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Histamine and the Parietal Cell

  • Chapter
Histamine and Histamine Antagonists

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 97))

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Abstract

It has been known for more than 160 years that a strong mineral acid, hydrochloric acid, is secreted in the stomach. The site of this HCl production has for several decades been considered to be the oxyntic or parietal cell. The first to make this suggestion were apparently Linderström- Lang et al. (1935), who correlated the production of acid with the presence of different types of cells. Thus all the evidence for the parietal cell as the site of acid formation was only indirect until 1979, when Di Bona et al. and Berglindh et al. (1980a) for the first time proved that this was the cell responsible. They visualized acid in the parietal cells by acridine orange fluoresence in combination with differential-interference-contrast microscopy with Nomarski prisms. But even before this conclusive proof the parietal cells had been the focus of numerous investigations over the years. Composite models such as whole animals, isolated stomachs, isolated mucosae and isolated glands were often used even when interest was focused on the physiology of the parietal cell

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Authors
  1. K. J. Öbrink
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Editors and Affiliations

  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Börje Uvnäs M.D.

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© 1991 Springer-Verlag Berlin Heidelberg

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Öbrink, K.J. (1991). Histamine and the Parietal Cell. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_18

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  • DOI: https://doi.org/10.1007/978-3-642-75840-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75842-3

  • Online ISBN: 978-3-642-75840-9

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