Skip to main content
SpringerLink
Log in

Structure and Functions of the Histaminergic Neurone System

  • Chapter
Histamine and Histamine Antagonists

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 97))

Abstract

Since the first issue on histamine in the Handbook of Pharmacology (Rocha E Silva 1966), in which only eight pages were devoted to brain histamine (White 1966), great progress has been made in this field. Pioneering neurochemical studies by Schwartz and his colleagues (see Scheartz et al. 1986a) were corroborated and refined in detail by immunohistochemical demonstration of the histaminergic neurone system in rat brain (Watanabe et al. 1984; Panula et al. 1984; Steinbusch and Mulder 1984). Now there is convincing evidence that histamine is a neurotransmitter or a neuromodulator in the mammalian brain.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Airaksinen MS, Panula P (1988) The histaminergic system in the guinea pig central nervous system: an immunocytochemical mapping study using an antiserum against histamine. J Comp Neurol 273:163–186

    PubMed  CAS  Google Scholar 

  • Airaksinen MS, Panula P (1990) Comparative neuroanatomy of the histaminergic system in the brain of Xenopus laevis. J Comp Neurol 292:412–423

    PubMed  CAS  Google Scholar 

  • Airaksinen MS, Flügge G, Fuchs E, Panula P (1989) The histaminergic system in the tree shrew brain. J Comp Neurol 286:289–310

    PubMed  CAS  Google Scholar 

  • Allolio B, Winkelmann W, Hipp FX (1981) Effect of meclastine, an Hi antihistamine, on plasma ACTH in adrenal insufficiency. Acta Endocrinol 97:98–102

    PubMed  CAS  Google Scholar 

  • Alvarez EO (1984) Induction of prolactin release by Hr or H2-histamine agonists in maturing male and female rats. J Neural Transm 59:241–250

    PubMed  CAS  Google Scholar 

  • Alvarez EO, Banzan AM (1985) Further evidence that histamine in hippocampus affects the exploratory behavior in the rat. Physiol Behav 34:661–664

    PubMed  CAS  Google Scholar 

  • Alvarez EO, Banzan AM (1986) Histamine in dorsal and ventral hippocampus. II. Effects of Ηχ and H2 histamine antagonists on exploratory behavior in male rats. Physiol Behav 37:39–45

    PubMed  CAS  Google Scholar 

  • Alvarez EO, Banzan AM (1987) Histamine sensitive sites in hippocampus: their probable role on prolactin release in male rats. Brain Res Bull 19:165–173

    PubMed  CAS  Google Scholar 

  • Alvarez EO, Donoso AO (1981) Effects of histamine implants in several brain regions on the release of prolactin in conscious adult rats. J Endocrinol 88:351–358

    PubMed  CAS  Google Scholar 

  • Alvarez EO, Fabra D (1980) Prolactin release induced by histamine in maturing male and female rats. J Neural Transm 49:187–195

    PubMed  CAS  Google Scholar 

  • Alvarez EO, Guerra FA (1982) Effects of histamine microinjections into the hippocampus on open-field behavior in rats. Physiol Behav 28:1035–1040

    PubMed  CAS  Google Scholar 

  • Ando-Yamamoto M, Hayashi H, Taguchi Y, Fukui H, Watanabe T, Wada H (1986) Demonstration of immunohistochemical and immunochemical cross-reactivity of L-histidine and l-DOPA decarboxylase using antibodies against the two enzymes. Biochem Biophys Res Commun 141:306–312

    PubMed  CAS  Google Scholar 

  • Arai R, Kimura H, Maeda T (1986) Topographic atlas of monoamine oxidasecontaining neurons in the rat brain studied by an improved histochemical method. Neuroscience 19:905–925

    PubMed  CAS  Google Scholar 

  • Arakelian MC, Libertun C (1977) Ηχ and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats. Endocrinology 100: 890–899

    PubMed  CAS  Google Scholar 

  • Arrang J-M, Garbarg M, Schwartz J-C (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832–837

    PubMed  CAS  Google Scholar 

  • Arrang J-M, Garbarg M, Schwartz J-C (1985) Autoregulation of histamine release in brain by presynaptic H3-receptors. Neuroscience 15:553–562

    PubMed  CAS  Google Scholar 

  • Arrang J-M, Garbarg M, Lancelot J-C, Lecome J-M, Pollard H, Robba M, Schunack W, Schwartz J-C (1987) Highly potent and selective ligands for histamine H3- receptors. Nature 327:117–123

    PubMed  CAS  Google Scholar 

  • Arrang J-M, Devaux B, Chodkiewicz J-P, Schwartz J-C (1988) H3-Receptors control histamine release in human brain. J Neurochem 51:105–108

    PubMed  CAS  Google Scholar 

  • Atack C, Carlsson A (1972) In vitro release of endogenous histamine, together with noradrenaline and 5-hydroxytryptamine, from slices of mouse cerebral hemispheres. J Pharm Pharmacol 24:990–992

    PubMed  CAS  Google Scholar 

  • Baba M, Nishibori M, Oishi R, Saeki K, Kosaka F (1987) Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice. Naunyn Schmiedebergs Arch Pharmacol 335:686–691

    PubMed  CAS  Google Scholar 

  • Barbin G, Hirsch JC, Garbarg M, Schwartz JC (1975) Decrease in histamine content and decarboxylase activities in an isolated area of the cerebral cortex of the cat. Brain Res 92:170–174

    PubMed  CAS  Google Scholar 

  • Barbin G, Garbarg M, Schwartz J-C, Storm-Mathisen J (1976) Histamine synthesizing afferents to the hippocampal region. J Neurochem 26:259–263

    PubMed  CAS  Google Scholar 

  • Ben-Ari Y, Le Gal La Salle G, Barbin G, Schwartz JC, Garbarg M (1977) Histamine synthesizing afferents within the amygdaloid complex and bed nucleus of the stria terminalis of the rat. Brain Res 138:285–294

    PubMed  CAS  Google Scholar 

  • Bennett CT, Pert A (1974) Antidiuresis produced by injections of histamine into the cat supraoptic nucleus. Brain Res 78:151–156

    PubMed  CAS  Google Scholar 

  • Bergman J, Spealman RD (1986) Some behavioral effects of histamine Ηχ antagonists in squirrel monkeys. J Pharmacol Exp Ther 239:104–110

    PubMed  CAS  Google Scholar 

  • Bergman J, Spealman RD (1988) Behavioral effects of histamine Ηχ antagonists: comparison with other drugs and modification by haloperidol. J Pharmacol Exp Ther 245:471–478

    PubMed  CAS  Google Scholar 

  • Berkenbosch F, Steinbusch HWM (1987) Histamine-immunostaining in the rat median eminence: an unexpected form of cross-reactivity with LH-RH. Brain Res 405:353–357

    PubMed  CAS  Google Scholar 

  • Betti R, Casanueva FF, Cella SG, Müller EE (1985) Activation of the cholinergic system and growth hormone release in the dog: functional interactions with other neurotransmitters. Acta Endocrinol 108:36–43

    PubMed  CAS  Google Scholar 

  • Bhargava KP, Kulshrestha VK, Santhakumari G, Srivastava YP (1973) Mechanism of histamine-induced antidiuretic response. Br J Pharmacol 47:700–706

    PubMed  CAS  Google Scholar 

  • Bhattacharya SK, Das N (1985) Anti-inflammatory effect of intraventricularly administered histamine in rats. Agents Actions 17:150–152

    PubMed  CAS  Google Scholar 

  • Bhattacharya SK, Parmar SS (1985) Antinociceptive effect of intracerebroventicularly administered histamine in rats. Res Commun Chem Pathol Pharmacol 49:125–136

    PubMed  CAS  Google Scholar 

  • Bischoff S, Korf J (1978) Different localization of histidine decarboxylase and histamine-N-methyltransferase in the rat brain. Brain Res 141:345–379

    Google Scholar 

  • Bleier R, Cohn P, Siggelcow IR (1979) A cytoarchitectonic atlas of the hypothalamus and hypothalamic third ventricle of the rat. In: Morgan PJ, Panksepp J (eds) Anatomy of the hypothalamus. Marcel Dekker, New York, pp 137–220 (Handbook of the hypothalamus, vol I)

    Google Scholar 

  • Bligh J, Silver A, Smith CA (1980) The effects on thermoregulatory mechanisms produced by intracerebroventricular injections of histamine in the sheep. J Therm Biol 5:41–51

    CAS  Google Scholar 

  • Bluhm R, Zsigmond EK, Winnie AP (1982) Potentiation of opioid analgesia by Hx and H2 antagonists. Life Sei 31:1229–1232

    CAS  Google Scholar 

  • Bouclier M, Jung MJ, Gerhart F (1983) Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations. Experientia 39:1303–1305

    PubMed  CAS  Google Scholar 

  • Bouthenet ML, Ruat M, Sales N, Garbarg M, Schwartz JC (1988) A detailed mapping of histamine Hrreceptors in guinea-pig central nervous system established by autoradiography with [125I]iodoborpyramine. Neuroscience 26:553–600

    PubMed  CAS  Google Scholar 

  • Brezenoff HE, Jenden DJ (1969) Modification of arterial blood pressure in rats following microinjection of drugs into the posterior hypothalamus. Int J Neuropharmacol 8:593–600

    PubMed  CAS  Google Scholar 

  • Brezenoff HE, Lomax P (1970) Temperature changes following microinjection of histamine into the thermoregulatory centers of the rat. Experientia 26:51–52

    PubMed  CAS  Google Scholar 

  • Bristow LJ, Bennett GW (1988) Biphasic effects of intra-accumbens histamine administration on spontaneous motor activity in the rat; a role for central histamine receptors. Br J Pharmacol 95:1292–1302

    PubMed  CAS  Google Scholar 

  • Brown DD, Tomchick R, Axerlod J (1959) The distribution and properties of a histamine-methylating enzyme. J Biol Chem 234:2948–2950

    PubMed  CAS  Google Scholar 

  • Bugajski J, Gadek A (1981) The involvement of central histamine receptors in stress-induced responses of serum corticosterone and free fatty acids and in gastric ulcer development. Agents Actions 11:151–155

    PubMed  CAS  Google Scholar 

  • Bugajski J, Gadek A (1983) Central Hr and H2-histaminergic stimulation of pituitaryadrenocortical response under stress in rats. Neuroendocrinology 36:424–430

    PubMed  CAS  Google Scholar 

  • Bugajski J, Gadek A (1984a) The effect of adrenergic and cholinergic antagonists on central histaminergic stimulation of pituitary-adrenocortical response under stress in rats. Neuroendocrinology 38:447–452

    PubMed  CAS  Google Scholar 

  • Bugajski J, Gadek A (1984b) Effect of intracerebroventricular impromidine on pituitary-adrenocortical response to stress in rats. Agents Actions 14:569–573

    PubMed  CAS  Google Scholar 

  • Bugajski J, Janusz Z (1983) Central histaminergic stimulation of pituitaryadrenocortical response in the rat. Life Sei 33:1179–1189

    CAS  Google Scholar 

  • Bugajski J, Zacny E (1979) Effect of histamine H2-receptor antagonists, cimetidine, on hypothermia induced by an α-adrenergic agonist, clonidine, in the rat. Agents Actions 9:86–87

    PubMed  CAS  Google Scholar 

  • Cacabelos R, Yamatodani A, Fukui H, Watanabe T, Hariguchi S, Nishimura T, Wada H (1985) Nature of histaminergic neuromodulation of the corticotropinergic system. Biogenic Amines 3:9–19

    CAS  Google Scholar 

  • Cacabelos R, Yamatodani A, Niigawa H, Hariguchi S, Tada K, Nishimura T, Wada H, Brandeis L, Pearson J (1989) Brain histamine in Alzheimer’s disease. Methods Find Exp Clin Pharmacol 11:353–360

    PubMed  CAS  Google Scholar 

  • Calcutt CR, Reynolds J (1976) Some behavioral effects following intracerebroventricular (i.c.v.) injection in rats of histamine Hr and H2-receptor agonists and antagonists. Neuroscience 3:82–83

    Google Scholar 

  • Carlini EA, Green JP (1963) The subcellular distribution of histamine, slow-reacting substance and 5-hydroxytryptamine in the brain of the rat. Br J Pharmacol 20:264–277

    CAS  Google Scholar 

  • Casanueva F, Betti R, Cocchi D, Chieli T, Mantegazza P, Müller EE (1981) Proof for histaminergic but not for adrenergic involvement in the growth hormone-releasing effect of an enkephalin analog in the dog. Endocrinology 108:157–163

    PubMed  CAS  Google Scholar 

  • Cetera B, Bugajski J, Gadek-Michalska A (1988) Involvement of central histamine receptors in corticosterone secretion induced by intraventricular administration of morphine. Agents Actions 23:250–253

    PubMed  CAS  Google Scholar 

  • Chopra YM, Dandiya PC (1974) The mechanism of the potentiating effect of antidepressant drugs on the protective influence of diphenhydramine in experimental catatonia. The role of histamine. Pharmacology 12:347–353

    PubMed  CAS  Google Scholar 

  • Chopra YM, Dandiya PC (1975) The relative role of brain acetylcholine and histamine in perphenazine catatonia and influence of antidepressants and diphenhydramine alone and in combination. Neuropharmacology 14:555–560

    PubMed  CAS  Google Scholar 

  • Chung YH, Miyake H, Kamei C, Tasaka K (1984) Analgesic effect of histamine induced by intracerebral injection into mice. Agents Actions 15:137–142

    PubMed  CAS  Google Scholar 

  • Clark WG, Clark YL (1980) Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents. Neurosci Biobehav Rev 4:175–240

    PubMed  CAS  Google Scholar 

  • Clark WG, Cumby HR (1976) Biphasic changes in body temperature produced by intracerebroventricular injections of histamine in the cat. J Physiol (Lond) 261:235–253

    CAS  Google Scholar 

  • Clark WG, Lipton JM (1985) Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: II. Neurosci Biobehav Rev 9:479–552

    PubMed  CAS  Google Scholar 

  • Clineschmidt BV, Lotti VJ (1973) Histamine: intraventricular injection suppresses ingestive behavior of the cat. Arch Int Pharmacodyn 206:288–298

    PubMed  CAS  Google Scholar 

  • Colboc O, Protais P, Costentin J (1982) Histamine-induced rise in core temperature of chloral-anaesthetized rats: mediation by H2-receptors located in the preopticus area of hypothalamus. Neuropharmacology 21:45–50

    PubMed  CAS  Google Scholar 

  • Correa FMA, Saavedra JM (1981) Increase in histamine concentrations in discrete hypothalamic nuclei of spontaneously hypertensive rats. Brain Res 205:445–451

    PubMed  CAS  Google Scholar 

  • Correa FMA, Saavedra JM (1983) High histamine levels in specific hypothalamic nuclei of Brattleboro rats lacking vasopressin. Brain Res 276:247–252

    PubMed  CAS  Google Scholar 

  • Cox B, Green MD, Chesarek W, Lomax P (1976) The effect of 4-methyl-histamine on temperature regulation in the rat. J Therm Biol 1:205–207

    CAS  Google Scholar 

  • Dahlström A, Fuxe K (1964) Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain neurons. Acta Physiol Scand 62 [Suppl 232]: 1–55

    Google Scholar 

  • De Almeida MAMR, Izquierdo I (1986) Memory facilitation by histamine. Arch Int Pharmacodyn 283:193–198

    PubMed  Google Scholar 

  • De Almeida MAMR, Izquierdo I (1988) Intracerebroventricular histamine, but not 48/80, causes posttraining memory facilitation in the rat. Arch Int Pharmacodyn 291:202–207

    PubMed  Google Scholar 

  • Delbarre B, Schmitt H, Senon D (1976) Effects of activation of Hr and H2-receptors on central cardiovascular structures in cats and on behaviour in chickens. Br J Pharmacol 58:443P-444P

    Google Scholar 

  • Dey PK, Mukhopadhaya N (1986) Involvement of histamine receptors in mediation of histamine induced thermoregulatory response in rats. Indian J Physiol Pharmacol 30:300–306

    PubMed  CAS  Google Scholar 

  • Dhawan BN, Shukla R, Srimal RC (1982) Analysis of histamine receptors in the central thermoregulatory mechanism of Mastomys natalensis. Br J Pharmacol 75:145–149

    PubMed  CAS  Google Scholar 

  • Diepen R (1962) Der Hypothalamus. In: Von Mollendorf W (ed) Handbuch der Mikroscopischen Anatomie des Menschen. Springer, Berlin Göttingen Heidelberg

    Google Scholar 

  • Dismukes K, Snyder SH (1974) Histamine turnover in rat brain. Brain Res 78:467–481

    PubMed  CAS  Google Scholar 

  • Dogterom J, Van Wimersma Greidanus Tj B, De Wied D (1976) Histamine as an extremely potent releaser of vasopressin in the rat. Experientia 32:659–660

    PubMed  CAS  Google Scholar 

  • Donoso AO (1978) Induction of prolactin and luteinizing hormone release by histamine in male and female rats and the influence of brain transmitter antagonists. J Endocrinol 76:193–202

    PubMed  CAS  Google Scholar 

  • Donoso AO (1986); The possible role of brain histamine in neuroendocrine and cardiovascular regulation. Med Res Rev 6:365–386

    PubMed  CAS  Google Scholar 

  • Donoso AO, Alvarez EO (1984) Brain histamine as neuroendocrine transmitter. Trends Pharmacol Sei 5:98–100

    CAS  Google Scholar 

  • Donoso AO, Bannza AM (1976) Acute effects of histamine on plasma prolactin and luteinizing hormone levels in male rat. J Neural Transm 39:95–101

    PubMed  CAS  Google Scholar 

  • Donoso AO, Banzan AM (1978) Failure of histamine to induce the release of luteinizing hormone in castrated rats primed with sex steroids. J Endocrinol 78:447–448

    PubMed  CAS  Google Scholar 

  • Donoso AO, Banzan AM (1980) Hr and H2-histamine receptor antagonists and induced release of prolactin in male rats. Neuroendocrinology 30:11–14

    PubMed  CAS  Google Scholar 

  • Donoso AO, Barontini M (1986) Increase in plasma catecholamines by intraventricular injection of histamine in conscious rats. Naunyn Schmiedebergs Arch Pharmacol 334:188–192

    PubMed  CAS  Google Scholar 

  • Donoso AO, Zarate MB (1981) Changes in prolactin release caused by GABA and endogenous GABA increase in rats. Brain Res Bull 7:359–364

    PubMed  CAS  Google Scholar 

  • Donoso AO, Zarate MB (1983) Release of prolactin and luteinizing hormone by histamine agonists in ovariectomized, steroid-treated rats under ether anesthesia. Exp Brain Res 52:277–280

    PubMed  CAS  Google Scholar 

  • Donoso AO, Banzan AM, Borzino MI (1976) Prolactin and luteinizing hormone release after intraventricular injection of histamine in rats. J Endocrinol 68:171–172

    PubMed  CAS  Google Scholar 

  • Donoso AO, Zarate MB, Seltzer A (1983) Histamine-induced prolactin release: pharmacological characterization of receptors in male rats. Neuroendocrinology 36:436–442

    PubMed  CAS  Google Scholar 

  • Doyle RL, Schatz RA, Sellinger OZ (1981) Differences in the methylation of brain histamine in vivo between audiogenic seizure-sensitive and -resistant deermice. Life Sei 28:2805–2810

    CAS  Google Scholar 

  • Driver PM, Forbes JM, Scanes CG (1979) Hormones, feeding and temperature in sheep following cerebroventricular injections of neurotransmitters and carbachol. J Physiol (Lond) 290:399–411

    PubMed  CAS  Google Scholar 

  • Dropp JJ (1972) Mast cells in the central nervous system of several rodents. Anat Rec 174:227–238

    PubMed  CAS  Google Scholar 

  • Edvinsson L, Cervos-Navarro J, Larsson L-I, Owman CH, Ronnberg A-L (1977) Regional distribution of mast cells containing histamine, dopamine, or 5- hydroxytryptamine in the mammalian brain. Neurology 27:878–883

    PubMed  CAS  Google Scholar 

  • Elias MS, Evans PD (1984) Autoradiographic localization of 3H-histamine accumulation by the visual system of the locust. Cell Tissue Res 238:105–112

    CAS  Google Scholar 

  • Ericson J, Watanabe T, Köhler C (1987) Morphological analysis of the tuberomammillary nucleus in the rat brain: delineation of subgroups with antibody against L-histidine decarboxylase as a marker. J Comp Neurol 263:1–24

    PubMed  CAS  Google Scholar 

  • Fennessy MR, Lewis SJ, Taylor DA, Verberne AJM (1983) Δ 9-Tetrahydrocannabinol reduces brain regional histamine concentrations. Br J Pharmacol 78:452–454

    PubMed  CAS  Google Scholar 

  • Finch L, Hicks PE (1976a) Central hypertensive action of histamine in conscious normotensive cats. Eur J Pharmacol 36:263–266

    PubMed  CAS  Google Scholar 

  • Finch L, Hicks PE (1976b) The cardiovascular effects of intraventricularly administered histamine in the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol 293:151–157

    PubMed  CAS  Google Scholar 

  • Finch L, Hicks PE (1977) Involvement of hypothalamic histamine receptors in the central cardiovascular actions of histamine. Neuropharmacology 16:211–218

    PubMed  CAS  Google Scholar 

  • Fukagawa K, Sakata T, Shiraishi T, Yoshimatsu H, Fujimoto K, Ookuma K, Wada H (1989) Neuronal histamine modulates feeding behavior through Hrreceptor in rat hypothalamus. Am J Physiol 256:R605-R611

    PubMed  CAS  Google Scholar 

  • Fukuda H, Kiyama H, Maeyama K, Kubota H, Yamatodani A, Watanabe T, Tohyama M, Wada H (1986) Immunohistochemical demonstration of histamine N-methyltransferase-like structures in rat kidney. Cell Tissue Res 243:681–684

    PubMed  CAS  Google Scholar 

  • Fukui H, Watanabe T, Wada H (1980) Immunochemical cross reactivity of the antibody elicited against L-histidine decarboxylase purified from the whole bodies of fetal rats with the enzyme from rat brain. Biochem Biophys Res Commun 93:333–339

    PubMed  CAS  Google Scholar 

  • Gadek-Michalska A, Bugajski J (1988) Naloxone antagonizes a central histaminergic stimulation of corticosterone secretion in rats. Agents Actions 23:254–256

    PubMed  CAS  Google Scholar 

  • Garbarg M, Kirishnamoorthy MS, Feger J, Schwartz JC (1973) Effects of mesencephalic and hypothalamic lesions on histamine levels in rat brain. Brain Res 50:361–367

    PubMed  CAS  Google Scholar 

  • Garbarg M, Barbin G, Feger J, Schwartz J-C (1974) Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle. Science 186:833–835

    PubMed  CAS  Google Scholar 

  • Garbarg M, Baudry M, Benda P, Schwartz JC (1975) Simultaneous presence of histamine-iV-methyltransferase and catechol-O-methyltransferase in neuronal and glial cells in culture. Brain Res 83:538–541

    PubMed  CAS  Google Scholar 

  • Garbarg M, Barbin G, Bischoff S, Pollard H, Schwartz JC (1976) Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area. Brain Res 106:333–348

    PubMed  CAS  Google Scholar 

  • Garbarg M, Barbin G, Palacios JM, Schwartz JC (1978) Effects of kainic acid on histaminergic systems in guinea pig hippocampus. Brain Res 150:638–641

    PubMed  CAS  Google Scholar 

  • Garbarg M, Barbin G, Rodergas E, Schwartz JC (1980) Inhibition of histamine synthesis in brain by α-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies. J Neurochem 35:1045–1052

    PubMed  CAS  Google Scholar 

  • Gatti PJ, Gertner SB (1983) The effect of a vasopressin antagonist on the pressor response to histamine administered centrally. Neuropharmacology 22:895–902

    PubMed  CAS  Google Scholar 

  • Gellai M, Edwards BR, Valtin H (1979) Urinary concentrating activity during dehydration in the absence of vasopressin. Am J Physiol 237:F100-F104

    PubMed  CAS  Google Scholar 

  • Gerald MC, Maickel RP (1972) Studies on the possible role of brain histamine in behavior. Br J Pharmacol 44:462–471

    PubMed  CAS  Google Scholar 

  • Gibbs DM, Plotsky PM, De Greef WJ, Neill JD (1979) Effect of histamine and acetylcholine on hypophyseal stalk plasma dopamine and peripheral plasma prolactin levels. Life Sei 24:2063–2070

    CAS  Google Scholar 

  • Glick SD, Crane LA (1978) Opiate-like and abstinence-like effects of intracerebral histamine administration in rats. Nature 273:547–549

    PubMed  CAS  Google Scholar 

  • Gogas KR, Hough LB (1988a) H2-Receptor-mediated stress-induced analgesia is dependent on neither pituitary nor adrenal activation. Pharmacol Biochem Behav 30:791–794

    PubMed  CAS  Google Scholar 

  • Gogas KR, Hough LB (1988b) Effects of zolantidine a brain-penetrating H2-receptor antagonist, on naloxone-sensitive and naloxone-resistant analgesia. Neuropharmacology 27:357–362.

    PubMed  CAS  Google Scholar 

  • Gogas KR, Hough LB, Glick SD, Su K (1986) Opposing actions of cimetidine on naloxone-sensitive and naloxone-insensitive forms of footshock-induced analgesia. Brain Res 370:370–374

    PubMed  CAS  Google Scholar 

  • Granata AR, Numao Y, Kumada M, Reis D (1986) A1 Noradrenergic neurons tonically inhibit sympathoexcitatory neurons of Cl area in rat brainstem. Brain Res 377:127–146

    PubMed  CAS  Google Scholar 

  • Green MD, Cox B, Lomax P (1975a) Histamine Hr and H2-receptors in the central thermoregulatory pathways of the rat. J Neurosci Res 1:353–359

    PubMed  CAS  Google Scholar 

  • Green MD, Simon ML, Lomax P (1975b) Histidine induced hypothermia in the rat. Life Sei 16:1293–1300

    CAS  Google Scholar 

  • Green MD, Cox B, Lomax P (1976) Sites and mechanisms of action of histamine in the central thermoregulatory pathways of the rat. Neuropharmacology 15:321–324

    PubMed  CAS  Google Scholar 

  • Gross PM (1982) Cerebral histamine: indications for neuronal and vascular regulation. J Cereb Blood Flow Metab 2:3–23

    PubMed  CAS  Google Scholar 

  • Gulat-Marnay C, Lafitte A, Arrang J-M, Schwartz J-C (1989) Regulation of histamine release and synthesis in the brain by muscarinic receptors. J Neurochem 52:248–254

    PubMed  CAS  Google Scholar 

  • Haas HL, Reiner PB (1988) Membrane properties of histaminergic tuberomammillary neurons of the rat hypothalamus in vitro. J Physiol (Lond) 399:633–646

    PubMed  CAS  Google Scholar 

  • Haas HL, Wolf P, Palacios JM, Garbarg M, Barbin G, Schwartz JC (1978) Hypersensitivity to histamine in the guinea-pig brain: microiontophoretic and biochemical studies. Brain Res 156:275–291

    PubMed  CAS  Google Scholar 

  • Haass HL, Greene RW, Reiner PB (1989) The brain histamine system in vitro. J Neurosci Method. 28:71–75

    Google Scholar 

  • Häkanson R (1970) New aspects of the formation and function of histamine, 5- hydroxytryptamine and dopamine in gastric mucosa. Acta Physiol Scand [Suppl] 340:1–134

    Google Scholar 

  • Häkanson R, Owman C (1967) Concomitant histochemical demonstration of histamine and catecholamines in enterochromaffin-like cells of gastric mucosa. Life Sei 6:759–766

    Google Scholar 

  • Hardie RC (1987) Is histamine a neurotransmitter in insect photoreceptors? J Comp Physiol [A] 161:201–213

    CAS  Google Scholar 

  • Hardie RC (1988) Effects of antagonists on putative histamine receptors in the first visual neuropile of the housefly (Musca domestica). J Exp Biol 138:221–241

    CAS  Google Scholar 

  • Hayashi H, Takagi H, Takeda N, Kubota Y, Tohyama M, Watanabe T, Wada H (1984) Fine structure of histaminergic neurons in the caudal magnocellular nucleus of the rat as demonstrated by immunocytochemistry using histidine decarboxylase as a marker. J Comp Neurol 29:233–241

    Google Scholar 

  • Hicks PE (1978) Central cardiovascular actions of histamine in rats: involvement of histamine H2-receptors. Clin Exp Hypertens 1:251–265

    PubMed  CAS  Google Scholar 

  • Hilakivi I (1987) Biogenic amines in the regulation of wakefulness and sleep. Med Biol 65:97–104

    PubMed  CAS  Google Scholar 

  • Hill SJ, Straw RM (1988) a2-Adrenoreceptor-mediated inhibition of histamine release from rat cerebral cortical slices. Br J Pharmacol 95:1213–1219

    PubMed  CAS  Google Scholar 

  • Hoffman WE, Schmid PG (1978) Cardiovascular and antidiuretic effects of central histamine. Life Sei 22:1709–1714

    CAS  Google Scholar 

  • Hökfelt t, Fuxe K, Goldstein M, Johansson O (1974) Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain. Brain Res 66:235–251

    Google Scholar 

  • Hough LB (1987) Barbiturate-induced inhibition of rat brain histamine turnover. Biochem Pharmacol 19:3321–3323

    Google Scholar 

  • Hough LB (1988) Cellular localization and possible functions for brain histamine: recent progress. Prog Neurobiol 30:469–505

    PubMed  CAS  Google Scholar 

  • Hough LB, Domino EF (1979) 7>/e-methylhistamine oxidation by type B monoamine oxidase. J Pharmacol Exp Ther 208:422–428

    PubMed  CAS  Google Scholar 

  • Hough LB, Khandelwal JK, Green JP (1982) Effect of pargyline on tele- methylhistamine and histamine in rat brain. Biochem Pharmacol 31:4074–4076

    PubMed  CAS  Google Scholar 

  • Hough LB, Khandelwal JK, Green JP (1984) Histamine turnover in regions of rat brain. Brain Res 291:103–109

    PubMed  CAS  Google Scholar 

  • Hough LB, Glick SD, Su K (1986) Cimetidine penetrates brain and inhibits nonopiate footshock-induced analgesia. Pharmacol Biochem Behav 24:1257–1261

    PubMed  CAS  Google Scholar 

  • Hui FW, Sun CJ, Tocus EC, Hanig JP (1983) The effect of tripelennamine alone and in combination with opiates to produce antinociception in mice. Life Sei 32:1531–1538

    CAS  Google Scholar 

  • Hui K-S, Roberts MB (1975) The effect of mepyramine on the development of morphine tolerance. Life Sei 17:891–900

    CAS  Google Scholar 

  • Ibrahim MZM (1974) The mast cells of the mammalian central nervous system. Part 1. Morphology, distribution and histochemistry. J Neurol Sei 21:431–478

    Google Scholar 

  • Inagaki N, Yamatodani A, Shinoda K, Shiotani Y, Tohyama M, Watanabe T, Wada Η (1987) The histaminergic innervation of the mesencephalic nucleus of the trigeminal nerve in rat brain: a light and electron microscopical study. Brain Res 418:388–391

    PubMed  CAS  Google Scholar 

  • Inagaki N, Yamatodani A, Ando-Yamamoto M, Tohyama M, Watanabe T, Wada H (1988) Organization of histaminergic fibers in the rat brain. J Comp Neurol 273:283–300

    PubMed  CAS  Google Scholar 

  • Inagaki N, Panula P, Yamatodani A, Wada H (1990a) Organization of the histaminergic system in the brain of the turtle, Chinemys reevesii. J Comp Neurol 297: 132–144

    PubMed  CAS  Google Scholar 

  • Inagaki N, Toda K, Taniuchi I, Panula P, Yamatodani A, Tohyama M, Watanabe T, Wada H (1990b) An analysis of histaminergic efferents of the tuberomammillary nucleus to the medial preoptic area and inferior colliculus of the rat. Exp Brain Res 80:374–380

    PubMed  CAS  Google Scholar 

  • Irwin S (1968) Comprehensive observational assessment: la. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 13:222–257

    PubMed  CAS  Google Scholar 

  • Itoh Y, Nishibori M, Oishi R, Saeki K (1984) Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice. Neurosci Lett 48:305–309

    PubMed  CAS  Google Scholar 

  • Itoh Y, Nishibori M, Oishi R, Saeki K (1985a) Changes in histamine metabolism in the mouse hypothalamus induced by acute administration of ethanol. J Neurochem 45:1880–1885

    PubMed  CAS  Google Scholar 

  • Itoh Y, Oishi R, Nishibori M, Saeki K (1985b) Phencyclidine and the dynamics of mouse brain histamine. J Pharmacol Exp Ther 235:788–792

    PubMed  CAS  Google Scholar 

  • Itoh Y, Oishi R, Nishibori M, Saeki K (1987) Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice. Naunyn Schmiedebergs Arch Pharmacol 335:285–289

    PubMed  CAS  Google Scholar 

  • Itoh Y, Oishi R, Nishibori M, Saeki K (1988) Involvement of mu receptors in the opioid-induced increase in the turnover of mouse brain histamine. J Pharmacol Exp Ther 244:1021–1026

    PubMed  CAS  Google Scholar 

  • Itoh Y, Oishi R, Nishibori M, Saeki K (1989) Effects of nociceptive stimuli on brain histamine dynamics. Jpn J Pharmacol 49:449–454

    PubMed  CAS  Google Scholar 

  • Itowi N, Yamatodani A, Cacabelos R, Goto M, Wada H (1989) Effect of histamine depletion on circadian variation of corticotropin and corticosterone in rats. Neuroendocrinology 50:187–192

    PubMed  CAS  Google Scholar 

  • Jaeger GB, Ruggiero DA, Albert VR, Joh TH, Reis DJ (1984) Immunocytochemical localization of aromatic-L-amino acid decarboxylase. In: Bjöklund A, Hökfelt T (eds) Handbook of chemical neuroanatomy, vol 2. Elsevier, Amsterdam, pp 387–408

    Google Scholar 

  • Jaju BP, Wang SC (1971) Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. J Pharmacol Exp Ther 176:718–724

    PubMed  CAS  Google Scholar 

  • Jewett RE (1968) Effects of promethazine on sleep stage in the cat. Exp Neurol 21:368–382

    PubMed  CAS  Google Scholar 

  • Kakucska I, Makara GB (1983) Various putative neurotransmitters affect growth hormone (GH) release in rats with anterolateral hypothalamic deafferentiation of the medial basal hypothalamus: evidence for mediation by a GH-releasing factor. Endocrinology 113:318–323

    PubMed  CAS  Google Scholar 

  • Kalivas PW (1982) Histamine-induced arousal in the conscious and pentobarbitalpretreated rat. J Pharmacol Exp Ther 222:37–42

    PubMed  CAS  Google Scholar 

  • Kamei C, Dabasaki T, Tasaka K (1983) Cataleptic effect of histamine induced by intraventricular injection in mice. Jpn J Pharmacol 33:1081–1084

    PubMed  CAS  Google Scholar 

  • Kataoka K, De Robertis E (1967) Histamine in isolated small nerve endings and synaptic vesicles of rat brain cortex. J Pharmacol Exp Ther 156:114–125

    PubMed  CAS  Google Scholar 

  • Katz RJ, Sibel M (1982) Further analysis of the specificity of a novel animal model of depression-effects of an antihistaminic, antipsychotic and anxiolytic compound. Pharmacol Biochem Behav 16:979–982

    PubMed  CAS  Google Scholar 

  • Kayed K, Hansen T, Godtlibsen OB (1977) Controlled clinical investigation of trimeprazine as a sleep-inducer in normal subjects. Eur J Clin Pharmacol 11:163–167

    PubMed  CAS  Google Scholar 

  • Khan RA, Gupta KP (1986) Effect of centrally administered histamine on body temperature in guinea pigs. Indian J Exp Biol 24:37–39

    PubMed  CAS  Google Scholar 

  • Kirsten EB, Sharma JN (1976) Microiontophoresis of acetylocholine, histamine and their antagonists on neurons in the medial and lateral vestibular nuclei of the cat. Neuropharmacology 15:743–747

    PubMed  CAS  Google Scholar 

  • Kitahama K, Saka K, Tago H, Kimura H, Maeda T, Jouvet M (1984) Monoamine oxidase-containing neurons in the cat hypothalamus: distribution and ascending projection to the cerebral cortex. Brain Res 324:155–159

    PubMed  CAS  Google Scholar 

  • Kitamura Y, Go S, Haranaka K (1978) Decrease of mast cells in W!WV mice and their increase by bone marrow transplantation. Blood 52:447–452

    PubMed  CAS  Google Scholar 

  • Kiyono S, Seo M, Shibagaki M, Watanabe T, Maeyama K, Wada H (1984) Effects of diphenhydramine, histamine Hrreceptor antagonist, and rat sleep-walking parameters. Neurosciences (Kobe) 10:241–248

    CAS  Google Scholar 

  • Kiyono S, Seo ML, Shibagaki M, Watanabe T, Maeyama K, Wada H (1985) Effects of α-fluoromethylhistidine on sleep-waking parameters in rats. Physiol Behav 34:615–617

    PubMed  CAS  Google Scholar 

  • Klein MC Gertner SB (1981) Evidence for a role of endogenous histamine in central cardiovascular regulation: inhibition of histamine-TV-methyltransferase by SKF 91488. J Pharmacol Exp Ther 216:315–320

    PubMed  CAS  Google Scholar 

  • Klein MC, Gertner SB (1983) Studies of the mechanism of the cardiovascular action of central injections of histamine. Neuropharmacology 22:1109–1115

    PubMed  CAS  Google Scholar 

  • Knigge U, Matzen S, Bach EW, Bang P, Warberg J (1986a) Effect of histamine receptor blocakade on stress-induced release of prolactin, beta-endorphin, and catecholamines in male rats. In: Müller EE, MacLeod RM (eds) Neuroendocrine perspectives, vol 5, Elsevier, Amsterdam, pp 297–301

    Google Scholar 

  • Knigge U, Matzen S, Warberg J (1986b) Histaminergic stimulation of prolactin secretion mediated via Hr or H2-receptors: dependence on routes of administration. Neuroendocrinology 44:41–48

    PubMed  CAS  Google Scholar 

  • Knigge U, Bach FW, Matzen S, Bang P, Warberg J (1988a) Effect of histamine on the secretion of pro-opiomelanocortin derived peptides in rats. Acta Endocrinol (Copenh) 119:312–319

    PubMed  CAS  Google Scholar 

  • Knigge U, Matzen S, Warberg J (1988b) Histaminergic mediation of the stressinduced release of prolactin in male rats. Neuroendocrinology 47:68–74

    PubMed  CAS  Google Scholar 

  • Knigge U, Matzen S, Warberg J (1988c) Histaminergic regulation of prolactin secretion: involvement of tuberoinfundibular dopaminergic neurons. Neuroendocrinology 48:167–173

    PubMed  CAS  Google Scholar 

  • Knigge U, Sleimann I, Matzen S, Warberg J (1988d) Histaminergic regulation of prolactin secretion: involvement of serotoninergic neurons. Neuroendocrinology 48:527–533

    PubMed  CAS  Google Scholar 

  • Kobayashi RM, Kopin IJ (1974) The effects of stress and environmental lighting on histamine in the rat. Brain Res 74:356–359

    PubMed  CAS  Google Scholar 

  • Köhler C, Swanson LW, Haglund L, Wu J-Y (1985) The cytoarchitecture, histochemistry and projections of the tuberomammillary nucleus in the rat. Neuroscience 16:85–110

    PubMed  Google Scholar 

  • Köhler C, Ericson H, Watanabe T, Polak J, Palay SL, Palay V, Chan-Palay V (1986) Galanin immunoreactivity in hypothalamic histamine neurons: further evidence for multiple chemical messengers in the tuberomammillary nucleus. J Comp Neurol 250:58–64

    PubMed  Google Scholar 

  • Kollonitsch J, Perkins LM, Patchett AA, Doldouras GA, Marburg S, Duggan DE, Maycock AL, Aster SD (1978) Selective inhibitors qf biosynthesis of aminergic neurotransmitters. Nature 274:906–908

    PubMed  CAS  Google Scholar 

  • Krishnamoorthy MS, Garbarg M, Feger J, Schwartz JC (1973) Augmentation in hypothalamic histamine induced by diencephalic lesions in rats. Agents Actions 3:181

    PubMed  CAS  Google Scholar 

  • Kuhar MJ, Taylor KM, Snyder SH (1971) The subcellular localization of histamine and histamine methyltransferase in rat brain. J Neurochem 18:1515–1527

    PubMed  CAS  Google Scholar 

  • Leibowitz SF (1973) Histamine: a stimulatory effect on drinking behavior in the rat. Brain Res 63:440–443

    PubMed  CAS  Google Scholar 

  • Libertun C, McCann SM (1976) The possible role of histamine in the control of prolactin and gonadotropin release. Neuroendocrinology 20:110–120

    PubMed  CAS  Google Scholar 

  • Lin J-S, Sakai K, Jouvet M (1988) Evidence for histaminergic arousal mechanism in the hypothalamus of cat. Neuropharmacology 27:111–122

    PubMed  CAS  Google Scholar 

  • Lipinski JF, Schaumburg HH, Baldessarini RJ (1973) Regional distribution of histamine in human brain. Brain Res 52:403–408

    PubMed  CAS  Google Scholar 

  • Maeda K, Frohman LA (1978) Dissociation of systemic and central effects of neurotensin on the secretion of growth hormone, prolactin, and thyrotropin. Endocrinology 103:1903–1909

    PubMed  CAS  Google Scholar 

  • Maeyama K, Watanabe T, Taguchi Y, Yamatodani A, Wada H (1982) Effect of α-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissue. Biochem Pharmacol 31:2367–2370

    PubMed  CAS  Google Scholar 

  • Maeyama K, Watanabe T, Yamatodani A, Taguchi Y, Kambe H, Wada H (1983) Effect of α-fluoromethylhistidine on the histamine content of the brain of W/Wv mice devoid of mast cells: turnover of brain histamine. J Neurochem 41: 128–134

    PubMed  CAS  Google Scholar 

  • Malec D, Langwmski R (1983) Is the brain histamine involved in cataleptogenic action of analgesics and haloperidol? Life Sei 33:623–625

    CAS  Google Scholar 

  • Mandelbrod I, Feldman S, Werman R (1983) The effects of iontophoretic application of putative neurotransmitters on the electrical activity of rat mediobasal hypothalamic neurons in relation to their steroid sensitivity. Brain Res 272:115–127

    PubMed  CAS  Google Scholar 

  • Maslmski Cz, Lebrecht U, Nowak JZ, Pile A, Wieczorek-Fila Z (1973) Catalepsia-like symptoms produced by histidine in rats. Agents Actions 3:185–186

    Google Scholar 

  • Mazurkiewicz-Kwilecki IM (1983) Brain histamine-plasma corticosterone interactions. Life Sei 32:1099–1106

    CAS  Google Scholar 

  • Mazurkiewicz-Kwilecki IM, Henwood RW (1976) Alterations in brain endogenous histamine levels in rats after chronic morphine treatment and morphine withdrawal. Agents Actions 6:402–408

    PubMed  CAS  Google Scholar 

  • Mazurkiewicz-Kwilecki IM, Nsonwah S (1987) The influence of a-fluoromethylhistidine on the regional brain histamine and plasma corticosterone levels in aging. Can J Physiol Pharmacol 65:2154–2157

    PubMed  CAS  Google Scholar 

  • Mazurkiewicz-Kwilecki IM, Prell GD (1980) Brain histamine: plasma corticosterone, spontaneous locomotor activity and temperature. Pharmacol Biochem Behav 12:533–549

    Google Scholar 

  • McCaman RE, Weinreich D (1985) Histaminergic synaptic transmission in the cerebral ganglion of Aplysia. J Neurophysiol 53:1016–1037

    PubMed  CAS  Google Scholar 

  • McKearney JW (1982) Stimulant actions of histamine Ηχ antagonists on operant behavior in the squirrel monkey. Psychopharmacology 77:156–158

    PubMed  CAS  Google Scholar 

  • McKearney JW (1985) Relative potencies of histamine Ηχ antagonists as behavioral stimulants in the squirrel monkey. Psychopharmacology 86: 380–381

    PubMed  CAS  Google Scholar 

  • Meitzer HY, Simonovic M, Gudelsky GA (1983) Effect of yohimbine on rat prolactin secretion. J Pharmacol Exp Ther 224:21–27

    Google Scholar 

  • Miki H, Inagaki N, Panula P, Imamura I, Yamatodani A, Wada H (1989) Phylogeny of the histaminergic system in vertebrate brain, Jpn J Pharmacol 49 [Suppl]:188P

    Google Scholar 

  • Monnier M, Sauer R, Hatt AM (1970) The activating effect of histamine on the central nervous system. Int Rev Neurobiol 12:265–305

    PubMed  CAS  Google Scholar 

  • Monti JM, Pellejero T, Jantos H (1986) Effects of Ηχand H2-histamine receptor agonists and antagonists on sleep and wakefulness in the rat. J Neural Transm 66:1–11

    PubMed  CAS  Google Scholar 

  • Monti JM, D’Angelo L, Jantos H, Pazos S (1988) Effects of a-fluoromethylhistidine on sleep and wakefulness in the rat. J Neural Transm 72:141–145

    PubMed  CAS  Google Scholar 

  • Morgan LO (1930) Cell groups in the tuber cinereum of the dog, with a discussion of their function. J Comp Neurol 51:271–297

    Google Scholar 

  • Mukhopadhyay N, Dey PK (1986) Thermoregulatory response in rats following administration of histamine in different CSF compartments. Indian J Physiol Pharmacol 30:31–42

    PubMed  CAS  Google Scholar 

  • Muley MP, Balsara JJ, Jadhav JH, Chandorkar AG (1982) Involvement of histaminergic mechanisms in the cataleptogenic effect of morphine in mice. J Pharm Pharmacol 34:34–37

    PubMed  CAS  Google Scholar 

  • Nässel DR, Holmqvist MH, Hardie RC, Häkanson R, Sundler F (1988) Histaminelike immunoreactivity in photoreceptors of the compound eyes and ocelli of the flies Calliphora erythrocephala and Musca domestica. Cell Tissue Res 253:639–646

    PubMed  Google Scholar 

  • Nath C, Gulati A, Dhawan KN, Gupta GP, Bhargave KP (1982) Evidence for central histaminergic mechanism in foot shock aggression. Psychopharmacology 76:228–231

    PubMed  CAS  Google Scholar 

  • Nath C, Gulati A, Dhawan KN, Gupta GP (1988) Role of central histamine mechanism in behavioural depression (swimming despair) in mice. Life Sei 42:2413–2417

    CAS  Google Scholar 

  • Netti C, Guidobono F, Olgiati VR, Sibilia V, Pecile A (1981) Histamine agonist and antagonist drugs: interference with CNS control of GH release in rats. Horm Res 14:180–191

    PubMed  CAS  Google Scholar 

  • Netti C, Guidobono F, Olgiati VR, Sibilia V, Pagani F, Pecile A (1982) Influence of brain histaminergic system on episodic growth hormone secretion in the rat. Neuroendocrinology 35:43–47

    PubMed  CAS  Google Scholar 

  • Netti C, Bossa R, Galatulas I, Sibilia V, Pecile A (1984a) Antinociceptive effect of centrally administered cimetidine and dimaprit in the rat. Pharmacology 28:262–267

    PubMed  CAS  Google Scholar 

  • Netti C, Guidobono F, Sibilia V, Olgiati VR, Pagani F, Pecile A (1984b) Failure of somatostatin antiserum to reverse histamine-induced inhibition of pulsatile growth hormone secretion. Horm Res 19:12–17

    PubMed  CAS  Google Scholar 

  • Netti C, Guidobono F, Silbilia V, Villa I, Cazzamalli E, Pecile A (1988a) Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat. Agents Actions 23:247–249

    PubMed  CAS  Google Scholar 

  • Netti C, Silbilia V, Guidonbono F, Villa I (1988b) Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat. Acta Endocrinol (Copenh) 119:488–492

    PubMed  CAS  Google Scholar 

  • Nicholson AN, Pascoe PA, Stone BM (1985) Histaminergic systems and sleep: studies in man with Hi and H2 antagonists. Neuropharmacology 24:245–250

    PubMed  CAS  Google Scholar 

  • Ninkovic M, Hunt SP, Gleave JRW (1982) Localization of opiate and histamine Hrreceptors in the primate sensory ganglia and spinal cord. Brain Res 241:197–206

    PubMed  CAS  Google Scholar 

  • Nishibori M, Oishi R, Saeki K (1984) Histamine turnover in the brain of different mammalian species: implication for neuronal histamine half-life. J Neurochem 43:1544–1549

    PubMed  CAS  Google Scholar 

  • Nishibori M, Oishi R, Itoh Y, Saeki K (1985) Morphine-induced changes in histamine dynamics in mouse brain. J Neurochem 45:719–724

    PubMed  CAS  Google Scholar 

  • Nishibori M, Oishi R, Itoh Y, Saeki K (1986) Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain. Jpn J Pharmacol 41:403–408

    PubMed  CAS  Google Scholar 

  • Nishibori M, Itoh Y, Oishi R, Saeki K (1987) Mechanism of the central hyperglycemic action of histamine in mice. J Pharmacol Exp Ther 241:582–586

    PubMed  CAS  Google Scholar 

  • Nistico G, Rotiroti D, De Sarro A, Naccari F, Stephenson JD (1980) Central effects of histamine and Ηχ and H2 receptor agonists and antagonists after intraventricular infusion in fowls. Res Commun Chem Pathol Pharmacol 27:431–450

    PubMed  CAS  Google Scholar 

  • Nowak JZ (1982) Impromidine-induced hypothermia in rats: effects of cimetidine and mianserine. Agents Action, 12:148–152

    CAS  Google Scholar 

  • Nowak JZ, Pile A (1975) The influence of mepyramine and burimamide on histamine induced catalepsy in the rat. Acta Physiol Pol 26:529–532

    PubMed  CAS  Google Scholar 

  • Nowak JZ, Bielkiewicz B, Lebrecht U (1979) Dimaprit-induced hypothermia in normal rats: its attenuation by cimetidine and by tricyclic antidepressant drugs. Neurophamacology 18:783–789

    CAS  Google Scholar 

  • Oishi R, Nishibori M, Saeki K (1983) Regional distribution of histamine and telemethylhistamine in the rat, mouse and guinea-pig brain. Brain Res 280:172–175

    PubMed  CAS  Google Scholar 

  • Oishi R, Nishibori M, Saeki K (1984) Regional differences in the turnover of neuronal histamine in the rat brain. Life Sei 34:691–699

    CAS  Google Scholar 

  • Oishi R, Itoh Y, Nishibori M, Saeki K (1985a) A9-Tetrahydrocannabinol decreases turnover of brain histamine. J Pharmacol Exp Ther 232:513–518

    PubMed  CAS  Google Scholar 

  • Oishi R, Itoh Y, Nishibori M, Saeki K (1985b) Decrease in histamine turnover in the brain of spontaneously hypertensive rats. Brain Res 343:180–183

    PubMed  CAS  Google Scholar 

  • Oishi R, Nishibori M, Itoh Y, Saeki K (1986) Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol 124:337–342

    PubMed  CAS  Google Scholar 

  • Oishi R, Itoh Y, Nishibori M, Saeki K (1987) Feeding-related circadian variation in tele-methylhistamine levels of mouse and rat brain. J Neurochem 49:541–547

    PubMed  CAS  Google Scholar 

  • Oishi R, Nishibori M, Itoh Y, Saeki K, Fukuda T, Araki Y (1988) Histamine turnover in the brain of morphine-dependent mice. Naunyn Schmiedebergs Arch Pharmacol 337:58–63

    PubMed  CAS  Google Scholar 

  • Ongini E, Marzanatti M, Guzzon V (1987) Comparative effects of loratadine and selected antihistamines on sleep-waking patterns in the cat. Drug Dev Res 10:75–83

    CAS  Google Scholar 

  • Onodera K, Ogura Y (1982) The effect of intraventricular injection of histamine on the behavior in mice and rats. In: Uväns B, Tasaka K (eds) Advances in histamine research. Pergamon, Oxford, pp 127–136 (Advances in the biosciences, vol 33)

    Google Scholar 

  • Onodera K, Ogura Y (1984) Effects of histaminergic drugs on muricide induced by thiamine deficiency. Jpn J Pharmacol 34:15–21

    PubMed  CAS  Google Scholar 

  • Onodera K, Sakurai E, Niwa H (1987) Effect of chlorpheniramine on muricide induced by thiamine deficiency: pharmacokinetic and behavioral studes. Agents Actions 20:229–232

    PubMed  CAS  Google Scholar 

  • Orr E, Quay WB (1975a) Hypothalamic 24-hour rhythms in histamine, histidine decarboxylase and histamine-iV-methyltransferase. Endocrinology 96:941–945

    PubMed  CAS  Google Scholar 

  • Orr E, Quay WB (1975b) The effects of castration on histamine levels and 24-hour rhythm in the male rat hypothalamus. Endocrinology 97:481–484

    PubMed  CAS  Google Scholar 

  • Palacios JM, Wamsley JK, Kuhar MJ (1981a) The distribution of histamine Ηχreceptors in the rat brain: an autoradiographic study. Neuroscience 6:15–37

    PubMed  CAS  Google Scholar 

  • Palacios JM, Wamsley JK, Kuhar MJ (1981b) GAB A, benzodiazepine and histamine- Ηχ receptors in the guinea pig cerebellum: effect of kainic acid injections studies by autoradiographic methods. Brain Res 214:155–162

    PubMed  CAS  Google Scholar 

  • Panula P, Yang H-YT, Costa E (1984) Histamine-containing neurons in the rat hypothalamus. Proc Natl Acad Sei USA 81:2572–2576

    CAS  Google Scholar 

  • Panula P, Häppölä O, Airaksinen MS, Auvinen S, Virkamäki A (1988) Carbodiimide as a tissue fixative in histamine immunohistochemistry and its application in developmental neurobiology. J Histochem Cytochem 36:259–269

    PubMed  CAS  Google Scholar 

  • Panula P, Airaksinen MS, Pirvola U, Kotilainen E (1990a) A histamine-containing neuronal system in human brain. Neuroscience 34:127–132

    PubMed  CAS  Google Scholar 

  • Panula P, Flügge G, Fuchs E, Pirvola U, Auvinen S, Airaksinen MS (1989a) Histamine-immunoreactive nerve fibers in the mammalian spinal cord. Brain Res 484:234–239

    PubMed  CAS  Google Scholar 

  • Panula P, Pirvola U, Auvinen S, Airaksinen MS (1989b) Histamine-immunoreactive nerve fibers in the rat brain. Neuroscience 28:585–610

    PubMed  CAS  Google Scholar 

  • Panula P, Wouterlood FG, Auvinen S (1990b) Histaminergic neurons in the mouse brain (to be published)

    Google Scholar 

  • Patel BT, Tudball N, Wada H, Watanabe T (1986) Adenosine deaminase and histidine decarboxylase coexist in certain neurons of the rat brain. Neurosci Lett 63:185–189

    PubMed  CAS  Google Scholar 

  • Pawlowski L, Sidorowicz L (1978) The effect of antihistamine drugs on the neuroleptic-induced catalepsy. Pol J Pharmacol Phar, 30:665–673

    CAS  Google Scholar 

  • Philippu A (1988) Regulation of blood pressure by central neurotransmitters and neuropeptides. Rev Physiol Biochem Pharmacol 111:1–115

    PubMed  CAS  Google Scholar 

  • Philippu A, Wiedemann K (1981a) Hypothalamic superfusion with histamine agonists and antagonists modifies the pressor response to hypothalamic stimulation. Agents Actions 11:143–144

    PubMed  CAS  Google Scholar 

  • Philippu A, Wiedmann K (1981b) Hypothalamic superfusion with histamine agonists and antagonists modifies the pressor response to hypothalamic stimulation. J Auton Pharmacol 1:111–117

    PubMed  CAS  Google Scholar 

  • Philippu A, Hanesch U, Hagen R, Robinson RL (1982) Release of endogenous histamine in the hypothalamus of anaesthetized cats and conscious, freely moving rabbits. Naunyn Schmiedebergs Arch Pharmacol 321:282–286

    PubMed  CAS  Google Scholar 

  • Philippu A, Hagen R, Hanesch U, Waldmann U (1983) Changes in the arterial blood pressure increase the release of endogenous histamine in the hypothalamus of anaesthetized cats. Naunyn Schmiedebergs Arch Pharmacol 323:162–167

    PubMed  CAS  Google Scholar 

  • Picatoste F, Blanco I, Palacios JM (1977) The presence of two cellular pools of rat brain histamine. J Neurochem. 29:735–737

    PubMed  CAS  Google Scholar 

  • Pile A, Nowak JZ (1980) The influence of 4-methylhistamine, an agonist of histamine H2 receptors on body temperature in rats. Neuropharmacology 19:773–775

    Google Scholar 

  • Pile A, Rokosz-Pelc A (1983) The attenuation by chronic electroconvulsive treatment of hypothermia induced by histamine H2-receptor stimulants in rats. Eur J Pharmacol 88:255–257

    Google Scholar 

  • Pile A, Rogož Z, Byrska B (1980) Some central effects of impromidine, a potent agonist of histamine H2 receptors. Neuropharmacology 19:947–950

    Google Scholar 

  • Pile A, Rogož Z, Skuza G (1982) Histidine-induced bizarre behaviour in rats: the possible involvement of central cholinergic system. Neuropharmacologv 21:781–785

    Google Scholar 

  • Pirvola U, Tuomisto L, Yamatodani A, Panula P (1988) Distribution of histamine in the cockroach brain and visual system: an immunohistochemical and biochemical study. J Comp Neurol 276:514–526

    PubMed  CAS  Google Scholar 

  • Pollard H, Schwartz J-C (1987) Histamine neuronal pathways and their functions. Trends Neurosci 10:86–89

    CAS  Google Scholar 

  • Pollard H, Bischoff S, Schwartz J-C (1973) Decreased histamine synthesis in the rat brain by hypnotics and anaesthetics. J Pharm Pharmacol 25:920–922

    PubMed  CAS  Google Scholar 

  • Pollard H, Biochoff S, Schwartz J-C (1974) Turnover of histamine in rat brain and its decrease under barbiturate anesthesia. J Pharmacol Exp Ther 190:88–99

    PubMed  CAS  Google Scholar 

  • Pollard H, Llorens-Cortes C, Barbin G, Garbarg M, Schwartz JC (1978) Histamine and histidine decarboxylase in brain stem nuclei: distribution and decrease after lesions. Brain Res 157:178–181

    PubMed  CAS  Google Scholar 

  • Pollard H, Pachot I, Schwartz J-C (1985) Monoclonal antibody against L-histidine decarboxylase for localization of histaminergic cells. Neurosci Lett 54:53–58

    PubMed  CAS  Google Scholar 

  • Prast H, Gujrati V, Walser S, Philippu A (1988a) Histamine, histidine decarboxylase and histamine-N-methyltransferase in brain areas of spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol 338:573–576

    PubMed  CAS  Google Scholar 

  • Prast H, Saxer A, Philippu A (1988b) Pattern of in vivo release of endogenous histamine in the mammillary body and the amygdala. Naunyn Schmiedebergs Arch Pharmacol 337:53–57

    PubMed  CAS  Google Scholar 

  • Prast H, Walser S, Saxer A, Philippu A (1989) The release of endogenous histamine in distinct brain areas is modified by electrical stimulation. Naunyn Schmiedebergs Arch Pharmacol 339:564–567

    PubMed  CAS  Google Scholar 

  • Prell GD, Green JP (1986) Histamine as a neuroregulator. Ann Rev Neurosci 9: 209–254

    PubMed  CAS  Google Scholar 

  • Rafalowska U, Waskiewicz J, Albrecht J (1987) Is neurotransmitter histamine predominantly inactivated in astrocytes? Neurosci Lett 80:106–110

    PubMed  CAS  Google Scholar 

  • Ray A, Sharma KK, Sen P (1981) Effect of histaminergic drugs on footshock-induced aggressive behaviour in rats. Eur J Pharmacol 73:217–219

    PubMed  CAS  Google Scholar 

  • Ray A, Sharma KK, Alkondon M, Sen P (1983) Possible interrelationship between the biogenic amines involved in the modulation of footshock aggression in rats. Arch Int Pharmacodyn 265:36–41

    PubMed  CAS  Google Scholar 

  • Reiner PB, McGeer EG (1987) Electrophysiological properties of cortically projecting histamine neurons of the rat hypothalamus. Neurosci Lett 73:43–47

    PubMed  CAS  Google Scholar 

  • Reiner PB, McGeer EG (1988) THA increases action potential duration of central histamine neurons in vitro. Eur J Pharmacol 155:265–270

    PubMed  CAS  Google Scholar 

  • Reynolds LR, Rubel AM, Nikitovitch-Winer MB (1980) Cimetidine inhibits the histamine-induced prolactin release in male rats. Proc Soc Exp Biol Med 163:322–325

    PubMed  CAS  Google Scholar 

  • Rivier C, Vale W (1977) Effects of γ-aminobutyric acid and histamine on prolactin secretion in the rat. Endocrinology 101:506–511

    PubMed  CAS  Google Scholar 

  • Rivier C, Brown M, Vale W (1977) Effect of neurotensin, substance P and morphine sulfate on the secretion of prolactin and growth hormone in the rat. Endocrinology 100:751–754

    PubMed  CAS  Google Scholar 

  • Rocha e Silva M (ed) (1966) Histamine and antihistaminics. Handbook of experimental pharmacology, vol 18. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Rotter A, Frostholm A (1986) Cerebellar histamine-Hx receptor distribution: an autoradiographic study of Purkinje cell degeneration, Staggerer, Weaver and Reeler mutant mouse strain. Brain Res Bull 16:205–214

    PubMed  CAS  Google Scholar 

  • Rumore MM, Schlichting DA (1985) Analgesic effects of antihistaminics. Life Sei 36:403–416

    CAS  Google Scholar 

  • Saavedra JM, Brownstein MJ, Palkovits M (1976) Distribution of catechol-O- methyltransferase, histamine TV-methyltransferase and monoamine oxidase in specific areas of the rat brain. Brain Res 118:152–156

    PubMed  CAS  Google Scholar 

  • Sakata T, Fukagawa K, Fujimoto K, Yoshimatsu H, Shiraishi T, Wada H (1988a) Feeding induced by blockade of histamine Hrreceptor in rat brain. Experientia 44:216–218

    PubMed  CAS  Google Scholar 

  • Sakata T, Fukagawa K, Ookuma K, Fujimoto K, Yoshimatsu H, Yamatodani A, Wada H (1988b) Modulation of neuronal histamine in control of food intake. Physiol Behav 44:539–543

    PubMed  CAS  Google Scholar 

  • Sakata T, Ookuma K, Fukagawa K, Fujimoto K, Yoshimatsu H, Shiraishi T, Wada H (1988c) Blockade of the histamine Hrrecptor in the rat ventromedial hypothalamus and feeding elicitation. Brain Res 441:403–407

    PubMed  CAS  Google Scholar 

  • Schayer RW, Reilly MA (1970) In vivo formation and catabolism of [14C]histamine in mouse brain. J Neurochem 17; 1649–1655

    CAS  Google Scholar 

  • Schayer RW, Reilly MA (1973) Formation and fate of histamine in rat and mouse brain. J Pharmacol Exp Ther 184:33–40

    PubMed  CAS  Google Scholar 

  • Schlemermeyer E, Schütte M, Ammermüller J (1989) Immunohistochemical and electrophysiological evidence that locust ocellar photoreceptors contain and release histamine. Neurosci Lett 99:73–78

    PubMed  CAS  Google Scholar 

  • Schwartz J-C, Pollard H, Bioschoff S, Rehault MC, Verdiere-Sahuque M (1971) Catabolism of 3H-histamine in the rat brain after intracisternal administration. Eur J Pharmacol 16:326–335

    PubMed  CAS  Google Scholar 

  • Schwartz J-C, Barbin G, Garbarg M, Pollard H, Rose C, Verdiere M (1976) Neurochemical evidence for histamine acting as a transmitter in mammalian brain. Adv Biochem Psychopharmacol 15:111–126

    PubMed  CAS  Google Scholar 

  • Schwartz J-C, Pollard H, Quach TT (1980) Histamine as a neurotransmitter in mammalian brain: neurochemical evidence. J Neurochem 35:26–33

    PubMed  CAS  Google Scholar 

  • Schwartz J-C, Garbarg M, Pollard H (1986a) Histaminergic transmission in the brain. In: Mountcastle VB (ed) The nervous system. American Physiological Society, Bethesda, pp 257–316 (Handbook of physiology, vol 4)

    Google Scholar 

  • Schwartz JH, Elste A, Shaprio E, Gotoh H (1986b) Biochemical and morphological correlates of transmitter type in C2, an identified histaminergic neuron in Aplysia. J Comp Neurol 245:401–421

    PubMed  CAS  Google Scholar 

  • Seltzer A, Donoso AO (1982) Involvement of specific receptors in the histamine stimulation of the pituitary-corticoadrenal system in the rat. Neyroendocrinol Lett 4:299–304

    CAS  Google Scholar 

  • Seltzer AM, Donoso AO, Podesta E (1986) Restraint stress stimulation of prolactin and ACTH secretion: role of brain histamine. Physiol Behav 36:251–255

    PubMed  CAS  Google Scholar 

  • Senba E, Daddona PE, Watanabe T, Wu J-Y, Nagy JI (1985) Coexistence of adenosine deaminase, histidine decarboxylase, and glutamate decarboxylase in hypothalamic neurons of the rat. J Neurosci 5:3393–3402

    PubMed  CAS  Google Scholar 

  • Sewell RG, Nanry KP, Kennedy J, Stiger TR, Harmon RE (1985) Supraadditive toxic interaction of nicotine with antihistamines, and enhancement by the proconvulsant pentylenetetrazole. Pharmacol Biochem Behav 22:469–477

    PubMed  CAS  Google Scholar 

  • Seybold VS (1985) Distribution of histaminergic, muscarinic and serotonergic binding sites in cat spinal cord with emphasis on the region surrounding the central canal. Brain Res 342:291–296

    PubMed  CAS  Google Scholar 

  • Shaw GG (1971) Hypothermia produced in mice by histamine acting on the central nervous system. Br J Pharmacol 42:205–214

    PubMed  CAS  Google Scholar 

  • Sheiner JB, Morris P, Anderson GH (1985) Food intake suppression by histidine. Pharmacol Biochem Behav 23:721–726

    PubMed  CAS  Google Scholar 

  • Shibata K, Yamada K, Furukawa T (1987) Possible neuronal mechanism involved in neurotensin-induced catalepsy in mice. Psychopharmacology 91:288–292

    PubMed  CAS  Google Scholar 

  • Shirouzu M, Kimura H, Yamamoto T, Ochi J, Inanaga K (1983) Production of new type of antisera to thyrotropin releasing hormone (TRH) using carbodiimide coupling and an application to immunohistochemistry. Kurume Med J 30 [Suppl]:Sl-S9

    Google Scholar 

  • Shotte A, Leysen JE (1988) Distinct autoradiographic labeling of serotonin 5-HT2 receptors, aradrenoreceptors and histamine-Hj receptors and of tetrabenazinedisplaceable ketanserin binding sites in rodent brain with [125I]7-amino-8-iodoketanserin. Eur J Pharmacol 145:213–216

    Google Scholar 

  • Shukla R, Srimal RC, Dhawan BN (1983) Analysis of hypothalamic response to centrally administered histamine in pigeons. J Auton Nerv Syst 8:373–381

    PubMed  CAS  Google Scholar 

  • Simmons PJ, Hardie RC (1988) Evidence that histamine is a neurotransmitter of photoreceptors in the locust ocellus. J Exp Biol 138:205–219

    CAS  Google Scholar 

  • Sinha JN, Gupta ML, Bhargava KP (1969) Effect of histamine and antihistaminics on central vasomotor loci. Eur J Pharmacol 5:235–238

    PubMed  CAS  Google Scholar 

  • Slotkin TA, Slepetis RJ, Weigel SJ, Whitmore WL (1983a) Effects of a- fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. Life Sei 32:2897–2903

    CAS  Google Scholar 

  • Slotkin TA, Bartolome J, Whitmore WL (1983b) Developmental effects of afiuoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines. Life Sei 33:2137–2145

    CAS  Google Scholar 

  • Smits RPJM, Steinbusch HWM, Mulder AH (1988) Studies on the specificity of uptake and release of radiolabelled histamine in rat brain slices. Neurochem Int 2:193–201

    Google Scholar 

  • Snyder SH, Brown B, Kuhar MJ (1974) The subsynaptosomal localization of histamine, histidine decarboxylase and histamine methyltransferase in rat hypothalamus. J Neurochem 23:37–45

    PubMed  CAS  Google Scholar 

  • Sokol HW, Valtin H (1965) Morphology of the neurosecretory system in rats homozygous and heterozygous for hypothalamic diabetes insipidus (Brattleboro strain). Endocrinology 77:692–700

    PubMed  CAS  Google Scholar 

  • Sperk G, Hörtnagl H, Reither H, Hornykiewicz O (1981) Evidence for neuronal localization of histamine-N-methyltransferase in rat brain. J Neurochem 37:525–526

    PubMed  CAS  Google Scholar 

  • Staines WA, Yamamoto T, Daddona PE, Nagy JI (1986) Neuronal colocalization of adenosine deaminase, monoamine oxidase, galanin and 5-hydroxytryptophan uptake in the tuberomammillary nucleus of the rat. Brain Res Bull 17:351–365

    PubMed  CAS  Google Scholar 

  • Staines WA, Daddona PE, Nagy JI (1987) The organization and hypothalamic projections of the tuberomammillary nucleus in the rat: an immunohistochemical study of adenosine deaminase-positive neurons and fibers. Neuroscience 23:571–596

    PubMed  CAS  Google Scholar 

  • Steinbusch HWM, Mulder AH (1984) Immunohistochemical localization of histamine in neurons and mast cells in the rat brain. In: Björklund A, Hökfelt T, Kuhar MJ (eds) Classical transmitters and transmitter receptors in the CNS, Prt II. Elsevier, Amsterdam, pp 126–140 (Handbook of chemical neuroanatomy, vol 3)

    Google Scholar 

  • Subramanian N, Mulder AH (1976) Potassium-induced release of tritiated histamine from rat brain tissue slices. Eur J Pharmacol 35:203–206

    PubMed  CAS  Google Scholar 

  • Sun C-L, Hui FW, Hanig JP (1985) Effect of Ηχ blockers alone and in combination with morphine to produce antinociception in mice. Neuropharmacology 24:1–4

    PubMed  CAS  Google Scholar 

  • Sweatman P, Jell RM (1977) Dopamine and histamine sensitivity of rostral hypothalamic neurons in the cat: possible involvement in thermoregulation. Brain Res 127:173–178

    PubMed  CAS  Google Scholar 

  • Tagashira E, Kachur JF, Carter Jr H, Dewey WL (1984) Potentiation of narcoticinduced antinociception by tripelennamine in morphine-tolerant and drug-naive mice. J Pharmacol Exp Ther 229:214–217

    PubMed  CAS  Google Scholar 

  • Taguchi Y, Watanabe T, Kubota H, Hayashi H, Wada H (1984) Purification of histidine decarboxylase from the liver of fetal rats and its immunochemical and immunohistochemical characterization. J Biol Chem 259:5214–5221

    PubMed  CAS  Google Scholar 

  • Taguchi Y, Watanabe T, Shiosaka S, Tohyama M, Wada H (1985) Immunohistochemical analysis of the cross-reaction of anti-rat histidine decarboxylase antibody with guinea-pig DOPA decarboxylase. Brain Res 340:235–242

    PubMed  CAS  Google Scholar 

  • Takagi H, Morishima Y, Matsuyama T, Hayashi H, Watanabe T, Wada H (1986) Histaminergic axons in the neostriatum and cerebral cortex of the rat: a correlated light and electron microscopic immunocytochemical study using histidine decarboxylase as a marker. Brain Res 364:114–123

    PubMed  CAS  Google Scholar 

  • Takeda N, Inagaki S, Shiosaka S, Taguchi Y, Oertel WH, Tohyama M, Watanabe T, Wada H (1984a) Immunohistochemical evidence for the coexistence of histidine decarboxylase-like and glutamate decarboxylase-like immunoreactivities in nerve cells of the magnocellular nucleus of the posterior hypothalamus of rats. Proc Natl Acad Sei USA 81:7647–7650

    CAS  Google Scholar 

  • Takeda N, Inagaki S, Taguchi Y, Tohyama M, Watanabe T, Wada H (1984b) Origins of histamine-containing fibers in the cerebral cortex of rats: studies by immunohistochemistry with histidine decarboxylase as a marker and transection. Brain Res 323:55–63

    PubMed  CAS  Google Scholar 

  • Takeda N, Morita M, Kubo T, Yamatodani A, Watanabe T, Wada H, Matsunaga T (1986) Histaminergic mechanism of motion sickness: neurochemical and neuropharmacological studies in rats. Acta Otolaryngol (Stockh) 101:416–421

    PubMed  CAS  Google Scholar 

  • Takeda N, Morita M, Kubo T, Yamatodani A, Wada H, Matsunaga T (1987a) Role of histamine in motion sickness and space motion sickness. In: Watanabe S, Mitarai G, Mori S (eds) Biological sciences in space 1986. Myu Research, Tokyo, pp 173–177

    Google Scholar 

  • Takemura M, Kishino J, Yamatodani A, Wada H (1989) Inhibition of histamine release from rat hypothalamic slices by ω-conotoxin GVIA, but not by nilvadipine, a dihydropyridine derivative. Brain Res 496:351–356

    PubMed  CAS  Google Scholar 

  • Tangri KK, Gupta GP, Vrat S (1989) Role of histamine receptor in mesencephalic nucleus dorsalis raphe in cardiovascular regulation. Naunyn Schmiedebergs Arch Pharmacol 339:557–563

    PubMed  CAS  Google Scholar 

  • Tasaka K, Kamei C, Akahori H, Kitazumi K (1985) The effects of histamine and some related compounds on conditioned avoidance response in rats. Life Sei 37:2005–2014

    CAS  Google Scholar 

  • Tasaka K, Chung YH, Sawada K, Mio M (1989) Excitatory effect of histamine on the arousal system and its inhibition by Hi blockers. Brain Res Bull 22:271–275

    PubMed  CAS  Google Scholar 

  • Taylor KM, Snyder SH (1971) Brain histamine: rapid apparent turnover altered by restraint and cold stress. Science 172:1037–1039

    PubMed  CAS  Google Scholar 

  • Taylor KM, Snyder SH (1972) Dynamics of the regulation of histamine levels in mouse brain. J Neurochem 19:341–354

    PubMed  CAS  Google Scholar 

  • Taylor KM, Snyder SH (1973) The release of histamine from tissue slices of rat hypothalamus. J Neurochem 21:1215–1223

    PubMed  CAS  Google Scholar 

  • Taylor KM, Gfeller E, Snyder SH (1972) Regional localization of histamine and histidine in the brain of the rhesus monkey. Brain Res 41:171–179

    PubMed  CAS  Google Scholar 

  • Ten Haaf JA, Van Wimersma Greidanus TB, Maigret C, De Wied D (1986) Effect of the opioid peptide beta-endorphin on the in vivo release of vasopressin in rats under various conditions. Neuroendocrinology 44:102–107

    PubMed  Google Scholar 

  • Trendelenburg U (1957) Stimulation of sympathetic centers by histamine. Circ Res 5:105–110

    PubMed  CAS  Google Scholar 

  • Tsai CL, Matsumura K, Kanosue K, Nakayama T, Itowi N, Yamatodani A, Wada H (1989) Effects of histamine on thermosensitive neurons in preoptic slice preparations. Neurosci Lett 102:297–302

    PubMed  CAS  Google Scholar 

  • Tuominen RK, Mattila J, Männistö PT (1983) Inhibition of the TSH secretion by histamine in male rats. Acta Endocrinol 103:88–94

    PubMed  CAS  Google Scholar 

  • Tuominen RK, Männistö PT, Mattila J (1985) Studies on the site and mechanism of the inhibitory action of intracerebral histamine on the cold-stimulated thyrotropin secretion in male rats. Brain Res 343:329–335

    PubMed  CAS  Google Scholar 

  • Tuomisto L (1986) Delayed ontogenesis of histamine in the hypothalamus of the homozygous Brattleboro rat. Agents Actions 18:219–221

    PubMed  CAS  Google Scholar 

  • Tuomisto L (1977) Ontogenesis and regional distribution of histamine and histamine- TV-methyltransferase in the guinea pig brain. J Neurochem 28:271–276

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Eriksson L (1979) Antidiuresis induced by infusions of histamine into the brain ventricles of conscious hydrated goats. Eur J Pharmacol 54:191–201

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Eriksson L (1980) Cardiovascular and behavioral changes after i.c.v. infusions of histamine and agonists in conscious goat. Agents Actions 10:165–166

    PubMed  CAS  Google Scholar 

  • Tuomisto J, Männistö P (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 37:249–332

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Tuomisto J (1982) Diurnal variations in brain and pituitary histamine and histamine-N-methyltransferase in the rat and guinea pig. Med Biol 60:204–209

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Tuomisto J, Walaszek EJ (1975) Uptake of histamine by rabbit hypothalamic slices. Med Biol 53:40–46

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Eriksson L, Fyhrquist F (1980) Vasopressin release by histamine in the conscious goat. Eur J Pharmacol 63:15–24

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Yamatodani A, Dietl H, Waldmann U, Philippu A (1983) In vivo release of endogenous catecholamines, histamine and GABA in the hypothalamus of Wistar Kyoto and spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol 323:183–187

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Eriksson L, Fyhrquist F (1984) Plasma vasopressin levels after I.C.V. infusion of histamine agonists in the consicous goat. Agents Actions 14:558–560

    PubMed  CAS  Google Scholar 

  • Tuomisto L, Tacke U, Willman A (1987) Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat. Agents Actions 20:252–254

    PubMed  CAS  Google Scholar 

  • Unger T, Bles F, Ganten D, Lang RE, Rettig R, Schwab NA (1983) GABAergic stimulation inhibits central actions of angiotensin II: pressor responses, drinking and release of vasopressin. Eur J Pharmacol 90:1–9

    PubMed  CAS  Google Scholar 

  • Vadlamani NL, Pontani RB, Misra AL (1984) Increased brain uptake of morphine in the presence of the antihistamine tripelennamine. J Pharm Pharmacol 36:61–63

    PubMed  CAS  Google Scholar 

  • Van der Vliet A, Van der Werf JF, Bast A, Timmerman H (1988) Frequencydependent autoinhibition of histamine release from rat cortical slices: a possible role for H3 receptor reserve. J Pharm Pharmacol 40:577–579

    PubMed  Google Scholar 

  • Van der Werf JF, Bast A, Bijloo GJ, Van der Vliet A, Timmerman H (1987) HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. Eur J Pharmacol 138:199–206

    PubMed  Google Scholar 

  • Verberne AJM, Fennessy MR, Lewis SJ, Taylor DA (1985) Involvement of brain histamine in A9-tetrahydrocannabinol tolerance and withdrawal. Pharmacol Biochem Behav 23:153–159

    PubMed  CAS  Google Scholar 

  • Verdiere M, Rose C, Schwartz J-C (1977) Turnover of cerebral histamine in a stressful situation. Brain Res 129:107–119

    PubMed  CAS  Google Scholar 

  • Wada H, Watanabe T, Yamatodani A, Maeyama K, Itoi N, Cacabelos R, Seo M, Kiyono S, Nagai K, Nakagawa H (1985) Physiological functions of histamine in the brain. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. A tribute to Heinz Schild. Pergamon, Oxford, pp 225–235 (Advances in the biosciences, vol 51)

    Google Scholar 

  • Waldmeier PC, Feldtrauer J-J, Matire L (1977) Methylhistamine: evidence for selective deamination by MAO B in the rat brain in vivo. J Neurochem 29:785–790

    PubMed  CAS  Google Scholar 

  • Watanabe T, Nakamura H, Liang LY, Yamatodani A, Wada H (1979) Partial purification and characterization of L-histidine decarboxylase from fetal rats. Biochem Pharmacol 28:1149–1155

    PubMed  CAS  Google Scholar 

  • Watanabe T, Taguchi Y, Hayashi H, Tanaka J, Shiosaka S, Tohyama M, Kubota H, Terano Y, Wada H. (1983) Evidence for the presence of a histaminergic neuron system in the rat brain: an immunocytochemical analysis. Neurosci Lett 39:249–254

    PubMed  CAS  Google Scholar 

  • Watanabe T, Taguchi Y, Shiosaka S, Tanaka J, Kubota H, Terano Y, Tohyama M, Wada H (1984) Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res 295:13–25

    PubMed  CAS  Google Scholar 

  • Wauquier A (1983) Drug effects on sleep-wakefulness patterns in dogs. Neuropsychobiology 10;60–64

    PubMed  CAS  Google Scholar 

  • Wauquier A, Van den Broeck WAE, Awouters F (1981) A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs. Neuropharmacology 20:853–859

    PubMed  CAS  Google Scholar 

  • Wauquier A, Van den Broeck WAE, Awouters F, Janssen PAJ (1984) Further studies on the distinctive sleep-wakefulness profiles of antihistamines (astemizole, ketotifen, terfenadine) in dogs. Drug Dev Res 4:617–625

    CAS  Google Scholar 

  • Weinreich D, Yu Y-T (1977) The characterization of histidine decarboxylase and its distribution in nerves, ganglia and in single neuronal cell bodies from the CNS of Aplysia californica. J Neurochem 28:361–369

    PubMed  CAS  Google Scholar 

  • White JM, Rumbold GR (1988) Behavioral effects of histamine and its antagonists: a review. Psychopharmacology 95:1–14

    PubMed  CAS  Google Scholar 

  • White T (1960) Formation and catabolism of histamine in cat brain in vivo. J Physiol (Lond) 152:299–308

    PubMed  CAS  Google Scholar 

  • White T (1966) Histamine in the brain. In: Rocha e Silva M (ed) Histamine and antihistaminics. Springer, Berlin Heidelberg New York, pp 789–796 (Handbook of experimental pharmacology, vol 18/1)

    Google Scholar 

  • Wilcox BJ, Seybold VS (1982) Localization of neuronal histamine in rat brain. Neurosci Lett 29:105–110

    PubMed  CAS  Google Scholar 

  • Wong CL, Roberts MB (1975) The possible role of brain histamine and Hj and H2 receptors in the development of morphine tolerance and physical dependence in mice. Agents Actions 5:476–483

    PubMed  CAS  Google Scholar 

  • Yamada M, Watanabe T, Fukui H, Taguchi Y, Wada H (1984) Comparison of histidine decarboxylases from rat stomach and brain with that from whole bodies of rat fetus. Agents Actions 14:143–152

    PubMed  CAS  Google Scholar 

  • Yamatodani A, Maeyama K, Watanabe T, Wada H, Kitamura Y (1982) Tissue distribution of histamine in a mutant mouse deficient in mast cells: clear evidence for the presence of non-mast-cell histamine. Biochem Pharmacol 31:305–309

    PubMed  CAS  Google Scholar 

  • Yanai K, Dannais RF, Wilson AA, Ravert HT, Scheffel U, Tanada S, Wagner HN (1988) (N-Methyl-[11 C])pyrilamine, a radiotracer for histamine H-l receptors: radiochemical synthesis and biodistribution study in mice. Nucl Med Biol 15:605–610

    CAS  Google Scholar 

  • Yanai K, Dannais RF, Wilson AA, Ravert HT, Scheffel U, Tanada S, Wagner HN (1989) Biodistribution and radiation absorbed dose of (jV-methyl-[ C])pyrilamine: a histamine H-l receptor radiotracer. Nucl Med Biol 16:361–363

    CAS  Google Scholar 

  • Yeh SY (1985) Potentiation of pentazocine antinociception by tripelennamine in the rat. J Pharmacol Exp Ther 235:683–689

    PubMed  CAS  Google Scholar 

  • Yoshitomi I, Itoh Y, Oishi R, Saeki K (1986) Brain histamine turnover enhanced by foot shock. Brain Res 362:195–198

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. Yamatodani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Inagaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Panula
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Itowi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Wada
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Börje Uvnäs M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Yamatodani, A., Inagaki, N., Panula, P., Itowi, N., Watanabe, T., Wada, H. (1991). Structure and Functions of the Histaminergic Neurone System. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75840-9_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75842-3

  • Online ISBN: 978-3-642-75840-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation