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The Transforming Activity of PP59C-MYCis Weaker Than That of v-myc

  • E. H. Humphries
  • E. J. Filardo
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)

Abstract

We and others have speculated that elevated expression of c-myc plays an important role in the establishment of the transformed follicle, a preneoplastic lesion essential for the development of the ALV-induced bursal-dependent lymphoma (Baba and Humphries 1985, Clurman and Hayward 1989, Neiman et al 1985). The discovery of base substitutions and missense mutations in some tumor c- myc alleles raises the possibility that qualitative as well as quantitative alterations within the chicken c-myc proto-oncogene may play a role in the genesis and/or progression of bursal lymphomas (Westaway et al 1984). In order to assess the contribution that deregulated expression of an unaltered c-myc allele makes during ALV lymphomagenesis (Hayward et al 1981) , we have constructed a recombinant avian retrovirus, SNVc-myc, that encodes the second and third exons of normal chicken c-myc and expresses only the smaller of the two c-myc proto-oncogene products, pp62c-myc and pp59c-myc (Hann et al 1988). Ultimately, this virus will enable the effects of specific mutations within the context of wild-type pp59c-myc to be assessed.

Keywords

Herpes Simplex Virus Thymidine Kinase Simplex Virus Thymidine Kinase Gene Reticuloendotheliosis Virus Spleen Necrosis Virus Peripheral Blood Cell Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • E. H. Humphries
    • 1
  • E. J. Filardo
    • 1
  1. 1.Department of MicrobiologyUniversity of Texas Southwestern Medical CenterDallasUSA

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