Abstract
The present study comprises a cytoarchitectonic analysis of the human substantia nigra (SN) and ventral tegmental area (VTA); a discussion of their chemoarchitecture and fiber connections (mainly based on tract-tracing studies in primates) preceded by an overview of the wealth of tract-tracing data in rodents; a discussion of the involvement of the SN/VTA complex in Parkinson’s disease (PD) and related disorders and in Alzheimer’s disease (AD), including some quantitative data; and finally, some functional and pathophysiological considerations, relating nigral organization to pathophysiology and hypotheses on the etiology and distribution of AD and PD.
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© 1991 Springer-Verlag Berlin Heidelberg
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van Domburg, P.H.M.F., ten Donkelaar, H.J. (1991). Summary. In: The Human Substantia Nigra and Ventral Tegmental Area. Advances in Anatomy Embryology and Cell Biology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75846-1_8
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DOI: https://doi.org/10.1007/978-3-642-75846-1_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52823-4
Online ISBN: 978-3-642-75846-1
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