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The Contractile Effect of Endothelin-1

  • Winifred G. Nayler
Chapter

Abstract

Now that the chemical structure and the biochemical pathways involved in the biosynthesis of the endothelins have been described (Chapters 2 and 3) the next problem to address is their mode of action, because when injected into the circulation endothelin-1 causes a marked and unusually sustained pressor response (Yanagisawa et al. 1988a), accompanied by sustained coronary artery constriction (Figure 5.1, and Kurihara et al. 1989a, b; Clozel and Clozel 1989) and a significant reduction in renal blood flow (King et al. 1989; Lopez-Farre et al. 1989).

Keywords

Vascular Smooth Muscle Contractile Response Positive Inotropic Effect Contractile Effect Smooth Muscle Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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