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The Natural History of Duodenal Ulcer Disease: Has it been Altered by Drug Therapy?

  • J. H. Lewis
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 99)

Abstract

Duodenal ulcer (DU) disease has been largely defined by aphorisms such as “once an ulcer, always an ulcer” (Spiro 1977). While there is general agreement that DU is a chronically relapsing disease characterized by recurrent exacerbations and remissions, our knowledge and understanding of this common disorder remain incomplete. Only a few studies have attempted to rigorously define the long-term natural history of DU, nearly all of which were conducted prior to endoscopy and the availability of H2 receptor antagonists and other new ulcer-healing drugs and the recognition of epidemiologic factors such as Helicobacter pylori (formerly Campylobacter pylori) as will be discussed.

Keywords

Peptic Ulcer Duodenal Ulcer Maintenance Therapy Peptic Ulcer Disease Ulcer Recurrence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adami H-O, Bergstrom R, Nyren O et al. (1987) Is duodenal ulcer really a psychosomatic disease? A population-based case-control study. Scand J Gastroenterol 22:889–896.PubMedGoogle Scholar
  2. Ahmed SZ, Levine M, Finkbiner R (1963) The seasonal incidence of complications of peptic ulcer. Ann Intern Med 59:165–171.PubMedGoogle Scholar
  3. Althausen TL (1949) Prevention of recurrence in peptic ulcer. Ann Intern Med 30:544–599.PubMedGoogle Scholar
  4. Andersen D (1985) Prevention of ulcer recurrence — medical vs. surgical treatment. The surgeon’s view. Scand J Gastroenterol [Suppl 110] 10:89–92.Google Scholar
  5. Bardhan KD (1981) Non-responders to cimetidine treatment, part 2. In: Baron JH (ed) Cimetidine in the 80’s. Churchill Livingstone, Edinburgh, pp 42–57.Google Scholar
  6. Bardhan KD (1984) Refractory duodenal ulcer. Gut 25:697–702.Google Scholar
  7. Bardhan KD (1986) Are antacids as effective as cimetidine in preventing duodenal ulcer relapse? A multi-center study. Gastroenterology 90:1336.Google Scholar
  8. Bardhan KD (1988) Intermittent treatment of duodenal ulcer for long-term medical management. Postgrad Med J [Suppl 1] 64:40–46.Google Scholar
  9. Bardhan KD, Hinchliffe RFC (1981) Effect of cimetidine on surgery for duodenal ulcer. Lancet 11:38.Google Scholar
  10. Bardhan K, Cole DS, Hawkins BW, Franks CR (1984) Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Br Med J 284:621–623.Google Scholar
  11. Battaglia G, Farini R, Di Mario F et al. (1984) Recurrence of duodenal ulcer under continuous antisecretory treatment: an approach to the detection of predictive markers. Am J Gastroenterol 1984; 79:831–834.Google Scholar
  12. Becker U, Faurschou V, Jensen J et al. (1984) Relapse prevention of duodenal ulcers with trimipramine, Ccimetidine or placebo. Scand J Gastroenterol 19:405–410.PubMedGoogle Scholar
  13. Behar J, Roufail W, Thomas E et al. (1986) Efficacy of sucralfate in the prevention of recurrence of duodenal ulcer. Gastroenterology 90:1343.Google Scholar
  14. Bianchi Porro G (1986) Maintenance therapy with De-Nol in peptic ulcer disease. De-Nol symposium: mucosal protection and peptic ulcer disease; World Congress of Gastroenterology, Sao Paulo, September 8, 1986.Google Scholar
  15. Bianchi Porro G, Petrillo M (1986) The natural history of peptic ulcer disease: the influence of H2-antagonist treatment. Scand J Gastroenterol [Suppl 121] 21:46–52.Google Scholar
  16. Bingham JR (1960) Relation between climate and hemorrhage from duodenal ulcer. Gastroenterology 38:959.Google Scholar
  17. Blumenthal IS (1968) Digestive disease as a national problem. III. Social cost of peptic ulcer. Gastroenterology 54:86–92.PubMedGoogle Scholar
  18. Bockus HL (1974) The therapy of peptic ulcer, part I. Management of uncomplicated peptic ulcer. Gastroenterology 1(30):674–710.Google Scholar
  19. Boles RS Jr, Westerman MP (1954) Seasonal incidence and precipitating causes of hemorrhage from peptic ulcer. JAMA 156:1379–1383.Google Scholar
  20. Bonfils S, Baron JH, Blum A (1984) Uncontrolled factors in controlled trials of peptic ulcer. Dig Dis Sci 29:858–861.PubMedGoogle Scholar
  21. Bonnevie O (1975) The incidence of duodenal ulcer in Copenhagen County. Scand J Gastroenterol 10:385–393.PubMedGoogle Scholar
  22. Bonnevie O (1977) Causes of death in duodenal and gastric ulcer. Gastroenterology 73:1000–1004.PubMedGoogle Scholar
  23. Bonnevie O (1978) Survival in peptic ulcer. Gastroenterology 75:1055–1060.PubMedGoogle Scholar
  24. Bonnevie O (1985) Changing demographics of peptic ulcer disease. Dig Dis Sci 30(Suppl):8s–14s.PubMedGoogle Scholar
  25. Bonnevie O (1987) Developments in the treatment of peptic ulcer. Scand J Gastroenterol [Suppl 127] 22:51–54.Google Scholar
  26. Boyd EJS, Wilson JA, Wormsley KG (1983a) Review of ulcer treatment; role of ranitidine. J Clin Gastroenterol [Suppl 1] 5:133–141.Google Scholar
  27. Boyd EJS, Wilson JA, Wormsely KG (1983b) Effects of treatment compliance and overnight gastric secretion on outcome of maintenance therapy of duodenal ulcer with ranitidine. Scand J Gastroenterol 18:193–200.PubMedGoogle Scholar
  28. Boyd EJS, Wilson JA, Wormsley KG (1983c) Smoking impairs therapeutic gastric inhibition. Lancet I:95–97.Google Scholar
  29. Boyd EJS, Wilson JA, Wormsley KG (1984a) Safety of ranitidine maintenance treatment of duodenal ulcer. Scand J Gastroenterol 19:394–400.PubMedGoogle Scholar
  30. Boyd EJS, Wilson JA, Wormsley KG (1984b) The fate of asymptomatic recurrences of duodenal ulcer. Scand J Gastroenterol 19:808–812.PubMedGoogle Scholar
  31. Boyd EJS, Penston JG, Johnston DA, Wormsley KG (1989) Does maintenance therapy keep duodenal ulcers healed? Lancet I:1324–1327.Google Scholar
  32. Bresci G, Capria A, Federici G, Rindi G, Geloni M, Corsini G (1986) Prevention of relapse with various antiulcer drugs. Scand J Gastroenterol [Suppl 121] 21:58–62.Google Scholar
  33. Brinton W (1857) On the pathology symptoms and treatment of ulcer of the stomach. Churchill, London, p 155.Google Scholar
  34. Brook CW, Yeomans ND, McCarthy PG, Dudley FJ, Smallwood RA (1987) Relapse of duodenal ulceration after healing with omeprazole. Med J Aust 147:595–597.PubMedGoogle Scholar
  35. Brown P, Salmon PR, Thien-Htut, Read AE (1972) Double-blind trial of carbenoxolone sodium capsules in duodenal ulcer therapy, based on endoscopic diagnosis and follow-up. Br Med J iii:661–664.Google Scholar
  36. Brown RC (1930) The results of medical treatment of peptic ulcer. JAMA 95:1144–1148.Google Scholar
  37. Bytzer P, Lauritsen K, Rask-Madsen J (1986) Symptomatic recurrence of healed duodenal and prepyloric ulcers after treatment with ranitidine or high-dose antacid. A 1-year follow-up study. Scand J Gastroenterol 21:765–768.PubMedGoogle Scholar
  38. Capurso L, Dal Monte PR, Mazzeo F et al. (1984) Comparison of cimetidine 800 mg once daily and 400 mg twice daily in acute duodenal ulceration. Br Med J 289:1418–1420.Google Scholar
  39. Cargill JM, Peden N, Saunders JHB, Wormsley KG (1978) Very long-term treatment of peptic ulcer with cimetidine. Lancet 11:1113–1115.Google Scholar
  40. Cayer D, Sohmer MF, Ruffin JM (1957) The effect of prolonged continuous therapy on the course of chronic recurring peptic ulcer. Antacid therapy with dihydroxy aluminum aminoacetate (Alglyn). NC J 18:315–317.Google Scholar
  41. Chambers JB, Pryce D, Bland JM, Northfield TC (1987) Effect of bedtime ranitidine on overnight gastric acid output and intragastric pH: dose/response study and comparison with cimetidine. Gut 28:294–299.PubMedGoogle Scholar
  42. Christensen A, Bousfield R, Christiansen J (1988) Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists. Ann Surg 207:4–6.PubMedGoogle Scholar
  43. Classen M, Bethge H, Brunner G et al. (1983) Effect of sucralfate on peptic ulcer recurrence: a controlled double-blind multicenter study. Scand J Gastroenterol [Suppl ] 18:61–68.Google Scholar
  44. Coggon D, Lambert P, Langman MJS (1981) 20 years of hospital admissions for peptic ulcer in England and Wales. Lancet I:1302–1304.Google Scholar
  45. Coghlan JG, Gilligan D, Humphries H et al. (1987) Campylobacter pylori and recurrence of duodenal ulcers — a 12 month follow-up study. Lancet II:1109–1111.Google Scholar
  46. Colgan SM, Faragher EB, Whorwell PJ (1988) Controlled trial of hypnotherapy in relapse prevention of duodenal ulceration. Lancet I:1299–1300.Google Scholar
  47. Collen MJ, Hanan MR, Maher JA et al. (1980) Cimetidine vs. placebo in duodenal ulcer therapy: six-week controlled double-blind investigation without any antacid therapy. Dig Dis Sci 25:744–749.PubMedGoogle Scholar
  48. Collen MJ, Stanczak VJ, Ciarleglio CA (1989) Refractory duodenal ulcers (nonhealing duodenal ulcers with standard doses of antisecretory medication). Dig Dis Sci 34:233–237.PubMedGoogle Scholar
  49. Collier DStJ, Pain JA (1985) Anti-inflammatory drugs and upper gastrointestinal ulcer perforation. Clin Rheumatol 4:389–391.PubMedGoogle Scholar
  50. Craig JD (1948) The evolution of gastric and duodenal ulceration. Br Med J 2:330–334.PubMedGoogle Scholar
  51. Danilewitz M, Tim LO, Hirschowitz B (1982) Ranitidine suppression of gastric hypersecretion resistant to cimetidine. N Engl J Med 306:20–22.PubMedGoogle Scholar
  52. De Gara CJ, Gledhill T, Hunt RH (1986) Nocturnal gastric acid secretion: its importance in the pathophysiology and rational therapy of duodenal ulcer. Scand J Gastroenterol [Suppl 121] 21:17–24.Google Scholar
  53. Dew MJ (1987) Asymptomatic peptic ulcer disease. Br Med J 295:401.Google Scholar
  54. Diaz-Rubio M (1988) Obstacles to maintenance therapy in peptic ulcer. Res Clin Forums 10(2):63–70.Google Scholar
  55. Dobrilla G, Vallaperta P, Amplatz S (1988) Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials. Gut 29:181–187.PubMedGoogle Scholar
  56. Doll R, Jones FA, Bukatzsch MM (1951) Occupational factors in the etiology of gastric and duodenal ulcers with an estimate of their incidence in the general population. Medical Research Cancelled Special Report Series, no 276, p 96. HRM Stationery Office.Google Scholar
  57. Donaldson RM (1975) Factors complicating observed associations between peptic ulcer and other diseases. Gastroenterology 68:1608–1614.PubMedGoogle Scholar
  58. Dooley CP, Larson AW, Stace NH et al. (1984) Double-contrast barium meal and upper gastrointestinal endoscopy: a comparative study. Ann Intern Med 101:538–545.PubMedGoogle Scholar
  59. Dragstedt LR (1969) Peptic ulcer, an abnormality in gastric secretion. Am J Surg 117:143–156.PubMedGoogle Scholar
  60. Dronfield MW, Batchelor AJ, Larkworthy W, Langman MJS (1979) Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects. Gut 20:526–530.PubMedGoogle Scholar
  61. Dunn JP, Etter LE (1962) Inaccuracy of the medical history in the diagnosis of duodenal ulcer. N Engl J Med 266:68–72.PubMedGoogle Scholar
  62. Dyck WP, Cloud ML, Offen WW et al. (1987) Treatment of duodenal ulceration in the United States. Scand J Gastroenterol [Suppl 136] 22:47–55.Google Scholar
  63. Editorial (1978) Cimetidine for ever (and ever and ever … )? Br Med J I:1435-1436.Google Scholar
  64. Einhorn M (1930) Seasonal incidence and study of factors influencing the production of one thousand recurrences in eight hundred patients. Am J Med Sci 179:259–264.Google Scholar
  65. Elashoff JD, Grossman MI (1980) Trends in hospital admissions and death rates for peptic ulcer in the United States from 1970 to 1978. Gastroenterology 78:280–285.PubMedGoogle Scholar
  66. Elashoff JD, Van Deventer G, Reedy TJ et al. (1983) Long-term follow-up of duodenal ulcer patients. J Clin Gastroenterol 5:509–515.PubMedGoogle Scholar
  67. Emery ES Jr, Monroe RT (1979) Peptic ulcer: a study of five hundred and fifty six cases. Arch Intern Med 43:846–873.Google Scholar
  68. Emery ES Jr, Monroe RT (1935) Peptic ulcer: nature and treatment based on a study of one thousand, four hundred and thirty five cases. Arch Intern Med 55:271–292.Google Scholar
  69. Eusterman GB, Balfour DC (eds) (1935) The stomach and duodenum. Saunders, Philadelphia.Google Scholar
  70. Fenwick S, Fenwick WS (1900) Ulcer of the stomach and duodenum. Churchill, London.Google Scholar
  71. Fich A, Goldin E, Zimmerman J, Rachmilewitz D (1988) Seasonal variations in the frequency of endoscopically diagnosed duodenal ulcer in Israel. J Clin Gastroenterol 10:380–382.PubMedGoogle Scholar
  72. Fineberg HV, Pearlman LA (1981) Surgical treatment of peptic ulcer in the United States: trends before and after the introduction of cimetidine. Lancet I:1305–1307.Google Scholar
  73. Fitzpatrick WJF, Blackwood WS, Northfield JC (1982) Bedtime cimetidine maintenance treatment: optimum dose and effect on subsequent natural history of duodenal ulcer. Gut 23:239–242.PubMedGoogle Scholar
  74. Flood CA (1948) Recurrence in duodenal ulcer under medical management. Gastroenterology 10:184–185.PubMedGoogle Scholar
  75. Flood CA (1955) The results of medical treatment of peptic ulcer. J Chronic Dis 1:43–50.PubMedGoogle Scholar
  76. Fontana G, Nizzoli N, Da Broi GL et al. (1986) Pirenzepine for long-term treatment of duodenal ulcer: a controlled multicenter trial. Dig Dis Sci [Suppl 10] 31:208s.Google Scholar
  77. Fordtran JS (1978) Placebo, antacids and cimetidine for duodenal ulcer. N Engl J Med 298:1081–1083.PubMedGoogle Scholar
  78. Frederiksen JHB, Matzen P, Madsen P et al. (1984) Spontaneous healing of duodenal ulcers. Scand J Gastroenterol 19:417–421.PubMedGoogle Scholar
  79. Friedenwald J (1912) A clinical study of a thousand cases of ulcers of the stomach and duodenum. Am J Med Sci 144:157–170.Google Scholar
  80. Fry J (1964) Peptic ulcer: a profile. Br Med J II:809–812.Google Scholar
  81. Fullman H, Van Deventer G, Schneidman D, Walsh J, Elashoff J, Weinstein W (1985) “Healed” duodenal ulcers are histologically ill. Gastroenterology 88:1390.Google Scholar
  82. Galmiche JP, Desechalliers JP, Denis P et al. (1982) Ranitidine treatment of cimetidine resistant peptic ulcers: preliminary clinical and 24-hour intragastric acidity results. In: Misiewicz JJ, Wormsley KG (eds) Clinical use of ranitidine. 2nd international symposium on ranitidine London, October 1981. Oxford, Medicine Publishing Foundation, pp 243–250.Google Scholar
  83. Gardiner GC, Pinsky W, Myerson RM (1966) The seasonal incidence of peptic ulcer activity — fact or fancy? With special reference to gastrointestinal hemorrhage. Am J Gastroenterol 45:22–28.PubMedGoogle Scholar
  84. Gibinski K (1983) Step by step towards the natural history of peptic ulcer disease. J Clin Gastroenterol 5:299–302.PubMedGoogle Scholar
  85. Gibinski K, Rybicka J, Nowak A, Czarneck A (1982) Seasonal occurrence of abdominal pain and endoscopic findings in patients with gastric and duodenal ulcer disease. Scand J Gastroenterol 17:481–485.PubMedGoogle Scholar
  86. Gibinski K, Nowak A, Butruk E et al. (1986) Seasonal prevention of duodenal ulcer recurrence with pirenzepine. Dig Dis Sci [Suppl 10] 31:200s.Google Scholar
  87. Gillen P, Ryan W, Peel ALG, Devlin HB (1986) Duodenal ulcer perforation: the effect of H2 antagonists? Ann R Coll Surg Engl 68:240–242.PubMedGoogle Scholar
  88. Gitlin N, McCullough AJ, Smith JL et al. (1987) A multicenter, double-blind, randomized, placebo-controlled comparison of nocturnal and twice-a-day famotidine in the treatment of active duodenal ulcer disease. Gastroenterology 92:48–53.PubMedGoogle Scholar
  89. Gough KR, Korman MG, Bardhand KD et al. (1984) Ranitidine and cimetidine in prevention of duodenal ulcer relapse. Lancet II:659–662.Google Scholar
  90. Greibe J, Bugge P, Gjorup T, Lauritzen T, Bonnevie O, Wulff HR (1977) Long-term prognosis of duodenal ulcers; follow-up study in survey of doctor’s estimates. Br Med J 2:1572–1574.PubMedGoogle Scholar
  91. Gustavsson S, Adami H-O, Loof L, Nyberg A, Nyren O (1983) Rapid healing of duodenal ulcers with omeprazole: double-blind dosecomparative trial. Lancet II:124–125.Google Scholar
  92. Gustavsson S, Kelly KA, Melton LJ III, Zinsmeister AR (1988) Trends in peptic ulcer surgery. A population-based study in Rochester, Minnesota, 1956–1985. Gastroenterology 94:688–694.PubMedGoogle Scholar
  93. Hamilton I, O’Conner JH, Wood NC, Bradbury I, Axon ATR (1986) Healing and recurrence of duodenal ulcer after treatment with tripotassium dicitrato bismuthate (TDB) tablets or cimetidine. Gut 27:106–110.PubMedGoogle Scholar
  94. Hasan M, Sircus W (1981) Factors determining success or failure of cimetidine treatment of peptic ulcer. J Clin Gastroenterol 3:225–229.PubMedGoogle Scholar
  95. Hollander D, Tarnawski A (1986) Dietary essential fatty acids and the decline in peptic ulcer disease — a hypohesis. Gut 27:239–242.PubMedGoogle Scholar
  96. Howden CW, Jones DB, Hunt RH (1985) Nocturnal doses of H2 receptor antagonists for duodenal ulcer. Lancet I:647–648.Google Scholar
  97. Hurst AF, Stewart MJ (1929) Gastric and duodenal ulcer. Oxford University Press, New York, p 544.Google Scholar
  98. Ippoliti AF (1985) Prognostic factors in ulcer disease: are they real, are they relevant? J Clin Gastroenterol 7:445–446.PubMedGoogle Scholar
  99. Ireland A, Colin-Jones DG, Gear P et al. (1984) Ranitidine 150 mg twice daily vs 300mg nightly in treatment of duodenal ulcers. Lancet II:274–276.Google Scholar
  100. Ivy AC (1946) The problem of peptic ulcer. JAMA 132:1053–1059.Google Scholar
  101. Ivy AC, Grossman MI, Bachrach WH (1950) Peptic ulcer. Blakiston, Philadelphia.Google Scholar
  102. Jennings D (1940) Perforated peptic ulcer. Changes in age-incidence and sex-distribution in the last 150 years. Lancet I:395–398; 444-447.Google Scholar
  103. Jensen DM, Machicado GA, Kovacs TOG et al. (1989) Long-term recurrence rates of peptic ulceration and rebleeding with H2 maintenance, surgery or no maintenance therapy. Gastroenterology 96:A239.Google Scholar
  104. Jonasson TA, Brekkan A, Jonmundsson E, Bjarnason T, Bonnevie O (1983) Epidemiologic study of peptic ulcer in Iceland. Scand J Gastroenterol [Suppl 86] 18:32.Google Scholar
  105. Jones DB, Howden CW, Burget DW, Kerr GD, Hunt RH (1987) Acid suppression in duodenal ulcer: a meta-analysis to define optimal dosing with antisecretory drugs. Gut 28:1120–1127.PubMedGoogle Scholar
  106. Jordan PH Jr. (1985) Duodenal ulcers and their surgical treatment: where did they come from. Am J Surg 149:2–14.PubMedGoogle Scholar
  107. Kang JY, Piper DW (1982) Cimetidine and colloidal bismuth in treatment of chronic duodenal ulcer. Comparison of initial healing and recurrence after healing. Digestion 23:73–79.PubMedGoogle Scholar
  108. Kikendall JW, Evaul J, Johnson LF (1984) Effect of cigarette smoking on gastrointestinal physiology and non-neoplastic digestive disease. J Clin Gastroenterol 6:65–79.PubMedGoogle Scholar
  109. Klein KB, Spiegel D (1989) Modulation of gastric acid secretion by hypnosis. Gastroenterology 96:1383–1387.PubMedGoogle Scholar
  110. Koo J, Ngany K, Lam SK (1983) Trends in hospital admissions, perforation, and mortality of peptic ulcer in Hong Kong from 1970 to 1980. Gastroenterology 84:1558–1562.PubMedGoogle Scholar
  111. Korman MG, Hetzel DJ, Hansky J, Shearman DJC, Don G (1980) Relapse rate of duodenal ulcer after cessation of long-term cimetidine treatment. A double-blind controlled study. Dig Dis Sci 25:88–91.PubMedGoogle Scholar
  112. Korman MG, Hansky J, Eaves ER, Schmidt GT (1983) Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology 85:871–874.PubMedGoogle Scholar
  113. Krag E (1966) Long-term prognosis in medically treated peptic ulcer. A clinical, radiographical and statistical follow-up study. Acta Med Scand 180:657–670.PubMedGoogle Scholar
  114. Krarup NB (1946) On the results of the medical treatment of peptic ulcer. Acta Med Scand 123:181–207.PubMedGoogle Scholar
  115. Krause U (1963) Long-term results of medical and surgical treatment of peptic ulcer. A follow-up investigation of patients initially treated conservatively between 1925–34. Acta Chir Scand [Suppl 310] 125:1–111.Google Scholar
  116. Kumar N, Vij JC, Sorin SK et al. (1984) DO chillies influence healing of duodenal ulcer? Br Med J 288:1803–1804.Google Scholar
  117. Kurata JH (1983) What in the world is happening to ulcers? Gastroenterology 84:1623–1625.PubMedGoogle Scholar
  118. Kurata JH (1989) Ulcer epidemiology: an overview and proposed research framework. Gastroenterology [2,2 Suppl] 96:569–580.Google Scholar
  119. Kurata JH, Corboy ED (1988) Current peptic ulcer time trends. An epidemological profile. J Clin Gastroenterol 10:259–268.PubMedGoogle Scholar
  120. Kurata JH, Haile DM (1984) Epidemiology of peptic ulcer disease. Clin Gastroenterol 13:289–307.PubMedGoogle Scholar
  121. Kurata JH, Elashoff JD, Haile BM et al. (1983) A reappraisal of time trends in ulcer disease: factors related to changes in ulcer hospitalization and mortality rates. Am J Public Health 73:1066–1072.PubMedGoogle Scholar
  122. Kurata JH, Haile BM, Elashoff JD (1985) Sex differences in peptic ulcer disease. Gastroenterology 88:96–100.PubMedGoogle Scholar
  123. Kurata JH, Koch GG, Nogawa AN (1987) Comparison of ranitidine and cimetidine ulcer maintenance therapy. J Clin Gastroenterol 9:644–650.PubMedGoogle Scholar
  124. Lam S-K, Lai C-L, Lee LNW et al. (1985) Factors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who fail to heal. Dig Dis Sci 30:45–51.PubMedGoogle Scholar
  125. Lane MR, Lee SP (1988) Recurrence of duodenal ulcer after medical treatment. Lancet I:1147–1149.Google Scholar
  126. Langman MJ (1989) Epidemologic evidence on the association between peptic ulceration and antiinflammatory drug use. Gastroenterology [2, 2 Suppl] 96:640–646.Google Scholar
  127. Lee FI, Samloff IM, Hardman M (1985) Comparison of tri-potassium di-citrato bismuthate tablets with ranitidine in healing and relapse of duodenal ulcers. Lancet I:1299–1302.Google Scholar
  128. Lee FI, Hardman M, Jaderberg M (1989a) Maintenance treatment of duodenal ulceration: comparison of ranitidine 300mg and 150mg at night. Am J Gastroenterol 84:1165.Google Scholar
  129. Lee S, Iida M, Yao T, Shindo S, Fujishima M, Okabe H (1989b) Long-term follow-up of 2529 patients with gastric and duodenal ulcer: survival rate and causes of death. Gastroenterology 96:381–386.Google Scholar
  130. Levrat M, Pasquier J, Lambert R, Tissot A (1966) Peptic ulcer in patients over 60. Experience in 287 cases. Am J Dig Dis 11:279–285.PubMedGoogle Scholar
  131. Levrat M, Descos L, Pasquier J et al. (1968) Evolution a long terme des ulceres gastro-duodenaux. Statistique de 421 malades avec un recurl de plus de 10 ans. Arch Fr Mal App Dig 57:141–152.PubMedGoogle Scholar
  132. Lewis JH (1985) Summary of the Gastrointestinal Drugs Advisory Committee Meeting-March 21 and 22, 1985. Am J Gastroenterol 80:581–583.PubMedGoogle Scholar
  133. Lewis JH. Summary of the 20th meeting of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee January 16–17, 1986. Am J Gastroenterol 1986; 81:495–498.PubMedGoogle Scholar
  134. Lewis JH (1989a) Long-term management of peptic ulcer disease. Compr Ther 15:55–61.PubMedGoogle Scholar
  135. Lewis JH (1989b) Safety profile of long-term H2-antagonist therapy. Transatlantic Converence on acid/peptic disorders. AV/MD Group, New York, pp 22–25.Google Scholar
  136. Lewis JH (1991) Peptic ulcer. In: Rakel RE (ed) Conn’s current therapy, 1991 edn. Saunders, Philadelphia, pp 474–481.Google Scholar
  137. Lewis JH, Woods M (1982) Gastric carcinoma occurring in patients with unoperated duodenal ulcer disease. Am J Gastroenterol 77:368–373.PubMedGoogle Scholar
  138. Lewis JH, Steinberg WS, Katz DM (1982) Variable pH response to cimetidine. Gastroenterology 82:1114.Google Scholar
  139. Loof L, Adami H-O, Bates S et al. (1987) Psychological group counseling for the prevention of ulcer relapses. J Clin Gastroenterol 9:400–407.PubMedGoogle Scholar
  140. Malmros H, Hiertonn T (1949) A post-investigation of 687 medically treated cases of peptic ulcer. Acta Med Scand 133:229–252.PubMedGoogle Scholar
  141. Marshall BJ (1988) The Campylobacter pylori story. Scand J Gastroenterol [Suppl 146] 23:58–66.Google Scholar
  142. Marshall BJ, Goodwin CS, Warren JR et al. (1988) Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet II:1437–14Google Scholar
  143. Martin DF, Hollanders D, May SJ, Ravenscroft MM, Tweedle DEF, Miller JP (1981) Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate. Lancet 1:7–10.PubMedGoogle Scholar
  144. Matthewson K, Pugh S, Northfield TC (1988) Which peptic ulcer patients bleed? Gut 29:70–74.PubMedGoogle Scholar
  145. Mayo WJ (1906) Ulcers of the duodenum from a surgical standpoint. Br Med J 2:1299–1302.Google Scholar
  146. Mazzacca G, D’Agostino L, D’Arienzo A et al. (1982) Cimetidine or ranitidine non-responder patients. Treatment of duodenal ulcers resistant to one H2 blocker with the other. Scand J Gastroenterol [Suppl 78] 17:103.Google Scholar
  147. McIsaac RL, McCanless I, Summers K, Wood JR (1987) Ranitidine and cimetidine and the healing of duodenal ulcer: meta-analysis of comparative clinical trials. Aliment Pharmacol Ther 1:369–381.PubMedGoogle Scholar
  148. Meade TW, Arie THD, Brewis M et al. (1968) Recent history of ischemic heart disease and duodenal ulcer in deaths. Br Med J 3:701–704.PubMedGoogle Scholar
  149. Mellem H, Stave R, Myren J et al. (1985) Symptoms in patients with peptic ulcer and hematemesis and/or melena related to the use of non-steroid anti-inflammatory drugs. Scand J Gastroenterol 20:1246–1248.PubMedGoogle Scholar
  150. Mendeloff AI (1974) What has been happening to duodenal ulcer? Gastroenterology 67:1020–1022.PubMedGoogle Scholar
  151. Michener WM, Kennedy RLJ, DuShane JW (1960) Duodenal ulcer in childhood: ninety-two cases with follow-up. Am J Dis Child 100:814–817.PubMedGoogle Scholar
  152. Miller JP (1990) Maintenance of duodenal ulcer healing by antacids. Scand J Gastroenterol 25(Suppl 174):54–59.Google Scholar
  153. Monson RR, MacMahon B (1969) Peptic ulcer in Massachusetts physicians. N Engl J Med 281:11–15.PubMedGoogle Scholar
  154. Moshal MG, Spitaels JM, Robbs JV, MacLeod IN, Good CJ (1981) Eight-year experience with 3392 endoscopically proven duodenal ulcers in Durban, 1972–79. Rise and fall of duodenal ulcers and a theory of changing dietary and social factors. Gut 22:327–331.PubMedGoogle Scholar
  155. Moshal MG, Spitaels JM, Khan F (1981) Short-and long-term studies of duodenal ulcer with sucralfate. J Clin Gastroenterol [Suppl 2] 3:159–161.Google Scholar
  156. Moynihan BGA (1910) Duodenal ulcer. Saunders, Philadelphia.Google Scholar
  157. Naesdal J, Lind T, Bergsaker-Aspoy J et al. (1985) The rate of healing of duodenal ulcers during omeprazole treatment. Scand J Gastroenterol 20:691–695.PubMedGoogle Scholar
  158. Nasiry RW, McIntosh JH, Byth K, Piper DU (1987) Prognosis of chronic duodenal ulcer: a prospective study of the effects of demographic and environmental factors and ulcer healing. Gut 28:533–540.PubMedGoogle Scholar
  159. Natvig P, Romcke O, Svaar-Seljesaeter O (1943) Results of medical treatment of gastric and duodenal ulcer. Acta Med Scand 113:444–458.Google Scholar
  160. O’Hara H (1875) Perforating or corrosive ulcer of the duodenum. Trans Pathol Soc Phil 6:37.Google Scholar
  161. Ostensen H, Burhol PG, Stormer J, Bonnevie O (1985a) The incidence of peptic ulcer disease related to occupation in the northern part of Norway. A prospective epidemiological and radiological study. Scand J Gastroenterol 20:79–82.PubMedGoogle Scholar
  162. Ostensen H, Gudmundsen TE, Bolz KD, Burhol PG, Bonnevie O (1985b) The incidence of gastric ulcer and duodenal ulcer in north Norway. A prospective epidemiological study. Scand J Gastroenterol 20:189–192.PubMedGoogle Scholar
  163. Ostensen H, Gudmundsen TE, Burhol PG, Bonnevie O (1985c) Seasonal periodicity of peptic ulcer disease. A prospective radiologic study. Scand J Gastroenterol 20:1281–1284.PubMedGoogle Scholar
  164. Palmas F, Andriulli A, Canepa G et al. (1984) Monthly fluctuations of active duodenal ulcers. Dig Dis Sci 29:983–987.PubMedGoogle Scholar
  165. Palmas F, Andriulli A, Verme G (1984) Seasonal treatment with ranitidine. Lancet II:698–699.Google Scholar
  166. Palmer WL (1974) The therapy of peptic ulcer. II. Radiation therapy. Gastroenterology 1(30):710–719.Google Scholar
  167. Paoluzi P, Ricotta G, Ripoli F et al. (1985) Incompletely and completely healed duodenal ulcers’ outcome in maintenance treatment: a double blind controlled study. Gut 26:1080.PubMedGoogle Scholar
  168. Penston JG (1990) The efficacy and safety of long-term maintenance treatment of duodenal ulcers with ranitidine. Scand J Gastroenterol 25 (Suppl) 177:1–104.Google Scholar
  169. Penston JG, Wormsley KG (1988) Long-term treatment of duodenal ulcers. Gastroenterology 94:A349.Google Scholar
  170. Permutt RP, Cello JP (1982) Duodenal ulcer disease in the hospitalized elderly patient. Dig Dis Sci 27:1–6.PubMedGoogle Scholar
  171. Perry EA, Shaw LE (1893) On disease of the duodenum. Guys Hosp Rep 50:171–176.Google Scholar
  172. Peters MN, Richardson CT (1983) Stressful life events, acid hypersecretion, and ulcer disease. Gastroenterology 84:114–119.PubMedGoogle Scholar
  173. Postlethwait RW (1979) Retrospective study of operations for peptic ulcer. Surg Gynecol Obstet 149:703–708.PubMedGoogle Scholar
  174. Pounder RE (1981) Model of medical treatment for duodenal ulcer. Lancet I:29–30.Google Scholar
  175. Pulvertaft CN (1968) Comments on the incidence and natural history of gastric duodenal ulcer. Postgrad Med J 44:597–602.PubMedGoogle Scholar
  176. Quatrini M, Basilisco G, Bianchi PA (1984) Treatment of “cimetidine-resistant” chronic duodenal ulcers with ranitidine or cimetidine: a randomized multicentre study. Gut 25:1113–1117.PubMedGoogle Scholar
  177. Quigstad I, Romcke O (1946) Post-investigation of medically treated gastric and duodenal ulcers. II. Acta Med Scand 126:34–39.Google Scholar
  178. Reynolds JC (1989) Famotidine therapy for active duodenal ulcers. A multivariate analysis factors affecting early healing. Ann Intern Med 111:7–14.PubMedGoogle Scholar
  179. Ries RK, Gilbert DA, Katon W (1984) Tricyclic antidepressant therapy for peptic ulcer disease. Arch Intern Med 144:566–569.PubMedGoogle Scholar
  180. Romcke O, Loken E (1956) Prognosis of peptic ulcer in young patients. Acta Med Scand 155:373–375.PubMedGoogle Scholar
  181. Rydning A, Berstad A (1985) Dietary aspects of peptic ulcer disease. Scand J Gastroenterol [Suppl 110] 20:29–33.Google Scholar
  182. Safrany L, Schott B, Portocarrero G, Krause S, Neuhaus B (1982) Spring and autumn disposition to gastroduodenal ulcer. Dtsch Med Wochenschr 107:685–687.PubMedGoogle Scholar
  183. Sargent J (1954) Fatal peritonitis from perforation of the duodenum. Am J Med Sci 28:116–117.Google Scholar
  184. Sasaki H, Nagulesparan M, Samloff IM, Straus E, Sievers ML, Dubois A (1984) Low acid output in Pirna Indians. A possible cause for the rarity of duodenal ulcer in this population. Dig Dis Sci 29:785–789.PubMedGoogle Scholar
  185. Scapa E, Horowitz M, Waron M, Eshchar J (1989) Duodenal ulcer in the elderly. J Clin Gastroenterol 11:502–506.PubMedGoogle Scholar
  186. Schmidt K, Mosbech J, Banke L (1984) Morbidity of peptic ulcer. Registration of hospital discharges in Denmark 1978–1980. Scand J Gastroenterol 19:849–852.PubMedGoogle Scholar
  187. Segawa K, Nakazawa S, Tsukamoto Y et al. (1987) Peptic ulcer is prevalent among shift workers. Dig Dis Sci 32:449–453.PubMedGoogle Scholar
  188. Shreeve DR, Klass HJ, Jones PE (1983) Comparison of cimetidine and tripotassium discitrato bismuthate in healing and relapse of duodenal ulcers. Digestion 28:96–101.PubMedGoogle Scholar
  189. Silvis SE et al. (1985) Final report on the United States multicenter trial comparing rantidine to cimetidine as maintenance therapy following healing of duodenal ulcer. J Clin Gastroenterol 7:482–487.PubMedGoogle Scholar
  190. Slater PE (1989) High winter incidence of duodenal ulcer in Israel. J Clin Gastroenterol 11:587–588.PubMedGoogle Scholar
  191. Smith LA, Rivers AB (1953) Peptic ulcer; pain patterns, diagnosis and medical treatment. Appleton-Century Crofts, New YorkGoogle Scholar
  192. Smith MP (1977) Decline in duodenal ulcer surgery. JAMA 237:987–988.PubMedGoogle Scholar
  193. Solhaug JH, Carling L, Glise H et al. (1987) Ulcer recurrences following initial ulcer healing with sucralfate or cimetidine. Scand J Gastroenterol [Suppl 127] 22:77–80.Google Scholar
  194. Somerville K, Faulkner G, Langman M (1986) Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet I:462–464.Google Scholar
  195. Sonnenberg A (1984) The occurrence of a cohort phenomenon in peptic ulcer mortality from Switzerland. Gastroenterology 86:398–401.PubMedGoogle Scholar
  196. Sonnenberg A (1985) Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol [Suppl 110] 20:11–24.Google Scholar
  197. Sonnenberg A (1985) Decision analysis of different strategies for long-term treatment of duodenal ulcer. Gastroenterology 88:1593.Google Scholar
  198. Sonnenberg A (1989) Costs of medical and surgical treatment of duodenal ulcer. Gastroenterology 96:1445–1452.PubMedGoogle Scholar
  199. Sonnenberg A (1987) Changes in physician visits for gastric and duodenal ulcer in the United States during 1958–1984 as shown by National Disease and Therapeutic Index (NDTI). Dig Dis Sci 32:1–7.PubMedGoogle Scholar
  200. Sonnenberg A, Fritsch A (1983) Changing mortality of peptic ulcer disease in Germany. Gastroenterology 84:1553–1557.PubMedGoogle Scholar
  201. Sonnenberg A, Muller-Lissner SA, Vogel E et al. (1981) Predictors of duodenal ulcer healing and relapse. Gastroenterology 81:1061–1067.PubMedGoogle Scholar
  202. Sonnenberg A, Muller H, Pace F (1985) Birth-cohort analysis of peptic ulcer mortality in Europe. J Chronic Dis 38:309–317.PubMedGoogle Scholar
  203. Sontag SJ (and the ACG Committee on FDA-Related Matters) (1988) Current status of maintenance therapy in peptic ulcer disease. Am J Gastroenterol 93:607–617.Google Scholar
  204. Sontag S, Graham DY, Belsito A et al. (1984) Cimetidine, cigarette smoking, and recurrence of duodenal ulcer. N Engl J Med 311:689–693.PubMedGoogle Scholar
  205. Spiro HM (1977) Clinical gastroenterology, 2nd edn. Macmillan, New York, p 270.Google Scholar
  206. Steinberg WM, Lewis JH, Katz DM (1984) Transient cimetidine resistance. J Clin Gastroenterol 6:355–359.PubMedGoogle Scholar
  207. Stern WR (1989) Summary of the 34th meeting of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee March 15 and 16, 1989 (omeprazole and domperidone). Am J Gastroenterol 84:1351–1355.PubMedGoogle Scholar
  208. Strom M, Berstad A, Bodemar G, Walan A (1986) Results of short-and long-term cimetidine treatment in patients with juxtapyloric ulcers, with special reference to gastric acid and pepsin secretion. Scand J Gastroenterol 21:521–530.PubMedGoogle Scholar
  209. Strum WB (1986) Prevention of duodenal ulcer recurrence. Ann Intern Med 105:757–761.PubMedGoogle Scholar
  210. Sturdevant RAL (1976) Epidemiology of peptic ulcer. Am J Epidemiol 104:9–14.PubMedGoogle Scholar
  211. Susser M (1961) Environmental factors and peptic ulcer. Practitioner 186:302–311.Google Scholar
  212. Susser M (1967) Causes of peptic ulcer. A selective epidemiologic review. J Chronic Dis 20:435–456.Google Scholar
  213. Susser M (1982) Period effects, generation effects and age effects in peptic ulcer mortality. J Chronic Dis 35:29–40.PubMedGoogle Scholar
  214. Susser M, Stein A (1962) Civilisation and peptic ulcer. Lancet I:115–119.Google Scholar
  215. Takemoto T, Okita K, Kimura K (1986) Efficacy of sucralfate, cimetidine and their combination in the prevention of peptic ulcer recurrence. A double-blind multicenter study. The 4th international sucralfate symposium, Sao Paulo, Brazil, September 8, 1986. Abstract no 9.Google Scholar
  216. Thomas JM, Misiewicz G (1984) Histamine H2-receptor antagonist in the short-and long-term treatment of duodenal ulcer. Clinics Gastroenterol 13:501–541.Google Scholar
  217. Thomas E, Reddy KR (1983) Nonhealing duodenal ulceration due to Candida. J Clin Gastroenterol 5:55–58.PubMedGoogle Scholar
  218. Tidy H (1945) The incidence of peptic ulcer at St. Thomas Hospital 1910–1937. Br Med J II:319.Google Scholar
  219. Tilvis RS, Vuoristo M, Varis K (1987) Changed profile of peptic ulcer disease in hospital patients during 1969–1984 in Finland. Scand J Gastroenterol 22:1238–1244.PubMedGoogle Scholar
  220. Tytgat GNJ, Hameeteman W, Van Olffer GH (1984) Sucralfate, bismuth compounds, substituted benzimidazoles, trimipramine and pirenzepine in the short-and long-term treatment of duodenal ulcer. Clin Gastroenterol 13:543–568.PubMedGoogle Scholar
  221. Valnes K, Myren J, Witterhus S et al. (1982) Long-term treatment of duodenal ulcer with trimipramine. Scand J Gastroenterol 17:1003–1007.PubMedGoogle Scholar
  222. Van Deventer GM (1984) Approaches to the long-term treatment of duodenal ulcer disease. Am J Med [Suppl 5b] 77:15–22.Google Scholar
  223. Van Deventer GM, Elashoff JD, Reedy TJ, Schneidman D, Walsh JH (1989) A randomized study of maintenance therapy with ranitidine to prevent the recurrence of duodenal ulcer. N Engl J Med 320:1113–1119.PubMedGoogle Scholar
  224. Vogt TM, Johnson RE (1980) Recent changes in the incidence of duodenal and gastric ulcer. Am J Epidemiol 111:713–720.PubMedGoogle Scholar
  225. Walan A (1984) Antacids and anticholinergics in the treatment of duodenal ulcer. Clin Gastroenterol 13:473–449.PubMedGoogle Scholar
  226. Walan A, Strom M (1985) Prevention of ulcer recurrence — medical vs. surgical treatment. The physician’s view. Scand J Gastroenterol [Suppl 110] 20:83–88.Google Scholar
  227. Walan A, Bardhan KD, Bianchi Porro G et al. (1985) A comparison of two different doses of omeprazole versus ranitidine in duodenal ulcer (DU) healing. Gastroenterology 88:1625.Google Scholar
  228. Walan A, Bianchi-Porro G, Hentschel E, Bardhan KD, Delattre M (1987) Maintenance treatment with cimetidine in peptic ulcer disease for up to 4 years. Scand J Gastroenterol 22:397–405.PubMedGoogle Scholar
  229. Walt R, Katschinski B, Logan R, Ashley J, Langman M (1986) Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet I:489–491.Google Scholar
  230. Welsh JD, Wolf S (1960) Geographical and environmental aspect of peptic ulcer. Am J Med 29:754–760.PubMedGoogle Scholar
  231. Wilbur DL (1935) The history of diseases of the stomach and duodenum with reference also to their etiology. In: Eusterman GB, Balfour DC (eds) The stomach and duodenum. Saunders, Philadelphia, pp 1–21.Google Scholar
  232. William Beaumont Society (1966) U.S. Army Report. Seasonal incidence of upper gastrointestinal tract bleeding; report of the standing committee on upper gastrointestinal bleeding. JAMA 198:184–185.Google Scholar
  233. Witzel L, Wolbergs E (1982) Peptic ulcer healing with ranitidine in cimetidine resistance. Lancet II:1224.Google Scholar
  234. Wolf S (1981) The psyche and the stomach. A historical vignette. Gastroenterology 80:605–614.PubMedGoogle Scholar
  235. Wormsley KG (1982) Problems in the treatment of peptic ulcer. Scand J Gastroenterol [Suppl 80] 17:43–48.Google Scholar
  236. Wormsley KG (1984) Assessing the safety of drugs for the long-term treatment of peptic ulcers. Gut 25:1416–1423.PubMedGoogle Scholar
  237. Wormsley KG (1988) Long-term treatment of duodenal ulcer. Postgrad Med J [Suppl 1] 64:47–53.Google Scholar
  238. Wylie CM (1981) The complex wane of peptic ulcer. I. Recent national trends in deaths and hospital care in the United States. J Clin Gastroenterol 3:327–332.PubMedGoogle Scholar
  239. Wyllie JH, Clark CG, Alexander-Williams J et al. (1981) Effect of cimetidine on surgery for duodenal ulcer. Lancet I:1307–1308.Google Scholar

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© Springer-Verlag Berlin Heidelberg 1991

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  • J. H. Lewis

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