In Vitro Granulopoiesis in Myelodysplastic Syndromes According to the FAB Classification

  • L. Florensa
  • S. Woessner
  • R. Lafuente
  • J. Buxó
  • J. Almarcha
  • M. R. Marill
  • J. Sans-Sabrafen
Conference paper


The myelodysplastic syndromes (MDS; preleukaemia) are a heterogeneous and variably defined group of disorders with a propensity to transform into acute leukaemia [13, 17]. The in vitro growth of granulocyte-macrophage progenitors from the marrow of patients with MDS has been investigated in several studies. While the numbers of granulocyte/macrophage colony-forming units (CFU-GM) derived from bone marrow (BM) may be normal in some patients, others show a variety of abnormal patterns including increased cluster formation and reduced or absent colony growth, such as in acute myeloid leukemia (AML) [3–11, 14–16, 19, 22, 23, 25].


Acute Myeloid Leukemia Growth Pattern Myelodysplastic Syndrome Bone Marrow Culture Normal Growth Pattern 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. Florensa
  • S. Woessner
  • R. Lafuente
  • J. Buxó
  • J. Almarcha
  • M. R. Marill
  • J. Sans-Sabrafen

There are no affiliations available

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