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Macrophages/Reticulum Cells in Early and Late Phases of Lymphogenous Metastasis

  • E. Vollmer
  • F. Shimamoto
  • V. Krieg
  • E. Grundmann
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 84/2)

Abstract

In recent years, increasing interest has focused on the role of macrophages/reticulum cells in the local immune defense against malignant tumors. Within the peritumoral field, these cells are supposed to bear the main functional burden, together with lymphocytes (for reviews see Macher and Sorg 1986; Roitt et al. 1985). At present information is still scarce about their functional role in the lymph nodes during lymphogenous metastasis (Fossum and Ford 1985; Meyer 1982; Syrjänen 1982). Besides their well-known phagocytic properties, cytotoxic, cytostatic, and cytolytic capacities may be involved. In addition, there are interactions between macrophages/reticulum cells and both T and B lymphocytes during immune defense, and so macrophages/reticulum cells may be regarded as accessory cells in the induction of the tumor-associated immune response.

Keywords

Gastric Carcinoma Mononuclear Phagocyte System Subcapsular Sinus Neck Dissection Specimen Interdigitating Reticulum Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • E. Vollmer
  • F. Shimamoto
  • V. Krieg
  • E. Grundmann

There are no affiliations available

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