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Peripheral Blood Stem Cell Autografts pp 243–249Cite as

Transplantation with Enriched Stem Cell Fractions

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Abstract

A technology that can be used to isolate hematopoietic progenitors will have widespread clinical applications. First, autologous marrow transplantation is finding an increasingly important role in the treatment of patients with malignant diseases, including breast cancer, leukemia, and lymphomas [1, 2]. However, primary (e.g., leukemia) or secondary (e.g., breast cancer and lymphoma) involvement of marrow with tumor seriously limits autologous marrow as a source of hematopoietic progenitor cells for transplants. To overcome this problem, a variety of technologies have been developed to remove or kill malignant cells in marrow. These methodologies include use of monoclonal antibodies combined with complement, magnetic beads or toxins, physical separation, photochemotherapy, and pharmacological purging [3–8]. The heterogeneity of antigenic expression in tumor cell populations and variable sensitivity to drugs, complement, and toxins have made complete elimination oftumor cells difficult [9–11]. Additionally, the toxic effects of these agents on normal hematopoietic progenitors may effect engraftment of the treated marrow. A device to select the small fraction of hematopoietic cells responsible for engraftment could overcome these problems, provide a population free of tumor cells and avoid the potential harmful effects of cytotoxic agents on normal marrow elements.

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Author information

Authors and Affiliations

  1. Cell Pro Incorporated, 22322 20th S.E., Bothell, Washington, 98040, USA

    R. J. Berenson

  2. Division of Clinical Research, Freed Hutchinson Cancer Rearch Center, 1124 Colulmbia Street, Seattle, Washington, 98104, USA

    W. I. Bensinger, C. D. Buckner & I. Bernstein

  3. Division of Pediatric Oncology, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington, 98104, USA

    R. G. Andrews

Authors
  1. R. J. Berenson
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  2. W. I. Bensinger
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  3. R. G. Andrews
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  4. C. D. Buckner
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  5. I. Bernstein
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Editor information

Editors and Affiliations

  1. Service d’Hématologie et Institut de Recherche en Hématologie, Transfusion Hospital du Hasenrain, 87 av. d’Altkirch, 68051, Mulhouse Cedex, France

    Eckart W. Wunder M.D. (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) & Philippe R. Henon M.D. (Chef de Service Prof. assoc., Director of Research) (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) &  (Chef de Service Prof. assoc., Director of Research)

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© 1993 Springer-Verlag Berlin Heidelberg

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Berenson, R.J., Bensinger, W.I., Andrews, R.G., Buckner, C.D., Bernstein, I. (1993). Transplantation with Enriched Stem Cell Fractions. In: Wunder, E.W., Henon, P.R. (eds) Peripheral Blood Stem Cell Autografts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75717-4_23

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  • DOI: https://doi.org/10.1007/978-3-642-75717-4_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75719-8

  • Online ISBN: 978-3-642-75717-4

  • eBook Packages: Springer Book Archive

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