Hematopiesis in mammals occurs in specific organs. During embryonic life, hematopoietic cells are first seen in the yolk sac. Subsequently, hematopoiesis develops in the liver (where erythropoiesis is predominant), then in the spleen, and eventually in the bone marrow. In adults, bone marrow is the major site of granulo-, mono-, erythro-, and megakaryopoiesis and of B-cell lymphopoiesis. The spleen in the mouse is still a site of hematopoiesis (mainly erythropoiesis), which is not the case in man.


Stromal Cell Bone Marrow Culture Adherent Layer Fresh Bone Marrow Human Marrow Stromal Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. Charbord
    • 1
  1. 1.INSERM/CRTSBesançonFrance

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