Endothelin and Hypertension

  • Winifred G. Nayler


Although Johnson was referring to Goldsmith’s apology for what must have been some unseemly behaviour, his words are equally applicable to the endothelins — because if:
  1. (i)

    they are secreted in excess (particularly endothelin-1);

  2. (ii)

    removed slowly;

  3. (iii)

    their receptor density increases or their affinity changes; or

  4. (iv)
    the compensatory dilator mechanisms which include the release of either
    1. (a)

      ANP (Fukuda et al. 1988),

    2. (b)

      EDRF and prostacyclin (de Nucci et al.1988) fail, or diminish, then systemic vascular resistance may increase, because endothelin (endothelin-1) has a potent and sustained vasoconstrictor effect (Table 17.1).



Vasoconstrictor Effect Hypertensive State Constrictor Effect Affinity Change Binding Site Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

Personalised recommendations