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HPV Infection and Precancer in Gynaecology — Diagnosis and Therapeutic Aspects

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Genital Papillomavirus Infections

Abstract

Both prevalence and incidence of genital HPV infections have significantly increased in most countries during the past 20 years (Powell 1978; Oriel 1981). The infection may cause a broad spectrum of characteristic dysplastic and neoplastic changes of the target tissue. Specific PV types have predilections for particular anatomical sites and tissues, affecting predominantly the different squamous epithelia of the anogenital area, the vagina, and both the original and metaplastic squamous epithelium of the uterine cervix. In metaplastic epithelium the proliferating cells susceptible to the infectious agent are superficially located. Thus, the immature transformation zone is the preferred target of HPV and other exogenous noxa, whereas in original squamous epithelium the compartment of mitotic active basal cells is protected by several rows of differentiating cells, and the susceptible cells can be reached only through epithelial defects and ulcerations.

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References

  • Abell MR, Gosling G jr (1961) Intraepithelial and infiltrative carcinoma of the vulva: Bowen’s type. Cancer 14: 318–329

    Article  PubMed  CAS  Google Scholar 

  • Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H (1984) A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines from cervical cancer. EMBO J 3: 1151–1157

    PubMed  CAS  Google Scholar 

  • Burk RD, Kadish AS, Calderin S, Romney SL (1986) Human papillomavirus infection of the cervix detected by cervicovaginal lavage and molecular hybridization: correlation with biopsy results and Papanicolaou smear. Am J Obstet Gynecol 154: 982–989

    PubMed  CAS  Google Scholar 

  • Burke L (1982) The use of carbon dioxide laser in the therapy of cervical intraepithelial neoplasia. Am J Obstet Gynecol 144: 337–340

    PubMed  CAS  Google Scholar 

  • Choo YC, Seto WH, Hsu C, Merigan TC, Tan YH, Ma HK, Ng NH (1986) Cervical intraepithelial neoplasia treated by perilesional injection of interferon. Br J Obstet Gynaecol 93: 372–379

    PubMed  CAS  Google Scholar 

  • Cole ST, Streek RE (1986) Genome organization and nucleotide sequence of humanpapillomavirus type 33, which is associated with cervical cancer. J Virol 58:991–995

    PubMed  CAS  Google Scholar 

  • Crum CP, Richart RM (1980) The out-patient approach to the patient with an abnormal Papanicolaou smear. In: Grundman E (ed) Cancer of the uterine cervix. Fischer, Stuttgart (Cancer campaign, vol 8 )

    Google Scholar 

  • Della Torre G, Pilotti S, de Palo G, Rike F (1978) Viral particles in cervical condylomatous lesions. Tumori 64: 549–553

    PubMed  Google Scholar 

  • De Villiers EM, Schneider A, Gross G, zur Hausen H (1986) Analysis of benign and malignant urogenital tumors for human papillomavirus infection by labelling cellular DNA. Med Microbiol Immuno1 174:281–286

    Article  Google Scholar 

  • Durst M, Kleinheinz A, Hotz M, Gissmann L (1985) The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors. J Gen Virol 66: 1515–1525

    Article  PubMed  Google Scholar 

  • Ferenczy A, Braun L, Shah KV (1981) Human papillomavirus (HPV) in condylomatous lesions of the cervix. Am J Surg Patho 15:661–670

    Article  Google Scholar 

  • Ferenczy A, Mitao M, Naga N, Silverstein SJ, Crum CP (1985) Latent papillomavirus and recurring genital warts. N Engl J Med 313: 784–788

    Article  PubMed  CAS  Google Scholar 

  • Fu YS, Braun L, Shah KV, Lawrence W, Robboy S (1983) Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. Cancer 52: 1705–1711

    Article  PubMed  CAS  Google Scholar 

  • Fukushima M, Yamakawa Y, Shimano S, Hashimoto M, Sawada Y, Fujinaga K (1987) The physical state of the human papillomavirus type 16 (HPV 16) DNA in carcinoma of the uterine cervix. In: Lancaster WD, Jenson AB (eds) 6th International Papillomavirus Workshop. Georgetown University, Washington

    Google Scholar 

  • Gall SA, Hughes CE, Mounts P, Segritti A, Weck PK, Whisnant JK (1986) Efficacy of human lymphoblastic interferon in the therapy of resistant condyloma acuminata. Obstet Gynecol 67: 643–651

    Article  PubMed  CAS  Google Scholar 

  • Gross G, Hagedorn M, Ikenberg H (1985a) Bowenoid papulosis. Presence of human papillomavirus (HPV) structural antigens and of HPV 16-related DNA sequence. Arch Dermatol 121: 858–863

    Article  PubMed  CAS  Google Scholar 

  • Gross G, Schneider A, Hauser-Brauner B, Wagner D, Ikenberg H, Gissmann L (1985b) Transmission of genital papillomavirus infections: a study of sexual partners. J Cell Biochem [Suppl] 69: 71

    Google Scholar 

  • Gross G, Roussaki A, Pfister H (1989) Recurrent vulvar Buschke-Löwenstein’s tumorlike condyloma acuminata and Hodgkin’s disease effectively treated with recombinant interferon a2c gel as adjuvant to electrosurgery. In: Fritsch P, Schuler G, Hintner H (eds) Immunodeficiency and skin. Karger, Basel, pp 178–184 (Current problems in dermatology, vol 18 )

    Google Scholar 

  • Guillet G, Braun L, Shah KV, Ferenczy A (1983) Papillomavirus in cervical condylomas with and without associated cervical intraepithelial neoplasia. J Invest Dermatol 81: 513–516

    Article  PubMed  CAS  Google Scholar 

  • Hatch GD (1989) Interferon treatment of human papillomavirus. Colposcopist 21: 1–4

    Google Scholar 

  • Heinzl S (1981) Die Behandlung benigner und prämaligner Zervixveränderungen mit CO2-Laser. Gynäkologe 14: 245–251

    PubMed  CAS  Google Scholar 

  • Heinzl S (1988) Destructive methods in the treatment of cervical and vulval intraepithelial neoplasia. In: Stegner H-E, Coppleson M (eds) Colposcopy in diagnosis and treatment of preneoplastic lesions. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Hilgarth HH, Hillemanns G, Göppinger A (1988) Therapy of intraepithelial neoplasia. In: Stegner H-E, Coppleson M (eds) Colposcopy in diagnosis and treatment of preneoplastic lesions. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Hills E, Laverty CR (1979) Electron-microscope detection of papillomavirus particles in selected koilocytic cells in routine cervical smears. Acta Cyto 123:53–56

    Google Scholar 

  • Ikenberg H, Gissmann L, Gross G, Grussendorf-Conen E, zur Hausen H (1983) Human papillomavirus type 16-related DNA in genital Bowen’s disease and in bowenoid papulosis. Int J Cancer 32: 563–565

    Article  PubMed  CAS  Google Scholar 

  • Ikenberg H, Spitz C, Schworer D, Pfleiderer A (1987) Human papillomavirus DNA in genital carcinomas. Correlation with clinical stage, histology and clinical course of the disease. In: Lancaster WD, Jenson AB (eds) 6th International Papillomavirus Workshop. Georgetown University, Washington

    Google Scholar 

  • Ikic D (1983) Intralesional therapy. In: Sikora K (ed) Interferon and cancer. Plenum Press, New York

    Google Scholar 

  • Kirby P, Wells D, Kiviat N, Corey L (1986) A phase-I trial of intramuscular recom- binant gamma interferon for refractory genital warts. J Invest Dermatol 86: 485

    Google Scholar 

  • Kurman RJ, Shah KV, Lancaster WD, Jenson AB (1982) Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas. Am J Obstet Gynecol 140: 931–935

    Google Scholar 

  • Kurman RJ, Jenson AB, Lancaster WD (1983) Papillomavirus infection of the cervix. II. Relationship to intraepithelial neoplasia based on the presence of specific viral structural proteins. Am J Surg Pathol 7: 39–52

    Article  PubMed  CAS  Google Scholar 

  • Lorincz AT, Quinn AP, Lancaster WD, Temple GF (1987) A new type of papillomavirus associated with cancer of the uterine cervix. Virology 159: 187–190

    Article  PubMed  CAS  Google Scholar 

  • MacNar JCM, Walkinshaw SA, Cordiner JW, Clements JB (1986) Human papillomavirus in clinically and histologically normal tissue of patients with genital cancer. N Engl J Med 315: 1052–1058

    Article  Google Scholar 

  • McCance DJ, Campion MJ, Clarkson PK, Chesters RM, Jenkins D, Singer A (1985) Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix. Br J Obstet Gynaecol 92: 1101–1105

    Article  PubMed  CAS  Google Scholar 

  • Meisels A, Morin C, Casas-Cordero M (1982) Human papillomavirus infection of the uterine cervix. Int J Gynecol Pathol 1: 75–94

    Article  PubMed  CAS  Google Scholar 

  • Morin C, Meisels A (1980) Human papillomavirus infection of the uterine cervix. Acta Cytol 24:82–84

    PubMed  CAS  Google Scholar 

  • Morin C, Braun L, Casas-Cordero M, Shah KV, Roy M, Fortier M, Meisels A (1981) Confirmation of the papillomavirus etiology of condylomatous cervical lesion by the peroxidase-antiperoxidase technique. JNCI 66: 831–835

    PubMed  CAS  Google Scholar 

  • Oriel JD (1981) Genital warts. Sex Transco Dis 8: 326–329

    CAS  Google Scholar 

  • Powell L (1978) Condyloma acuminatum. Recent advances in development, carcinogenesis and treatment. Clin Obstet Gynecol 21: 1061–1079

    Article  PubMed  Google Scholar 

  • Pratili MA, Ledoussal V, Harvey P, Laval C, Bertrand F, Jibard N, Croissant O, Orth G (1986) Human papillomavirus in the epithelial cells of the cervix uteri: frequency of types 16 and 18. Preliminary results of a clinical, cytologic and viral study. J Gynecol Obstet Biol Reprod (Paris) 15: 45–50

    CAS  Google Scholar 

  • Reid R, Laverty CR, Coppleson M, Isarangkul W, Hills E (1980) Noncondylomatous cervical wart virus infection. Obstet Gynecol 55: 476–483

    PubMed  CAS  Google Scholar 

  • Sato S, Okagaki T, Clark BA, Twiggs LB, Fukushima M, Ostrow RS, Faras AJ (1987) Sensitivity of koilocytosis, immunocytochemistry, and electron microscopy as compared to DNA hybridization in detecting human papillomavirus in cervical and vaginal condyloma and intraepithelial neoplasia. Int J Gynecol Pathol 5: 297–307

    Article  Google Scholar 

  • Schneider A (1987) Morphologische und klinische Aspekte humaner Papillomavirus- Infektionen im unteren Genitaltrakt. Habilitationsschrift, University of Ulm

    Google Scholar 

  • Schneider A, Schuhmann R, de Villiers E-M, Gissmann L (1986) Klinische Bedeutung von humanen Papillomavirus-(HPV)-Infektionen im unteren Genitaltrakt. Geburtshilfe Frauenheilkd 46: 261–266

    Article  PubMed  CAS  Google Scholar 

  • Schonfeld A, Nitke S, Schattner A, Wallach D, Crespi M, Hahn T, Levavi H, Yarden O, Shoham J, Doerner T, Revel M (1984) Intramuscular human interferon-beta injections in treatment of condylomata acuminata. Lancet 1: 1038–1042

    Article  PubMed  CAS  Google Scholar 

  • Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, Stremlau A, zur Hausen H (1985) Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314: 111–114

    Article  PubMed  CAS  Google Scholar 

  • Seedorf K, Krämmer G, Dürst M, Suhai S, Röwekamp WG (1985) Human papillomavirus type 16 DNA sequence. Virology 145: 181–185

    Article  PubMed  CAS  Google Scholar 

  • Singer A, Jordan JA (1978) The management of premalignant cervical disease. Clin Obstet Gynaecol 5: 629

    PubMed  CAS  Google Scholar 

  • Syrjänen KJ (1983) Human papillomavirus lesions in association with cervical dysplasias and neoplasias. Obstet Gynecol 62: 617–624

    PubMed  Google Scholar 

  • Tase T, Okagaki T, Clark BA, Twiggs LB, Ostrow RS, Faras AJ (1989) Human papillomavirus DNA in adenocarcinoma in situ, microinvasive adenocarcinoma of the uterine cervix, and coexisting squamous intraepithelial neoplasia. Int J Gynecol Pathol 8: 8–17

    Article  PubMed  CAS  Google Scholar 

  • Wade TR, Kopf AW, Ackerman AB (1979) Bowenoid papulosis of the genitalia. Arch Dermatol 115: 306–308

    Article  PubMed  CAS  Google Scholar 

  • Wagner D, Ikenberg H, Boehm N, Gissmann L (1984) Identification of human papillomavirus in cervical swabs by deoxyribonucleic acid in situ hybridization. Obstet Gynecol 64: 767–772

    PubMed  CAS  Google Scholar 

  • Warhol MJ, Pinkus GS, Rice RH, El-Tawil GH, Lancaster WD, Jenson AB, Kurman RJ (1984) Papillomavirus infection of the cervix. III. Relationship of the presence of viral structural proteins to the expression of involucrin. Int J Gynecol Pathol 3: 71–81

    Article  PubMed  CAS  Google Scholar 

  • Wickenden C, Steele A, Malcolm AD, Coleman DV (1985) Screening for wart virus infection in normal and abnormal cervices by DNA hybridization of cervical scrapes. Lancet 1: 65–67

    Article  PubMed  CAS  Google Scholar 

  • Woodruff JD, Braun L, Cavalieri R, Gupta P, Pass F, Shah KV (1980) Immunologic identification of papillomavirus antigen in condyloma tissues from the female genital tract. Obstet Gynecol 56: 727–732

    PubMed  CAS  Google Scholar 

  • Yoshikawa H, Matsukura T, Yamamoto E, Kawana T, Mizuno M, Yoshike K (1985) Occurrence of hunian papillomavirus type 16 and 18 DNA in cervical carcinomas from Japan: Age of patients and histological type of carcinomas. Gann 76: 667–671

    PubMed  CAS  Google Scholar 

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Authors
  1. H.-E. Stegner
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Editors and Affiliations

  1. Hautklinik und -Poliklinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 2000, Hamburg 20, Germany

    Gerd Gross

  2. Department of Dermatology, Warsaw School of Medicine, Koszykowa 82a, 02-008, Warsaw, Poland

    Stefania Jablonska

  3. Institut für Klinische und molekulare Virologie, Universität Erlangen-Nürnberg, Loschgestr. 7, 8520, Erlangen, Germany

    Herbert Pfister

  4. Universitätskrankenhaus Eppendorf, Frauenklinik, Martinistr. 52, 2000, Hamburg 20, Germany

    Hans-Egon Stegner

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© 1990 Springer-Verlag Berlin Heidelberg

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Stegner, HE. (1990). HPV Infection and Precancer in Gynaecology — Diagnosis and Therapeutic Aspects. In: Gross, G., Jablonska, S., Pfister, H., Stegner, HE. (eds) Genital Papillomavirus Infections. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75723-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-75723-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75725-9

  • Online ISBN: 978-3-642-75723-5

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