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Bunyavirus RNA Synthesis: Genome Transcription and Replication

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Bunyaviridae

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 169))

Abstract

The three bunyavirus genome segments, termed small (S), medium (M), and large (L), are found both in virions and infected cells as viral nucleocapsids (NCs). These are large, possibly helical, structures in which the RNA is complexed with predominantly the viral N protein, with sedimentation constants (S20,w)for La Crosse virus (LAC) of 115S (L), 90S (M), and 65S (S) in sucrose gradients. Based on the chemical composition of the virus and the proportion of each protein by SDS-PAGE, Obijeski et al. (1976) estimated that there would be one N protein for every six nucleotides.

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Authors and Affiliations

  1. Department of Microbiology, University of Genewa School of Medicine, CMU, 9 Ave de Champel, 1211, Geneva, Switzerland

    D. Kolakofsky & D. Hacker

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  1. D. Kolakofsky
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  2. D. Hacker
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Editors and Affiliations

  1. School of Medicine, C.M.U., University of Geneva, Avenue de Champel 9, 1211, Geneva 4, Switzerland

    Daniel Kolakofsky (Professor of Microbiology) (Professor of Microbiology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Kolakofsky, D., Hacker, D. (1991). Bunyavirus RNA Synthesis: Genome Transcription and Replication. In: Kolakofsky, D. (eds) Bunyaviridae. Current Topics in Microbiology and Immunology, vol 169. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76018-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-76018-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76020-4

  • Online ISBN: 978-3-642-76018-1

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