Abstract
The role of air pollution in human lung cancer has been difficult to assess or quantitate due to the many confounding exposures and factors that influence human cancer (see Chapter 5). This is especially true for cancers of the respiratory tract where the vast majority of cancers have been related to cigarette smoking. Much of our understanding of the potential human risk from air pollution is derived from experimental cancer studies on both individual chemicals and mixtures of air pollutants [1]. This chapter discusses the experimental evidence for the carcinogenicity of air pollutants in long-term animal cancer studies and from short-term bioassays. The evidence is organised and discussed in 3 categories of exposures: (a) individual chemicals found as air pollutants (e.g., formaldehyde); (b) mixtures emitted from air pollution sources (e.g., automotive emissions); and (c) mixtures of air pollution taken from ambient air (e.g., urban air particulate matter).
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References
Higginson J, Jensen OM: Epidemiological review of lung cancer in man. In: Mohr U, Schmahl D, Tomatis L (eds) Air Pollution and Cancer in Man. IARC Scientific Publications No. 16. International Agency for Research on Cancer, Lyon 1977 pp 169–189
IARC: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl 7. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1-42. International Agency for Research on Cancer, Lyon 1987 pp 17– 34
Wilbourn J, Haroun L, Heseltine E, Kaldor J, Partensky C, Vainio H: Response of experimental animals to human carcinogens: An analysis based upon the IARC Monographs Programme. Carcinogenesis 1986 (7):1853–1863
Tomatis L, Aitio, A, Wilbourn, J and Shuker L: Human carcinogens so far identified. Jpn J Cancer Res 1989 (80)795–807
Huff JE, McConnell EE, Haseman, JK, Boorman, GA, Eustis SL, Schwartz BA, Rao GN, Jameson CK, Hart LG, and Rall DP: Carcinogenesis studies: results of 398 experiments on 104 chemicals from the US National Toxicology Program. Ann NY Acad Sci 1988 (534): 1–30
Montesano R, Bartch H, Vainio H, Wilbourn J, Yamasaki H (Eds) Long-Term and Short-Term Assays for Carcinogenesis -A Critical Appraisal, IARC Scientific Publications No. 83. International Agency for Research on Cancer, Lyon 1986
Miller EC, Miller JA: The mutagenicity of chemical carcinogens: Correlations, problems, and interpretations. In Hollaender A (ed) Chemical Mutagens: Principles and Methods for Their Detection, Vol. 1. Plenum Press, New York 1971 pp 83–94
IARC: Approaches to Classifying Chemical Carcinogens According to Mechanism of Action. IARC Internal Technical Report 1983 No. 83/001
Yamasaki H: Multistage carcinogenesis: implications for risk estimation. Cancer Metastasis Rev 1988 (7):5–18
Farber E: Cellular biochemistry of the stepwise development of cancer with chemicals: GHA Clowes Memorial Lecture. Cancer Res 1984 (44):5463
Farber E: Possible etiologic mechanisms in chemical carcinogenesis. Environ Health Perspect 1987 (75):65
Butterworth BE and Slaga TU: A perspective on cell proliferation in rodent carcinogenicity studies: relevance to human beings. In: Chemically Induced Cell Proliferation: Implications for Risk Assessment. Wiley/Liss, New York 1989 (in press)
Trosko JE and Chang CC: Non-genotoxic mechanisms in carcinogenesis: role of inhibited intercellular communication. In: Hart RW and Hoerger FD (eds) Carcinogen Risk Assessment, Banbury Report 31. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 1988 pp139–174
Waters, MD, Auletta, A: The GENE-TOX program: genetic activity evaluation. J Chem Inf Comput Sci 1981(21):35–38
McCann J, Choi E, Yamasaki E and Ames BN: Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc Natl Acad Sci USA 1975 (72):5135– 5139
Bartsch H: Predictive value of mutagenicity tests in chemical carcinogenesis. Mutat Res 1976 (38):177–190
Sugimura TS, Sato M, Nagao T, Yahagi T, Matsushima Y, Seino M, Takeuch and Kawachi T: Overlapping of carcinogens and mutagens. In: Magee PN, Takayama S, Sugimura T and Matsushima T (eds) Fundamentals of Cancer Prevention. University Park Press, Baltimore MD 1976 pp191–213
Ashby J and Tennant RW: Chemical structure, salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents of the U.S. NCI/NTP Mutat Res 1988 (204):17–115
Tennant RW, Margolin BH, Shelby MD, Zeiger E, Haseman JK, Spalding, J, Caspary W, Resnick M, Stasiewlcz S, Anderson B, Minor R: Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 1987 (236):933– 941
Brockman HE and DeMarini DM: Utility of short-term tests for genetic toxicity in the aftermath of the NTP’s analysis of 73 chemicals. Environ Mol Mutagen 1988 (11):421–435
Bartch H and Malaveille C: Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series. Cell Biol Toxicol 1989 (5):115–127
Lave LB, Ennever FK, Rosenkranz HS and Omenn GS: Information value of the rodent bioassay. Nature 1988 (336):431–433
Claxton LD, Stead AG and Walsh D: An analysis by chemical class of Salmonella mutagenicity tests as predictors of animal carcinogenicity. Mutat Res 1988 (205):197–225
Ashby J: The separate identities of genotoxic and non-genotoxic carcinogens. Mutagenesis 1988 (3):365–366
Gold LS, Slone TH, Backman GM, Eisenberg S, DaCosta M, Wong M, Manley, NB, Rohrbach L, and Ames BN: Third chronological supplement to the carcinogenic potency database: Standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environ Health Perspect 1989 (84)
Garrett, NE, Stack, HF, Gross, MR, Waters, MD: An analysis of the spectra of genetic activity produced by known or suspected human carcinogens. Mutat Res 1984 (134):89–111
Ames BM, Magaw R and Gold LS: Ranking possible carcinogenic hazards. Science 1987 (236):271
Ames BN, Magaw R and Gold LS: Response to letter: Risk assessment. Science 1987 (237):235
Anderson EL and the Cancer Assessment Group of the US Environmental Protection Agency: Quantitative approaches in use to assess cancer risk. Risk Anal 1983 (3):277–295
Crump KS: An improved procedure for low-dose carcinogenic risk assessment from animal data. J Environ Pathol Toxicol 1981 (5):675–684
Armitage P and Doll R: A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer 1957 (11):161–169
Moolgavkar SH and Knudson AG: Mutation and cancer: A model for human carcinogenesis. JNCI 1981 (66):1037–1052
Thorslund TW, Brown CC and Charnley G: Biologically motivated cancer risk models. Risk Anal 1987 (7):109–119
Graedel, TE, Hawkins, DT, Claxton, LD: Atmospheric Chemical Compounds: Sources, Occurrence, and Bioassay. Academic Press Inc, Orlando FL 1986 p 732
IARC: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volumes 1–46. International Agency for Research on Cancer, Lyon
US Environmental Protection Agency: Cancer Risk from Outdoor Exposure to Air Toxics. Office of Air Quality Planning and Standards, Research Triangle Park, NC 27711. EPA-450/2-89
Lewtas J: Genotoxicity of complex mixtures: strategies for the identification and comparative assessment of airborne mutagens and carcinogens from combustion sources. Fundam Appl Toxicol 1988 (10):571 -589
Claxton, LD: Assessment of bacterial bioassay methods for volatile and semivolatile compounds and mixtures. Environ Int 1985 (11):375–382
Searle CE (ed) Chemical Carcinogens. ACS Monograph No 173. American Chemical Society, Washington DC 1976
IARC: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Polynuclear Aromatic Compounds. Part 1, Chemical, Environmental and Experimental Data. Vol 32. International Agency for Research on Cancer, Lyon 1983
IARC: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Polynuclear Aromatic Compounds. Part 4, Bitumens, Coal-tar and Derived Products, Shale Oils and Soots. Vol 35. International Agency for Research on Cancer, Lyon 1985
Hoffman, D, Wynder, EL: Environmental respiratory carcinogenesis. In: Searle CE (ed) Chemical Carcinogens. ACS Monograph 173. American Chemical Society, Washington DC 1976 (7): 324– 365
Lewtas J: Combustion emissions: Characterization and comparison of their mutagenic and carcinogenic activity. In: HF Stich (ed) Carcinogens and Mutagens in the Environment. Vol V, The Workplace. CRC Press, Boca Raton F, 1985 pp 59– 74
IARC: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Diesel and Gasoline Engine Exhausts and Some Nitroarenes. Vol 46. International Agency for Research on Cancer, Lyon 1989
Leiter J, Shimkin MB, Shear MJ: Production of subcutaneous sarcomas in mice with tars extracted from atmospheric dusts. J Natl Cancer Inst 1942 (3):155–165
Kotin P, Falk HL, Mader P, Thomas M: Aromatic hydrocarbons. 1. Presence in the Los Angeles atmosphere and the carcinogenicity of atmospheric extracts. Arch Indust Hyg 1954 (9):153–163
Hueper WC, Kotin P, Tabor EC, Payne W, Falk HL, Sawiciki E: Carcinogenic bioassays on air pollutants. Arch Pathol 1962 (74):89–116
Alfheim I, Lofroth G, Moller M: Bioassay of extracts of ambient particulate matter. Environ Health Persp 1983 (47):227–238
Matsushita H, Goto S, Takagi Y: Human exposure to airborne mutagens indoors and outdoors using mutagenesis and chemical analysis methods. In: Waters M, Lewtas J, Nesnow S, Moore M, Daniel FB (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures VI. Plenum Press, New York 1990 (in press)
Barale R, Migliore L, Cellini B, Francioni L, Giogelli F, Barai I, Loprieno N: Genetic toxicology of airborne particulate matter using cytogenetic assays and microbial mutagenicity assays. In: Waters M, Lewtas J, Nesnow S, Moore M, Daniel FB (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures VI. Plenum Press, New York 1990 (in press)
Schuetzle D, Lewtas J: Bioassay-directed chemical analysis in environmental research. Anal Chem 1986 (58):1060A–1075A
Lewis CW, Baumgardner RE, Claxton LD, Lewtas J, Stevens RK: The contribution of woodsmoke and motor vehicle emissions to ambient aerosol mutagenicity. Environ Sci Technol 1988 (22):968– 971
Tokiwa H, Morita K, Takeyoshi H, Takahashi K, Ohnishi Y: Detection of mutagenic activity in particulate air pollutants. 1977 Mutat Res (48):237– 248
Tice RR, Costa DL, Schaich KM: Genotoxic Effects of Airborne Agents Vol 25, Environmental Science Research. Plenum Press, New York 1980
Claxton LD, Kleindienst TE, Perry E and Cupitt LT: Assessment of the mutagenicity of organic air pollutants before and after atmospheric transformation. In: Waters M, Lewtas J, Nesnow S, Moore M, Daniel FB (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures VI. Plenum Press, New York 1990 (in press)
Kleindienst TE, Shepson PB, Edney EO, Claxton LD, Cupitt LT: Wood smoke: measurement of the mutagenic activities of its gas-and particulatephase photooxidation products. Environ Sci Technol 1986 (20): 493–501
Kamens RM, Rives GD, Perry JM, Bell DA, Paylor RF, Goodman RG, Claxton LD: Mutagenic changes in dilute wood smoke as it ages and reacts with ozone and nitrogen dioxide: An outdoor chamber study. Environ Sci Technol 1984 (7):523–530
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© 1990 Springer-Verlag Berlin Heidelberg
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Lewtas, J. (1990). Experimental Evidence for the Carcinogenicity of Air Pollutants. In: Tomatis, L. (eds) Air Pollution and Human Cancer. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75906-2_4
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DOI: https://doi.org/10.1007/978-3-642-75906-2_4
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