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Stroma and Hematopoiesis

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Peripheral Blood Stem Cell Autografts

Abstract

Hematopiesis in mammals occurs in specific organs. During embryonic life, hematopoietic cells are first seen in the yolk sac. Subsequently, hematopoiesis develops in the liver (where erythropoiesis is predominant), then in the spleen, and eventually in the bone marrow. In adults, bone marrow is the major site of granulo-, mono-, erythro-, and megakaryopoiesis and of B-cell lymphopoiesis. The spleen in the mouse is still a site of hematopoiesis (mainly erythropoiesis), which is not the case in man.

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Authors and Affiliations

  1. INSERM/CRTS, 1, Boulevard Fleming, 25000, Besançon, France

    P. Charbord

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  1. P. Charbord
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  1. Service d’Hématologie et Institut de Recherche en Hématologie, Transfusion Hospital du Hasenrain, 87 av. d’Altkirch, 68051, Mulhouse Cedex, France

    Eckart W. Wunder M.D. (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) & Philippe R. Henon M.D. (Chef de Service Prof. assoc., Director of Research) (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) &  (Chef de Service Prof. assoc., Director of Research)

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© 1993 Springer-Verlag Berlin Heidelberg

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Charbord, P. (1993). Stroma and Hematopoiesis. In: Wunder, E.W., Henon, P.R. (eds) Peripheral Blood Stem Cell Autografts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75717-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-75717-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75719-8

  • Online ISBN: 978-3-642-75717-4

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