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Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

  • Chapter
Histamine and Histamine Antagonists

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 97))

Abstract

Histamine, like many other mediators, has over the years been assigned a greater or lesser role in diseases of the gastrointestinal tract. Existing controversies are well illustrated by the fact that, in spite of successful treatment of peptic ulcer with histamine H2 receptor antagonists, many doubt a causal role of histamine in this common disease. Many new mediators such as prostaglandins, leukotrienes, and platelet-aggregating factors and bacteria such as Helicobacter have been incriminated in gastrointestinal diseases, like peptic ulcer and gastritis. The average scientist tends to interpret reported findings from clinical trials or animal experiments concerning causal associations, but also to utter statements like: “Nothing is known about the aetiopathogenesis of peptic ulcer, pancreatitis etc.”. However, many scientists are not aware of a series of new instruments available for solving multicausal problems.

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  1. J. Sattler
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  2. W. Lorenz
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  3. R. Lindlar
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  4. U. Schäfer
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Editors and Affiliations

  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Börje Uvnäs M.D.

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Sattler, J., Lorenz, W., Lindlar, R., Schäfer, U. (1991). Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_22

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