Cellular Biology of the Experimental Peripheral Nerve Lesion

  • G. W. Kreutzberg
  • M. B. Graeber
Conference paper


The interruption of the continuity of axons, such as may occur with spinal or cranial nerve injury or as a result of compression or inflammation, leads to characteristic retrograde changes in the cell bodies of the affected neurons. These changes are part of a regenerative process which involves not only the lesioned neurons but also their microenvironment. Although regeneration may result in the anatomical restitution of a lesioned nerve, i.e., by neurite outgrowth and reinnervation of the musculature, functional recovery does not always take place.


Glial Fibrillary Acidic Protein Facial Nerve Microglial Cell Astrocytic Process Facial Nucleus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • G. W. Kreutzberg
    • 1
  • M. B. Graeber
    • 1
  1. 1.MartinsriedGermany

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