Patterns of Fibronectin Induction in Lymph Nodes Affected by Metastatic Growth of Adenocarcinomas

  • N. Beck
  • D. Lorke
  • P. Möller
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 84/2)


The extracellular matrix contains a number of adhesive glycoproteins designated entactin, fibronectin, laminin, tenascin, and vitronectin. The molecule best characterized is fibronectin, a family of closely related fibril-forming glycoproteins with molecular weights of 440–550 kDa secreted by many cells such as fibroblasts. At least three forms of fibronectin are produced from a single gene by alternative RNA splicing: the complete molecule and two derivates lacking 95 and 120 amino acids, respectively (Tamkun et al. 1984). Moreover, three functional forms of fibronectin have been described: (a) a soluble dimeric (plasma) fibronectin, (b) oligomers of fibronectin transiently attached to the cell surface (cell surface fibronectin), and (c) highly insoluble polymeric matrix fibronectin. In cell surface and matrix aggregates, fibronectin dimers are cross-linked by disulfide bonds (for review see Ruoslathi 1988).


Plasma Fibronectin Tissue Polypeptide Antigen Reticulin Fiber Fibronectin Receptor Cell BioI 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • N. Beck
  • D. Lorke
  • P. Möller

There are no affiliations available

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