Detection of EBNA2-mRNA in Primary Central Nervous System Lymphomas in Patients with AIDS
Epstein-Barr virus (EBV) is commonly associated with two different tumours — the Burkitt-lymphoma (BL), in which it has been primarily isolated and the nasopharyngeal carcinoma (NPC), an undifferentiated carcinoma. In both kinds of tumours association has been demonstrated by serological data and the identification of viral structures (DNA or antigen) within malignant cells. EBV infections are mostly asymptomatic and B lymphocytes are the target cells for the virus. In the phase of latency there is one infected cell in relation to 105 to 107 non-infected cells . The importance of the immune system for the control of an EBV infection will be apparent in the scope of connated immunodeficiencies in which uncontrolled polyclonal proliferation of EBV-immortalized lymphoid cells is induced. Human- Immunodeficiency-Virus Type I (HIV-I) infected individuals take an elevated risk for the development of malignant lymphoma, mainly highly malignant non-Hodgkin-lymphoma. Obviously there is a significantly higher incidence (about 2% in HIV-I-infected subjects ) of primary intracerebral non-Hodgkin-lymphomas (PINHL). The yearly incidence of Aquired immunodeciency syndrome (AIDS)-associated PINHL has surpassed the incidence from all other causes for CNS tumors and could become as frequent als low-grade astrocytomas until 1991.
KeywordsPrimary Central Nervous System Lymphoma Brain Biopsy Stereotactic Brain Biopsy Burkitt Lymphoma Cell Line Human Lymphoid Cell Line
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