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Targeted Drug Delivery pp 181–230Cite as

Systemic Delivery of Pharmacologically Active Molecules Across the Skin

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 100))

Abstract

Continuous intravenous infusion of a systemically active drug at a programmed rate has been recognized as a superior mode of drug delivery not only to bypass hepatogastrointestinal “first-pass” elimination, but also to maintain a constant and prolonged plasma drug level within the therapeutically effective range. A closely monitored intravenous infusion can provide both the advantages of direct entry of drug into the systemic circulation and also the control of circulating drug levels. However, this mode of drug delivery entails certain potential risks and, therefore, necessitates hospitalization of the patient and close medical supervision of the drug administration.

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Authors
  1. Y. W. Chien
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Editors and Affiliations

  1. Department of Pharmacology, University of North Carolina School of Medicine, CB#7365, Faculty Laboratory Office Building, 27599-7365, Chapel Hill, NC, USA

    Rudolph L. Juliano Prof., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 1991 Springer-Verlag Berlin Heidelberg

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Chien, Y.W. (1991). Systemic Delivery of Pharmacologically Active Molecules Across the Skin. In: Juliano, R.L. (eds) Targeted Drug Delivery. Handbook of Experimental Pharmacology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75862-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-75862-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75864-5

  • Online ISBN: 978-3-642-75862-1

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