The Natural History of Duodenal Ulcer Disease: Has it been Altered by Drug Therapy?

  • J. H. Lewis
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 99)


Duodenal ulcer (DU) disease has been largely defined by aphorisms such as “once an ulcer, always an ulcer” (Spiro 1977). While there is general agreement that DU is a chronically relapsing disease characterized by recurrent exacerbations and remissions, our knowledge and understanding of this common disorder remain incomplete. Only a few studies have attempted to rigorously define the long-term natural history of DU, nearly all of which were conducted prior to endoscopy and the availability of H2 receptor antagonists and other new ulcer-healing drugs and the recognition of epidemiologic factors such as Helicobacter pylori (formerly Campylobacter pylori) as will be discussed.


Peptic Ulcer Duodenal Ulcer Maintenance Therapy Peptic Ulcer Disease Ulcer Recurrence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1991

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  • J. H. Lewis

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