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The Chemistry of the Endothelins

  • Winifred G. Nayler

Abstract

Readers might be forgiven for asking what prompted O’Brien and McMurtry (1984, Table 1.1) to search for an endothelial-derived constrictor substance at a time when most investigators were busy following up Furchgott and Zawadzki’s discovery relating to the ability of vascular endothelial cells to release the potent vasodilator endothelial-derived relaxing factor, (EDRF) (Furchgott and Zawadzki 1980). Moreover only a few years had elapsed since Moncada and his colleagues (Moncada et al. 1976) had discovered prostacyclin — the potent vasoactive substance released by arteries. It should be remembered, however, that these discoveries — and particularly those of Furchgott and Zawadzki - had alerted physiologists to the importance of the hitherto neglected endothelial cells.

Keywords

Disulphide Bond Charged Residue Tracheal Epithelial Cell Cell Dorsal Root Ganglion Retinal Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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