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Chromosome Aberrations of Blood Lymphocytes Induced by Low-Level Doses of Ionizing Radiation

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Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 2))

Abstract

Many reports can be found in the literature on the effects on the chromosomes of pheripheral blood lymphocytes due to almost all kinds of ionizing radiation, with low and high LET (Linear Energy Transfer), delivered acutely, fractionated or continously, in vivo as well as in vitro (e.g., Evans and Lloyd 1978; Ishihara and Sasaki 1983). The frequencies of structural aberrations were even taken for dose assessment in radiation-exposed persons (e.g., Lloyd and Purrott 1981; International Atomic Energy Agency 1986; Carrano and Natarajan 1988). Most of these investigations, however, dealt with high (over 50 cGy) and some with medium (above 5 cGy) doses2.

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References

  • Anderson D. Jenkinson PC, Dewdney RS, Francis AJ, Godbert P, Butterworth KR (1988) Chromosome aberrations, mitogen-induced blastogenesis and proliferative rate index in peripheral lymphocytes from 106 control individuals of the U.K. population. Mutat Res 204: 407–420

    Article  PubMed  CAS  Google Scholar 

  • Andersson HC, Kihlman BA (1987) Effects of G2 treatments with inhibitors of DNA synthesis and repair on chromosome damage induced by X-rays and chemical clastogens in root tips of Vicia faba. Mutat Res 181: 173–185

    Article  PubMed  CAS  Google Scholar 

  • Aptikaeva GF, Rozanova OM, Saugabaeva KM, Ganassi EE (1988) Proteinases involved in radiation injury to chromosomes. On the effect of phenyl-methyl-sulfonyl fluorid. Radio-biologica 28: 297–302

    CAS  Google Scholar 

  • Archer VJ (1984) Oncology Overview: Selected abstracts on risk of cancer from exposure to low level ionizing radiation. PB84–922906, Int Cancer Res Data Bank Progr, Nat Cancer Inst, US Dept Health Human Serv, Salt Lake City, Utah

    Google Scholar 

  • Barcinski MA, Do Céu M, Abreu A, De Almeida JCC, Naya JM, Fonseca LG, Castro E (1975) Cytogenetic investigations in a Brazilian population living in an area of high natural radioactivity. Am J Hum Genet 27: 802–806

    PubMed  CAS  Google Scholar 

  • Bauchinger M, Kolin-Gerresheim J, Schmid E, Dresp J (1980). Chromosome analyses of nuclear-power plant workers. Int J Radiat Biol 38: 577–581

    Article  CAS  Google Scholar 

  • Baum JW (1982) Clonal theory of radiation carcinogenesis. In Proc. of the symposium of microdosimetry pp 12. Nat Tech Inf Serv, Springfield, VA, DE 82022044

    Google Scholar 

  • Benjamin RC, Gill DM (1980) Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA: A comparison of DNA molecules containing different types of strand breaks. J Biol Chem 255: 10502–10508

    PubMed  CAS  Google Scholar 

  • Boyd JT, Court Brown WM, Woodcock GE, Vennart J (1967) Relationship between external radiation exposure and chromosome aberrations among luminous dial painters. In: Evans et. al. (eds) Human radiation cytogenetics. Elsevier North Holland, Amsterdam, pp 208–214

    Google Scholar 

  • Brandom WF, Saccomano G, Archer VE, Archer PG, Bloom AD (1978) Chromosome aberrations as a biological dose-response indicator of radiation exposure in unranium mines. Radiat Res 76: 159–171

    Article  PubMed  CAS  Google Scholar 

  • Brown JM (1977) The shape of the dose-response curve for radiation carcinogenesis: Extrapolation to low doses. Radiat Res 71: 34–50

    Article  PubMed  CAS  Google Scholar 

  • Buckton KE, Dolphin GW, McLean AS (1967) Studies of chromosome aberrations in cultures of peripheral blood from men employed at UKAEA establishments. In: Evans HJ, Court-Brown WM, McLean AS (eds) Human radiation Cytogenetics. Elsevier North-Holland, Amsterdam, pp 174–182

    Google Scholar 

  • Buckton KE, Langlands AO, Smith PG, Woodcock GE, Looby PC (1971) Further studies on chromosome aberration production after whole-body irradiation in man. Int J Radiat Biol 19: 369–378

    Article  CAS  Google Scholar 

  • Burch PRJ (1983) Problems with the linear-quadratic dose-response relationship. Health Phys 44: 411–413

    PubMed  CAS  Google Scholar 

  • Cao S, Deng Z, Zhen Z, Li Y, Yu C (1981) Lymphocyte chromosome aberrations in personnel occupationally exposed to low levels of radiation. Health Phys (Abstr) 41: 586

    Google Scholar 

  • Carrano AV, Natarajan AT (1988) Considerations for population monitoring using cytogenetic techniques. Mutat Res 204: 379–406

    Article  PubMed  CAS  Google Scholar 

  • Chen D (1985) Cytogenetic investigations on populations residing in high background radiation area of Yangjiang, China. Environ Mutagen Soc JPN 14: 12

    Google Scholar 

  • Collins A, Downes CS, Johnson RT (eds) (1984) DNA repair and its inhibition. Oxford, IRL Press Limited, 371 pp

    Google Scholar 

  • Costa-Ribeiro C, Barcinsky MA, Figueiredo N, Penna-Franca E, Lobao N (1975) Radiobiological aspects and radiation levels associated with the milling of monazite sand. Health Phys 28: 225–231

    Article  PubMed  CAS  Google Scholar 

  • Court Brown WM, Buckton KE, Jacobs PA, Tough IM, Kuensberg EV, Knox JDE (1966) Chromosome studies on adults. Eugenics Laboratory Memoires 47. Cambridge Univ Press, Cambridge

    Google Scholar 

  • Crawford-Brown DJ, Hofmann W (1990a) A generalized state-vector model for radiation induced cellular transformation. Int J Radiat Biol 57: 407–423

    Article  PubMed  CAS  Google Scholar 

  • Crawford-Brown DJ, Hofmann W (1990b) Extension of state-vector model of radiation carcinogenesis to consider the influence of dose-rate. J Comput Biomed Res (in press)

    Google Scholar 

  • Elkind MM (1984) Repair processes in radiation biology. Radiat Res 100: 425–449

    Article  PubMed  CAS  Google Scholar 

  • Evans HJ, Lloyd DC (eds) (1978) Mutagene-induced chromosome damage in man. Univ Press, Edingburgh

    Google Scholar 

  • Evans HJ, Court Brown WM, McLean AS (eds) (1967) Human radiation cytogenetics. Elsevier North Holland, Amsterdam, 218 pp

    Google Scholar 

  • Evans HJ, Buckton KE, Hamilton GE, Carothers A (1979) Radiation induced chromosome aberrations in nuclear-dockyard workers. Nature (Lond) 277: 531–534

    Article  CAS  Google Scholar 

  • Evensen JF, Reitan J, Westerlund EA, Bragger A, (1989) Caesium 137 body burden and chromosome aberrations in Norwegian lapps. 1965–1978. In: Brustad T, Langmark F, Reitan JB (eds) Radiation and Cancer Risk. Hemisphere Publ. Corp, New York, pp 21–30

    Google Scholar 

  • Ferguson SW et al. (1982) Private communication from: The Environmental Protection Agency, Office of Radiation Program: Cytologic studies in areas with atypical environmental radon concentrations. Project No: WA-78-C243

    Google Scholar 

  • George KF, Aravindan KV, Joseph B et al. (1982) Investigations on human populations residing in high background radiation areas of Kerala and adjoining regions: Cytogenetic studies. (unpubl)

    Google Scholar 

  • Han A, Hill CK, Elkind MM (1984) Repair processes and radiation quality in neoplastic transformation of mammalian cells. Radiat Res 99: 249–261

    Article  PubMed  CAS  Google Scholar 

  • Harris G, Holmes A (1986) Sensitivity to X-irradiation of peripheral blood lymphocytes from aging donors. Int J Radiat Biol, Relat Stud Phys, Chem Med 50: 685–694

    CAS  Google Scholar 

  • Heartlein MW, Preston RI (1985) The effect of 3-aminobenzamide on the frequency of X-ray-or neutron-induced chromosome aberrations in cycling or non-cycling human lymphocytes. Mutat Res 148: 91–97

    Article  PubMed  CAS  Google Scholar 

  • Hedner K, Högstedt B, Kolnig AM, Mark-Vendel E, Strömbeck B, Mitelman F (1983) Sister chromatid exchanges and structural chromosome aberrations in relation to smoking in 91 individuals. Heredidas 98: 77–81

    Article  CAS  Google Scholar 

  • Heindorff K, Rieger R, Schubert I, Michaelis A, Aurich 0 (1987) Clastogenic adaptation of plant cells — reduction of the yield of clastogen-induced chromatin aberrations by various pretreatment procedures. Mutat Res 181: 157–171

    Article  CAS  Google Scholar 

  • Hickey RJ (1988) Health benefits from low-level ionizing radiation: radiation hormesis and the question of stimulation of immunological efficiency. Physikalische Medizin, Balneol, Med Klimatol, Ergänzungsb, Int Symp Bad Hofgastein/Austria 1987: 8–17

    Google Scholar 

  • High Background Radiation Research Group of China (1980) Health survey in high background radiation areas in China. Science 209: 877–880

    Article  Google Scholar 

  • High Background radiation Research Group of China (1981) Aspects of environmental radiation and dosimetry concerning the high background radiation area in China. J Radiat Res 22: 88–100

    Article  Google Scholar 

  • Horsman MR, Brown DM, Hirst DG, Brown JM (1984) Inhibitors of poly(ADP-ribose) polymerase and their enhancement of ankylating agent cytotoxicity in vivo. Abstr Pap. Thirty-second Annu Meet Radiat Res Soc, Orlando, Florida, p 116

    Google Scholar 

  • Horvat DJ, Baumann A, Racic J (1980) Genetic effect of low doses of radiation in occupationally exposed workers in coal mines and coal fired plants. Radiat Environ Biophys 18: 81–97.

    Article  Google Scholar 

  • International Atomic Energy Agency, Vienna (1986) Biological dosimetry: chromosomal aberration analysis for dose assessment. Tech Rep Ser No 260

    Google Scholar 

  • Ishihara T, Sasaki MS (eds) (1983) Radiation-induced chromosome damage in man. Alan R Liss, Now York, 636 pp

    Google Scholar 

  • Ivanov B, Praskova L, Mileva M, Bulanova M, Georgieva I (1978) Spontaneous chromosomal aberration levels in human peripheral lymphocytes. Mutat Res 51: 421–426

    Google Scholar 

  • Katz R, Hofmann W (1982) Biological effects of low doses of ionizing radiations: particle tracks in radiobiology. Nucl Instrum Methods 203: 433–442

    Article  CAS  Google Scholar 

  • Kellerer AM, Rossi HH (1972) The theory of dual radiation action. Current Topics Radiat. Res Q 8: 85–158

    CAS  Google Scholar 

  • Kimball RF (1987) The development of ideas about the effect of DNA repair on the induction of gene mutations and chromosomal aberrations by radiation and by chemicals. Mutat Res 186: 1–34

    PubMed  CAS  Google Scholar 

  • Kucerovä M, Anderson AJB, Buckton K, Evans HJ (1972) X-ray-induced chromosome aberrations in human peripheral blood lymphocytes: the response to low levels of exposure in vitro. Int J Radiat Biol 21: 389–396

    Article  Google Scholar 

  • Léonard A, Deknudt GH, Léonard ED, Decat G (1984) Chromosome aberrations in employees from fossil-fuel and nuclear-power plants. Mutat Res 138: 205–212

    Article  PubMed  Google Scholar 

  • Lloyd DC, Purrott RJ (1981) Chromosome aberration analysis in radiological protection dosimetry. Radiat Prot Dosimetry 1: 19–29

    CAS  Google Scholar 

  • Lloyd DC, Purrott RI, Reeder EJ (1980) The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people. Mutat Res 72: 523–532

    Article  PubMed  CAS  Google Scholar 

  • Lloyd CD, Edwards AA, Léonard A, de Knudt G, Obe G, Palitti F, Tanzarella C (1988) Frequencies of chromosomal aberrations induced in human lymphocytes by low doses of X-rays. Int J Radiat Biol 53: 49–55

    Article  CAS  Google Scholar 

  • Luchnik NV, Sevankaev AV (1976) Radiation induced chromosomal aberrations in human lymphocytes. 1. Dependency on the dose of gamma rays and an anomaly at low doses. Mutat Res 36: 363–3

    Article  PubMed  CAS  Google Scholar 

  • Luckey TD (1980) Hormesis with ionizing radiation. CRP Press, Boca Raton, Florida, USA Luckey TD (1984) Hormesis from ionizing radiation. Health Phys 46: 705

    Google Scholar 

  • Mello R, Santos D, Norman K, Norman A (1974) Chromosome aberrations and T-cell survival in human lymphocytes. Radiat Res 60: 482–488

    Article  Google Scholar 

  • Morinaga H, Mifune M, Furuno K (1984) Medical experiences in the Japanese radon spa Misasa. Radiat Prot Dosimetry 7: 295–297

    CAS  Google Scholar 

  • Obe G, Herha J (1978) Chromosomal aberrations in heavy smokers. Human Office of Radiation Programs. Project No WA-78-C243 Final Rep Table 60

    Google Scholar 

  • Obe G, Göbel D, Engeln H, Herha J, Natarajan AT (1980) Chromosomal aberrations in peripheral lymphocytes of alcoholics. Mutat Res 73: 377–386

    Article  PubMed  CAS  Google Scholar 

  • Olienick NL, Evans HH (1985) Poly(ADP-ribose) and the response of cells to ionizing radiation. Radiat Res 101: 29–46

    Article  Google Scholar 

  • Olivieri G, Bodycote J, Wolff S (1984) Adaptive response to human lymphocytes to low concentrations of radioactive thymidin. Science 223: 594–597

    Article  PubMed  CAS  Google Scholar 

  • Planel G, Soleihavoup JP, Tixador R, Croute F, Richoilley G (1976) Demonstration of a stimulating effect of natural ionizing radiation and of very low radiation doses on cell multiplication. In: Proc Biol Environ Effects Low-Level Radiat. IAEA, Vienna, pp 127–140

    Google Scholar 

  • Pohl E, Pohl-Ruling J (1977) Dose calculations due to the inhalation of Rn-222, Rn-220 and their daughters. Health Phys 32: 552–555

    PubMed  CAS  Google Scholar 

  • Pohl E, Pohl–Ruling J (1982). Dose distribution in the human organism due to incorporation of radon and decay products in relation to epidemiological studies. Proc Int Radon Spec Meet “The Assessment of Radon Daughter Exposure and Related Biological Effects”, Rome RD Press Univ Utah USA ISBN 0–940636–01–8, pp 75–83

    Google Scholar 

  • Pohl E, Steinhäusler F, Hofmann W (1978) Die natürliche Strahlenexposition der Bevölkerung der Stadt Salzburg. Ergebnisse einer vierjährigen Untersuchung des Institutes für Physik für Bio-and Geowissenschaften. Jahrb 1975–1977 Univ Salzburg, Universitätsdruckerei Pustet, Salzburg, pp 105–116

    Google Scholar 

  • Pohl-Ruling J (1968) The assessment of radioactivity in people of Brazil. In: Report of Technical Assistance Experts to Government of Brazil. Vienna, Int Atomic Energy Agency, WP/5/359

    Google Scholar 

  • Pohl-Ruling J (1989) Chromosome aberrations in man in areas with elevated natural radioactivity. In: Proc XVth Berzelius Symp Somatic Genet Effects Ionizing Radiat, Umea Sweden, 1988, pp 103–111

    Google Scholar 

  • Pohl-Ruling J, Fischer P (1979) The dose-effect relationship of chromosome aberrations to alpha and gamma irradiation in a population subjected to an increased burden of natural radioactivity. Radiat Res 80: 61–81

    Article  PubMed  CAS  Google Scholar 

  • Pohl-Ruling J, Fischer P (1983) chromosome aberrations in inhabitants of areas with elevated radioactivity. In: Ishihara T, Sasaki MS (eds) Radiation-induced chromosome damage in man. Alan R Liss, New York, NY 10011, pp 527–560

    Google Scholar 

  • Pohl-Ruling J, Pohl E (1990) Method for alpha irradiation of blood cultures with short-lived radon-222 decay products. Mutat Res 234: 43–45

    PubMed  CAS  Google Scholar 

  • Pohl-Ruling J, Scheminzky F (1972). The natural radiation environment of Badgastein/Austria and its biological effects. Proc 2nd Symp Nat Rad Environ, Houston NTIS — CONF — 720805Pí, pp 393–420

    Google Scholar 

  • Pohl-Ruling J, Fischer P, Pohl E (1978) The low-level shape of dose response for chromosome aberrations. In: Proc Int Symp Late Biol Effects Ionizing Radiat, Vol II. Int Atomic Energy Agency, Vienna, (STI/PUB/489), pp 315–326

    Google Scholar 

  • Pohl-Ruling J, Fischer P, Haas O et al. (1983a) Effect of low dose acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro. Mutat Res 110: 71–82

    Article  PubMed  CAS  Google Scholar 

  • Pohl–Ruling J, Fischer P, Buckton KE et al. (1983b) Lymphocytes at low levels of acute in vitro irradiation with 250kV X–rays and 14 MeV neutrons. In: Proc Int Symp Biol Effects Low–Level Radiat Spec Regard Stochastic Non–Stochastic Effects. Int Atomic Energy Agency, Vienna ISBN92–0–010183–6, pp 171–184

    Google Scholar 

  • Pohl-Ruling J, Fischer P, Lloyd DC et al. (1986a) Chromosomal damage induced in human lymphocytes by low doses of D-T neutron. Mutat Res 173: 267–272

    Article  PubMed  CAS  Google Scholar 

  • Pohl-Ruling J, Fischer P, Pohl E (1986b) The effect of radon and decay products on peripheral blood chromosomes. In: Proc Symp Radon Decay Products. 191st Nat Meet Am Chem Soc Radiat Biol, New York, pp 487–501

    Google Scholar 

  • Pohl-Ruling J, Haas O, Obe G et al. (1990a) The Chernobyl fallout in Salzburg/Austria and its effects on blood chromosomes. In: Proc Int Symp DNA Repair, Chromosome Alterations Chromatin Structure Under Environ Pollut. USSR Academy Sci, Moscow, 1988. Acta Biol Hungaria 41 (12): 215–222

    Google Scholar 

  • Pohl-Ruling J, Haas O, Brogger A et al. (1990b) The effect on lymphocyte chromosomes of additional radiation burden due to fall out in Salzburg/Austria from the Chernobyl accident. Mutat Res (submitted)

    Google Scholar 

  • Preston RJ, Brewen JG, Gengozian N (1974) Persistence of radiation-induced chromosome aberrations in marmoset and man. Radiat Res 60: 516–524

    Article  PubMed  CAS  Google Scholar 

  • Roser FX, Cullen TL (1965) External radiation levels in high-background regions of Brazil. In: Adams JAS, Lowder WM (eds) Natural Radiation Environment. Rice Univ Houston, pp 825–836

    Google Scholar 

  • Schmickel R (1967) Chromosome aberrations in leucocytes exposed in vitro to diagnostic levels of X-rays. Am J Hum Genet 19: 1

    PubMed  CAS  Google Scholar 

  • Shadley JD, Wiencke JK (1989) Induction of adaptive response by X-rays is dependent on radiation intensity. Int J Radiat Bic)! 56: 107–118

    Article  CAS  Google Scholar 

  • Shadley JD, Wolff S (1987) Very low doses of X-rays can cause human lymphocytes to become less susceptible to ionizing radiation. Mutagenesis 2: 95–96

    Article  PubMed  CAS  Google Scholar 

  • Shadley JD, Afzal V, Wolff S (1987) Characterisation of the adaptive response to ionizing radiation induced by low doses of X-rays to human lymphocytes. Radiat Res 111: 511–517

    Article  PubMed  CAS  Google Scholar 

  • Sinha AK, Linscombe A, Gollapudi BB, Jersey GC, Flake RE, Park CN (1986) Cytogenetic variability of lymphocytes from phenotypically normal men: Influence of age, smoking, season and sampling storage. J Toxicol Environ Health 17: 327–345

    Article  PubMed  CAS  Google Scholar 

  • Steinhäusler F, Pohl E (1973) The concentration of Rn-222, Rn-220 and their daughters in the air, the dependence on meteorological variables and contribution to the radiation dose for the inhabitants of a radon spa. In: Proc Health Phys Problems Internal Contam, Akadémiai Kaidó, Budapest, pp 397–400

    Google Scholar 

  • Steinhäusler F, Hofmann W, Pohl E, Pohl-Ruling J (1980) Local and temporal distribution pattern of radon and daughters in an urban environment and determination of organ dose frequency distribution with demoscopical methods. Proc Symp Nat Radiat Environ III, Houston USA, CONF-780422-Vol 2, DOE Symp Ser 51: 1145–1151

    Google Scholar 

  • Steinhäusler F, Hofmann W, Daschil F, Reubel B (1988) Chernobyl and its radiological consequences for the Province of Salzburg, Austria. Environ Int, Spec Issue-Chernobyl Accident: Regional and Global Impact, 14: 2

    Google Scholar 

  • Stenstrand K (1985) Effects of ionizing radiation on chromosome aberrations, sister chromatid exchanges and micronuclei in lymphocytes of smokers and nonsmokers. Hereditas 102: 7176

    Google Scholar 

  • Stenstrand K, Annanmäki M, Rytömaa (1979a) Cytogenetic investigations of people in Finland using household water with high natural radioactivity. Health Phys 36: 441–443

    CAS  Google Scholar 

  • Stenstrand K, Toivonen H, Rytömaa T (1979b) Radiation induced chromosome aberrations in human lymphocytes: Dose–response relationship after irradiation in vitro with 200 kV X–rays and Co–60 gamma rays. Inst Radiat Protect, Helsinky, Rep STL–A29, ISBN 951–46–4042–X, ISSN 0355–7006. 1–14

    Google Scholar 

  • Stephan G, Oestreicher U (1989) An increased frequency of structural chromosome aberrations in persons present in the vicinity of Chernobyl during and after the reactor accident. Is this effect caused by radiation exposure? Mutat Res 223: 7–12

    Article  PubMed  CAS  Google Scholar 

  • Stokke T, Oftedal P, Pappas A (1968) Effects of small doses of radioactive strontium on the rat bone marrow. Acta Radiol, Radiol Soc Denmark, Finland, Norway, Sweden, 7: 321–329

    Article  CAS  Google Scholar 

  • Takahashi E, Hirai M, Tobari I, Nakai S (1979) Dose-response relations for dicentric yields in Go lymphocytes of man and crab-eating monkey following acute and chronic gamma-irradiation. Mutat Res 60: 357–365

    Article  PubMed  CAS  Google Scholar 

  • Takahashi E, Hirai M, Tobari I, Utsugi T, Nakay S (1982) Radiation induced chromosome aberrations in lymphocytes from man and crab-eating monkey. Mutat Res 94: 115–123

    Article  PubMed  CAS  Google Scholar 

  • Tonomura A, Kishi K, Saito F (1983) Types and frequencies of chromosome aberrations in peripheral lymphocytes of general populations. In: Ishihara T, Sasaki MS (eds) Radiation-induced chromosome damage in man. Alan R Liss, New York, NY 10011, pp 605–616

    Google Scholar 

  • Tuschl H, Altmann H, Kovac R, Topaloglou A, Egg D, Günther R (1980) Effects of low-dose radiation on repair processes in human lymphocytes. Radiat Res 81: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Tuschl H, Altmann H, Kovac R (1983) The effects of chronic low dose exposure on DNA repair processes and sister chromatid exchanges. In Proc Int Sym biol Effects Low-Level Radiat Spec Regard Stochastic Non-Stochastic Effects. Int Atomic Energy Agency, Vienna, pp 185–190

    Google Scholar 

  • United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) (1986) Genetic and somatic effects of ionizing radiation, pp 95–97

    Google Scholar 

  • Van Bekkum DW, Bentvelzen P (1982) The concept of gene transfer-misrepair mechanism of radiation carcinogenesis may challenge the risk estimation for low radiation doses. Health Phys 43: 231–237

    Article  PubMed  Google Scholar 

  • Vulpis N, Panetta G, Tognacci L (1976) Radiation induced chromosome aberrations in radiol- ogical protection. Dose response curves at low dose-levels. Int J Radiat Biol 29: 595–600

    Article  CAS  Google Scholar 

  • Wiencke JK (1987) Nicotinamide deficiency in human lymphocytes prevents the (3H)thymidineinduced adaptive response for the repair of X-ray-induced chromosomal damage. Exp Cell Res 171: 518–523

    Article  PubMed  CAS  Google Scholar 

  • Wiencke JK, Afzal V, Olivieri G, Wolff S (1986) Evidence that the tritium thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism. Mutagenesis 1: 375–380

    Article  PubMed  CAS  Google Scholar 

  • Wolff S, Afzal V, Wiencke JK, Olivieri G, Michaeli A (1988) Human lymphocytes exposed to low doses of ionizing radiation become refractoral to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA. Int J Radiat Biol 53: 39–48

    Article  CAS  Google Scholar 

  • Wolff S, Wiencke JK, Afzal V, Youngblom J, Córtes F (1990) The adaptive response of human lymphocytes to very low doses of ionizing radiation: A case of induced chromosomal repair with the induction of specific proteins. In: Low dose radiation: biological basis of risk assessment. Taylor Francis, London (in press)

    Google Scholar 

  • World Health Organization (WHO) (1986) Summary Rep No ICP/COR 129 (S) Rev 1. 5134 V

    Google Scholar 

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Pohl-Rüling, J. (1990). Chromosome Aberrations of Blood Lymphocytes Induced by Low-Level Doses of Ionizing Radiation. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75599-6_5

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