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Heterogeneity of Mast Cells

  • Chapter
Histamine and Histamine Antagonists

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 97))

Abstract

The mast cell, the major cellular respository of tissue histamine, is a widely distributed granular element of all tissues so far examined. It is present in particularly large numbers in tissues that come into frequent contact with the external environment, such as the lungs, airways, skin and gastrointestinal tract. The mast cell, together with its circulating counterpart, the basophil, represents the major cellular effector of immediate hypersensitivity reactions, or allergies. Mast cells and their mediators have also been implicated (based on varying amounts of experimental data) in the pathogenetic mechanisms of a variety of other disease states, such as parasitosis, inflammatory bowel disease, psoriasis and gastric ulcer formation (Barrett and Metcalfe 1988). The physiological role of the mast cell, however, remains unclear.

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  1. K. E. Barrett
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  2. F. L. Pearce
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Editors and Affiliations

  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Börje Uvnäs M.D.

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Barrett, K.E., Pearce, F.L. (1991). Heterogeneity of Mast Cells. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-75840-9_11

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