Cellular Biology of the Experimental Peripheral Nerve Lesion
The interruption of the continuity of axons, such as may occur with spinal or cranial nerve injury or as a result of compression or inflammation, leads to characteristic retrograde changes in the cell bodies of the affected neurons. These changes are part of a regenerative process which involves not only the lesioned neurons but also their microenvironment. Although regeneration may result in the anatomical restitution of a lesioned nerve, i.e., by neurite outgrowth and reinnervation of the musculature, functional recovery does not always take place.
KeywordsNeurol Macromolecule Thymidine Lost Hexose
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- Kreutzberg GW (1968) Über perineuronale Mikrogliazellen (Autoradiographische Untersuchungen). Acta Neuropathol, Suppl 4:141–145.Google Scholar
- Kreutzberg GW (1982) Acute neural reaction to injury. In: Nicholls JG (ed) Repair and regeneration of the nervous system, life sciences research report 24, Dahlem Konferenzen 1982. Springer, Berlin Heidelberg New York, pp 57–69.Google Scholar
- Kreutzberg GW (1986) Neurobiology of regeneration and degeneration. In: May M (ed) The facial nerve. Thieme, New York, pp 75–83.Google Scholar
- Kreutzberg GW, Tetzlaff W, Toth L (1984) Cytochemical changes of cholinesterases in motor neurons during regeneration. In: Brzin M, Barnard EA, Sket D (eds) Cholinesterases — fundamental and applied aspects. de Gruyter, Berlin, pp 273–288.Google Scholar