Influence of Nutrition on Respiratory System

  • J. Zander
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 215)


The influences between nutrition and respiration are mutual. This holds for the function of the respiratory system as well as for the structure of the lung. On one hand malnutrition can have a negative influence on respiration within a Short time, but on the other hand nutritional support can cause respiratory problems up to the full clinical picture of respiratory insufficiency. Very often this is almost neglected in clinical practice. This overview will point out some important problems of the relation between nutrition and respiration, mainly in regard to acute diseases.


Chronic Obstructive Pulmonary Disease Parenteral Nutrition Respiratory Muscle Respiratory Insufficiency Respiratory Quotient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Arora, N. and D. Rochester. “Effect of body weight and muscularity on human diaphragm muscle mass, thickness and area.” J Appl Physiol. 52:63–70, 1982.Google Scholar
  2. 2.
    Arora, N. and D. Rochester. “Respiratory muscle strength and maximal voluntary Ventilation in undernourished patients.” Am Rev Respir Dis. 126:5–8, 1982.PubMedGoogle Scholar
  3. 3.
    Askanazi, J., S. Rosenbaum, A. Hyman, P. Silverberg, J. Milic–Emili and J. Kinney. “Respiratory changes induced by the large glucose loads of parenteral nutrition.” J Am Med Assoc. 243:1444–1447, 1980.Google Scholar
  4. 4.
    Askanazi, J., C. Weissman, P. LaSala and P. Charlesworth. “Nutrients and Ventilation.” Adv in Shock Res. 9:69–79, 1983.Google Scholar
  5. 5.
    Askanazi, J., C. Weissman, P. LaSala, J. Milic–Emili and J. Kinney. “Effect of protein intake on ventilatory drive.” Anesthesiology. 60:106–110, 1984.Google Scholar
  6. 6.
    Askanazi, J., C. Weissman, S. Rosenbaum, A. Hyman, J. Milic–Emili and J. Kinney. “Nutrition and the respiratory system.” Crit Care Med. 10:163–172, 1982.Google Scholar
  7. 7.
    Askenazi, J., J. Nordenstroem, S. Rosenbaum et al.. “Nutrition for the patient with respiratory failure:Glucose versus fat. ” Anesthesiology. 54:373–377, 1981.CrossRefGoogle Scholar
  8. 8.
    Aub, J. and E. Du Bois. “Clinical calorimetry. The basal metabolism of old men.” Arch Int Med. 19:823–831, 1917.Google Scholar
  9. 9.
    Best, C. and N. Taylor. “The physiological Basis of Medical Practice.” 9th edition, Williams & Wilkins, Baltimore:1946.Google Scholar
  10. 10.
    Boles, J., M. Garrie, P. Youinou et al.. “Nutritional status in intensive care patients:Evaluation in 84 selected patients. ” Crit Care Med. 11:87–90, 1983.PubMedCrossRefGoogle Scholar
  11. 11.
    Boothby, W., J. Berkson and H. Dunn. “Studies of the energy metabolism of normal individuals.” Am J Physiol. 116:468–484, 1936.Google Scholar
  12. 12.
    Covelli, H., J. Black, M. Olsen et al.. “Respiratory failure precipitated by high carbohydrate loads. ” Ann Int Med. 95:579–581, 1981.PubMedGoogle Scholar
  13. 13.
    Delafosse, B., Y. Bouffard, J. Viale, G. Annat, O. Bertrand and J. Motin. “Respiratory changes induced by parenteral nutrition in postoperative patients undergoing inspiratory pressure support Ventilation.” Anesthesiology. 66:393–396, 1987.PubMedCrossRefGoogle Scholar
  14. 14.
    Doekel, R. J., C. Zwillich, C. Scoggin et al.. “Clinical semi-starvation depression of hypoxic ventilatory response. ” N Engl J Med. 295:358, 1976.PubMedCrossRefGoogle Scholar
  15. 15.
    Driver, A. and M. LeBrun. “Iatrogenic malnutrition in patients receiving ventilatory support.” JAMA. 244:2195–2196, 1980.PubMedCrossRefGoogle Scholar
  16. 16.
    Fletcher, J. and J. Little. “A compoarison of parenteral nutrition and early postoperative feeding on nitrogen balance after major surgery.” Surgery. 100:21–24, 1986.PubMedGoogle Scholar
  17. 17.
    Fromme, H. “Systematische Untersuchungen über die Gewichtsverhältnisse des Zwerchfells.” Virchows Arch. 221:117–155, 1916.CrossRefGoogle Scholar
  18. 18.
    Ganger, D., U. Taitelman and S. Bursztein. “Comparison of enteral and parenteral nutrition in hypercatabolic states.” Crit Care med. 9:280, 1981.CrossRefGoogle Scholar
  19. 19.
    Gazzaniga, A., J. Polachek, A. Wilson and A. Day. “Indirect calorimetry as a guide to caloric replacement during total parenteral nutrition.” Am J Surg. 136:128–134, 1978.PubMedCrossRefGoogle Scholar
  20. 20.
    Gernstrom, J., F. Larin and R. Wurtman. “Correlations between brain tryptophan and plasma neutral amino acid levels following food consumption in rats.” Life Sei. 13:517– 524, 1973.Google Scholar
  21. 21.
    Goldstein, S., B. Thomashow and J. Askenazi. “Functional changes during nutritional repletion in patients with lung disease.” Clin Chest Med. 7:141–151, 1986.PubMedGoogle Scholar
  22. 22.
    Greene, H., D. Hazlett and R. Demaree. “Relationship between Intralipid-induced hyperlipemia and pulmonary function.” Am J Clin Nutr. 29:127, 1976.PubMedGoogle Scholar
  23. 23.
    Greene, H., D. Hazlett, R. Herman et al.. “Effect of intralipid on pulmonary membrane diffusing capacity (Dm) and pumonary capillary blood volume (Vc). ” Clin Res. 19:677, 1971.Google Scholar
  24. 24.
    Hageman, J., K. McCulloch, P. Gora et al.. “Intralipid alterations in pulmonary Prostaglandin metabolism and gas exchange. ” Crit Care Med. 11:794, 1983.PubMedCrossRefGoogle Scholar
  25. 25.
    Harris, J. and F. Benedict. “A biometric study of basal metabolism in man.” Washington DC, Carnegie Inst Wash. Publ No 279:1919.Google Scholar
  26. 26.
    Jequier, E. “The influence of nutrient administration on energy expenditure in man.” Clin Nutrition. 5:181–186, 1986.CrossRefGoogle Scholar
  27. 27.
    Kimure, T., J. Toung, S. Margolis et al.. “Respiratory failure in acute pancreatitis. A possible role for triglycerides. ” Ann Surg. 189:509, 1979.Google Scholar
  28. Knochel, J. “Neuromuscular manifestations of electrolyte disorders.” Am J Med. 72:521, 1982.PubMedCrossRefGoogle Scholar
  29. Larca, L. and D. Greenbaum. “Effectiveness of intensive nutritional regimes in patients who fail to wean from mechanical Ventilation.” Crit Care Med. 10:297, 1982.PubMedCrossRefGoogle Scholar
  30. 30.
    Lusk, G. “The elements of the science of nutrition.” 4th edition, WB Saunders & Co, Philadelphia:17–45, 1931.Google Scholar
  31. 31.
    Martin, T., L. Altman and O. Alvares. “The effects of severe protein–calorie malnutrition on antibacterial defense mechanisms in the rat lung.” Am Rev Respir Dis. 128:1013–1019, 1983.PubMedGoogle Scholar
  32. 32.
    McCamish, M., R. Dena and R. Ouellette. “Assessing energy requirements of patients on respirators.” JPEN. 5:513, 1981.CrossRefGoogle Scholar
  33. 33.
    McKeen, C., K. Brigham, R. Bowers et al.. “Pulmonary vascular effects of fat emulsion infusion in anesthetized sheep. ” J Clin Invest. 61:1291, 1978.PubMedCrossRefGoogle Scholar
  34. 34.
    Newman, J., T. Neff and P. Ziporin. “Acute respiratory failure associated with hypophosphatemia.” N Engl J Med. 296:1101, 1977.PubMedCrossRefGoogle Scholar
  35. 35.
    Niederman, M., W. Merrill, L. Polomski et al.. “Influence of Sputum IgA and elastase on tracheal cell bacterial adherence. ” Am Rev Respir Dis.. 133:255–260, 1986.PubMedGoogle Scholar
  36. 36.
    Niederman, M., T. Rafferty, C. Sasaki et al.. “Comparison of bacterial adherence to ciliated and squamous epithelial cells obtained from the human respiratory tract. ” Am Rev Respir Dis. 127:85–90, 1983.PubMedGoogle Scholar
  37. 37.
    Nixon, J. and J. Brock-Utne. “Free fatty acid and arterial oxygen changes following major injury:correlation between hypoxemia and increased free fatty acid levels.” J Trauma. 18:509, 1978.CrossRefGoogle Scholar
  38. 38.
    Pflüger, E. “Über die Ursache der Atembewegungen, sowie der Dyspnoe und Apnoe.” Arch. ges. Physiol. 1:61, 1868.Google Scholar
  39. 39.
    Rochester, D. “Malnutrition and the respiratory muscles.” Clin Chest Med. 7:91–99, 1986.PubMedGoogle Scholar
  40. 40.
    Rochester, D. and N. Brown. “Determinants of maximal inspiratory pressure in chronic obstructive pulmonary disease.” Am Rev Respir Dis. 132:42–47, 1985.PubMedGoogle Scholar
  41. 41.
    Roulet, M., A. Detsky, E. Marliss, T. Todd, W. Mahon, G. Anderson, S. Steward and K. Jeejeebhoy. “A controlled trial of the effect of parenteral nutrition support on patients with respiratory failure and sepsis.” Clin Nutrition. 2:97–107, 1983.CrossRefGoogle Scholar
  42. Schmitz, J., P. Lötz, A. Grünert and F. Ahnefeld. “Untersuchungen zum energieumsatz und zur Energieversorgung beatmeter Intensivpatienten.” Infusionstherapie. 11:100–108, 1984.Google Scholar
  43. Silberman, H. and A. Silberman. “Parenteral nutrition, biochemistry and respiratory gas exchange.” JPEN. 10:154–154, 1986.CrossRefGoogle Scholar
  44. Smith, H., D. Kennedy and G. Park. “A nomogram for rapid calculation of metabolic requirements on intubated patients.” Intensive Care Med. 10:147–148, 1984.PubMedCrossRefGoogle Scholar
  45. Starker, P., P. LaSala and J. Askanazi. “Nutritional support and weaning from mechanical Ventilation.” Crit Care Med. 11 (2):149, 1983.PubMedCrossRefGoogle Scholar
  46. Stone, J. “Phophate homeostasis and hypophosphatemia.” Am J Med. 72:521, 1982.CrossRefGoogle Scholar
  47. Sundstrom, G., C. Zauner and A. Mans. “Decrease in pulmonary diffusing capacity during lipid infusion in healthy men.” J Appl Physiol. 34:816, 1973.PubMedGoogle Scholar
  48. 48.
    van den Berg, B. and H. Stam. “Metabolie and respiratory effects of enteral nutrition in patients during mechanical Ventilation.” Intensive Care Med. 14:206–211, 1988.PubMedCrossRefGoogle Scholar
  49. 49.
    Vandenbergh, E., K. Van de Woestijne and A. Gyselen. “Weight changes in the terminal stages of chronic obstructive pulmonary disease:Relation to respiratory function and prognosis.” Am Rev Respir Dis. 95:556–566, 1967.PubMedGoogle Scholar
  50. 50.
    Venus, B., C. Patel, M. Mathru et al.. “Pulmonary effects of lipid infusion in patients with acute respiratory failure. ” Crit Care med. 12:293, 1984.Google Scholar
  51. 51.
    Wolfe, R., J. Snowden and J. Burke. “Influence of insulin and palmitic acid concentration on pulmonary Surfactant synthesis.” J Surg Res. 27:262–267, 1979.PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1990

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  • J. Zander

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