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In Vitro Granulopoiesis in Myelodysplastic Syndromes According to the FAB Classification

  • L. Florensa
  • S. Woessner
  • R. Lafuente
  • J. Buxó
  • J. Almarcha
  • M. R. Marill
  • J. Sans-Sabrafen
Conference paper

Abstract

The myelodysplastic syndromes (MDS; preleukaemia) are a heterogeneous and variably defined group of disorders with a propensity to transform into acute leukaemia [13, 17]. The in vitro growth of granulocyte-macrophage progenitors from the marrow of patients with MDS has been investigated in several studies. While the numbers of granulocyte/macrophage colony-forming units (CFU-GM) derived from bone marrow (BM) may be normal in some patients, others show a variety of abnormal patterns including increased cluster formation and reduced or absent colony growth, such as in acute myeloid leukemia (AML) [3–11, 14–16, 19, 22, 23, 25].

Keywords

Acute Myeloid Leukemia Growth Pattern Myelodysplastic Syndrome Bone Marrow Culture Normal Growth Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. Florensa
  • S. Woessner
  • R. Lafuente
  • J. Buxó
  • J. Almarcha
  • M. R. Marill
  • J. Sans-Sabrafen

There are no affiliations available

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