Quantitative Aspects

  • Peter Henricus Maria Franciscus van Domburg
  • Hendrik Jan ten Donkelaar
Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 121)


Relatively little attention has been paid to the exact involvement of DAergic structures in the midbrain in diseases of the aging brain, especially dementia (see Sect. 5 for review). Cell loss in the SN and VTA is one of the main features in PD, whereas degenerative changes characteristic for AD have been suggested in the VTA and adjacent part of the SNc, i.e., those parts of the DAergic mesencephalic cell continuum with cortical projections (see Sects 4.4, 4.5, and 5.3). However, apart from Bogert’s study (Bogerts et al. 1983), neuronal densities in only a few sections were measured, which have to be considered carefully (see Coleman and Flood 1987 for discussion) and which at best give only a rough estimation of the actual cell loss in a given structure.


Cell Loss Spherical Diameter DAergic Neuron Ventral Cochlear Nucleus Pigment Neuron 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Peter Henricus Maria Franciscus van Domburg
    • 1
  • Hendrik Jan ten Donkelaar
    • 2
  1. 1.Departments of Anatomy/Embryology and Neurology Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department of Anatomy and Embryology Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands

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