Abstract
The myelodysplastic syndrome (MDS), as currently defined, incorporates the clinical states earlier recognised as “chronic refractory anaemia” (RA), “primary acquired sideroblastic anaemia” (PASA) and “smouldering leukaemia”. It is now generally accepted that this disorder results from the proliferation of an abnormal clone of haemopoietic stem cells which gradually predominates over normal haemopoiesis and may undergo clonal evolution [14, 21]. There is a diversity of abnormalities affecting all cell lines, and although it is possible to group certain cases together, as in the FAB classification [3], the biological and functional aberrations vary from case to case, and the mechanisms causing anaemia may not be the same in all patients. While this paper relates only to erythroid abnormalities, it should be remembered that even when only erythropoiesis appears to be involved by the pathological process, apparently normal cells of other lineages may be derived from the abnormal clone [22].
Leukaemia Research Fund, Preleukaemia Unit, University of Wales, College of Medicine, Cardiff, UK
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baines P. Masters GS, Lush C, Jacobs A (1989) Enrichment of haemopoietic progenitor cells from the marrow of patients with myelodysplasia. Br J Haematol 68: 159–164
Barosi G, Cazzola M, Morandi S, Stefanelli M, Perugini S (1978) Estimation of ferrokinetic parameters by a mathematical model in patients with primary acquired sideroblastic anaemia. Br J Haematol 39: 409–423
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 15: 189–199
Boehme WM, Para TA, Kurnick JE, Bethlenfalvay NC (1978) Acquired hemoglobin H in refractory sideroblastic anemia. Arch Intern Med 138: 601–606
Bowen DT, Jacobs A (1988) Sideroblastic erythropoiesis in non anaemic subjects. International Symposium on Myelodysplastic Syndromes
Cazzola AM, Barosi G, Berzuini, Dacco M, Orlandi D, Stefanelli M, Ascari B (1982) Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes. Br J Haematol 50: 55–62
Cetto GL, Vettore L, De Matteis MC, Piga A, Perona G (1982) Erythrocyte cation content, globin chain synthesis and glucose metabolism in dysmyelopoeietic syndromes. Acta Haematol 68: 124–130
Chui DHK, Clarke BJ (1982) Abnormal erythroid progenitor cells in human preleukaemia. Blood 60: 362–367
Dormer P. Hershko C, Wilmanns W (1987) Mechanisms and prognostic value of cell kinetics in the myelodysplastic syndromes. Br J Haematol 67: 147–152
Fitzsimons EJ, May A, Elder GH, Jacobs A (1988) D-Aminolaevulinic acid synthase activity in developing human erythroblasts. Br J Haematol 69: 281–285
Fohlmeister I, Fischer R, Schaefer H-E (1985) Preleukaemic myelodysplastic syndromes (MDS): pathogenetical considerations based on retrospective clinicomorphological sequential studies. Anticancer Res 5: 179–188
Greenberg P, Mara B, Bax I, Brossel R, Schrier S (1976) The myeloproliferative disorders: correlation between clinical evolution and alternations in granulopoiesis. Am J Med 61: 878–891
Jacobs A (1986) Primary acquired sideroblastic anaemia. Br J Haematol 64: 415–418
Jacobs A, Clark RE (1986) Pathogenesis and clinical variations in the myelodysplastic syndromes. Clin Haematol 15: 925–951
Juneja SK, Imbert M, Sigaux S, Jouault H, Sultan C (1983) Prevalence and distribution of ringed sideroblasts in primary meylodysplastic syndromes. J Clin Pathol 36: 566–569
Levine MN, Kuhns WK, Bolk TA, Beyer TA, Rosse WF (1984) Acquired alteration in the expression of blood groups in a patient with sideroblastic anaemia and chronic renal failure. Transfusion 24: 8–12
May A, De Souza P, Barnes K, Kaaba S, Jacobs A (1982) Erythroblast iron metabolism in sideroblastic marrows. Br J Haematol 52: 611–621
May SJ, Smith SA, Jacobs A, Williams A, Bailey-Wood R (1985) The myelodysplastic syndrome: analysis of laboratory characteristics in relation to the FAB classification. Br J Haematol 59: 311–319
Mecucci C, Van Orshoven A, Vermaelen K, Michaux J-L, Tricot G. Louwagie A, Delannoy A, Van den Berghe H (1987) llq-Chromosome is associated with abnormal iron stores in myelodysplastic syndromes. Cancer Genet Cytogenet 2739–44
Mitrou PS, Fischer M (1979) Cell proliferation in refractory anaemia with hyperplastic bone marrow (preleukaemia). In Schmalzl F, Hellriegel KP (eds) Preleukaemia. Springer, Berlin, Heidelberg, New York
Oscier DG (1987) Myelodysplastic syndromes. Clin Haematol 1: 389–426
Prchal JT, Throckmorton DW, Carroll AJ, Fuson EW, Gams RA, Prchal JS (1978) A common progenitor for human myeloid and lymphoid cells. Nature 274: 590–591
Reizenstein P, Lagerlof B, Skarberg KO, Carlmark B, Kock Y, Jores S (1975) Alterations in erythropoiesis preceding leukaemia. Acta Haematol 54: 152–158
Ricard MF, Sigaux F, Imbert M, Sultan C (1979) Complementary investigations in myelodysplastic syndromes. In: Schmalzl F, Hellriegel KP (eds) Preleukaemia. Springer, Berlin Heidelberg New York
Ricketts C, Jacobs A, Cavill I (1975) Ferrokinetics and erythropoiesis in man: the measurement of effective erythropoiesis, ineffective erythropoiesis and red cell lifespan using 59Fe. Br J Haematol 31: 65–75
Romslo I, Brun A, Sandberg S, Bottomley SS, Hovding G, Talstad I (1982) Sideroblastic anaemia with markedly increased free erythrocyte protoporphyrin without dermal photosensitivity. Blood 59: 628–633
Ruutu T, Partanen S, Lintula R, Teerenhovi L, Knuutila S (1984) Erythroid and granulocyte-macrophage colony formation in myelodysplastic syndromes. Scand J Haematol 32: 395–402
Valentine WN, Konrad PB, Paglia DE (1973) Dyserythropoiesis, refractory anaemia and “preleukaemia”. Blood 59: 857–875
Wickramasinghe SN, Chalmers DG, Cooper EH. (1986) A study of ineffective erythropoiesis in sideroblastic anaemia and erythraemic myelosis. Cell Tissue Kinet 1: 43–50
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Jacobs, A. (1992). Pathogenesis of Anaemia in the Myelodysplastic Syndrome. In: Schmalzl, F., Mufti, G.J. (eds) Myelodysplastic Syndromes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75952-9_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-75952-9_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52966-8
Online ISBN: 978-3-642-75952-9
eBook Packages: Springer Book Archive