31P Magnetic Resonance Spectroscopy of Muscle: The Missing Link Between Physiology and Sports Practice

  • E. Achten
  • K. Vandenborne
  • M. Osteaux
  • K. De Meirleir


Muscle is the motor of movement. The performance of an individual is highly dependent upon the adequate output of force by his muscles. In the world of sports physiology muscle is the system with the fastest changes in performance because it can be trained in a few weeks to become several times as powerful as initially. However, if a sufficient level of exercise is not maintained, it quickly loses its force. Force development is not the only adaptation in muscle related to exercise; the efficiency of oxygen consumption, adaptation to the use of more efficient fuel sources, changes related to different muscle fibers, and innervation play key roles in the performance of athletes.


Magnetic Resonance Spectroscopy Calf Muscle Anaerobic Glycolysis Sedentary Subject Creatine Kinase Reaction 
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  1. Achten E, De Meirleir K, van Cauteren M, Osteaux M (1988) In vivo magnetic resonance spectroscopy of muscle metabolism. Belg Tijdschr Radiol 71: 255–257Google Scholar
  2. Achten E, van Cauteren M, Willem R, Luypaert R, Malaisse WJ, van Bosch G, Delanghe G, DeMeirleir K, Osteaux M (1990) 31P NMR spectroscopy and the metabolic properties of different muscle fibers. J Appl Physiol (in press)Google Scholar
  3. Argov Z, Maris J, Damico L, Koruda M, Roth Z, Leigh JS, Chance B (1987) Continuous graded steady state muscle work in rats studied with in vivo 31 phosphorous magnetic resonance. J Appl Physiol 63: 1428–1433PubMedGoogle Scholar
  4. Arnold DL, Taylor DJ, Radda GK (1985) Investigation of human mitochondrial myopathies by phosphorous magnetic resonance spectroscopy. Ann Neurol 18: 189–196PubMedCrossRefGoogle Scholar
  5. Carson PJ, Moussavi RS, Miller RG, Weiner WM (1987) Evidence for a constant relationship between fatigue, high-energy phosphates and pH in different muscle types and in varying forms of exercise. SMRM, 6th annual meeting and exhibition, New York, p 583 (Book of abstracts, vol 2)Google Scholar
  6. Chance B, Sapega A, Sokolow D, Eleff S, Leigh JS, Graham T, Armstrong J, Warnell R (1983) Fatigue in retrospect and prospect: 31P NMR studies of exercise performance. In: Knuttgen HG, Vogel JA, Poortmans J (eds) Biochemistry of exercise. Human Kinetics, Chicago, pp 895–908 (International series in sport sciences, vol 13 )Google Scholar
  7. Chance B, Nioka S, Leigh JS Jr (1987) Metabolic control principles: importance of the steady state reaffirmed and quantified by 31P MRS. In: Oxygen transport and utilization. Society of Critical Care Medicine, Fullerton, pp 215–228Google Scholar
  8. Dawson MJ (1982) Quantitative analysis of metabolite levels in normal human subjects by 31-P topical magnetic resonance. Biosci Rep 2: 727–733PubMedCrossRefGoogle Scholar
  9. Dawson MJ, Gadian DG, Wilkie DR (1978) Muscular fatigue investigated by phosphorus magnetic resonance. Nature 274: 861–866PubMedCrossRefGoogle Scholar
  10. Gadian D (1982) Nuclear magnetic resonance and its applications to living systems. Oxford University Press, pp 1–41Google Scholar
  11. Grisogono V, Yaffé M (1986) In: Helal B, King JB, Grange WJ (eds) Sports injuries and their treatment. Chapman and Hall, London pp 1–32Google Scholar
  12. Huxley AF, Gordon AM (1962) Striated patterns in active and passive shortening of muscle. Nature 193: 280PubMedCrossRefGoogle Scholar
  13. Jue T, Rothman L, Tavitian A, Shulman RG (1989) Natural-abundance 13 C NMR study of glycogen repletion in human liver and muscle. Proc Natl Acad Sci USA 86: 1439–1442PubMedCrossRefGoogle Scholar
  14. Karlsson J (1971) Lactate and phosphagen concentrations in working muscle of man. Acta Physiol Scand Suppl 358: 1–72PubMedGoogle Scholar
  15. Lehninger AL (1982) Enzymes. In: Anderson S, Fox J (eds) Principles of biochemistry. Worth, New York, pp 207–247Google Scholar
  16. March GD, Thompson RT, Paterson DH, Driedger AA (1989) Assessment of oxydative metabolism in normal and phosphorilase deficient patients using a ramp exercise protocol and P 31 NMR spectroscopy. SMRM, 8th annual meeting and exhibition, 12–18 Aug 1989. Works in progress. p 1089Google Scholar
  17. McCully KK, Kent JA, Chance B (1988a) Application of 31 P Magnetic Resonance Spectroscopy to the study of athletic performance. Sports Med 5: 312–321PubMedCrossRefGoogle Scholar
  18. McCully KK, Argov Z, Boden BP, Brown RL, Bank WJ, Chance B (1988b) Detection of muscle injury in humans with 31 P magnetic resonance spectroscopy. Muscle Nerve 2: 212–216CrossRefGoogle Scholar
  19. McCully KK, Argov Z, Boden, BP, Brown RL, Bank WJ, Chance B (1988c) Detection of muscle injury in humans with 31-P magnetic resonance spectroscopy. Muscle Nerve 2: 212–216CrossRefGoogle Scholar
  20. Molé PA, Coulson RL, Caton JR, Nichols BG, Barstow TJ (1985) In vivo 31 P-NMR in human muscle: transient patterns with exercise. J Appl Physiol 59: 101–104PubMedGoogle Scholar
  21. Newman RJ, Bore Pi, Chan L (1982) Nuclear magnetic resonance studies of forearm muscles in Duchenne dystrophy. Br Med J 284: 1072–1074CrossRefGoogle Scholar
  22. Newsholme EA (1988) Basic aspects of metabolic regulation and their application to provision of energy in exercise. In: Poortmans JR (ed) Principles of exercise biochemistry. Karger, Basel, pp 40–77 (Medicine and sport science, vol 127 )Google Scholar
  23. Park JH, Brown RL, Park CR, McCully KK, Cohn M, Chance B (1987a) High energy phosphate metabolism in athletes and normal subjects during prolonged exercise. SMRM, 6th annual meeting and exhibition, New York, p 1041 (Book of abstracts, vol 2)Google Scholar
  24. Park JH, Brown RL, Park CR, McCully K, Cohn M, Haselgrove J, Chance B (1987b) Functional pools of oxidative and glycolytic fibers in human muscle observed by 31 P magnetic resonance spectroscopy during exercise. Proc Natl Acad Sci USA 84: 8976–8980PubMedCrossRefGoogle Scholar
  25. Peter JB, Barnard RJ, Edgerton VR, Gillespie CA, Stemple KE (1972) Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits. Biochemistry 11:2627–2633PubMedCrossRefGoogle Scholar
  26. Petroff OAC, Prichard JW, Behar KL, Alger JR, den Hollander JA, Shulman RG (1985) Cerebral intracellular pH by 31 P nuclear magnetic resonance spectroscopy. Neurology 35: 781–788PubMedGoogle Scholar
  27. Radda G (1988) Clinical applications of magnetic resonance spectroscopy. In: Budinger TF, Margulis AR (eds) Medical magnetic resonance: a primer. SMRM, pp 295–307Google Scholar
  28. Taylor DJ, Bore P, Styles P, Gadian DG, Radda GK (1983) Bioenergetics of intact human muscle. A 31 phosphorous nuclear magnetic resonance study. Mol Biol Med 1: 77–94PubMedGoogle Scholar
  29. Taylor DJ, Styles P, Matthews PM, Arnold DA, Gadian DG, Bore P, Radda GK (1986) Energetics of human muscle: exercise induced ATP depletion. Magn Reson Med 3: 44–54 (1986)PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • E. Achten
  • K. Vandenborne
  • M. Osteaux
  • K. De Meirleir

There are no affiliations available

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