Skip to main content
SpringerLink
Log in
Book cover

Peripheral Blood Stem Cell Autografts pp 132–144Cite as

Stem Cell Mobilization by Myelosuppressive Chemotherapy

  • Chapter

Abstract

Increased peripheral blood (PB) levels of granulocyte macrophage colony-froming units (CFU-GM) during haematopoietic recovery following cytotoxic-induced myelosuppression were first described in 1976 and 1979 [1, 2]. Richman et al. postulated that sufficient haematopoietic stem cells for autologous haematopoietic reconstitution could be collected by leukapheresis during such recovery. Further investigation of this alternative source of haematopoietic stem cells was initially limited, partly by the lack of technical expertise in stem cell apheresis and partly by the general view that PB stem cells (PBSC) were inferior to bone marrow stem cells in self-renewal and capacity to produce haematopoietic reconstitution (HR). This latter view resulted from murine studies [3–5] and from two reports of failed HR after PBSC infusion in humans [6, 7].

The authors acknowledge the grant support of the National Health and Medical Research Council of Australia, the Anti-Cancer Foundation of the Universities of South Australia and the Baxter Healthcare Corporation, Illinois, USA.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Richman CM, Weiner RS, Yankee RS (1976) Increase in circulating stem cells following chemotherapy in man. Blood 47: 1031–1039

    PubMed  CAS  Google Scholar 

  2. Lohrmann HP, Schreml W, Fliedner TM, Heimpel H (1979) Reaction of human granulopoiesis to high-dose cyclophosphamide therapy. Blut 38: 9–16

    Article  PubMed  CAS  Google Scholar 

  3. Micklem HS, Anderson N, Ross R (1975) Limited potential of circulating haemopoietic stem cells. Nature 256: 41–43

    Article  PubMed  CAS  Google Scholar 

  4. Monette FC, Stockel JB (1980) Blood-borne stem cells are immunologically distinct from those in other haemopoietic tissues. Exp Hematol 8: 89–95

    PubMed  CAS  Google Scholar 

  5. Chertkov JL, Gurevitch OA, Udalov G A (1982) Self-maintenance ability of circulating hemopoietic stem cells. Exp Hematol 10: 90–97

    PubMed  CAS  Google Scholar 

  6. Hershko C, Ho WG, Gale RP, Cline MJ (1979) Cure of aplastic anaemia in paroxysmal nocturnal haemoglobulinuria by marrow transfusion from identical twin: failure of peripheral leucocyte transfusion to correct marrow aplasia. Lancet i: 945–947

    Article  Google Scholar 

  7. Abrams RA, Glaubiger D, Appelbaum FR, Deisseroth AB (1980) Result of attempted hematopoietic reconstitution using isologous peripheral blood mononuclear cells: a case report. Blood 56: 516–520

    PubMed  CAS  Google Scholar 

  8. Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED (1977) Demonstraton of hemopoietic stem cells in the peripheral blood of baboons by cross circulation. Blood 50: 537–542

    PubMed  CAS  Google Scholar 

  9. Nothdurft W, Brush C, Fliedner TM, Ruber E (1977) Studies on the regeneration of the CFUc-population in blood and bone marrow of lethally irradiated dogs after autologous transfusion of cryopreserved mononuclear blood cells. Scand J Haematol 19: 470–481

    Article  PubMed  CAS  Google Scholar 

  10. Abrams RA, McCormack K, Bowles C, Deisseroth AB (1981) Cyclophosphamide treatment expands the circulating haematopoietic stem cell pool in dogs. J Clin Invest 67: 1392–1399

    Article  PubMed  CAS  Google Scholar 

  11. Korbling M, Burke P, Braine H, Elfenbein G, Santos GW, Kaizer H (1981) Successful engraftment of blood-derived normal hemopoietic stem cells in chronic myelogenous leukemia. Exp Hematol 9: 684–690

    PubMed  CAS  Google Scholar 

  12. Goldman JM, Lu DP (1982) New approaches in chronic granulocytic leukemia - origin, prognosis and treatment. Semin Hematol 19: 241–256

    PubMed  CAS  Google Scholar 

  13. McCarthy DM, Goldman JK (1984) Transfusion of circulating stem cells. CRC Crit 20: 1–24

    CAS  Google Scholar 

  14. To LB, Haylock DN, Kimber RJ, Juttner CA (1984) High levels of circulating haemopoietic stem cells in very early remission from acute non-lymphoblastic leukaemia and their collection and cryopreservation. Br J Haematol 58: 399–410

    Article  PubMed  CAS  Google Scholar 

  15. Juttner CA, To LB, Haylock DN, Branford A, Kimber RJ (1985) Circulating autologous stem cells collected in very early remission from acute non-lymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan and supralethal chemoradiotherapy. Br J Haematol 61: 739–746

    Article  PubMed  CAS  Google Scholar 

  16. Korbling M, Dorken B, Ho AD, Pezzuto A, Hunstein W, Fliedner TM (1986) Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkett’s lymphoma. Blood 67: 629–632

    Google Scholar 

  17. Reiffers J, Bernard P, David B, Veszon G, Sarrat A, Marit G, Moulinier J, Broustet A (1986) Successful autologous transplantation with peripheral blood haemapoietic cells in a patient with acute leukaemia. Exp Hematol 14: 312–315

    PubMed  CAS  Google Scholar 

  18. Bell AJ, Figes A, Oscier DG, Hamblin TJ (1986) Peripheral blood stem cell autografting. Lancet i: 1027

    Article  Google Scholar 

  19. Tilly H, Bastit D, Lucet JC, Esperou H, Monconduit M, Piguet H (1986) Haemopoietic reconstituion after autologous peripheral blood stem cell transplantation in acute leukaemia. Lancet ii: 154–155

    Article  Google Scholar 

  20. Mauch P, Ferrara J, Hellman S (1989) Stem cell self-renewal considerations in bone marrow transplantation. Bone Marrow Transplant 4: 601–607

    PubMed  CAS  Google Scholar 

  21. Korbling M, Haas R, Knauf W, Holle R, Hunstein W (1990) Therapeutic efficacy of autologous blood stem cell transplantation (ABSCT): the role of cytotoxic/cytokine stem cell mobilization. Bone Marrow Transplant 5: 39–40

    PubMed  Google Scholar 

  22. Brito-Babapulle F, Bowcock SJ, Marcus RE, Apperly J, Th’ng KH, Dowding C, Rassool F, Guo A-P, Catovsky D, Galton DAG, McCarthy D, Goldman JM (1989) Autografting for patients with chronic myeloid leukaemia in chronic phase: peripheral blood stem cells may have a finite capacity for maintaining haemopoiesis. Br J Haematol 73: 76

    Article  PubMed  CAS  Google Scholar 

  23. Kessinger A, Armitage JO, Landmark JD, Weisenburger DD (1986) Reconstitution of human hematopoietic function with autologous cryopreserved circulating stem cells. Exp Hematol 14: 192–196

    PubMed  CAS  Google Scholar 

  24. Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger DD (1988) Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 71: 723–727

    PubMed  CAS  Google Scholar 

  25. Kessinger A, Armitage JO, Smith DM, Landmark JD, Bierman PJ, Weisenburger DD (1989) High-dose therapy and autologous peripheral blood stem cell transplantation for patients with lymphoma. Blood 74: 1260–1265

    PubMed  CAS  Google Scholar 

  26. Arlin ZA, Fried J, Clarkson BD (1978) Therapeutic role of cell kinetics in acute leukaemia. Clin Haematol 7: 339–362

    PubMed  CAS  Google Scholar 

  27. To LB, Russell J, Moore S, Juttner CA (1987) Residual leukaemia cannot be detected in very early remission peripheral blood stem cell collections in acute non-lymphoblastic leukaemia. Leuk Res 4: 327–330

    Article  Google Scholar 

  28. Langlands K, Craig JIO, Parker AC, Anthony RS (1990) Molecular determination of minimal residual disease in peripheral blood stem cell harvests. Bone Marrow Transplant 5: 64–65

    PubMed  Google Scholar 

  29. Sharp JG, Kessinger MA, DeBoer J, Mann S, Weisenburger DD (1989) Occult tumor cells in peripheral blood stem cell and bone marrow harvests of candidates for autologous transplantation. Exp Hematol 17: 650

    Google Scholar 

  30. Sieff CA (1990) Biology and clinical aspects of the hematopoietic growth factors. Annu Rev Med 41: 483–496

    Article  PubMed  CAS  Google Scholar 

  31. Appelbaum FR (1989) The clinical use of hematopoietic growth factors. Semin Hematol 26: 7

    PubMed  CAS  Google Scholar 

  32. Bell AJ, Oscier DG, Figes A, Hambin TJ (1987) Use of circulating stem cells to accelerate myeloid recovery after autologous bone marrow transplantation. Br J Haematol 67: 252–253

    Article  PubMed  CAS  Google Scholar 

  33. To LB, Sheppard KM, Haylock DN, Dyson PG, Charles P, Thorp D, Dale BM, Dart GW, Roberts MM, Sage RE, Juttner CA (1990) Single high doses of cyclophosphamide enable the collection of high numbers of haemopoietic stem cells from the peripheral blood. Exp Hematol 18: 442–447

    PubMed  CAS  Google Scholar 

  34. Broxmeyer HE, Jacobsen N, Kurland J, Mendelsohn N, Moore MAS (1978) In vitro suppression of normal granulocytic stem cells by inhibitory activity derived from human leukaemia cells. J Natl Cancer Inst 60: 497–511

    PubMed  CAS  Google Scholar 

  35. Reiffers J, Bernard PH, Marit G, et al. (1986) Collection of blood-derived hemopoietic stem cells and applications for autologous transplantation. Bone Marrow Transplant 1: 371–372

    Google Scholar 

  36. To LB, Haylock DN, Dyson PG, Thorp D, Roberts MM, Juttner CA (1990) An unusual pattern of hemopoietic reconstitution in patients with acute myeloid leukaemia trans-planted with autologous recovery phase peripheral blood. Bone Marrow Transplant 6: 109–114

    PubMed  CAS  Google Scholar 

  37. Lemischka IR, Raulet DH, Mulligan RC (1986) Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 45: 917–927

    Article  PubMed  CAS  Google Scholar 

  38. Jones RJ, Celano P, Sharkis S, Sensenbrenner LL (1989) Two phases of engraftment established by serial bone marrow transplantation in mice. Blood 73: 397–401

    PubMed  CAS  Google Scholar 

  39. Reiffers J, Leverger G, Marit G, Castaigne S, Tilley H, et al. (1988) Haematopoietic reconstitution after autologous blood stem cell transplantation. In: Gale RP, Champlin RE (eds) Bone marrow transplantation, current controversies, proceedings of Sandoz- UCLA symposium. Liss, New York

    Google Scholar 

  40. To LB, Haylock DN, Thorp D, Dyson PG, Branford AL, Ho JQKH, Dart GW, Roberts MM, Horvath N, Bardy P, Russell JA, Millar JL, Kimber RJ, Juttner C (1989) The optimisation of collection of peripheral blood stem cells for autotransplantation in acute myeloid leukaemia. Bone Marrow Transplant 4: 41–47

    PubMed  CAS  Google Scholar 

  41. Stiff PJ, Koester AR, Lanzotti VJ (1986) Autologous transplantation using peripheral blood stem cells. Exp Hematol 14: 311

    Google Scholar 

  42. Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (1984) Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-la cells. J Immunol 133: 157–165

    PubMed  CAS  Google Scholar 

  43. Andrews RG, Singer JW, Bernstein ID (1989) Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properteis. J Exp Med 169: 1721–1730

    Article  PubMed  CAS  Google Scholar 

  44. Berenson RJ, Andrews RG, Bensinger WI, Kalamasz D, Knitter G, Buckner CD, Bernstein ID (1988) Antigen CD34+ marrow cells engraft lethally irradiated babbons. J Clin Invest 81: 951–955

    Article  PubMed  CAS  Google Scholar 

  45. Bender JG, Unverzagt KL, Walker DE, Lee W, Van Epps DE, Smith DH, Stewart CC, To LB (1991) Identification and comparison of CD34 positive cells from normal peripheral blood and bone marrow using multicolor flow cytometry. Blood 77: 259–296

    Google Scholar 

  46. Siena S, Bregni M, Brando B, Ravagnani F, Bonadonna G, Gianni AM (1989) Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high dose cyclophospha- mide-treated patients: enhancement by intravenous recombinant human granulocyte- macrophage colony-stimulating factor. Blood 74: 1905

    PubMed  CAS  Google Scholar 

  47. Juttner CA, To LB, Haylock DN, Dyson PG, Bradstock KF, Dale BM, Enno A, Sage RE, Szer J, Toogood IRG (1990) Approaches to blood stem cell mobilisation: initial Australian clinical results. Bone Marrow Transplant 5: 22–24

    PubMed  Google Scholar 

  48. Lasky LC, Smith JA, McCullogh J, Zanjani (1987) Three-hour collection of committed and multipotent hematopoietic progenitor cells by apheresis. Transfusion 27: 276–278

    CAS  Google Scholar 

  49. Gianni AM, Siena S, Bregni M, et al. (1989) Granulocyte-macrophage colony-stimulating factor to harvest circulating haematopoietic stem cells for autotransplantation. Lancet 2: 580–585

    Article  PubMed  CAS  Google Scholar 

  50. Gianni AM, Bregni M, Siena S, et al. (1989) Rapid and complete hemopoietic reconstitution following combined transplantation of autologous blood and bone marrow cells: a changing role for high dose chemoradiotherapy. Hematol Oncol 7: 139–148

    Article  PubMed  CAS  Google Scholar 

  51. Klein B, Zhang XG, Jourdan M, Bataille R (1989) GM-CSF synergizes with IL-6 in supporting proliferation of human myeloma cells. Blood 74: 749

    Google Scholar 

  52. Bell AJ, Williamson PJ, North J, Watts EJ, Stephens JR (1989) Circulating stem cell autografts in high risk myeloma. Br J Haematol 71: 162–163

    Article  PubMed  CAS  Google Scholar 

  53. Henon PH, Beck G, Debecker A, Eisenmann JC, Lepers M, Kandel G (1988) Autograft using peripheral blood stem cells collected after high dose melphalan in high risk multiple myeloma. Br J Haematol 70: 254–255

    Article  PubMed  CAS  Google Scholar 

  54. Fernand JP, Levy Y, Gerota J, Cosset JM, Benbunan MN, Castaigne S, Seligman M, Broustet JC (1988) Treatment of aggressive multiple myeloma by high dose chemoradio-therapy and autologous blood stem cell graft. Bone Marrow Transplant 3: 80

    Google Scholar 

  55. Watanabe T, Takaue Y, Kawano Y, Koyama T, Huq MAHM, Shimokawa T, Ninomiya T, Aga Y, Inai T, Hiño M, Takehara H, Komi N, Kuroda Y (1989) Peripheral blood stem cell autotransplantation in treatment of childhood cancer. Bone Marrow Transplant 4: 261–265

    PubMed  CAS  Google Scholar 

  56. Bell A J, Figes A, Oscier DG, Hamblin TJ (1987) Peripheral blood stem cell autografts in the treatment of lymphoid malignancies: initial experience in three patients. Br J Haematol 66: 63–68

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Haematology, Institute of Medical and Veterinary Science, and Clinical Haematology and Bone Marrow Transplantation Unit, Royal Adelaide Hospital, P.O. Box 14, Rundle Mall, Adelaide, SA, 5000, Australia

    L. B. To & C. A. Juttner

Authors
  1. L. B. To
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. Juttner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Service d’Hématologie et Institut de Recherche en Hématologie, Transfusion Hospital du Hasenrain, 87 av. d’Altkirch, 68051, Mulhouse Cedex, France

    Eckart W. Wunder M.D. (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) & Philippe R. Henon M.D. (Chef de Service Prof. assoc., Director of Research) (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) &  (Chef de Service Prof. assoc., Director of Research)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

To, L.B., Juttner, C.A. (1993). Stem Cell Mobilization by Myelosuppressive Chemotherapy. In: Wunder, E.W., Henon, P.R. (eds) Peripheral Blood Stem Cell Autografts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75717-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75717-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75719-8

  • Online ISBN: 978-3-642-75717-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation