Immunological Dysregulation of Lymph Nodes in AIDS Patients

  • G. R. F. Krueger
  • D. V. Ablashi
  • P. Lusso
  • S. F. Josephs
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 84/2)


Acquired immune deficiency syndrome (AIDS) is characterized by a progressive loss in T lymphocytes with CD4 phenotype. This cell represents one of the major components in the immune regulatory network controlling the function not only of the immune system itself but also of macrophages and of natural killer cells as well as the proliferation of hematopoietic stem cells and of fibroblasts. CD4 cell loss will result in rather complex and individually variable defects in host defense and cell proliferation. The consequence of such defects are recurrent infections by opportunists and other agents and uncontrolled cell proliferation in the immune system and in other cells with ultimate death from infections or neoplasia. Since the human immune deficiency virus HIV-1 (formerly HTLV-III, LAV-1) was detected in patients with AIDS and was identified to cause lytic infections in CD4 lymphocytes, this virus is regarded as the etiological agent of AIDS (Gallo et al. 1983, 1985; Barre-Sinoussi et al. 1983; Montagnier 1986). There are, however, a number of phenomena in AIDS which are not readily explained by HIV-1 infection alone (Duesberg 1987), so that a search for additional mechanisms contributing to the pathogenesis of the disease seems warranted (Purtilo et al. 1985 a; Krueger 1986 b). Even if HIV-1 should ultimately prove to be the sole etiopathogenic agent, lytic infection of CD4 cells alone can hardly explain the entire functional defect in this cell population. Critical analysis of all parameters of immune deficiency developing during the course of AIDS is thus indicated and may provide further clues as to the complex pathogenesis of the disease.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Acquire Immune Deficiency Syndrome Immune Deficiency Syndrome Postcapillary Venule 
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  1. Ablashi DV, Fladager A, Markham D, Salahuddin SZ (1987a) Isolation of transforming Epstein Barr virus from plasma of HTLVIII/LAV-infected patients. Intervirology 27: 25–31CrossRefGoogle Scholar
  2. Ablashi DV, Sturzenegger S, Hunter EA et al. (1987 b) Presence of HTLVIII in tears from the eyes of AIDS patients. J Exp Pathol 3:693–703Google Scholar
  3. Ablashi DV, Luka J, Buchbinder A et al. (1989) Interaction of HBLV (HHV-6) with EBV and HIV. In: Ablashi DV, Faggioni A, Krueger GRF, Pagano J, Pearson R (eds) Epstein-Barr virus and human disease 1988. Humana, Clifton NJ, pp 489–494CrossRefGoogle Scholar
  4. Ablashi V, Luca J, Salahuddin SZ et al. (1988) Interaction of HBLV (HHV-6) with EBV and HIV-1 (abstr). Ann Meeting Lab Tumor Cell Biol, Bethesda, Aug 22–27Google Scholar
  5. Ablin J, Gonder MJ (1985) Male accessory sexual gland’s secretion and their antithetical role in immune surveillance. pp 271–276. In: Peeters H (ed) Protides of the biological fluids, vol 32, Pergamon, OxfordGoogle Scholar
  6. Ablin J, Polgar J, Bartkus JM, Muszbek L (1987) Identification of transglutaminase in human prostate and seminal plasma. Fed Proc 46: 1495Google Scholar
  7. Ablin RJ, Bartkus JM, Gonder MJ (1986) Blood product immunosuppression and the acquired immunodeficiency syndrome. Ann Intern Med 104: 130PubMedGoogle Scholar
  8. Alavaikko M, Rinne A, Jarvinen M et al. (1986) Damage to secondary lymphoid follicles in AIDS-related persistent generalized lymphadenopathy, as revealed by the behaviour of dendritic reticulum cells possessing immunoreactive acid cysteine-proteinase inhibitor. Virchows Arch [B] 50: 299–311CrossRefGoogle Scholar
  9. Andiman WA, Katz BZ, Miller G (1986) Progressive Epstein-Barr virus infection. In: Notkins AL, Oldstone MBA (eds) Concepts in viral pathogenesis II, Springer, New York, pp 276–286Google Scholar
  10. Auffermann W, Krueger GRF, Boecking A (1985) DNA image cytometry in acquired immune deficiency syndrome (AIDS). Anal Quant Cytol Histol 8: 19–24Google Scholar
  11. Barre-Sinoussi F, Cherman C, Rey F et al. (1983) Isolation of a T lymphotrophic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220: 868–870PubMedCrossRefGoogle Scholar
  12. Baurmann H, Miclea J-M, Ferchal F et al. (1988) Adult T-cell leukemia associated with HTLV I and simultaneous infection by human immunodeficiency virus type 2 and human herpesvirus 6 in an African woman: a clinical, virologic, and familial serologic study. Am J Med 85: 853–896PubMedCrossRefGoogle Scholar
  13. Becker J, Ulrich P, Kunze R, Gelderblom H, Langford A, Reichart P (1988) Immunohistochemical detection of HIV structural proteins and distribution of T-lymphocytes and Langerhans cells in the oral mucosa of HIV infected patients. Virchows Arch [A] 412: 413–419CrossRefGoogle Scholar
  14. Berman A, Espinoza LR, Diaz JD, Aguilar JL, Rolando T, Vasey FB, Germain BF, Lockey RF (1988) Rheumatic manifestations of human immunodeficiency virus infection. Am J Med 85: 59–64PubMedCrossRefGoogle Scholar
  15. Biberfeld P, Porwit-Ksiazek A, Bottiger B, Morfeldt-Mansson L, Biberfeld G (1985) Immunohistopathology of lymph nodes in HTLVIII infected homosexuals with persistent adenopathy or AIDS. Cancer Res [Suppl] 45:4665s-4670sGoogle Scholar
  16. Biberfeld P, Chayt K, Marselle LM, Biberfeld G, Gallo RC, Harper ME (1986) HTLV III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy. Am J Pathol 125: 436–442PubMedGoogle Scholar
  17. Biberfeld P, Ost A, Porwit A et al. (1987) Histopathology and immunohistology of HTLV III/LAV related lymphadenopathy and AIDS. Acta Pathol Microbiol Scand [A] 95: 47–65Google Scholar
  18. Biberfeld P, Porwit A, Biberfeld G, Harper M, Bodner A, Gallo R (1988) Lymphadenopathy in HIV (HTLV III/LAV) infected subjects: the role of virus and follicular dendritic cells. Cancer Detect Prey 12: 217–224Google Scholar
  19. Blumberg S, Paradis TJ, Crawford D, Byington RE, Hirsch MS, Schooley RT (1987) Effects of human immunodeficiency virus (HIV) on the cytotoxic response to Epstein Barr virus (EBV) transformed B lymphocytes. AIDS Res Human Retrovir 3: 303–315CrossRefGoogle Scholar
  20. Borzy MS (1987) Interleukin 2 production and responsiveness in individuals with acquired immunodeficiency syndrome and the generalized lymphadenopathy syndrome. Cell Immunol 104: 142–153PubMedCrossRefGoogle Scholar
  21. Bost KL, Hahn BH, Aag MS et al. (1988) Individuals infected with HIV posses antibodies against IL-2. Immunology 65: 611–615PubMedGoogle Scholar
  22. Boyd AW, Fisher DC, Fox DA, Schlossman SF, Nadler LM (1985) Structural and functional characterization of IL2 receptors on activated human B cells. J Immunol 134: 2387–2392PubMedGoogle Scholar
  23. Boylston AW, Cook HT, Francis ND, Goldin RD (1987) Biopsy pathology of acquired immune deficiency syndrome (AIDS). J Clin Pathol 40: 1–8PubMedCrossRefGoogle Scholar
  24. Brasseur R, Cornet B, Burny M, Vandenbranden M, Ruysschaert JM (1988) Mode of insertion into a lipid membrane of the N-terminal HIV gp41 peptide segment. AIDS Res Human Retrovir 4: 83–90CrossRefGoogle Scholar
  25. Buchbinder A, Josephs SF, Ablashi DV et al. (1988) Polymerase chain reaction amplification and in situ hybridization for the detection of human B-lymphotropic virus. J Virol Methods 21: 191–197PubMedCrossRefGoogle Scholar
  26. Burkes RL, Abo W, Levine AM et al. (1987) Characterization of immunologic function in homosexual men with persistent, generalized lymphadenopathy and acquired immune deficiency syndrome. Cancer 59: 731–738PubMedCrossRefGoogle Scholar
  27. Cauda R, Ttimbarello M, Ortona L, Kanda P, Kennedy RC, Chan TC (1988) Inhibition of normal human natural killer cell activity by human immunodeficiency virus synthetic transmembrane peptides. Cell Immunol 115: 57–65PubMedCrossRefGoogle Scholar
  28. Centers for Disease Control (1987) Revision of the CDC surveillance case definition for acquired immune deficiency syndrome. CDC Mortal Morbid Wkly Rep 36: 1Google Scholar
  29. Chen-Mayer C, Seto B, Tateno M, Levy JA (1988) Biologic features of HIV-1 that correlate with virulence in the host. Science 240: 80–82CrossRefGoogle Scholar
  30. Clayton LK, Sieh M, Pious DA, Reinherz EL (1989) Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Nature 339: 548–551PubMedCrossRefGoogle Scholar
  31. Cunningham-Rundles S, Safai B, Metroka CE, Lange M (1986) Modulation of immune response in the acquired immunodeficiency disease syndrome. Leukocytes and host defense. Alan R. Liss, New York, pp 175–184Google Scholar
  32. Current Topics (1988) Brain and immune system cross-talk. ASM News 54: 350–351Google Scholar
  33. Dabrowski MP, Dabrowska-Bernstein BK (1989) Immunoregulatory role of the thymus, part I and II, CRC, Boca RatonGoogle Scholar
  34. Daefler S, Krueger GRF (1989a) Expression of proliferation and differentiation antigens in response to modulation of membrane fluidity in chronic lymphocytic leukemia lymphocytes. Anticancer Res 9: 501–506Google Scholar
  35. Daefler S, Krueger GRF (1989b) Lack of dynamic lipid changes after binding of interleukin 2 in chronic lymphatic leukemia lymphocytes indicates defective transmembrane signalling. Anticancer Res 9: 743–748Google Scholar
  36. Dalgleish AG, Beverley CL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS virus. Nature 312: 763–767PubMedCrossRefGoogle Scholar
  37. Dardenne M, Bach JF, Safai B (1983) Low serum thymic hormone levels in patients with acquired immunodeficieny syndrome. N Engl J Med 309: 48–49PubMedCrossRefGoogle Scholar
  38. Davis MG, Kenney SC, Markovitz J, Pagano JS, Huang ES (1987) Immediate-early gene region of human cytomegalovirus transactivates the promoter of human immunodeficiency virus. Proc Natl Acad Sci USA 84: 8642–8646PubMedCrossRefGoogle Scholar
  39. Deen KC, McDougal JS, Inacker R et al. (1988) A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature 331: 82–84PubMedCrossRefGoogle Scholar
  40. Dewhurst S, Sakai K, Bresser J, Stevenson M, Evinger-Hodges MJ, Volsky DJ (1987) Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV. J Virol 61: 3774–3782PubMedGoogle Scholar
  41. Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ (1988) Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. J Immunol 141: 3715–3717PubMedGoogle Scholar
  42. Dobs AS, Dempsey MA, Landenson PW, Polk BF (1988) Endocrine disorders in men infected with human immunodeficiency virus. Am J Med 84: 611–615PubMedCrossRefGoogle Scholar
  43. Drew WL, Mintz L, Miner RC, Sands M, Ketterer B (1981) Prevalence of cytomegalvirus infection in homosexual men. J Infect Dis 143: 188–192PubMedCrossRefGoogle Scholar
  44. Duesberg PH (1987) Retrovirus as carcinogens and pathogens: expectation and reality. Cancer Res 47: 1199–1220PubMedGoogle Scholar
  45. Dylewski J, Chou S, Merigan T (1985) Absence of detectable IgM antibody during cytomegalovirus disease in patients with AIDS. N Engl J Med 309: 493–495Google Scholar
  46. Edelman AS, Zolla-Pazner S (1989) AIDS: a syndrome of immune dysregulation, dysfunction, and deficiency. FASEB J 3: 22–30PubMedGoogle Scholar
  47. Elie R, Laroche AC, Arnoux E et al. (1983) Thymic dysplasia in acquired immunodeficiency syndrome. N Engl J Med 309: 841–842CrossRefGoogle Scholar
  48. Fauci A (1985) Immunologic abnormalities in the acquired immunodeficiency syndrome (AIDS). Clin Res 32: 491–499Google Scholar
  49. Fields AP, Bednarik DP, Hess A, May WS (1988) Human immunodeficiency virus induced phosphorylation of its cell surface receptor. Nature 333: 278–280PubMedCrossRefGoogle Scholar
  50. Fisher AG, Ensoli B, Looney D et al. (1988b) Biological diverse molecular variants within a single HIV-1 isolate. Nature 334: 444–447CrossRefGoogle Scholar
  51. Fisher RA, Bertonis JM, Meier W et al. (1988a) HIV infection is blocked in vitro by recombinant soluble CD4. Nature 331: 76–78CrossRefGoogle Scholar
  52. Folks TM, Kessler SW, Orenstein M et al. (1988) Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow. Science 242: 919–922PubMedCrossRefGoogle Scholar
  53. Fouchard M, Reveil B, Mbayo K, Lurhuma A, Sarin PS, Gallo RC, Zagury D (1986) Evidence of HTLVIII/LAV expression by primary cultures of cells. Int J Cancer 38: 657–659PubMedCrossRefGoogle Scholar
  54. Gallo RC, Wong-Staal F (1985) A human T-lymphotropic retrovirus (HTLVIII) as the cause of the acquired immunodeficiency syndrome. Ann Intern Med 103: 679–689PubMedGoogle Scholar
  55. Gallo RC, Larin PS, Gelman EP et al. (1983) Isolation of human T cell leukiemia virus in acquired immune deficiency syndrome (AIDS). Science 220: 865–867PubMedCrossRefGoogle Scholar
  56. Gartner S, Markovitz P, Markovitz DM, Kaplan MH, Gallo RC, Popivic M (1986) The role of mononuclear phagocytes in HTLVIII/LAV infection. Science 233: 215–219PubMedCrossRefGoogle Scholar
  57. Gelderblom H, Reupke H, Winkel T, Kunze R, Pauli G (1987) MHC-antigens: constituents of the envelope of human and simian immunodeficiency viruses. Z Naturforsch [Cl 42: 1328–1334Google Scholar
  58. Gelderblom HR, Ozel M, Hausmann EHS, Winkel T, Pauli G, Koch MA (1988) Fine structure of human immunodeficiency virus (HIV), immunolocalization of structural proteins and virus-cell relation. Micron Microscopica 19: 41–60CrossRefGoogle Scholar
  59. Gendelman HE, Phelps W, Feigenbaum L, Ostrove JM, Adachi A, Howley PM, Khoury G, Ginsberg HS, Martin MA (1986) Transactivation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. Proc Natl Acad Sci USA 83: 9759–9763PubMedCrossRefGoogle Scholar
  60. Gimble JM, Duh E, Ostrove JM, Gendelman HE, Max EE, Rabson AB (1988) Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kB/core enhancer sequency. J Virol 62: 4104–4112PubMedGoogle Scholar
  61. Gleichmann E, Gleichmann H (1976) Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in nonchimeric individuals. Z Krebsforsch 85: 91–109CrossRefGoogle Scholar
  62. Gleichmann E, Vohr H-W, Stringer C, Nuyens J, Gleichmann H (1989) Testing the sensitization of T cells to chemicals. From murine graft-versus-host (GVH) reactions to chemical-induced GVH-like immunological diseases. In: Kammuller ME, Bloksma N, Seinen W (eds) Autoimmunity and toxicology. Elsevier, Amsterdam, pp 363–390Google Scholar
  63. Goldstein J, Braverman M, Salafia C, Buckley P (1988) The phenotype of human placental macrophages and its variation with gestational age. Am J Pathol 133: 648–659PubMedGoogle Scholar
  64. Gordon LM, Jensen FC, Curtain CC, Mobley PW, Aloia RC (1988) Lipid compositions and fluidities of the human immunodeficiency virus (HIV) and related viruses. In: Lipid domains and relationship to membrane function. Alan R. Liss, New York, pp 255–294Google Scholar
  65. Goudsmit J, Ljunggren K, Smit L et al. (1988) Biological significance of the antibody response to HIV antigens expressed on the cell surface. Arch Virol 103: 189–206PubMedCrossRefGoogle Scholar
  66. Grant IH, Armstrong D (1986) Management of infectious complications in acquired immunodeficiency syndrome. Am J Med 81 [Suppl 1A]: 59–72PubMedCrossRefGoogle Scholar
  67. Griffith PD (1988) Chronic cytomegalovirus infection. J Virol Methods 21: 79–86CrossRefGoogle Scholar
  68. Guarda LA, Butler JJ, Mansell P, Hersh EM, Reuben J, Newell GR (1983) Lymphadenopathy in homosexual men. Morbid anatomy with clinical and immunological correlations. Am J Clin Pathol 79: 559–568PubMedGoogle Scholar
  69. Habu S, Fukui H, Shimamura K, Kasai M, Nagai Y, Okamura K, Tàmaoki N (1981) In vivo effects of anti-asialo GM1. 1. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice. J Immunol 127: 34–37PubMedGoogle Scholar
  70. Halbert SP, Kiefer DJ, Friedman-Kien E, Poiez B (1986) Antibody levels for cytomegalovirus, herpes simplex virus and rubella virus in patients with acquired immunodeficiency syndrome. J Clin Microbiol 23: 318–321PubMedGoogle Scholar
  71. Harada S, Yamamoto N, Hinuma Y (1987) Clonal analysis of functional differences among strains of human immunodeficiency virus (HIV). J Virol Methods 18: 291–304PubMedCrossRefGoogle Scholar
  72. Harouse JM, Kunsch C, Hartle HT, Laughlin MA, Hoxie JA, Wigdahl B, Gonzales-Scarano F (1989) CD4-independent infection of human neural cells by human immunodeficiency virus type 1. J Virology 63: 2527–2533PubMedGoogle Scholar
  73. Harper ME, Marselle LM, Gallo RC, Wong-Staal F (1986) Detection of lymphocytes expressing human T lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc Natl Acad Sci USA 83: 772–776PubMedCrossRefGoogle Scholar
  74. Harrer T, Messing K, Bienzle U, Meyer E, Giedl J, Kalden JR (1987) Verlaufsbeobachtungen bei HIV infizierten homosexuellen Männern mit Lymphadenopathiesyndrom. Klin Wochenschr 65: 864–872PubMedCrossRefGoogle Scholar
  75. Haseltine WA, Terwilliger EF, Rosen CA, Sodroski JG (1988) Structure and function of human pathogenic retrovirus. In: Gallo RC, Wong-Staal F (eds) Retrovirus biology: an emerging role im human diseases. Marcel Dekker, New YorkGoogle Scholar
  76. Hirsch MS (1988) Antiviral therapy for human immunodeficiency virus infections. In: Lopez C (ed) Immunobiology and pathogenesis of persistent virus infections. Am Soc Microbiol, Washington DC, pp 262–277Google Scholar
  77. Hirsch MS, Wormser GP, Schooley RT et al. (1985) Risk of nosocomial infections with human T lymphotropic virus III (HTLV III). N Engl J Med 312: 1–4PubMedCrossRefGoogle Scholar
  78. Ho DD, Rota TR, Hirsch MS (1986) Infection of monocyte/macrophages by human T lymphotropic virus type III. J Clin Invest 77: 1712–1715PubMedCrossRefGoogle Scholar
  79. Hockley DJ, Wood RD, Jacobs JP, Garrett AJ (1988) Electron microscopy of human immunodeficiency virus. J Gen Virol 69: 2455–2469PubMedCrossRefGoogle Scholar
  80. Horvat RT, Wood C, Balachandran N (1989) Transactivation of human immunodeficiency virus promoter by human herpesvirus 6. J Virol 63: 970–973PubMedGoogle Scholar
  81. Hussey RE, Richardson NE, Kowalski M et al. (1988) A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature 331: 78–81PubMedCrossRefGoogle Scholar
  82. Ioachim HL, Lerner CW, Tapper ML (1983) Lymphadenopathies in homosexual men: relationships with the acquired immune deficiency syndrome. JAMA 250: 1306–1309PubMedCrossRefGoogle Scholar
  83. James K (1984) Scientific correspondence. Nature 309: 117CrossRefGoogle Scholar
  84. Kanner SB, Parks ES, Scott GB, Parks WP (1987) Simultaneous infections with human T cell leukemia virus type 1 and the human immunodeficiency virus. J Infect Dis 155: 617–625PubMedCrossRefGoogle Scholar
  85. Kasai M, Iwamori M, Nagai Y, Okamura K, Tada T (1980) A glycolipid on the surface of mouse natural killer cells. Eur J Immunol 10: 175–180PubMedCrossRefGoogle Scholar
  86. Kenney S, Kamine J, Markovits D, Fenrick R, Pagano JS (1988) An Epstein-Barr virus immediate early gene product transactivates gene expression from the human immunodeficiency virus long terminal repeat. Proc Natl Acad Sci USA 85: 1652–1656PubMedCrossRefGoogle Scholar
  87. Knowles DM, Chamulak GA, Subar M et al. (1988) Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 108: 744–753PubMedGoogle Scholar
  88. Koenig S, Gendelman HE, Orenstein JM et al. (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233: 1089–1093PubMedCrossRefGoogle Scholar
  89. Kohn A (1979) Early interactions of viruses with cellular membranes. Adv Virus Res 24: 223–275PubMedCrossRefGoogle Scholar
  90. Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM (1988) Lymphocyte activation by HIV-1 envelope glycoprotein. Nature 335: 445–448PubMedCrossRefGoogle Scholar
  91. Koyanagi Y, O’Brien WA, Zhao JQ, Golde DW, Gasson JC, Chen ISY (1988) Cytokines alter production of HIV-1 from primary mononuclear phagocytes. Science 241: 1673–1675PubMedCrossRefGoogle Scholar
  92. Krueger GRF (1984) Pathologie des abwehrgeschwächten erwachsenen Patienten. Fortschr Antimikrob Antineoplast Chemother 3–6: 863–876Google Scholar
  93. Krueger GRF (1985a) Klinische Immunpathologie. Kohlhammer, StuttgartGoogle Scholar
  94. Krueger GRF (1985b) Pathology of Epstein-Barr virus (EBV)-associateddisease (the lymphatic system). In: Levine PH, Ablashi DV, Pearson GR, Kottaridis SD (eds) Epstein-Barr virus and associated diseases. Martinus Nijhoff, Boston, pp 106–130Google Scholar
  95. Krueger GRF (1985c) Pathologie and Immunpathologie des AIDS. In: Steigleder GK (ed) AIDS Bericht 1. Grosse, Berlin, pp 59–76Google Scholar
  96. Krueger GRF (1986a) Klinische Pathologie bei AIDS-Patienten und bei AIDS-Risikopersonen. AIDS Forschung (AIFO) 1:83–87, 139–147, 195–202Google Scholar
  97. Krueger GRF (1986b) Infectious cofactors in HIV (HTLVIII/LAV)-positive individuals and their implication for course and prognosis of acquired immune deficiency. AIDS Forschung (AIFO) 1: 652–660Google Scholar
  98. Krueger GRF, Ramon A (1988) Overview of immunopathology of chronic active herpesvirus infection. J Virol Methods 21: 11–18PubMedCrossRefGoogle Scholar
  99. Krueger GRF, Sander C (1989) What’s new in human herpesvirus 6? Clinical immunopathology of the HHV-6 infection. Pathol Res Pract 185: 915–929PubMedCrossRefGoogle Scholar
  100. Krueger GRF, Papadakis T, Michel R (1983) Spezielle pathologisch-anatomische Aspekte des AIDS, Acquired Immune deficiency Syndrome. Z Hautkr 59: 507–522Google Scholar
  101. Krueger GRF, Otten JK, Ortmann M et al. (1985) Immunopathology of AIDS (acquired immune deficiency syndrome). Observation in 75 patients with Pre-AIDS and AIDS. Pathol Res Pract 180: 463–480PubMedCrossRefGoogle Scholar
  102. Krueger GRF, Ostmeier HF, Ramon A, Koch B, Raftery B (1986) Immunpathologie der LAV/HTLV-III Infektion. In: Steigleder GK (ed) AIDS Bericht 2. Grosse, Berlin, pp 38–44Google Scholar
  103. Krueger GRF, Stolzenburg T, Muller C (1987 a) Cell membrane lipid fluidity and receptor expression in Moloney-and Friend virus-transformed cells. In Vivo 1:343–346Google Scholar
  104. Krueger GRF, Ostmeier H, Koch B et al. (1987b) Lymphatic tissue response to persistent active virus infections in immune deficiency. In: Levine PH, Ablashi DV, Nonoyama M, Pearson GR, Glaser R (eds) Epstein-Barr virus and human disease. Humana, Clifton NJ, pp 361–366CrossRefGoogle Scholar
  105. Krueger GRF, Koch B, Ramon A et al. (1988a) Antibody prevalence to HBLV (human herpesvirus-6, HHV-6) and suggestive pathogenicity in the general population and in patients with immune deficiency syndromes. J Virol Methods 21: 125–131CrossRefGoogle Scholar
  106. Krueger GRF, Ablashi DV, Salahuddin SZ, Josephs SF (1988 b) Diagnosis and differential diagnosis of progressive lymphoproliferation and malignant lymphoma in persistent active herpesvirus infection. J Virol Methods 21:255–264Google Scholar
  107. Krueger GRF, Manak M, Bourgeois N et al. (1989) Persistent active herpesvirus infection associated with atypical polyclonal lymphoproliferation (APL) and malignant lymphoma. Anticancer Res 9: 1457–1476PubMedGoogle Scholar
  108. Lähdevirta J, Maury CPJ, Teppo A-M, Repo H (1988) Elevated levels of circulating cachectin/ tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 85: 289–291PubMedCrossRefGoogle Scholar
  109. Lai PK, Takayama H, Nonoyama M (1988) Activation of Epstein-Barr virus by human immunodeficiency virus (abstr). Ann Meeting Lab Timor Cell Biol, Bethesda, Aug 22–27Google Scholar
  110. Lane HC, Depper JM, Greene WC, Whalen G, Waldmann TA, Fauci AS (1985) Qualitative analysis of immune functions in patients with acquired immune deficiency syndrome. N Engl J Med 313: 79–84PubMedCrossRefGoogle Scholar
  111. Lennert K, Schwarze E-W, Krueger GRF (1981) Lymphknotenveränderungen durch Virusinfektion. Verh Dtsch Ges Pathol 65: 151–171PubMedGoogle Scholar
  112. Levine PH (1988) Human T lymphotropic virus type I (HTLV-1) and adult T cell lymphoma/leukemia (ATLL) in Panama (abstr). Annu Meeting Lab Tìrmor Cell Biol, Bethesda Aug 22–27Google Scholar
  113. Levine PH, Jaffe ES, Manns A et al. (1988) Human T cell lymphotropic virus type I and adult T cell leukemia/lymphoma outside Japan and the Caribbean basin. Yale J Biol Med 61: 215–222PubMedGoogle Scholar
  114. Lifson AR, Rutherford GW, Jaffe HW (1988) The natural history of human immunodeficiency virus infection. J Infect Dis 158: 1360–1367PubMedCrossRefGoogle Scholar
  115. Linette GP, Hartzman RJ, Ledbetter JA, June CH (1988) HIV-infected T cells show a selective signalling defect after perturbation of CD3/antigen receptor. Science 241: 573–576PubMedCrossRefGoogle Scholar
  116. Lucey DR, Dorsky DI, Nicholson-Weller A, Weller PF (1989) Human eosinophils express CD4 protein and bind human immunodeficiency virus gp120. J Exp Med 169: 327–332PubMedCrossRefGoogle Scholar
  117. Lusso P, Markham PD, Tschachler E et al. (1988) In vitro cellular tropism of human B-lym-photropic virus (human herpesvirus-6). J Exp Med 167: 1659–1670PubMedCrossRefGoogle Scholar
  118. Lusso P, Ensoli B, Markham PD et al. (1989) Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 337: 370–373PubMedCrossRefGoogle Scholar
  119. Lyerly HK, Cohen OJ, Weinhold KJ (1987) Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3’-azido-3’-deoxythymidine. AIDS Res Human Retrovir 3: 87–94CrossRefGoogle Scholar
  120. Lynn WS, Tweedale A, Cloyd MW (1988) Human immunodeficiency virus (HIV-1) cytotoxicity: perturbation of the cell membrane and depression of phospholipid synthesis. Virology 163: 43–51PubMedCrossRefGoogle Scholar
  121. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333–348PubMedCrossRefGoogle Scholar
  122. Madea B, Roewert H-J, Krueger GRF, Ablashi DV, Josephs SF (1990) Search for early lesions following HIV-1 infection. A study of six individuals who died a violent death after seroconversion. Arch Pathol Lab Med 114: 379–382PubMedGoogle Scholar
  123. Malkovsky M, Philpott K, Dalgleish AG et al. (1988) Infection of B lymphocytes by the human immunodeficiency virus and their susceptibility to cytotoxic cells. Eur J Immunol 18: 1315–1321PubMedCrossRefGoogle Scholar
  124. Margolick JB, Volkman DJ, Folks TM, Fauci AS (1987) Amplification of HTLV III/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic response. J Immunol 138: 1719–1723PubMedGoogle Scholar
  125. Mathur S, Goust JM, Williamson HO, Fudenberg HH (1981) Cross-reactivity of sperm and T lymphocyte antigens. Am J Reprod Immunol 1: 113–118PubMedGoogle Scholar
  126. McDougal S, Mawle A, Cort P et al. (1985) Cellular tropism of the human retrovirus HTLV III/LAV. I. Role of T cell activation and expression of the T4 antigen. J Immunol 135: 3151–3162PubMedGoogle Scholar
  127. McHugh TM, Stites DP, Busch MP, Krowka JF, Stricker RB, Hollander H (1988) Relation of circulating levels of human immunodeficiency virus (HIV) antigen, antibody to p24, and HIV-containing immune complexes in HIV-infected patients. J Infect Dis 158: 1088–1091PubMedCrossRefGoogle Scholar
  128. Molgaard CA, Nakamura C, Hovell M, Elder JP (1988) Assessing alcoholism as a risk factor for acquired immunodeficiency syndrome (AIDS). Soc Sci Med 27: 1147–1152PubMedCrossRefGoogle Scholar
  129. Monroe JE, Calender A, Mulder C (1988) Epstein-Barr virus-positive and -negative B-cell lines can be infected with human immunodeficiency virus types 1 and 2. J Virol 62: 497–500Google Scholar
  130. Montagnier L (1986) Lymphadenopathy associated virus: its role in the pathogenesis of AIDS and related diseases. Prog Allergy 37: 46–64PubMedGoogle Scholar
  131. Montagnier L, Gruest J, Chamaret S et al. (1984) Adaptation of lymphadenopathy-associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines. Science 225: 63–65PubMedCrossRefGoogle Scholar
  132. Morrow WJW, Wharton M, Stricker RB, Levy JA (1986) Circulating immune complexes in patients with acquired immune deficiency syndrome contain the AIDS-associated retrovirus. Clin Immunol Immunopathol 40: 515–524PubMedCrossRefGoogle Scholar
  133. Mueller H, Falk S, Stutte HJ (1986) Proliferation akzessorischer Zellen bei LAS and AIDS. Dtsch Med Wochenschr 111: 278Google Scholar
  134. Murray HW, Godbold JH, Jurica KB, Roberts RB (1989) Progression to AIDS in patients with lymphadenopathy or AIDS-related complex: reappraisal of risk and predictive factors. Am J Med 86: 533–546PubMedCrossRefGoogle Scholar
  135. Murray JL, Reuben JM, Munn CG, Mansell PWA, Newell GR, Hersh EM (1984) Decreased 5’nucleotidase activity in lymphocytes from asymptomatic sexually active homosexual men and patients with the acquired immune deficiency syndrome. Blood 64: 1016–1021PubMedGoogle Scholar
  136. Nguyen TD (1988) Peptide T from human immunodeficiency virus envelope does not interact with hepatic, intestinal and colonic vasoactive intestinal peptide (VIP) receptors. Peptides 9: 425–428PubMedCrossRefGoogle Scholar
  137. O’Murchadha MT, Wolf BC, Neiman RS (1987). The histologic features of hyperplastic lymphadenopathy in AIDS-related complex are nonspecific. Am J Surg Pathol 11: 94–99PubMedCrossRefGoogle Scholar
  138. Orenstein JM, Meltzer MS, Phipps T, Gendelman HE (1988) Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-l-treated human monocytes: an ultrastructural study. J Virol 62: 2578–2586PubMedGoogle Scholar
  139. Ostrove M, Leonard J, Weck KE, Rabson L, Gendelman HE (1987) Activation of the human immunodeficiency virus by herpes simplex virus type 1. J Virol 61: 3726–3732PubMedGoogle Scholar
  140. Ou C-Y, Kwok S, Mitchell SW et al. (1988) DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science 239: 295–297PubMedCrossRefGoogle Scholar
  141. Pagano JS, Kenney S, Markovitz D, Kamine J (1988) Epstein-Barr virus and interactions with human retrovirus. J Virol Methods 21: 229–239PubMedCrossRefGoogle Scholar
  142. Pahwa S, Pahwa R, Saxinger C, Gallo RC, Good RA (1985) Influence of the human T lymphotropic virus/lymphadenopathy associated virus on function of human lymphocytes: evidence for immunosuppressive effects and polyclonal B lymphocyte activation by banded viral preparation. Proc Natl Acad Sci USA 82: 8198–8202PubMedCrossRefGoogle Scholar
  143. Pallesen G, Gerstoft J, Mathiesen L (1987) Stages in LAV/HTLV III lymphadenitis. I. Histological and immunohistological classification. Scand J Immunol 25: 83–91.PubMedCrossRefGoogle Scholar
  144. Pauza CD (1988) HIV persistence in monocytes leads to pathogenesis and AIDS. Cell Immunol 112: 414–424PubMedCrossRefGoogle Scholar
  145. Pearson GR (1988) Recommended procedures for the diagnosis of persistent active herpesvirus infections. J Virol Methods 21: 291–300PubMedCrossRefGoogle Scholar
  146. Pizzo PA, Eddy J, Faloon J (1988) Acquired immune deficiency syndrome in children. Am J Med 85 [Suppl 2A]: 195–202PubMedGoogle Scholar
  147. Purtilo DT, Lipscomb H, Krueger GRF, Sonnabend J, Casareale D, Volsky DJ (1985 a) Role of Epstein-Barr virus in acquired immune deficiency syndrome. Adv Exp Med Biol 187:53–65Google Scholar
  148. Purtilo DT, Tatsumi E, Manolov G, Manolova Y, Harada S, Lipscomb H, Krueger GRF (1985b) Epstein-Barr virus as an etiological agent in the pathogenesis of lymphoproliferative and aproliferative diseases in immune deficient patients. Int Rev Exp Pathol 27: 113–183Google Scholar
  149. Purtilo DT, Linder J, Volsky DJ (1986) Acquired immune deficiency syndrome (AIDS). Clin Lab Med 6: 3–26PubMedGoogle Scholar
  150. Quinnan GV, Masur H, Rook AH et al. (1984) Herpesvirus infection in the acquired immunodeficiency syndrome. JAMA 252: 72–77PubMedCrossRefGoogle Scholar
  151. Racz P, Tenner-Racz K, Kahl C, Feller AC, Kern P, Dietrich M (1986) Spectrum of morphologic changes of lymph nodes from patients with AIDS or AIDS-related complexes. Prog Allergy 37: 81–181PubMedGoogle Scholar
  152. Racz P, Tenner-Racz K, Schmidt H, Gartner S, Louie A, Popovic M (1988) Spread of HIV-1 through lymphatics (abstr). Annu Meeting Lab Tumor Cell Biol, Bethesda, Aug 22–27Google Scholar
  153. Rappersberger K, Gartner S, Schenk P et al. (1988) Langerhans’ cells are an actual site of HIV-1 replication. Intervirology 29: 185–194PubMedGoogle Scholar
  154. Ratner L (1989) Human immunodeficiency virus-associated autoimmune thrombocytopenic purpura: a review. Am J Med 86: 194–198PubMedCrossRefGoogle Scholar
  155. Redfield RR, Wright DC, Tramont EC (1986) The Walter Reed staging classification for HTLV I/LAV infection. N Engl J Med 314: 131–132PubMedCrossRefGoogle Scholar
  156. Reiher III WE, Blalock E, Brunck TK (1986) Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2. Proc Natl Acad Sci USA 83: 9188–9192PubMedCrossRefGoogle Scholar
  157. Richman DD, McCutchan JA, Spector SA (1987) Detecting human immunodeficiency virus RNA in peripheral blood mononuclear cells by nucleic acid hybridization J Infect Dis 156: 823–827Google Scholar
  158. Rinaldo CR, Kingsley A, Lyter DW et al. (1986) Association of HTLV-III with Epstein-Barr virus infection and abnormalities of T lymphocytes in homosexual men. J Infect Dis 154: 556–561PubMedCrossRefGoogle Scholar
  159. Rubinstein A (1986) Pediatric AIDS. Curr Probl Pediatr 16: 361–409Google Scholar
  160. Rynes RI, Goldenberg DL, Digiacomo R, Olson R, Hussain M, Veazey J (1988) Acquired immunodeficiency syndrome-associated arthritis. Am J Med 84: 810–816PubMedCrossRefGoogle Scholar
  161. Saag MS, Hahn BH, Gibbons J, Li Y, Parks ES, Parks WP, Shaw GM (1988) Extensive variation of human immunodeficiency virus type-1 in vivo. Nature 334: 440–444PubMedCrossRefGoogle Scholar
  162. Sakai K, Dewhurst S, Ma X, Volsky DJ (1988) Differences in cytopathogenicity and host cell range among infectious molecular clones of human immunodeficiency virus type 1 simultaneously isolated from an individual. J Virol 62: 4078–4085PubMedGoogle Scholar
  163. Salahuddin SZ, Rose RM, Groopman JE, Markham PD, Gallo RC (1986) Human T lymphotropic virus type III infection of human alveolar macrophages. Blood 68: 281–284PubMedGoogle Scholar
  164. Salmon P, Olivier R, Riviere Y et al. (1988) Loss of CD4 membrane expression and CD4 mRNA during acute human immunodeficiency virus replication. J Exp Med 168: 1953–1969PubMedCrossRefGoogle Scholar
  165. Sarin PS, Gallo RC, Scheer DI, Crews F, Lippa AS (1985) Effects of a novel compound (AL 721) on HTLV-III infectivity in vivo. N Engl J Med 343: 1289–1290Google Scholar
  166. Savino W, Dardenne M, Marche C et al. (1986) Thymic epithelium in AIDS. Am J Pathol 122: 302–307PubMedGoogle Scholar
  167. Schnittman SM, Lane HC, Roth J et al. (1988) Characterization of gp120 binding to CD4 and an assay that measures ability of sera to inhibit this binding. J Immunol 141: 4181–4186PubMedGoogle Scholar
  168. Schonnebeck M, Krueger GRF, Braun M (1991) Cell membrane rigidification and receptor expression in HHV-6 infected prethymic T cells. In Vivo (in print)Google Scholar
  169. Schuurman H-J, Kluin PM, Meijling FHJG, VanUnnik JAM, Kater L (1985) Lymphocyte status of lymph node and blood in acquired immunodeficiency syndrome (AIDS) and AIDS-related complex disease. J Pathol 147: 269–280PubMedCrossRefGoogle Scholar
  170. Seemayer TA, Laroche AC, Russo P et al. (1984) Precocious thymic involution manifest by epithelial injury in acquired immunodeficiency syndrome. Hum Pathol 15: 469–475PubMedCrossRefGoogle Scholar
  171. Serke M, Huhn D, Dienemann D, Eichenlaub D, Sterke St, Stein H (1988) HIV-related malignantlymphomas. Klin Wochenschr 66: 682–685PubMedCrossRefGoogle Scholar
  172. Seto E, Yen TS, Peterlin BM, Ou JH (1988) Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci USA 85: 8286–8290PubMedCrossRefGoogle Scholar
  173. Seyda M, Krueger GRF (1987) Complex infectious copathogenesis of AIDS in HIV-positive individuals. Clin Immunol Newsletter 8: 81–86CrossRefGoogle Scholar
  174. Shaw GM, Harper ME, Hahn BH et al. (1985) HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science 227: 177–181PubMedCrossRefGoogle Scholar
  175. Shearer G, Moser M (1986) AIDS as a consequence of la antigen recognition: a closer look. Immunol Today 7: 34–36CrossRefGoogle Scholar
  176. Shearer GM, Singer A, Mizuochi T, Buller M, Hugin A, Morse III HC (1988) Importance of CD8+ T helper cell function in AIDS. J Infect Dis 158: 893PubMedCrossRefGoogle Scholar
  177. Sinangil F, Loyter A, Volsky DJ (1988) Quantitative measurement of fusion between human immunodeficiency virus and cultured cells using membrane fluorescence dequenching. FEBS Lett 239: 88–92PubMedCrossRefGoogle Scholar
  178. Solomon GF (1981) Emotional and personality factors in the onset and the course of autoimmune disease, particularly rheumatoid arthritis. In: Ader R, Psychoneuroimmunology, Academic Press, NY, pp 159–179Google Scholar
  179. Solomon GF, Levine S, Kraft JK (1968) Early experience and immunity. Nature 220: 821–822PubMedCrossRefGoogle Scholar
  180. Somasundaran M, Robinson HL (1987) A major mechanism of human immunodeficiency virus-induced cell killing does not involve cell fusion. J Virol 61: 3114–3119PubMedGoogle Scholar
  181. Sonnabend J, Witkin S, Purtilo DT (1983) Acquired immunodeficiency syndrome, opportunistic infections and malignancies in male homosexuals. A hypothesis of etiologic factors in pathogenesis. JAMA 249: 2370–2374PubMedCrossRefGoogle Scholar
  182. Stevenson M, Chang X, Volsky DJ (1987) Downregulation of cell surface molecules during non- cytopathic infection of T cells with human immunodeficiency virus. J Virol 61: 3741–3748PubMedGoogle Scholar
  183. Straus SE (1988) Chronic Epstein-Barr virus infection: a critical assessment. In: Lopez C (ed) Immunobiology and pathogenesis of persistent virus infections. Am Soc Microbiol, Washington DC, pp 281–293Google Scholar
  184. Sumaya CV, Boswell RN, Ench Y, Kisner DL, Hersh EM, Reuben JM, Mansell PWA (1986) Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex. J Infect DIS 154: 864–870PubMedCrossRefGoogle Scholar
  185. Takahashi K, Sonoda S, Higashi K, Kondo T, Takahashi H, Takahashi M, Yamanishi K (1989) Predominent CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J Virol 63: 3161–3163PubMedGoogle Scholar
  186. Takeda A, Tuazon CU, Ennis FA (1988) Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science 242: 580–583PubMedCrossRefGoogle Scholar
  187. Tenner-Racz K, Racz P, Bofill M et al. (1986) HTLV III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am J Pathol 123: 1–9Google Scholar
  188. Tersmette M, Gruters RA, DeWolf F et al. (1989) Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J Virol 63: 2118–2125PubMedGoogle Scholar
  189. Traunecker A, Luke W, Karjalainen K (1988) Soluble CD4 molecules neutralize human immunodeficiency virus type 1. Nature 331: 84–86PubMedCrossRefGoogle Scholar
  190. Tschachler E, Groh V, Popvic M et al. (1987) Epidermal Langerhans cells — a target for HTLV III/LAV infection. J Invest Dermatol 88: 233–237PubMedCrossRefGoogle Scholar
  191. Tschachler E, Robert-Guroff M, Gallo RC, Reitz MS Jr (1989) Human T-lymphotropic virus 1-infected T cells constitutively express lymphotoxin in vitro. Blood 73: 194–201PubMedGoogle Scholar
  192. Vidal C, Matsushita S, Colamonici OR, Trepel JB, Mitsuya H, Neckers LM (1988) Human T lym-photropic virus 1 infection deregulates surface expression of the transferrin receptor. J Immunol 141: 984–988PubMedGoogle Scholar
  193. Watanabe M, Reimann KA, DeLong PA et al. (1989) Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques. Nature 337: 267–270PubMedCrossRefGoogle Scholar
  194. Webster A, Lee CA, Cook DG, Grundy JE, Emery VC, Kernoff PBA, Griffith PD (1989) Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet II: 63–66Google Scholar
  195. Weiss RA (1988) Receptor molecule blocks HIV. Nature 331: 15PubMedCrossRefGoogle Scholar
  196. Wigzell H, Asjö B, Fenyö EM et al. (1988) Monocytes and human immunodeficiency virus. In: Lopez C (ed) Immunobiology and pathogenesis of persistent virus infections. Am Soc Microbiol, Washington DC, pp 223–233Google Scholar
  197. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 83: 7089–7093PubMedCrossRefGoogle Scholar
  198. Williamson JD (1984) Semen polyamines in AIDS pathogenesis. Nature 310: 103PubMedCrossRefGoogle Scholar
  199. Wood GS, Garcia CF, Dorfman RF, Warnke RA (1985) The immunohistology of follicle lysis in lymph node biopsies from human homosexual men. Blood 66: 1092–1097PubMedGoogle Scholar
  200. Young JAT (1988) HIV and LA similarity. Nature 333: 215PubMedCrossRefGoogle Scholar
  201. Ziegler JL, Miner R, Rosenbaum E et al. (1982) Outbreak of Burkitt’s-like lymphoma in homosexual men. Lancet II: 631–633Google Scholar
  202. Ziegler JL; Beckstead JA, Volberding PA et al. (1984) Non-hodgkin lymphoma in 90 homosexual men. Relation to generalized lymphadenopathy and acquired immunodeficiency syndrome. N Engl J Med 310: 565–570CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • G. R. F. Krueger
  • D. V. Ablashi
  • P. Lusso
  • S. F. Josephs

There are no affiliations available

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