The Endothelins and Platelet Aggregation

  • Winifred G. Nayler


Oscar Wilde might have been referring to the endothelins, since on the one hand they have the potential for causing or exacerbating systemic hypertension, renal artery stenosis, coronary artery occlusion, cerebral vasospasm, and atherosclerosis whilst on the other they inhibit platelet aggregation (Thiemermann et al. 1990) and can be fibrinolytic (Korbut et al. 1989). Except under conditions of severe trauma, when excessive blood loss might be a problem, the ability of these polypeptides to slow platelet aggregation and to activate the fibrinolytic system, must surely be regarded as desirable.


Platelet Aggregation Platelet Rich Plasma Renal Artery Stenosis Fibrinolytic Activity Cerebral Vasospasm 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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