Clinical Usefulness and Optimal Harvesting of Peripheral Blood Stem Cells Mobilized by High Dose Cyclophosphamide and Recombinant Human GM-CSF

  • A. M. Gianni
  • M. Bregni
  • S. Siena
  • C. Tarella
  • D. Caracciolo
  • F. Ravagnani
  • A. C. Stern


The existence of normal hematopoietic stem cells in the peripheral blood of mammals has been known for a quarter of a century [1]; however, they were first used to reconstitute the bone marrow of patients after myeloablative chemoradiotherapy only 4–5 years ago [2–6]. After obtaining proof that circulating progenitors are capable of complete and long-lasting hematopoietic reconstitution, clinicians have increasingly employed them as an alternative to bone marrow-derived stem cells. By the end of 1989, over 200 autotransplants of peripheral blood stem cells had been reported or published.


Peripheral Blood Stem Cell Bone Marrow Involvement Peripheral Blood Stem Cell Transplant Optimal Harvesting Peripheral Blood Progenitor Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • A. M. Gianni
    • 1
  • M. Bregni
    • 1
  • S. Siena
    • 1
  • C. Tarella
    • 2
  • D. Caracciolo
    • 3
  • F. Ravagnani
    • 4
  • A. C. Stern
    • 5
  1. 1.Istituto Nazionale Tumori per lo Studio e la Cura dei TumoriMilanItaly
  2. 2.Division of ImmunohaematologyIstituto Nazionale per lo Studio e la Cura dei TumoriMilanItaly
  3. 3.Istituto di Scienze MedicheUniversity of MilanMilanItaly
  4. 4.Cattedra di EmatologiaUniversità di TorinoTurinItaly
  5. 5.Sandoz Clinical ResearchBaselSwitzerland

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