Suggestions to Those Who Have Become Histaminologists at a Time of Overflooding and Biased Information
In the first two volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines (18/1, 18/2) several chapters were written about histamine assays. Mc Intire (1966) described the determination of histamine by chemical means, Vugman and Rocha e Silva (1966) its biological determination and Beaven and Horakova (1978) the enzymatic isotopic assay of histamine. Now, about 10 years after the last update, the editor of Vol. 97, B. Uvnäs, has followed a new strategy: instead of a single author or a single group of authors from the same laboratory a panel of experts for the principal techniques of histamine determination have been chosen to write the subchapters of Chap. 1. More importantly, however, a new instrument for technology assessment [which includes diagnostic and laboratory tests (Mosteller 1985)] has been used: the Consensus Development Conference (Perry 1987). This conference took place in Munich, 4–6 December, 1988. The consensus statement is published in detail in this chapter of the handbook (Sect. C), but also, following the rules of such conferences, in more general publications such as the Lancet (Lorenz and Uvnäs 1989).
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