Readers might be forgiven for asking what prompted O’Brien and McMurtry (1984, Table 1.1) to search for an endothelial-derived constrictor substance at a time when most investigators were busy following up Furchgott and Zawadzki’s discovery relating to the ability of vascular endothelial cells to release the potent vasodilator endothelial-derived relaxing factor, (EDRF) (Furchgott and Zawadzki 1980). Moreover only a few years had elapsed since Moncada and his colleagues (Moncada et al. 1976) had discovered prostacyclin — the potent vasoactive substance released by arteries. It should be remembered, however, that these discoveries — and particularly those of Furchgott and Zawadzki - had alerted physiologists to the importance of the hitherto neglected endothelial cells.
KeywordsDisulphide Bond Charged Residue Tracheal Epithelial Cell Cell Dorsal Root Ganglion Retinal Endothelial Cell
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