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Helicobacter pylori and Gastric Mucus Integrity

  • Conference paper
Helicobacter pylori 1990

Abstract

A unique property of gastric mucosa is its ability to withstand the insults imposed by the luminal contents and to resist the challenge by invading bacteria. Although there is no general agreement as to the mechanism of mucosal protection, the consensus is that this phenomenon is multicomponential in nature, and includes at least three major defense perimeters, which are the mucus-bicarbonate zone, the cell membranes of gastric epithelium, and the mucosal blood flow [1–4]. Hence, the brunt of luminal insults, at least in the initial stage, falls on the mucus layer, which constitutes the only identifiable physical barrier between the gastric lumen and the surface epithelial cells of the mucosa. The integrity of this defense perimeter depends upon a delicate dynamic equilibrium, controlled by factors affecting the synthesis, secretion, and breakdown of its constituents [3, 5, 6]. While this equilibrium is maintained successfully under normal physiological conditions, injury to the mucosa ensues when aggressive forces overcome factors that control mucosal defense.

This work was supported by USPHS grant #DK21684-13 from the National Institute of Diabetes and Digestive and Kidney Diseases and Grant # AA05 858-08 from the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health.

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References

  1. Silen W (1987) Gastric mucosal defense and repair. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven, New York, pp:1055–1069

    Google Scholar 

  2. Flemstrom G (1987) Gastric and duodenal mucosal bicarbonate secretion. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven, New York, pp:1011–1029

    Google Scholar 

  3. Slomiany BL, Sarosiek J, Slomiany A (1987) Gastric mucus and the mucosal barrier. Dig Dis 5:125–145

    Article  PubMed  CAS  Google Scholar 

  4. Szabo S, Pihan G, Triers S (1986) Alteration in blood vessels during gastric injury and protection. Scand J Gastroenterol 21[Suppl 125]:92–96

    Article  CAS  Google Scholar 

  5. Slomiany A, Takagi A, Slomiany BL (1985) The synthesis and secretion of gastric mucus glycoprotein by mucosal cells cultured in the presence of ethanol. Arch Biochem Biophys 236:654–666

    Article  PubMed  CAS  Google Scholar 

  6. Slomiany BL, Piasek A, Sarosiek J, Slomiany A (1986) The role of surface and preformed intracellular mucus in gastric mucosal protection against hydrogen ion. Scand J Gastroenterol 20:1191–1196

    Article  Google Scholar 

  7. Glass GBJ, Slomiany BL (1977) Derangement of biosynthesis, production and secretion of mucus gastrointestinal injury and disease. In: Elstein M, Parke DV (eds) Mucus in health and disease. Plenum, New York, pp:311–347

    Google Scholar 

  8. Witas H, Slomiany BL, Zdebska E, Kojima K, Liau YH, Slomiany A (1983) Lipids associated with dog gastric mucus glycoprotein. J Appl Biochem 5:16–24

    PubMed  CAS  Google Scholar 

  9. Slomiany A, Jozwiak Z, Takagi A, Slomiany BL (1984) The role of covalently bound fatty acids in the degradation of human gastric mucus glycoprotein. Arch Biochem Biophys 229:560–567

    Article  PubMed  CAS  Google Scholar 

  10. Slomiany A, Witas H, Aono M, Slomiany BL (1983) Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients. J Biol Chem 258:8535–8538

    PubMed  CAS  Google Scholar 

  11. Gwozdzinski K, Slomiany A, Nishikawa H, Okazaki K, Slomiany BL (1988) Gastric mucin hydrophobicity: effects of associated and covalently bound lipids, proteolysis and reduction. Biochem Int 17:907–917

    PubMed  CAS  Google Scholar 

  12. Bilski J, Sarosiek J, Murty VLN, Aono M, Moriga M, Slomiany A, Slomiany BL (1987) Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. Biochem Pharmacol 36:4059–4065

    Article  PubMed  CAS  Google Scholar 

  13. Slomiany BL, Murty VLN, Carter SR, Slomiany A (1986) Effect of covalently bound fatty acids and associated lipids on the viscosity of mucus glycoprotein in cystic fibrosis. Digestion 34:275–280

    Article  PubMed  CAS  Google Scholar 

  14. Allen A (1981) Structure and function of gastrointestinal mucus. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp:617–639

    Google Scholar 

  15. Slomiany BL, Bilski J, Sarosiek J, Murty VLN, Dworkin B, VanHorn K, Zielenski J, Slomiany A (1987) Campylobacter pyloridis degrades mucin and undermines gastric mucosal integrity. Biochem Biophys Res Commun 144:307–314

    Article  PubMed  CAS  Google Scholar 

  16. Sarosiek J, Slomiany A, Slomiany BL (1988) Evidence for weakening of gastric mucus integrity by Campylobacter pylori. Scand J Gastroenterol 23:585–590

    Article  PubMed  CAS  Google Scholar 

  17. Barrett-Bee K, Hayes Y, Wilson RG, Ryler JF (1985) A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts. J Gen Microbiol 131:1217–1221

    PubMed  CAS  Google Scholar 

  18. Rollof J, Braconier JH, Soderstorm C, Nillson-Ehle P (1988) Interference of Staphylococcus aureus lipase with human granulocyte function. Eur J Clin Microbiol Infect Dis 7:505–510

    Article  PubMed  CAS  Google Scholar 

  19. Slomiany BL, Nishikawa K, Piotrowski J, Okazaki K, Slomiany A (1989) Lipolytic activity of Campylobacter pylori: effect of sofalcone. Gastroenterology 94:399

    Google Scholar 

  20. Slomiany BL, Murty VLN, Piotrowski J, Okazaki K, Slomiany A (1988) Effect of colloidal bismuth subcitrate (De-Nol) on the lipolytic activity of Campylobacter pylori. Am J Gastroenterol 83:1029

    Google Scholar 

  21. Rollof J, Hedstrom SA, Nilsson-Ehle P (1987) Lipolytic activity of Staphylococcus aureus strains from disseminated and localized infections. Acta Pathol Microbiol Immunol Scand A, B 95:109–113

    CAS  Google Scholar 

  22. Brockerhoff H, Jensen RG (1974) Lipolytic enzymes. Academic, New York

    Google Scholar 

  23. Lichtenberger LM, Graziani LA, Dial EJ, Butler BD, Hills BA (1983) Role of surface-active phospholipids in gastric cytoprotection. Science 219:1327–1329

    Article  PubMed  CAS  Google Scholar 

  24. Slomiany BL, Sarosiek J, Liau YH, Laszewicz W, Slomiany A (1986) Lysolecithin affects the viscosity, permeability and peptic susceptibility of gastric mucin. Scand J Gastroenterol 21:1073–1079

    Article  PubMed  CAS  Google Scholar 

  25. Slomiany BL, Glass GBJ, Kojima K, Banas-Gruszka Z, Slomiany A (1982) Effect of lysolecithin on the constituents of gastric mucus. In: Chandler EN, Elder JB, Elstein M (eds) Mucus in health and disease, vol 2. Plenum, New York, pp:163–174

    Google Scholar 

  26. Slomiany BL, Laszewicz W, Slomiany A (1986) Effect of sucralfate on the viscosity of gastric mucus and the permeability to hydrogen. Digestion 33:146–151

    Article  PubMed  CAS  Google Scholar 

  27. Slomiany BL, Liau YH, Mizuta K, Slomiany A (1987) Fatty acylation of mucin by gastric mucosa: effect of sofalcone and sucralfate. Biochem Pharmacol 36:3273–3276

    Article  PubMed  CAS  Google Scholar 

  28. Tytgat GNJ (1987) Colloidal bismuth subcitrate in peptic ulcer: a review. Digestion 37:31–41

    Article  PubMed  Google Scholar 

  29. Sarosiek J, Bilski J, Murty VLN, Slomiany A, Slomiany BL (1989) Colloidal bismuth subcitrate (De-Nol) inhibits degradadation of gastric mucus by Campylobacter pylori protease. Am J Gastroenterol 84:506–510

    PubMed  CAS  Google Scholar 

  30. Bilski J, Sarosiek J, Nishikawa H, Slomiany A, Slomiany BL (1988) Colloidal bismuth subcitrate (De-Nol) inhibits peptic degradation of gastric mucus. Am J Gastroenterol 83:1029

    Google Scholar 

  31. Slomiany BL, Nishikawa H, Piotrowski J, Okazaki K, Slomiany A (1989) Lipolytic activity of Campylobacter pylori: effect of sofalcone. Digestion 43:33–40

    Article  PubMed  CAS  Google Scholar 

  32. Slomiany BL, Kasinathan C, Slomiany A (1989) Lipolytic activity of Campylobacter pylori: effect of colloidal bismuth subcitrate (De-Nol). Am J Gastroenterol 84:1273–1277

    PubMed  CAS  Google Scholar 

  33. Graham DY (1989) Campylobacter pylori and peptic ulcer disease. Gastroenterology 96:615–625

    PubMed  CAS  Google Scholar 

  34. Slomiany BL, Piotrowski J, Samanta A, VanHorn K, Slomiany A (1989) Gastric mucosal sulfatides and sucralfate inhibit agglutination of erythrocytes by C. pylori. Am J Gastroenterol 84:1169

    Google Scholar 

  35. Slomiany BL, Piotrowski J, Samanta A, VanHorn K, Murty VLN, Slomiany A (1989) Campylobacter pylori colonization factor shows specificity for lactosylceramide sulfate and GM3 ganglioside. Biochem Intern 19:929–936

    CAS  Google Scholar 

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Authors
  1. B. L. Slomiany
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  2. V. L. N. Murty
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  3. J. Piotrowski
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  4. S.-L. Wang
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  5. A. Slomiany
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Editor information

Editors and Affiliations

  1. Medizinische Klinik II, Krankenanstalten der Stadt Remscheid, Akademisches Lehrkrankenhaus der Universität Bonn, Hans-Potyka-Str. 28, 5630, Remscheid, Germany

    H. Menge

  2. Abteilung für Innere Medizin mit Schwerpunkt Gastroenterologie, Klinikum Steglitz der Freien Universität Berlin, Hindenburgdamm 30, 1000, Berlin 45, Germany

    M. Gregor

  3. Department of Gastroentero-Hepatology, Academisch Ziekenhuis bij de Universiteit van Amsterdam, Academisch Medisch Centrum, Meibergdreef 9, 1105 AZ, Amsterdam Zuidoost, The Netherlands

    G. N. J. Tytgat

  4. Division of Gastroenterology, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA

    B. J. Marshall

  5. Public Health Laboratory, Gloucestershire Royal Hospital, Great Western Road, Gloucestershire, GL1 3NN, UK

    C. A. M. McNulty

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© 1991 Springer-Verlag Berlin Heidelberg

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Slomiany, B.L., Murty, V.L.N., Piotrowski, J., Wang, SL., Slomiany, A. (1991). Helicobacter pylori and Gastric Mucus Integrity. In: Menge, H., Gregor, M., Tytgat, G.N.J., Marshall, B.J., McNulty, C.A.M. (eds) Helicobacter pylori 1990. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75726-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-75726-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75728-0

  • Online ISBN: 978-3-642-75726-6

  • eBook Packages: Springer Book Archive

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