Limb Salvage pp 107-115 | Cite as

Chemotherapy Effect on the Clinical Results of Allograft Transplantation in the Treatment of Malignant Bone Tumors

  • K. M. Yaw
  • M. C. Gebhardt
  • H. J. Mankin
Conference paper


The clinical use of allografts to reconstruct major skeletal defects dates in legend at least to the fifth century a.d. At that time in Rome a faithful church warden reportedly underwent miraculous resection of a lower extremity tumor as he slept and was reconstructed with an allograft from a Moor who had died earlier that same day. The surgery was performed by the spirits of Saints Cosmos and Damian, physicians who had lived approximately 200 years earlier.


Limb Salvage Functional Grade Malignant Bone Tumor Allograft Transplantation Free Vascularized Fibula Graft 
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  1. 1.
    Berrey BH Jr, Lord CF, Gebhardt MC, Mankin HJ (1990) Allograft fractures: frequency, treatment and end results. (in press)Google Scholar
  2. 2.
    Curtiss PH Jr, Herndon CH (1956) Immunological factors in homogenous bone transplantation I. Serological studies. J Bone Joint Surg 38A: 103–110Google Scholar
  3. 3.
    Curtiss PH Jr, Powell AE, Herndon CH (1959) Immunological factors in homogenous rabbit bone to induce circulating antibodies in rabbits. J Bone Joint Surg 41A: 1482–1488Google Scholar
  4. 4.
    Czitrom AA, Langer F, McKee N, Gross A (1986) Bone and cartilage allotransplantation. A review of 14 years of research and clinical studies. clin Orthop 208: 141–145PubMedGoogle Scholar
  5. 5.
    Dick HM, Malinin TI, Mnaymneh WA (1985) Massive allograft implantation following radical resection of high-grade tumors requiring adjuvant chemotherapy treatment. Clin Orthop 197: 88–95PubMedGoogle Scholar
  6. 6.
    Eliber FR, Morton DL, Eckardt J, Grant T, Weisenburger T (1984) Limb salvage for skeletal and soft tissue sarcomas. Multidisciplinary preoperative therapy. Cancer 53: 2579–2584CrossRefGoogle Scholar
  7. 7.
    Friedlaender GE, Tross RB, Doganis AC, Kirkwood JM, Baron R (1984) Effects of chemotherapeutic agents on bone. J Bone Joint Surg 66-A: 602–607Google Scholar
  8. 8.
    Friedlaender GE (1987) Current concepts review. Bone grafts. J Bone Joint Surg 69-A: 786–790Google Scholar
  9. 9.
    Goldberg VM, Stevenson S (1987) Natural history of autografts and allografts. Clin Orthop 225: 7–16PubMedGoogle Scholar
  10. 10.
    Goorin AM, Abelson HT, Frei E (1985) Osteosarcoma: fifteen years later. N Engl J Med 313: 1637–1643PubMedCrossRefGoogle Scholar
  11. 11.
    Herndon CH, Chase SW (1952) Experimental studies in the transplantation of whole joints. J Bone Joint Surg 34-A: 564–578Google Scholar
  12. 12.
    Herndon CH, Chase SW (1954) The fate of massive autogenous on homogenous bone grafts including articular surfaces. Surg Gynecol Obstet 98: 273–290PubMedGoogle Scholar
  13. 13.
    Lexer E (1925) Joint transplantation and arthroplasty. Surg Gynecol Obstet 40: 782–809Google Scholar
  14. 14.
    Lexer E (1908) Die Verwendung der frien Knochebplastik Nebst Versuchen uber Gelenkversteifung und Gelenktransplantation. Arch Klin Chir 86: 939–954Google Scholar
  15. 15.
    Lord CF, Gebhardt MC, Tomford WW, Mankin HJ (1988) Infection in bone allografts. Incidence, nature and treatment. J Bone Joint Surg 70-A: 369–376Google Scholar
  16. 16.
    Makley JT (1985) The use of allografts to reconstruct intercalary defects of long bones. Clin Orthop 197: 58–75PubMedGoogle Scholar
  17. 17.
    Malejczyk J, Moskalewski S (1988) Effect of immunosuppression on survival and growth of cartilage produced by transplanted allogenic epiphyseal chondrocytes. Clin Orthop 232: 292–303PubMedGoogle Scholar
  18. 18.
    Mankin HJ, Doppelt SH, Sullivan TR, Tomford WW (1982) Osteoarticular and intercalary allograft transplantation in the management of malignant tumors of bone. Cancer 50: 613–630PubMedCrossRefGoogle Scholar
  19. 19.
    Mankin HJ, Doppelt SH, Tomford WW (1983) Clinical experience with allograft implantation. The first ten years. Clin Orthop 174: 69–86PubMedGoogle Scholar
  20. 20.
    Mankin HJ, Gebhardt MC, Tomford WW (1987) The use of frozen cadaveric allografts in management of patients with bone tumors of the extremities. Orthop Clin North 18: 275–289Google Scholar
  21. 21.
    Ragab AH, Frech RS, Vietti TJ (1970) Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer 25: 580–585PubMedCrossRefGoogle Scholar
  22. 22.
    Rosen G (1985) Preoperative (neoadjuvant) chemotherapy for osteogenic sarcoma: a ten year experience. Orthopedics, 8: 659--664PubMedGoogle Scholar
  23. 23.
    Sim FH, Beauchamp CP, Chao EYS (1987) Reconstruction of musculoskeletal defects about the knee for tumor. Clin Orthop 221: 188–201PubMedGoogle Scholar
  24. 24.
    Springfield DS, Schmidt R, Graham-Pole J, Marcus RB, Spanier SS, Enneking WF (1988) Surgical treatment for osteosarcoma. J Bone Joint Surg 70-A: 1124–1130Google Scholar
  25. 25.
    Taylor WF, Ivins JC, Pritchard DJ, Dahlin DC, Gilchrist GS, Edmonson JH (1985) Trends and variability in survival among patients with osteosarcoma: a 7-year update. Mayo Clin Proc 60: 91–104PubMedGoogle Scholar
  26. 26.
    Tomford WW, Doppelt SH, Mankin HJ, Friedlaender GE (1983) Bone Bank Procedure. Clin. Orthop 174: 15–21PubMedGoogle Scholar
  27. 27.
    Tomford WW, Duff GP, Mankin HJ (1985) Experimental freeze-preservation of chondrocytes. Clin Orthop 197: 11–14PubMedGoogle Scholar
  28. 28.
    Tomford WW, Mankin HJ, Friedlaender GE, Doppelt SH, Gebhardt MC (1987) Methods of banking bone and cartilage for allograft transplantation. Ortho Clin North Am 18: 241–247Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • K. M. Yaw
    • 1
  • M. C. Gebhardt
    • 1
  • H. J. Mankin
    • 1
  1. 1.Department of OrthopaedicsMassachusetts General HospitalBostonUSA

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