Management of Non-Hodgkin’s Lymphomas in Adults in Scandinavia, the United Kingdom and the Netherlands: Conclusions of the Fourth Intercity Meeting, 1988

  • Gunnar Juliusson
  • Arne F. Abrahamsen
  • Eva Cavallin-Ståhl
  • Anthony H. Goldstone
  • Andrew Lister
  • Nis I. Nissen
  • Karl-Hendrik Robèrt
  • Charles R. J. Singer
  • Reinier Somers
  • Åke Öst
  • Gösta Gahrton
Conference paper
Part of the ESO Intercity Report book series (ESO INTERCITY)


The fourth Intercity Meeting of the European School of Oncology on non-Hodgkin’s lymphoma, chaired by Professor Gösta Gahrton, was held at Huddinge Hospital on 3rd June, 1988. The purpose of the meeting was to present and challenge current treatment strategies in Scandinavia, the United Kingdom and the Netherlands. The discussion was based on the following papers: “Critical analysis of pretreatment staging in non-Hodgkin’s lymphoma” (Öst), “High-grade malignant non-Hodgkin’s lymphoma in Norway. Treatment and clinical aspects” (Abrahamsen), “EORTC studies in malignant lymphoma” (Somers), “Management of high-grade malignant non-Hodgkin’s lymphoma. Report from a Swedish multi-centre study” (Cavallin-Ståhl), “Biological tumour progression in low-grade malignant non-Hodgkin’s lymphoma” (Nissen), “Management of follicular lymphoma” (Lister), and “Bone marrow transplantation in non-Hodgkin’s lymphoma” (Goldstone).


Chronic Lymphocytic Leukemia Follicular Lymphoma Complete Remission Rate Bone Marrow Involvement Autologous Bone Marrow Transplantation 
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  1. 1.
    Horning SJ, Rosenberg SA: The natural history of initially untreated low-grade non-Hodgkin’s lymphomas. N Engl J Med 1984 (311):1471–1475PubMedCrossRefGoogle Scholar
  2. 2.
    Yunis JJ, Frizzera G, Oken MM, McKenna J, Theologides A, Arnesen M: Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N Engl J Med 1987 (316):79–84PubMedCrossRefGoogle Scholar
  3. 3.
    Gahrton G, Lindsten J, Zech L: Involvement of chromosomes 8, 9, 19 and 22 in Ph1 positive and Ph1 negative chronic myelocytic leukemia in the chronic and blastic stage. Acta Med Scand 1974 (196):355–360PubMedCrossRefGoogle Scholar
  4. 4.
    Rowley JD: Ph1 positive leukaemia including chronic myelogeneous leukaemia. Clin Haematol 1980 (9):55–86PubMedGoogle Scholar
  5. 5.
    Juliusson G, Friberg K, Gahrton G: Consistency of chromosomal aberrations in chronic lymphocytic leukemia. A longitudinal study of 41 patients. Cancer 1988 (62):500–506PubMedCrossRefGoogle Scholar
  6. 6.
    Bakhshi A, Jensen JP, Goldman P et al: Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985 (41):899–906PubMedCrossRefGoogle Scholar
  7. 7.
    Stansfeld AG, Diebold J, Kapanci Y, Kelényi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundström C, Van Unnik JAM, Wright DH: Updated Kiel classification for lymphomas. Lancet 1988 (i):292–293CrossRefGoogle Scholar
  8. 8.
    Somers R, Burgers JMV, Qasim M, van Glabbeke M, Duez N, Hayat M: EORTC trial non-Hodgkin’s lymphomas. Eur J Cancer Clin Oncol 1987 (23):283–293PubMedCrossRefGoogle Scholar
  9. 9.
    Filly RA, Blank N, Castellino RA: Radiographic distribution of intrathoracic disease in previously untreated patients with Hodgkin’s disease and non-Hodgkin’s lymphoma. Radiology 1976 (120):277PubMedGoogle Scholar
  10. 10.
    Reznek RH, Richards MA: The radiology of lymphoma. In: Bailliere’s Clinical Hematology 1987 (1):77–108CrossRefGoogle Scholar
  11. 11.
    Bartl R, Frisch B, Burkhardt R (eds) Bone Marrow Biopsies Revisited. S. Karger, Basle 1985Google Scholar
  12. 12.
    Lindemalm C, Mellstedt H, Nilsson B, Biberfeld P, Björkholm M, Christensson B, Holm G, Johansson B: Blood clonal B cell excess (CBE) at diagnosis in patients with non-Hodgkin’s lymphoma (NHL). Relation to clinical stage, histopathology and response to treatment. Eur J Cancer 1987 (23):749–753CrossRefGoogle Scholar
  13. 13.
    Goffinet DR, Warnke R, Dunnick NR et al: Clinical and surgical (laparotomy) evaluation of patients with non-Hodgkin’s lymphomas. Cancer Treat Rep 1977 (61):881–922Google Scholar
  14. 14.
    Lindgren PG, Hagberg H, Eriksson B, Glimelius B, Magnusson A, Sundström C: Excision biopsy of the spleen by ultrasonic guidance. Br J Radiol 1985 (58):653–657CrossRefGoogle Scholar
  15. 15.
    Lewin KJ, Rachod M, Dorfman RF: Lymphomas of the gastrointestinal tract — a study of 117 cases presenting with gastrointestinal disease. Cancer 1978(42):693–707PubMedCrossRefGoogle Scholar
  16. 16.
    Caletti GC, Lorenza Z, Bolondi L, Guizzardi G, Brocchi E, Barbara L: Impact of endoscopic ultrasonography on diagnosis and treatment of primary gastric lymphoma. Surgery 1988 (103):315–320PubMedGoogle Scholar
  17. 17.
    Hoerni-Simon G, Suchaud JP, Eghbali H, Coindre JM, Hoerni B: Secondary involvement of the central nervous sytem in malignant non-Hodgkin’s lymphoma. A study of 30 cases in a series of 498 patients. Oncology 1987 (44):98–101PubMedCrossRefGoogle Scholar
  18. 18.
    Parvinen LM, Jereb B, Nisce L: Primary non-Hodgkin’s lymphoma (‘reticulum cell sarcoma’) of bone in adults. Acta Radiol Oncol 1983 (22):449–454PubMedCrossRefGoogle Scholar
  19. 19.
    French Cooperative Group on CLL (chairman J-L Binet): A randomized comparison of no treatment versus daily chlorambucil in 612 patients with stage A CLL. (Abstract). 4th International Workshop on CLL, Paris 1988Google Scholar
  20. 20.
    Callagher CJ, Gregory WM, Jones AE et al: Follicular lymphoma: prognostic factors for response and survival. J Clin Oncol 1986 (4):1470–1480Google Scholar
  21. 21.
    Leavitt RD, Ratanatharathorn V, Ozer H et al: Alpha-2b-interferon in the treatment of Hodgkin’s disease and non-Hodgkin lymphoma. Semin Oncol 1987 (14 suppl 2):18–23PubMedGoogle Scholar
  22. 22.
    Young RC, Longo DL, Glatsein E, Matis LA, Ostchega Y, Nanfro J, DeVita VR Jr: Watchful waiting versus aggressive combined modality therapy in the treatment of stage III-IV indolent non-Hodgkin’s lymphoma. Proc Ann Meeting Am Soc Clin Oncol 1987 (6):A790Google Scholar
  23. 23.
    Knospe WH, Loeb V, Hugley CM: Biweekly chlorambucil treatment of chronic lymphocytic leukemia. Cancer 1974 (33):555–562PubMedCrossRefGoogle Scholar
  24. 24.
    McKelvey EM, Gottlieb JA, Wilson HE et al: Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 1976 (38):1484–1493PubMedCrossRefGoogle Scholar
  25. 25.
    Klimo P, Connors JM: MACOP-B chemotherapy for the treatment of diffuse large cell lymphomas. Ann Int Med 1985 (102):596–602PubMedGoogle Scholar
  26. 26.
    Singer CRJ, Goldstone AH: Clinical studies of ABMT in non-Hodgkin’s lymphoma. Clin Haematol 1986 (15):105–150PubMedGoogle Scholar
  27. 27.
    Bruce WB, Meeker BG, Valeriote FA: Comparison of the sensitivity of normal haemopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo. JNCI 1966(36):233–245Google Scholar
  28. 28.
    Frei III E, Canellos GP: Dose: a critical factor in cancer chemotherapy. Am J Med 1980 (69):585–594PubMedCrossRefGoogle Scholar
  29. 29.
    Coleman CN, Picozzi VJ, Cox RS et al: Treatment of lymphoblastic lymphoma in adults. J Clin Oncol 1986 (4):1628–1637PubMedGoogle Scholar
  30. 30.
    Goldstone AH, Gribben JG, Dones L: Fourth report of EBMT experience of autologous bone marrow transplantation in lymphoma. Bone Marrow Transpl 1987(2 Suppl 1):200–203Google Scholar
  31. 31.
    Goldsfone AH, Singer CRJ, Gribben JG, Jarrett M: Autologous bone marrow transplantation in lymphoma. Bone Marrow Transpl 1988 (in press)Google Scholar
  32. 32.
    Appelbaum FR, Sullivan KM, Buckner CD, Clift RA, Deeg HJ, Fefer A, Hill R, Mortimer J, Neiman PE, Sanders JE, Singer J, Stewart P, Storb R, Thomas ED: Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and marrow transplantation. J Clin Oncol 1987 (5):1340–1347PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Gunnar Juliusson
    • 1
  • Arne F. Abrahamsen
    • 4
  • Eva Cavallin-Ståhl
    • 3
  • Anthony H. Goldstone
    • 6
  • Andrew Lister
    • 7
  • Nis I. Nissen
    • 5
  • Karl-Hendrik Robèrt
    • 1
  • Charles R. J. Singer
    • 6
  • Reinier Somers
    • 8
  • Åke Öst
    • 2
  • Gösta Gahrton
    • 1
  1. 1.Division of Clinical Haematology and Oncology, Department of MedicineKarolinska Institute at Huddinge HospitalHuddingeSweden
  2. 2.Department of PathologyKarolinska HospitalStockholmSweden
  3. 3.Department of OncologyUniversity HospitalLundSweden
  4. 4.Department of Medical OncologyThe Norwegian Radium HospitalOsloNorway
  5. 5.Department of HaematologyThe Finsen InstituteCopenhagenDenmark
  6. 6.Department of HaematologyUniversity College HospitalLondonUK
  7. 7.Department of Medical OncologySt. Bartholomew’s HospitalLondonUK
  8. 8.Department of MedicineThe Netherlands Cancer InstituteAmsterdamThe Netherlands

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