Abstract
Myelodysplastic syndromes (MDS) constitute a group of diverse disorders characterized by bone marrow (BM) dysplasia of one or more hemopoietic lineages and peripherally by varying degrees of anemia, leukopenia, and thrombocytopenia. Diagnosis is based mainly on examination of smears of aspirates which, however, may sometimes be inadequate because of failure to obtain sufficient material. For this reason a BM core biopsy is always recommended in order to better evaluate some morphological parameters such as overall cellularity, presence of reticulin fibrosis, and particularly degree of blastic infiltration. Furthermore, studies on BM sections have demonstrated some discrepancies in the criteria of the FAB Cooperative Group [1], so that a modified classification of MDS on the basis of histological findings has been proposed [2].
This work was supported by the Italian National Research Council (CNR, Progetto finalizzato Oncologia, Contract no. 87.01326.44). Institute of Medical Sciences, University of Milan, Italy
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© 1992 Springer-Verlag Berlin Heidelberg
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Lambertenghi-Deliliers, G., Soligo, D., Annaloro, C., Pozzoli, E., Riva, A. (1992). Bone Marrow Biopsy in RAEB and RAEB-t Myelodysplastic Syndromes. In: Schmalzl, F., Mufti, G.J. (eds) Myelodysplastic Syndromes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75952-9_11
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DOI: https://doi.org/10.1007/978-3-642-75952-9_11
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