Endothelin-1 and the Heart

  • Winifred G. Nayler


The previous chapter (Chapter 13) described the effect of endothelin-1 on the coronary circulation, where the polypeptide evokes a small but transient dilator response followed by a dose-dependent, sustained and potent constriction. The constrictor response was described as being receptor mediated, and involving
  1. (i)

    an enhanced influx of Ca2+ ions through the Ca2+-selective channels, and

  2. (ii)

    a phosphoinositol-mediated mobilization of intracellular Ca2+.



Polypeptide Verapamil PGE2 Nifedipine Vasopressin 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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