The Biochemical Events Involved in the Contractile and Positive Inotropic Activity of Endothelin-1
The previous chapter concluded with the statement that “the contractile effect of endothelin-1 is accompanied by a raised cytosolic Ca 2+ . Whilst it is a truism to say that it is the raised cytosolic Ca2+ (Figure 6.1) which is directly responsible for the contractile and positive inotropy of this polypeptide the cascade of events which culminates in this increase are complex.
KeywordsVascular Smooth Muscle Vascular Smooth Muscle Cell Sarcoplasmic Reticulum Calcium Antagonist Spontaneous Contraction
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