Abstract
Monoclonal antibody Due ABC 3 recognizes a differentiation antigen in urologic epithelia. This antigen is expressed in proximal tubular epithelium as well as in renal cell carcinomas and in urothelial carcinomas. The epitope recognized by this antibody was shown to be part of the carbohydrate structure of a glycolipid, a structure related to Lewis X blood group antigen (CD 15). Occurrence of this antigen in lipid extracts from kidney tissue and transitional cell carcinoma cell lines was assayed by immuno-TLC.
This work was supported by the Bundesminister für Forschung und Technologie (grant 01GA8701/7) and the Minister für Wissenschaft und Forschung des Landes Nordrhein-Westfalen.
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References
Arndt R, Dürkopf H, Huland H, Donn F, Loening T, Kalthoff H (1987) Monoclonal antibodies for characterization of the heterogeneity of normal and malignant transitional cells. J Urol 137:758–763.
Decken K, Schmitz-Dräger BJ, Rohde D, Nakamura S, Ebert T, Ackermann R (1991) Monoclonal antibody Due ABC 3 directed against transitional cell carcinoma. I. Production, specificity analysis and preliminary characterization of the antigen. J Urol (in press).
Nakamura S, Schmitz-Dräger BJ, Rottmann-Ickler C, Decken K, Pfitzer P, Bojar H, Ackermann R (1989) The value of immunocytology in the diagnosis of bladder cancer. J Urol 141:319 A.
Rauvala H (1976) Gangliosides of human kidney. J Biol Chem 251:7517–7520.
Schmitz-Dräger BJ (1989) Monoklonale Antikörper gegen urologische Tumoren — Produktion: Spezifität und klinische Anwendung. Thesis, Medical Faculty, University of Düsseldorf.
Schmitz-Dräger BJ, Nakamura S, Decken K, Pfitzer P, Rottmann-Ickler C, Ebert T, Ackermann R (1991) Monoclonal antibody Due ABC 3 directed against transitional cell carcinoma. IL Prospective trial on the diagnostic value of immunocytology using monoclonal antibody Due ABC 3. J Urol (in press).
Schmitz-Dräger BJ, Rohde D, Peschkes C, Ebert T, Ackermann R (1988) Monoklonale Antikörper gegen Harnblasenkarzinome — ein Beitrag zur Verbesserung der Diagnostik? Akt Urol 19:117–123.
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© 1991 Springer-Verlag Berlin Heidelberg
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Decken, K., Sieth, P., Schlichtherle, S., Ebert, T., Schmitz-Dräger, B.J. (1991). Characterization of a Differentiation Antigen Defined by Monoclonal Antibody Due ABC 3. In: Jocham, D., Thüroff, J.W., Rübben, H. (eds) Investigative Urology 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75972-7_2
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DOI: https://doi.org/10.1007/978-3-642-75972-7_2
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