Abstract
Interferon treatment is effective in hairy cell and chronic granulocytic leukaemia although the exact mechanism of its antileukaemic action is uncertain. Since its cytoreductive, differentiation and immunoregulatory effects are potentially useful in myelodysplastic syndromes (MDS), a therapeutic study was undertaken on this condition.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bennett TM, Catovsky D, Daniel MT et al. (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51: 189–199
Mufti GJ, Stevens JR, Oscier DG, Hamblin TJ, Machin D (1985) Myelodysplastic states — a scoring system with prognostic significance. Br J Haematol 59: 425–433
Herberman RB, Ortaloo JR, Mantovani A et al. (1982) Effect of human recombinant interferon on cytotoxic activity of natural killer ( NK) cells and monocytes. Cell Immunol 67: 160–167
Grant S, Bhalla K, Weinstein IB et al. (1982) Differential effect of recombinant human leucocyte interferon on human leukaemic and normal myeloid progenitor cells. Biochem Biophys Res Commun 108: 1048–1055
Quesada JR, Reuben J, Manning JT, Harsh EM, Gutterman JU (1984) Alpha interferon for induction of remission in hairy-cell leukaemia. N Engl J Med 310: 15–18
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Donohue, S.M., Lim, S., Boughton, B.J. (1992). Recombitant α2b-Interferon in the Management of Myelodysplastic Syndromes. In: Schmalzl, F., Mufti, G.J. (eds) Myelodysplastic Syndromes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75952-9_42
Download citation
DOI: https://doi.org/10.1007/978-3-642-75952-9_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52966-8
Online ISBN: 978-3-642-75952-9
eBook Packages: Springer Book Archive