Now that the chemical structure and the biochemical pathways involved in the biosynthesis of the endothelins have been described (Chapters 2 and 3) the next problem to address is their mode of action, because when injected into the circulation endothelin-1 causes a marked and unusually sustained pressor response (Yanagisawa et al. 1988a), accompanied by sustained coronary artery constriction (Figure 5.1, and Kurihara et al. 1989a, b; Clozel and Clozel 1989) and a significant reduction in renal blood flow (King et al. 1989; Lopez-Farre et al. 1989).
KeywordsVascular Smooth Muscle Contractile Response Positive Inotropic Effect Contractile Effect Smooth Muscle Preparation
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