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The Pathology of Asthma: An Overview

  • Chapter
Pharmacology of Asthma

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 98))

Abstract

Classical dogma equates asthma with mucus plugs, bronchial smooth muscle hyperplasia, eosinophilia and thickening of the epithelial basement membrane. However, these characteristics are those seen at autopsy of lungs obtained from asthmatics who died from status asthmaticus and neither reflect the changes in early disease nor how they relate to disease severity (Houston et al. 1953; Cardell 1956; Dunnill et al. 1969; Thurlbeck et al. 1970). So far the fatal cases have contributed the most to our understanding of the pathological changes in asthma. In fact, until recent years it has been very uncommon to see biopsy material from asthmatics, and thus the histology of the airways of living stable asthmatics was unknown. The hallmark of asthma is the functional change associated with airways obstruction. At least in the early stages, bronchospasm is a function of smooth muscle tone, and it has been suggested that there may even not be any early morphological changes. Developments in bronchoscopic and electron microscopic techniques have been essential in obtaining knowledge of airway morphology in living asthmatics. In the future, along with the introduction of new techniques, special attention must be paid to careful patient characterization.

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Authors
  1. L. A. Laitinen
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  2. A. Laitinen
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, King’s College University of London, Manresa Road, SW3 6LX, London, Great Britain

    Clive P. Page B.Sc.,Ph.D. (Reader in Pharmacology) (Reader in Pharmacology)

  2. Department of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, Great Britain

    Peter J. Barnes M.A.,D.M.,D.Sc.,FRCP (Professor of Thoracic Medicine) (Professor of Thoracic Medicine)

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© 1991 Springer-Verlag Berlin Heidelberg

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Laitinen, L.A., Laitinen, A. (1991). The Pathology of Asthma: An Overview. In: Page, C.P., Barnes, P.J. (eds) Pharmacology of Asthma. Handbook of Experimental Pharmacology, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75855-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-75855-3_1

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