988) Physiological approaches to respiratory control mechanisms in infants. Assessing the risk for SIDS. Annals N Y Acad Sci 533: 376–389

    Article  CAS  Google Scholar 

  13. Haidmayer R, Kerbl R, Meyer U, Kerschhaggl P, Kurz R, Kenner T (1986) Effects of naloxone on apnoea duration during sleep in infants at risk for SIDS. Eur J Pediatr 145: 357–360

    Article  PubMed  CAS  Google Scholar 

  14. Haidmayer R, Pfeiffer KP, Kenner T, Kurz R (1982) Statistical evaluation of respiratory control in infants to assess possible risk for the sudden infant death syndrome ( SIDS ). Eur J Pediatr 138: 145–150

    Article  PubMed  CAS  Google Scholar 

  15. Harris JD, Radford M, Wailoo M, Carpenter RG, Machin D (1982) Sudden infant death in Southampton and an evaluation of the Sheffield scoring system. J Epid Com HIth 36: 162–166

    Article  CAS  Google Scholar 

  16. Hunt CE (1981) Abnormal hypercarbic and hypoxic sleep arousal responses in near-miss SIDS infants. Pediatr Res 15: 1462–1464

    PubMed  CAS  Google Scholar 

  17. Kelly DE, Shannon DC (1979) Periodic breathing in infants with near-miss sudden infant death syndrome. Pediatrics 63: 355–360

    PubMed  CAS  Google Scholar 

  18. Kelly DH, Stellwagen LM, Kaitz E, Shannon DC (1985) Apnea and periodic breathing in normal full-term infants during the first twelve months. Pediatr Pulmonol 1: 215–219

    Article  PubMed  CAS  Google Scholar 

  19. Kerschhaggl P, Haidmayer R, Kerbl R, Pfeiffer KP, Kurz R, Kenner T (1986) Computer-assisted evaluation of respiration in newborns and infants during sleep. In: Rolfe P (ed) Neonatal physiological measurements. Butterworths & Co, London, pp 301–307

    Google Scholar 

  20. Lagercrantz H, Yamamoto Y, Fredholm BB, Prabhakar NR, von Euler C (1984) Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors? Pediatr Res 18: 387–389

    Article  PubMed  CAS  Google Scholar 

  21. Moss IR, Denavit-Saubie M, Eldridge FL, Gillis RA, Herkenham M, Lahiri S (1986) Neuromodulators and transmitters in respiratory control. Federation Proc 45: 2133–2147

    CAS  Google Scholar 

  22. Naeye RL (1976) Brain-stem and adrenal abnormalities in the sudden infant death syndrome. Am J Clin Pathol 66: 526–569

    PubMed  CAS  Google Scholar 

  23. Oakley JR, Tavare CJ, Stanton AN (1978) Evaluation of the Sheffield scoring system for identifying children at risk from unexpected death in infancy. Arch Dis Child 53: 649–652

    Article  PubMed  CAS  Google Scholar 

  24. Peiper A (1938) Das Zusammenspiel des Saugzentrums mit dem Atemzentrum beim menschlichen Saugling. Pflügers Arch 240: 312–324

    Article  Google Scholar 

  25. Peters TJ, Golding J (1985) Assessing risk assessment. In: Milunsky A, Friedman EA, Gluck L (eds) Advances in perinatal medicine. Vol 4, Plenum Books, New York, pp 235–266

    Google Scholar 

  26. Pfeiffer KP, Haidmayer R, Kerschhaggl P, Kurz R, Kenner T (1984) Statistical evaluation of the respiratory pattern as a risk factor for the sudden infant death syndrome. Meth Inform Med 23: 41–46

    PubMed  CAS  Google Scholar 

  27. Quattrochi JJ, McBride PT, Yates AJ (1985) Brainstem immaturity in sudden infant death syndrome: a quantitative rapid Golgi study of dendritic spines in 95 infants. Brain Res 325: 39–48

    Article  PubMed  CAS  Google Scholar 

  28. Shannon DC, Kelly DH, O’Connell K (1977) Abnormal regulation of ventilation in infants at risk for sudden infant death syndrome. N Engl J Med 297: 747–750

    Article  PubMed  CAS  Google Scholar 

  29. Steinschneider A (1972) Prolonged apnea and the sudden infant death syndrome: clinical and laboratory observations. Pediatrics 50: 646–654

    PubMed  CAS  Google Scholar 

  30. Steinschneider A, Weinstein SL, Diamond E (1982) The sudden infant death syndrome and obstructive apnea during neonatal sleep and feedings. Pediatrics 70: 858–863

    PubMed  CAS  Google Scholar 

  31. Takashima S, Becker LE (1986) Prenatal and postnatal maturation of medullary “respiratory centers.” Dev Brain Res 26: 173–177

    Article  Google Scholar 

  32. Valdes-Dapena MA, Gillane MM, Catherman R (1976) Brown fat retention in sudden infant death syndrome. Arch Pathol Lab Med 100: 547–549

    PubMed  CAS  Google Scholar 

  33. Wilson SL, Thach BT, Brouillette RT, Abu-Osba YK (1981) Coordination of breathing and swallowing in human infants. J Appl Physiol 50: 851–858

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Physiologisches Institut und Abteilung Pädiatrie, Karl-Franzens-Universität Graz, Harrachgasse 21/V, 8010, Graz, Austria

    T. Kenner

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  1. R. Haidmayer
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  2. C. Einspieler
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  3. W. Löscher
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  4. F. Reiterer
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  5. T. Kenner
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Editors and Affiliations

  1. Zentrum für Innere Medizin Abteilung Poliklinik, Klinikum der Philipps-Universität Marburg, Baldinger Straße, W-3550, Marburg, Bundesrepublik Deutschland

    Jörg H. Peter , Thomas Penzel , Thomas Podszus  & Peter von Wichert , ,  & 

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© 1991 Springer-Verlag Berlin Heidelberg

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Haidmayer, R., Einspieler, C., Löscher, W., Reiterer, F., Kenner, T. (1991). Respiratory Mechanisms During Sleep that Might Be Responsible for Sudden Infant Death Syndrome. In: Peter, J.H., Penzel, T., Podszus, T., von Wichert, P. (eds) Sleep and Health Risk. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76034-1_49

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  • DOI: https://doi.org/10.1007/978-3-642-76034-1_49

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53083-1

  • Online ISBN: 978-3-642-76034-1

  • eBook Packages: Springer Book Archive

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