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The Effects of Sevoflurane on Heterosegmental Slow Positive Cord Potentials in the Rat

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Spinal Cord Monitoring and Electrodiagnosis

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Abstract

To define the effects of sevoflurane on brain and spinal cord functions, simultaneous recordings of cortical evoked potentials as well as segmental and heterosegmental spinal cord potentials (SCPs), in response to fore- and hindpaw stimulations, were made in the rat. The heterosegmental slow positive potentials, suggested to be a primary afferent depolarization exerted by the descending impulses via the supraspinal structures, were most vulnerable to the anesthetic. The second component of the segmental slow positive wave (P2s) of the segmental SCP, also thought to be produced by a feed-back loop, was more strongly suppressed by sevoflurane than the first component (P2f). The negative wave (N1) of segmental SCP, believed to be a synchronized activity of dorsal horn interneurons, was not significantly affected in either peak latency or amplitude, but was prolonged in duration by sevoflurane. No differential effects of sevoflurane on spinal cord potentials produced by fore- and hindpaw stimulations were found.

Thus, the results suggest that clinical concentration of sevoflurane has a minimum direct effect on the synaptic transmission from the first to second order neurons in the spinal dorsal horn, but a profound blocking effect on primary afferent depolarization particularly activated by a feed-back loop via supraspinal structures.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1-757, Niigata, 951, Japan

    M. Tohyama

Authors
  1. M. Tohyama
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  2. S. Denda
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  3. Y. Sato
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  4. N. Fujiwara
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  5. K. Shimoji
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Niigata University School of Medicine, Asahi-Machi 1, Niigata 951, Japan

    Koki Shimoji M.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

    Takahide Kurokawa M.D. (Professor and Director) (Professor and Director)

  3. Department of Orthopaedics, Wakayama Medical College, Wakayama, Japan

    Tetsuya Tamaki M.D. (Professor and Chairman) (Professor and Chairman)

  4. Marine Biomedical Institute Ashbel Smith, Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, 200 University Boulevard, 77550-2772, Galveston, Texas, USA

    William D. Willis Jr. M.D., PhD. (Director) (Director)

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© 1991 Springer-Verlag Berlin Heidelberg

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Tohyama, M., Denda, S., Sato, Y., Fujiwara, N., Shimoji, K. (1991). The Effects of Sevoflurane on Heterosegmental Slow Positive Cord Potentials in the Rat. In: Shimoji, K., Kurokawa, T., Tamaki, T., Willis, W.D. (eds) Spinal Cord Monitoring and Electrodiagnosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75744-0_11

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  • DOI: https://doi.org/10.1007/978-3-642-75744-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75746-4

  • Online ISBN: 978-3-642-75744-0

  • eBook Packages: Springer Book Archive

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