Do the Endothelins have a Future?

  • Winifred G. Nayler


There can be little doubt now that investigators will continue to probe the mysteries of the endothelins until their properties are fully elucidated, their mode of action thoroughly exposed, their receptors cloned, and their patho- and physiological significance determined. Explorations will not stop here, however, because if these polypeptides are involved in certain pathologies — including cerebral vasospasm, renal failure, hypertension, myocardial infarction, atherosclerosis, mental depression and possibly neurosecretory abnormalities then it will be important to establish whether a specific receptor antagonist can be developed - or should the effort be directed towards searching for substances which will inhibit the activity of the converting enzyme which is responsible for releasing the biologically active “mature” endothelin from its precursor state. Experience with inhibitors of the angiotensin converting enzyme has shown that such an approach is both practical, and profitable. On the other hand experience in the beta adrenoceptor and calcium antagonist field has shown that specific receptor antagonists have wide therapeutic applications.


Myocardial Infarction Angiotensin Converting Enzyme Calcium Antagonist Converting Enzyme Lower Blood Pressure 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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