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Role of Histamine in the Actions of Neuropeptides and Local Hormones

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Histamine and Histamine Antagonists

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 97))

Abstract

The major emphasis of this chapter is the contribution of histamine to the actions of neuropeptides. Over the past 10 years the study of neuropeptides has become one of the major areas of physiological research and has led to a new understanding of the complexities of the nervous system. The modern field of neuropeptide research had its beginnings with the isolation and structural characterization of the oldest neuropeptide, substance P, in the early 1970s. This was rapidly followed by discoveries of a number of other peptides which were present in the brain and peripheral tissues.

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References

  • Ali H, Leung KBP, Pearce FL, Hayes NA, Foreman JC (1986) Comparison of the histamine-releasing action of substance P on mast cells and basophils from different species and tissues. Int Arch Allergy Appl Immunol 79:413–418

    Article  PubMed  CAS  Google Scholar 

  • Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244

    Article  PubMed  CAS  Google Scholar 

  • Anand P, Bloom SR, McGregor GP (1983a) Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin. Br J Pharmacol 78:665–669

    PubMed  CAS  Google Scholar 

  • Anand P, Gibson SJ, McGregor GP, Blank MA, Ghatei MA, Bacarese-Hamilton AJ, Polak JM, Bloom SR (1983b) A VIP containing system concentrated in the lumbosacral region of human spinal cord. Nature 305:143–145

    Article  PubMed  CAS  Google Scholar 

  • Andrews PV, Helme RD (1986) Neurogenic plasma extravasation in response to mechanical, chemical and thermal stimuli. Clin Exp Neurol 23:95–100

    Google Scholar 

  • Arvier PT, Chahl LA Ladd RJ (1977) Modification by capsaicin and compound 48/80 of dye leakage induced by irritants in the rat. Br J Pharmacol 59:61–68

    PubMed  CAS  Google Scholar 

  • Barnes PJ, Brown MJ, Dollery CT, Fuller RW, Heavey DJ, Ind PW (1986) Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Br J Pharmacol 88:741–745

    PubMed  CAS  Google Scholar 

  • Bar-Shavit Z, Goldman R, Stabinsky Y, Gottlieb P, Fridkin M, Teichberg VI, Blumberg S (1980) Enhancement of phagocytosis-a newly found activity of substance P residing in its N-terminal tetrapeptide sequence. Biochem Biophys Res Commun 94:1445–1451

    Article  PubMed  CAS  Google Scholar 

  • Benyon RC, Lowman MA, Church MK (1987) Human skin mast cells: their dispersion, purification and secretory characterization. J. Immunol 138:861–867

    PubMed  CAS  Google Scholar 

  • Benyon RC, Robinson C, Church MK (1989) Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. Br J Pharmacol 97:898–904

    PubMed  CAS  Google Scholar 

  • Bienenstock J, Perdue M, Blennerhassett M, Stead R, Kakuta N, Sestini P, Vancheri C, Marshall J (1988) Inflammatory cells and the epithelium. Mast cell/nerve interactions in the lung in vitro and in vivo. Am Rev Respir Dis 138:S31-34

    Article  PubMed  CAS  Google Scholar 

  • Bissette G, Manberg P, Nemeroff CB, Prange AJ (1978) Neurotensin, a biologically active peptide. Life Sci 23:2173–2182

    Article  PubMed  CAS  Google Scholar 

  • Björklund H, Dalsgaard C-J, Jonsson C-E, Hermansson A (1986) Sensory and autonomic innervation of non-hairy and hairy human skin. An immunohistochemical study. Cell Tissue Res 243:51–57

    Article  PubMed  Google Scholar 

  • Brain SD, Williams TJ (1985) Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmacol 86:855–860

    PubMed  CAS  Google Scholar 

  • Brain SD, Williams TJ (1988) Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature 335:73–75

    Article  PubMed  CAS  Google Scholar 

  • Brain SD, Williams TJ (1989) Interactions between the tachykinins and calcitonin gene-related peptide lead to the modulation of oedema formation and blood flow in rat skin. Br J Pharmacol 97:77–82

    PubMed  CAS  Google Scholar 

  • Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 13:54–56

    Article  Google Scholar 

  • Brain SD, Tippins JR, Morris HR, MacIntyre I, Williams TJ (1986) Potent vasodilator activity of calcitonin gene-related peptide in human skin. J Invest Dermatol 87: 533–536

    Article  PubMed  CAS  Google Scholar 

  • Brazeau P, Vale W, Burgus R, Ling H, Butcher M, Rivier J, Guillemin R (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179:77–79

    Article  PubMed  CAS  Google Scholar 

  • Buck SH, Burks TF (1986) The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev 38:179–226

    PubMed  CAS  Google Scholar 

  • Buck SH, Walsh JH, Yamamura HI, Burks TF (1982) Neuropeptides in sensory neurones. Life Sci 30:1857–1866

    Article  PubMed  CAS  Google Scholar 

  • Butler JM, Hammond BR (1980) The effects of sensory denervation on the responses of the rabbit eye to prostaglandin E1 bradykinin and substance P. Br J Pharmacol 69:495–502

    PubMed  CAS  Google Scholar 

  • Carraway R, Leeman SE (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 248:6854–6861

    PubMed  CAS  Google Scholar 

  • Carraway R, Leeman SE (1976) Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine and stomach. J Biol Chem 251:7045–7052

    PubMed  CAS  Google Scholar 

  • Carraway R, Cochrane DE, Lansman JB, Leeman SE, Paterson BM, Welch HJ (1982) Neurotensin stimulates exocytolic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol (Lond) 323:403–414

    PubMed  CAS  Google Scholar 

  • Carraway RE, Cochrane DE, Granier C, Kitabgi P, Leeman E, Singer EA (1984) Parallel secretion of endogenous 5-hydroxytryptamine and histamine from mast cells stimulated by vasoactive peptides and compound 48/80. Br J Pharmacol 81:227–229

    PubMed  CAS  Google Scholar 

  • Casale TB, Bowman S, Kaliner M (1984) Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: evidence for opiate and non-opiate receptor participation. J Allergy Clin Immunol 73:775–781

    Article  PubMed  CAS  Google Scholar 

  • Celander O, Folkow B (1953) The nature and the distribution of afferent fibres provided with the axon reflex arrangement. Acta Physiol Scand 29:359–370

    Article  PubMed  CAS  Google Scholar 

  • Chahl LA (1979) The effect of putative peptide neurotransmitters on cutaneous vascular permeability in the rat. Naunyn Schmiedebergs Arch Pharmacol 309: 159–163

    Article  PubMed  CAS  Google Scholar 

  • Chahl LA (1988) Antidromic vasodilatation and neurogenic inflammation. Pharmacol Ther 37:275–300

    Article  PubMed  CAS  Google Scholar 

  • Chahl LA, Chahl JS (1986) Plasma extravasation induced by dynorphin-(l-13) in rat skin. Eur J Pharmacol 124:343–347

    Article  PubMed  CAS  Google Scholar 

  • Chahl LA, Ladd RJ (1976) Local oedema and general excitation of cutaneous sensory receptors produced by electrical stimulation of the saphenous nerve in the rat. Pain 2:25–34

    Article  PubMed  CAS  Google Scholar 

  • Chang MM, Leeman SE Niall HD (1971) Amino-acid sequence of substance P. Nature [New Biol] 232:86–87

    Article  CAS  Google Scholar 

  • Church MK, Pao GJ-K, Holgate ST (1982) Characterization of histamine secretion from mechanically dispersed human lung mast cells: effects of anti-IgE, calcium ionophore A23187, compound 48/80, and basic polypeptides. J Immunol 129: 2116–2121

    PubMed  CAS  Google Scholar 

  • Church MK, Lowman MA, Robinson C, Holgate ST, Benyon RC (1989) Interaction of neuropeptides with human mast cells. Int Arch Allergy Appl Immunol 88: 70–78

    Article  PubMed  CAS  Google Scholar 

  • Coleman JW (1982) Neuraminidase- and benzalkonium chloride-dependent inhibition of peptide-induced rat mast cell secretion. Immunol Lett 5:197–201

    Article  PubMed  CAS  Google Scholar 

  • Coleman JW, Huang Q, Stanworth DR (1986) The mast cell response to substance P: effects of neuraminidase, limulin and some novel synthetic peptide antagonists. Peptides 7:171–175

    Article  PubMed  CAS  Google Scholar 

  • Costa M, Furness JB, Gibbins IL (1986) Chemical coding of enteric neurons. Prog Brain Res 68:217–239

    Article  PubMed  CAS  Google Scholar 

  • Dalsgaard C-J, Jonsson C-E, Hökfelt T, Cuello AC (1983) Localization of substance P-immunoreactive nerve fibers in the human digital skin. Experientia 39: 1018–1020

    Article  PubMed  CAS  Google Scholar 

  • Dalsgaard C-J, Haegerstrand A, Theodorsson-Norheim E, Brodin E, Hökfelt T (1985) Neurokinin A-like immunoreactivity in rat primary sensory neurons; coexistence with substance P. Histochemistry 83:37–39

    Article  PubMed  CAS  Google Scholar 

  • Devillier P, Renoux M, Giroud J-P Regoli D (1985) Peptides and histamine release from rat peritoneal mast cells. Eur J Pharmacol 117:89–96

    Article  PubMed  CAS  Google Scholar 

  • Devillier P, Regoli D, Asseraf A, Descours B, Marsac J, Renoux M (1986) Histamine release and local responses of rat and human skin to substance P and other mammalian tachykinins. Pharmacology 32:340–347

    Article  PubMed  CAS  Google Scholar 

  • Dianzani C, Foreman JC (1988) Desensitization of rat peritoneal mast cells to substance P. Agents Actions 23:214–216

    Article  PubMed  CAS  Google Scholar 

  • Diel F, Usadel KH (1984) Somatostatin-induced histamine release in mast cell incubates from thymusaplastic nude rats. Agents Actions 14:506–509

    Article  PubMed  CAS  Google Scholar 

  • Duggan AW, Morton CR, Zhao ZQ, Hendry IA (1987) Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: a study with antibody microprobes. Brain Res 403:345–349

    Article  PubMed  CAS  Google Scholar 

  • Ebertz JM, Hirshman CA, Kettelkamp NS, Uno H, Hanifin JM (1987) Substance P-induced histamine release in human cutaneous mast cells. J Invest Dermatol 88: 682–685

    Article  PubMed  CAS  Google Scholar 

  • Ellis HV, Johnson AR, Moran NC (1970) Selective release of histamine from rat mast cells by several drugs. J Pharmacol Exp Ther 175:627–631

    PubMed  CAS  Google Scholar 

  • Erjavec F, Lembeck F, Florjanc-Irman T, Skofitsch G, Donnerer J, Saria A, Holzer P (1981) Release of histamine by substance P. Naunyn Schmiedebergs Arch Pharmacol 317:67–70

    Article  PubMed  CAS  Google Scholar 

  • Fewtrell CMS, Foreman JC, Jordan CC, Oehme P, Renner H, Stewart JM (1982) The effects of substance P on histamine and 5-hydroxytryptamine release in the rat. J Physiol (Lond) 330:393–411

    PubMed  CAS  Google Scholar 

  • Fitzgerald M (1983) Capsaicin and sensory neurones-a review. Pain 15:109–130

    Article  PubMed  CAS  Google Scholar 

  • Fjellner B, Hägermark O (1982) Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK33-824, β-endorphin and morphine. Arch Dermatol Res 274:29–37

    Article  PubMed  CAS  Google Scholar 

  • Folkers K, Hörig J, Rosell S, Björkroth V (1981) Chemical design of antagonists of substance P. Acta Physiol Scand 111:505–506

    Article  PubMed  CAS  Google Scholar 

  • Foreman JC (1987) Peptides and neurogenic inflammation. Br Med Bull 43:386–400

    PubMed  CAS  Google Scholar 

  • Foreman JC, Jordan C (1983) Histamine release and vascular changes induced by neuropeptides. Agents Actions 13:105–116

    Article  PubMed  CAS  Google Scholar 

  • Foreman JC, Mongar JL (1973) The action of lanthanum and manganese on anaphylactic histamine secretion. Br J Pharmacol 48:527–537

    PubMed  CAS  Google Scholar 

  • Foreman JC, Jordan CC, Piotrowski W (1982) Interaction of neurotensin with the substance P receptor mediating histamine release from rat mast cells and the flare in human skin. Br J Pharmacol 77:531–539

    PubMed  CAS  Google Scholar 

  • Foreman JC, Jordan CC, Oehme P, Renner H (1983) Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin. J Physiol (Lond) 335:449–465

    CAS  Google Scholar 

  • Gamse R, Saria A (1985) Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide Eur J Pharmacol 114:61–66

    Article  PubMed  CAS  Google Scholar 

  • Gamse R, Saria A (1987) Antidromic vasodilatation in the rat hindpaw measured by laser Doppler flowmetry: pharmacological modulation. J Auton Nerv Syst 19:105–111

    Article  PubMed  CAS  Google Scholar 

  • Gamse R, Holzer P, Lembeck F (1980) Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin. Br J Pharmacol 68:207–213

    PubMed  CAS  Google Scholar 

  • GaÅ¡parović I, Hadzović S, Huković S, Stern P (1964) Contribution to the theory that substance P has a transmitter role in sensitive pathways. Med Exp 10:303–306

    PubMed  Google Scholar 

  • Gibbins IL, Furness JB, Costa M, MacIntyre I, Hillyard CJ, Girgis S (1985) Colocalization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurones of guinea pigs. Neurosci Lett 57: 125–130

    Article  PubMed  CAS  Google Scholar 

  • Gibbins IL, Furness JB, Costa M (1987) Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynor-phin in neurons of the dorsal root ganglia of the guinea-pig. Cell Tissue Res 248: 417–437

    Article  PubMed  CAS  Google Scholar 

  • Goodman EC, Iversen LL (1986) Calcitonin gene-related peptide: novel neuropeptide. Life Sci 38:2169–2178

    Article  PubMed  CAS  Google Scholar 

  • Greaves MW, Yamamoto S, Mahzoon B (1976) The mast cell: interrelationships between histamine and prostaglandins. Clin Exp Dermatol 1:327–329

    Article  PubMed  CAS  Google Scholar 

  • Grosman N (1981) Histamine release from isolated rat mast cells: effect of morphine and related drugs and their interaction with compound 48/80. Agents Actions 11:196–203

    Article  PubMed  CAS  Google Scholar 

  • Hägermark O, Hökfelt T, Pernow B (1978) Flare and itch induced by substance P in human skin. J Invest Dermatol 71:233–235

    Article  PubMed  Google Scholar 

  • Hall ME, Grantham P, Limoli J, Stewart JM (1987) Effects of substance P and neurokinin A (substance K) on motor behaviour; unique effect of substance P attributable to its amino-terminal sequence. Brain Res 420:82–94

    Article  PubMed  CAS  Google Scholar 

  • Hartschuh W, Weihe E, Reinecke M (1983) Peptidergic (neurotensin, VIP, substance P) nerve fibres in the skin. Immunohistochemical evidence of an involvement of neuropeptides in nociception, pruritus and inflammation. Br J Dermatol [Suppl 25] 109:14–17

    PubMed  CAS  Google Scholar 

  • Hellauer HF, Umrath K (1947) The transmitter substance of sensory nerves. J Physiol (Lond) 106:20–21P

    PubMed  CAS  Google Scholar 

  • Hinsey JC, Gasser HS (1930) The component of the dorsal root mediating vasodilatation and the Sherrington contracture. Am J Physiol 92:679–689

    Google Scholar 

  • Hökfelt T, Kellerth J-O, Nilsson G, Pernow B (1975a) Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 100:235–252

    Article  PubMed  Google Scholar 

  • Hökfelt T, Kellerth J-O, Nilsson G, Pernow B (1975b) Substance P: localization in the central nervous system and in some primary sensory neurons. Science 190: 889–890

    Article  PubMed  Google Scholar 

  • Hökfelt T, Elde R, Johansson O, Luft R, Nilsson G, Arimura A (1976) Immuno-histochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurones in the rat Neuroscience 1: 131–136

    Article  PubMed  Google Scholar 

  • Hökfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M (1980) Peptidergic neurones. Nature 284:515–521

    Article  PubMed  Google Scholar 

  • Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739–768

    Article  PubMed  CAS  Google Scholar 

  • Hua X-Y, Theodorsson-Norheim E, Brodin E, Lundberg JM, Hökfelt T (1985) Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig. Regul Pept 13:1–19

    Article  PubMed  CAS  Google Scholar 

  • Jahnke GD, Lazarus LH, DiAugustine RP, Soldato CM, Erisman MD (1981) Peptide hormone degradation by a rat mast cell chymase-heparin complex. Life Sci 29: 397–403

    Article  PubMed  CAS  Google Scholar 

  • Jancsó G, Király E, Jancsó-Gábor A (1977) Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270:741–743

    Article  PubMed  Google Scholar 

  • Jancsó N (1960) Role of the nerve terminals in the mechanism of inflammatory reactions. Bull Millard Fillmore Hosp 7:53–77

    Google Scholar 

  • Jancsó N, Jancsó-Gábor A, Szolcsányi J (1967) Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol 1:138–151

    Google Scholar 

  • Jancsó N, Jancsó-Gábor A, Szolcsányi J (1968) The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br J Pharmacol 32:32–41

    Google Scholar 

  • Jasani B, Kreil G, Mackler BI, Stanworth DR (1979) Further studies on the structural requirements for polypeptide-mediated histamine release from rat mast cells. Biochem J 181:623–632

    PubMed  CAS  Google Scholar 

  • Jessell TM, Iversen LL, Cuello AC (1978) Capsaicin-induced depletion of substance P from primary sensory neurones. Brain Res 152:183–188

    Article  PubMed  CAS  Google Scholar 

  • Johnson AR, Erdös EG (1973) Release of histamine from mast cells by vasoactive peptides. Proc Soc Exp Biol Med 142:1252–1256

    PubMed  CAS  Google Scholar 

  • Johnson AR, Hugli TE, Müller-Eberhard HJ (1975) Release of histamine from rat mast cells by the complement peptides C3a and C5a. Immunology 28:1067–1080

    PubMed  CAS  Google Scholar 

  • Jorizzo JL, Coutts AA, Eady RAJ, Greaves MW (1983) Vascular responses of human skin to injection of substance P and mechanism of action. Eur J Pharmacol 87: 67–76

    Article  PubMed  CAS  Google Scholar 

  • Kangawa K, Minamino N, Fukuda A, Matsuo H (1983) Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord. Biochem Biophys Res Commun 114:533–540

    Article  PubMed  CAS  Google Scholar 

  • Kenins P (1981) Identification of the unmyelinated sensory nerves which evoke plasma extravasation in response to antidromic stimulation. Neurosci Lett 25:137–141

    Article  PubMed  CAS  Google Scholar 

  • Khalil Z, Andrews PV, Helme RD (1988) VIP modulates substance P-induced plasma extravasation in vivo. Eur J Pharmacol 151:281–287

    Article  PubMed  CAS  Google Scholar 

  • Kiernan JA (1971) Degranulation of mast cells following antidromic stimulation of cutaneous nerves. J Anat 111:349–350

    Google Scholar 

  • Kiernan JA (1972) The involvement of mast cells in vasodilatation due to axon reflexes in injured skin. Q J Exp Physiol 57:311–317

    CAS  Google Scholar 

  • Kimura S, Okada M, Sugita Y, Kanazawa I, Munekata E (1983) Novel neuropeptides, neurokinin α and β, isolated from porcine spinal cord. Proc Jpn Acad [B] 59: 101–104

    Article  CAS  Google Scholar 

  • Kowalski ML, Kaliner MA (1988) Neurogenic inflammation, vascular permeability, and mast cells. J Immunol 140:3905–3911

    PubMed  CAS  Google Scholar 

  • Krüger PG, Aas P, Onarheim J, Helle KB (1982) Neurotensin-induced release of histamine from rat mast cells in vitro. Acta Physiol Scand 114:467–469

    Article  PubMed  Google Scholar 

  • Kurose M, Saeki K (1981) Histamine release induced by neurotensin from rat peritoneal mast cells. Eur J Pharmacol 76:129–136

    Article  PubMed  CAS  Google Scholar 

  • Lagunoff D, Martin TW, Reid G (1983) Agents that release histamine from mast cells. Annu Rev Pharmacol Toxicol 23:331–351

    Article  PubMed  CAS  Google Scholar 

  • Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O, Sundler F, Häkanson R, Rehfeld JF (1976) Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons. Proc Natl Acad Sci USA 73:3197–3200

    Article  PubMed  CAS  Google Scholar 

  • Lawrence ID, Warner JA, Cohan VL, Hubbard WC, Kagey-Sobotka A, Lichtenstein LM (1987) Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. J Immunol 139:3062–3069

    PubMed  CAS  Google Scholar 

  • Lawson SN, Harper AA (1984) Neonatal capsaicin is not a specific neurotoxin for sensory C-fibres or small dark cells of rat dorsal root ganglia. In: Chahl LA, Szolcsányi J, Lembeck F (eds) Antidromic vasodilatation and neurogenic inflammation. 29th IUPS Satellite Symposium, Australia. Akadémiai Kiadó, Budapest, pp 111–116.

    Google Scholar 

  • Lazarus LH, Perrin MH, Brown MR (1977a) Mast cell binding of neurotensin. I. Iodination of neurotensin and characterization of the interaction of neurotensin with mast cell receptor sites. J Biol Chem 252:7174–7179

    PubMed  CAS  Google Scholar 

  • Lazarus LH, Perrin MH, Brown MR, Rivier JE (1977b) Mast cell binding of neurotensin. II. Molecular conformation of neurotensin involved in the stereospecific binding to mast cell receptor sites. J Biol Chem 252:7180–7183

    PubMed  CAS  Google Scholar 

  • Leah JD, Cameron AA, Snow PJ (1985) Neuropeptides in physiologically identified mammalian sensory neurones. Neurosci Lett 56:257–263

    Article  PubMed  CAS  Google Scholar 

  • Leander S, Häkanson R, Rosell S, Folkers K, Sundler F, Tornqvist K (1981) A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation. Nature 294:467–469

    Article  PubMed  CAS  Google Scholar 

  • Lee Y, Takami K, Kawai Y, Girgis S, Hillyard CJ, MacIntyre I, Emson PC, Tohyama M (1985) Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P. Neuroscience 15:1227–1237

    Article  PubMed  CAS  Google Scholar 

  • Lembeck F (1953) Zur Frage der zentralen Ãœbertragung afferenter Impulse. III. Mitteilung. Das Vorkommen und die Bedeutung der Substanz P in den dorsalen Wurzeln des Rückenmarks. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 219:197–213

    Article  PubMed  CAS  Google Scholar 

  • Lembeck F (1983) Sir Thomas Lewis’s nocifensor system, histamine and substance P-containing primary afferent nerves. Trends Neurosci 6:106–108

    Article  Google Scholar 

  • Lembeck F, Holzer P (1979) Substance P as neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch Pharmacol 310:175–183

    Article  PubMed  CAS  Google Scholar 

  • Lembeck F, Gamse R, Juan H (1977) Substance P and sensory nerve endings. In: von Euler US, Pernow B (eds) Substance P. Raven, New York, pp 169–181

    Google Scholar 

  • Lewis T (1927) The blood vessels of the human skin and their responses. Shaw, London

    Google Scholar 

  • Lowman MA, Rees PH, Benyon RC, Church MK (1988a) Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli. J Allergy Clin Immunol 81:590–597

    Article  PubMed  CAS  Google Scholar 

  • Lowman MA, Benyon RC, Church MK (1988b) Characterization of neuropeptide-induced histamine release from human dispersed skin mast cells. Br J Pharmacol 95:121–130

    PubMed  CAS  Google Scholar 

  • Maggio JE, Hunter JC (1984) Regional distribution of kassinin-like immunoreactivity in rat central and peripheral tissues and the effect of capsaicin. Brain Res 307: 370–373

    Article  PubMed  CAS  Google Scholar 

  • Matsuda H, Kawakita K, Kiso Y, Nakano T, Kitamura Y (1989). Substance P induces granulocyte infiltration through degranulation of mast cells. J. Immunol 142: 927–931

    CAS  Google Scholar 

  • Mazurek N, Pecht I, Teichberg VI, Blumberg S (1981) The role of the N-terminal tetrapeptide in the histamine releasing action of substance P. Neuropharmacology 20:1025–1027

    Article  PubMed  CAS  Google Scholar 

  • Minamino N, Kangawa K, Fukuda A, Matsuo H (1984) Neuromedin L: a novel mammalian tachykinin identified in porcine spinal cord. Neuropeptides 4:157–166

    Article  PubMed  CAS  Google Scholar 

  • Morton CR, Chahl LA (1980) Pharmacology of the neurogenic oedema response to electrical stimulation of the saphenous nerve in the rat. Naunyn Schmiedebergs Arch Pharmacol 314:271–276

    Article  PubMed  CAS  Google Scholar 

  • Mousli M, Bronner C, Bueb JL, Tschirhart E, Gies JP, Landry Y (1989) Activation of rat peritoneal mast cells by substance P and mastoparan. J Pharmacol Exp Ther 250:329–335

    PubMed  CAS  Google Scholar 

  • Nagy JI, Iversen LL, Goedert M, Chapman D, Hunt SP (1983) Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci 3:399–406

    PubMed  CAS  Google Scholar 

  • Nawa H, Hirose T, Takashima H, Inayama S, Nakanishi S (1983) Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306:32–36

    Article  PubMed  CAS  Google Scholar 

  • Nawa H, Doteuchi M, Igano K, Inouye K, Nakanishi S (1984) Substance K: a novel mammalian tachykinin that differs from substance P in its pharmacological profile. Life Sci 34:1153–1160

    Article  PubMed  CAS  Google Scholar 

  • Ogawa T, Kanazawa I, Kimura S (1985) Regional distribution of substance P, neurokinin a and neurokinin β in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection. Brain Res 359:152–157

    Article  PubMed  CAS  Google Scholar 

  • O’Shaughnessy DJ, McGregor GP, Chatei MA, Blank MA, Springall DR, Gu J, Polak JM, Bloom SR (1983) Distribution of bombesin, somatostatin, substance-P and vasoactive intestinal polypeptide in feline and porcine skin. Life Sci 32: 2827–2836

    Article  PubMed  Google Scholar 

  • Parratt JR, West GB (1957) 5-Hydroxytryptamine and tissue mast cells. J Physiol (Lond) 137:169–178

    PubMed  CAS  Google Scholar 

  • Paton WDM (1957) Histamine release by compounds of simple chemical structure. Pharmacol Rev 9:269–328

    PubMed  CAS  Google Scholar 

  • Pernow B (1953) Studies on substance P. Purification, occurrence and biological actions. Acta Physiol Scand 29 Suppl 105:1–90

    Google Scholar 

  • Piotrowski W, Foreman JC (1985) On the actions of the substance P, somatostatin and vasoactive intestinal polypeptide on rat peritoneal mast cells and in human skin. Naunyn Schmiedebergs Arch Pharmacol 331:364–368

    Article  PubMed  CAS  Google Scholar 

  • Piotrowski W, Foreman JC (1986) Some effects of calcitonin gene-related peptide in human skin and on histamine release. Br J Dermatol 114:37–46

    Article  PubMed  CAS  Google Scholar 

  • Piotrowski W, Devoy MAB, Jordan CC, Foreman JC (1984) The substance P receptor on rat mast cells and in human skin. Agents Actions 14:420–424

    Article  PubMed  CAS  Google Scholar 

  • Piotrowski W, Mead M, Foreman JC (1987) Action of the SP2-11 and SP3-11 fragments of substance P on rat peritoneal mast cells. Agents Actions 20:178–180

    Article  PubMed  CAS  Google Scholar 

  • Quirion R, Rioux F, Regoli D, St-Pierre S (1980) Compound 48/80 inhibits neurotensin-induced hypotension in rats. Life Sci 27:1889–1895

    Article  PubMed  CAS  Google Scholar 

  • Read GW, Kiefer EF (1979) Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines. J Pharmacol Exp Ther 211:711–715

    PubMed  CAS  Google Scholar 

  • Read GW, Koerker DJ, Lagunoff D (1977) Failure of somatostatin to inhibit histamine secretion by mast cells. J Endocrinol 72:403–404

    Article  PubMed  CAS  Google Scholar 

  • Regoli D, Barabé J (1980) Pharmacology of bradykinin and related kinins. Pharmacol Rev 32:1–46

    PubMed  CAS  Google Scholar 

  • Repke H, Bienert M (1987) Mast cell activation-a receptor-independent mode of substance P action? FEBS Lett 221:236–240

    Article  PubMed  CAS  Google Scholar 

  • Repke H, Bienert M (1988) Structural requirements for mast cell triggering by substance P-like peptides. Agents Actions 23:207–210

    Article  PubMed  CAS  Google Scholar 

  • Repke H, Piotrowski W, Bienert M, Foreman JC (1987) Histamine release induced by Arg-Pro-Lys-Pro (CH2)11CH3 from rat peritoneal mast cells. J Pharmacol Exp Ther 243:317–321

    PubMed  CAS  Google Scholar 

  • Riley JF (1959) The mast cells. Livingstone, Edinburgh

    Google Scholar 

  • Rioux F, Kérouac R, St-Pierre S (1983) Characterization of the inhibitory effect of (d- Trp11)-NT toward some biological actions of neurotensin in rats. Neuropeptides 3:345–354

    Article  PubMed  CAS  Google Scholar 

  • Rioux F, Kérouac R, St-Pierre S (1985) Potency of various peptides as histamine liberators in the rat hind limb. Neuropeptides 6:311–319

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld MG, Mermod J-J, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129–135

    Article  PubMed  CAS  Google Scholar 

  • Rossie SS, Miller RJ (1982) Regulation of mast cell histamine release by neurotensin. Life Sci 31:509–516

    Article  PubMed  CAS  Google Scholar 

  • Russell LC, Burchiel KJ (1984) Neurophysiological effects of capsaicin. Brain Res Rev 8:165–176

    Article  CAS  Google Scholar 

  • Sagi-Eisenberg R, Ben-Neriah Z, Pecht I, Terry S, Blumberg S (1983) Structure-activity relationship in the mast cell degranulating capacity of neurotensin fragments. Neuropharmacology 22:197–201

    Article  PubMed  CAS  Google Scholar 

  • Said SI, Mutt V (1970) Potent peripheral and splanchnic vasodilator peptide from normal gut. Nature 225:863–864

    Article  PubMed  CAS  Google Scholar 

  • Saria A, Lundberg JM, Skofitsch G, Lembeck F (1983) Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge. Naunyn Schmiedebergs Arch Pharmacol 324:212–218

    Article  PubMed  CAS  Google Scholar 

  • Selbekk BH, Flaten O, Hanssen LE (1980) The in vitro effect of neurotensin on human jejunal mast cells. Scand J Gastroenterol 15:457–460

    Article  PubMed  CAS  Google Scholar 

  • Selye H (1965) The mast cells. Butterworth, Washington

    Google Scholar 

  • Shanahan F, Lee TDG, Bienenstock J, Befus AD (1984) The influence of endorphins on peritoneal and mucosal mast cell secretion. J Allergy Clin Immunol 74:499–504

    Article  PubMed  CAS  Google Scholar 

  • Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D (1985) Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. J Immunol 135: 1331–1337

    PubMed  CAS  Google Scholar 

  • Skofitsch G, Jacobowitz DM (1985) Calcitonin gene-related peptide coexists with substance P in capsaicin sensitive neurones and sensory ganglia of the rat. Peptides 6:747–754

    Article  PubMed  CAS  Google Scholar 

  • Skofitsch G, Donnerer J, Petronijevic S, Saria A, Lembeck F (1983) Release of histamine by neuropeptides from the perfused rat hindquarter. Naunyn Schmiedebergs Arch Pharmacol 322:153–157

    Article  PubMed  CAS  Google Scholar 

  • Skofitsch G, Savitt JM, Jacobowitz DM (1985) Suggestive evidence for a functional unit between mast cells and substance P fibres in the rat diaphragm and mesentery. Histochemistry 82:5–8

    Article  PubMed  CAS  Google Scholar 

  • Stanisz A, Scicchitano R, Stead R, Matsuda H, Tomioka M, Denburg J, Bienenstock J (1987) Neuropeptides and immunity. Am Rev Respir Dis 136.S48-S51

    PubMed  CAS  Google Scholar 

  • Stanworth DR, Coleman JW, Khan Z (1984) Essential structural requirements for triggering of mast cells by a synthetic peptide comprising a sequence in the Cε4 domain of human IgE. Mol Immunol 21:243–247

    Article  PubMed  CAS  Google Scholar 

  • Szolcsányi J (1977) The local efferent function of capsaicin sensitive C-nociceptors. Proc Int Union Phys Sci (Paris) 73:736

    Google Scholar 

  • Szolcsányi J (1982) Capsaicin type pungent agents producing pyrexia. In: Milton AS (ed) Handbook of experimental pharmacology, vol 60. Springer, Berlin Heidelberg New York, pp 437–478

    Google Scholar 

  • Szolcsányi J (1984) Capsaicin and neurogenic inflammation: history and early findings. In: Chahl LA, Szolcsányi J, Lembeck F (eds) Antidromic vasodilatation and neurogenic inflammation. 29th IUPS Satellite Symposium, Australia. Akadémiai Kiadó, Budapest, pp 7–25

    Google Scholar 

  • Theoharides TC, Douglas WW (1978) Somatostatin induces histamine secretion from rat peritoneal mast cells. Endocrinology 102:1637–1640

    Article  PubMed  CAS  Google Scholar 

  • Theoharides TC, Douglas WW (1981) Mast cell histamine secretion in response to somatostatin analogues: structural considerations. Eur J Pharmacol 73:131–136

    Article  PubMed  CAS  Google Scholar 

  • Theoharides TC, Betchaku T, Douglas WW (1981) Somatostatin-induced histamine secretion in mast cells. Characterization of the effect Eur J Pharmacol 69:127–137

    Article  PubMed  CAS  Google Scholar 

  • Tregear GW, Niall HD, Potts JT Jr, Leeman SE, Chang MM (1971) Synthesis of substance P. Nature [New Biol] 232:87–89

    CAS  Google Scholar 

  • Vale W, Rivier C, Brown M (1977) Regulatory peptides of the hypothalamus. Annu Rev Physiol 39:473–527

    Article  PubMed  CAS  Google Scholar 

  • Von Euler US, Gaddum JH (1931) An unidentified depressor substance in certain tissue extracts. J Physiol (Lond) 72:74–87

    Google Scholar 

  • Wallengren J, Häkanson R (1987) Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nervemediated responses. Eur J Pharmacol 143:267–273

    Article  PubMed  CAS  Google Scholar 

  • Watson SP (1984) Are the proposed substance P receptor sub-types, substance P receptors? Life Sci 25:797–808

    Article  Google Scholar 

  • Woodward DF, Owen DAA, Pipkin MA, Ledgard SE (1985) Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P. Agents Actions 17:126–130

    Article  PubMed  CAS  Google Scholar 

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  1. A. Chahl
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  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Börje Uvnäs M.D.

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Chahl, A. (1991). Role of Histamine in the Actions of Neuropeptides and Local Hormones. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_25

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  • DOI: https://doi.org/10.1007/978-3-642-75840-9_25

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