The previous chapter (Chapter 13) described the effect of endothelin-1 on the coronary circulation, where the polypeptide evokes a small but transient dilator response followed by a dose-dependent, sustained and potent constriction. The constrictor response was described as being receptor mediated, and involving
an enhanced influx of Ca2+ ions through the Ca2+-selective channels, and
a phosphoinositol-mediated mobilization of intracellular Ca2+.
KeywordsPolypeptide Verapamil PGE2 Nifedipine Vasopressin
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