Endothelin-1 and the Heart

  • Winifred G. Nayler


The previous chapter (Chapter 13) described the effect of endothelin-1 on the coronary circulation, where the polypeptide evokes a small but transient dilator response followed by a dose-dependent, sustained and potent constriction. The constrictor response was described as being receptor mediated, and involving
  1. (i)

    an enhanced influx of Ca2+ ions through the Ca2+-selective channels, and

  2. (ii)

    a phosphoinositol-mediated mobilization of intracellular Ca2+.



Atrial Natriuretic Peptide Positive Inotropic Effect Ventricular Muscle Inotropic Response High Affinity Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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