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Cellular Biology of the Experimental Peripheral Nerve Lesion

  • G. W. Kreutzberg
  • M. B. Graeber
Conference paper

Abstract

The interruption of the continuity of axons, such as may occur with spinal or cranial nerve injury or as a result of compression or inflammation, leads to characteristic retrograde changes in the cell bodies of the affected neurons. These changes are part of a regenerative process which involves not only the lesioned neurons but also their microenvironment. Although regeneration may result in the anatomical restitution of a lesioned nerve, i.e., by neurite outgrowth and reinnervation of the musculature, functional recovery does not always take place.

Keywords

Glial Fibrillary Acidic Protein Facial Nerve Microglial Cell Astrocytic Process Facial Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • G. W. Kreutzberg
    • 1
  • M. B. Graeber
    • 1
  1. 1.MartinsriedGermany

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