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Patterns of Fibronectin Induction in Lymph Nodes Affected by Metastatic Growth of Adenocarcinomas

  • N. Beck
  • D. Lorke
  • P. Möller
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 84/2)

Abstract

The extracellular matrix contains a number of adhesive glycoproteins designated entactin, fibronectin, laminin, tenascin, and vitronectin. The molecule best characterized is fibronectin, a family of closely related fibril-forming glycoproteins with molecular weights of 440–550 kDa secreted by many cells such as fibroblasts. At least three forms of fibronectin are produced from a single gene by alternative RNA splicing: the complete molecule and two derivates lacking 95 and 120 amino acids, respectively (Tamkun et al. 1984). Moreover, three functional forms of fibronectin have been described: (a) a soluble dimeric (plasma) fibronectin, (b) oligomers of fibronectin transiently attached to the cell surface (cell surface fibronectin), and (c) highly insoluble polymeric matrix fibronectin. In cell surface and matrix aggregates, fibronectin dimers are cross-linked by disulfide bonds (for review see Ruoslathi 1988).

Keywords

Plasma Fibronectin Tissue Polypeptide Antigen Reticulin Fiber Fibronectin Receptor Cell BioI 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams JC, Watt FM (1989) Fibronectin inhibits the terminal differentiation of human keratocytes. Nature 340: 307–309PubMedCrossRefGoogle Scholar
  2. Akiyama SK, Yamada SS, Chen WT, Yamada KM (1989) Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly and cytoskeletal organization. J Cell Biol 109: 863–875PubMedCrossRefGoogle Scholar
  3. Ali IU, Hynes RO (1978) Effects of LETS glycoprotein on cell mobility. Cell 14: 429–446CrossRefGoogle Scholar
  4. Argraves WS, Suzuki S, Hiroharu A, Thompson K, Pirschbacher MD, Ruoslathi E (1987) Amino acid sequence of the human fibronectin receptor. J Cell Biol 105: 1183–1190PubMedCrossRefGoogle Scholar
  5. Asch BB, Kama BB, Burstein NA (1981) Interactions of normal, dysplastic, and malignant mammary epithelial cells with fibronectin in vivo and in vitro. Cancer Res 41: 2115–2125PubMedGoogle Scholar
  6. Chen LB, Gallimore PH, McDougall JK (1976) Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. Proc Natl Acad Sci USA 73: 3570–3574PubMedCrossRefGoogle Scholar
  7. Clark RAF, Quinn JH, Winn HJ, Lanigan JM, Dellapelle P, Colvin RV (1982) Fibronectin is produced by blood vessels in response to injury. J Exp Med 156: 646–651PubMedCrossRefGoogle Scholar
  8. Couchman JR, Rees DA, Green MR, Smith CA (1982) Fibronectin has a dual role in locomotion and anchorage of primary chick fibroblasts and can promote entry in the division cycle. J Cell Biol 93: 402–410PubMedCrossRefGoogle Scholar
  9. Degener T, Momburg F, Möller P (1988) Differential expression of HLA-DR, HLA-DP, HLA-DQ and associated invariant chain (Ii) in normal colorectal mucosa, adenoma and carcinoma. Virchows Arch [A] 412: 315–322CrossRefGoogle Scholar
  10. Der JC, Stanbridge E (1978) Lack of correlation between the decreased expression of cell surface LETS protein and tumorigenicity in human cell hybrids. Cell 15: 1241–1251PubMedCrossRefGoogle Scholar
  11. Duband J-L, Nuckolls GH, Ishihara A, Hasegawa T, Yamada KM, Thiery JP, Jacobson K (1988) Fibronectin receptor exhibits high lateral mobility on embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cells. J Cell Biol 107: 1385–1396PubMedCrossRefGoogle Scholar
  12. Gallimore PH, McDougall JK, Chen LB (1979) Malignant behaviour of three adenovirus 2-transformed brain cell lines and their methylcellulose selected subclones. Int J Cancer 24: 477–484PubMedCrossRefGoogle Scholar
  13. Grinell F, Feld M, Minter D (1980) Fibroblast adhesion to fibrinogen and fibrin substrata: requirement of cold-insoluble globulin (plasma fibronectin). Cell 19: 517–525CrossRefGoogle Scholar
  14. Grinell F, Billingham RE, Burgess L (1981) Distribution of fibronectin during wound healing in vivo. J Invest Dermatol 76: 181–189CrossRefGoogle Scholar
  15. Hynes RO (1987) Integrins: a family of cell surface receptors. Cell 48: 549–554PubMedCrossRefGoogle Scholar
  16. Jones PA, Laug WE, Gardner A, Nye CA, Fink LM, Benedict WF (1976) In vitro correlates of transformation in C3H/10t-1/2 clone 8 mouse cells. Cancer Res 36: 2863–2867PubMedGoogle Scholar
  17. Khan P, Shin SI (1979) Cellular tumorigenicity in nude mice: test of association among loss of cell surface fibronectin, anchorage independence and tumor forming ability. J Cell Biol 82: 1–16CrossRefGoogle Scholar
  18. Klebe JR (1974) Isolation of a collagen-dependent cell attachment factor. Nature 250: 248–251PubMedCrossRefGoogle Scholar
  19. Kubo M, Norris DA, Howell SE, Ryan SR, Clark RAF (1984) Human keratinocytes synthesize, secrete, and deposit fibronectin in the pericellular matrix. J Invest Dermatol 82, 6: 580–586PubMedCrossRefGoogle Scholar
  20. Lacovara J, Cramer EB, Quigley JP (1984) Fibronectin enhancement of directed migration of B 16 melanoma cells. Cancer Res 44: 1657–1663PubMedGoogle Scholar
  21. Möller P, Feichter GE, Fritze D, Haag D, Schule B (1982) J-chain-producing immunoblastic lymphoma in a case of Richter’s syndrome. Virchows Arch [A] 396: 213–224CrossRefGoogle Scholar
  22. Möller P, Achtstätter H, Butzengeiger N, Schule B (1983) The distribution of fibronectin in lymph nodes infiltrates by Hodgkin’s disease. Virchows Arch [A] 400: 319–329CrossRefGoogle Scholar
  23. Moll R (1987) Epithelial tumor markers: cytokeratins and tissue polypeptide antigen (TPA). In: Seifert G (ed) Morphological tumor markers. Springer, Berlin Heidelberg New York, pp 71–101CrossRefGoogle Scholar
  24. Neri A, Nicolson GL (1981) Phenotypic drift of metastatic and cell surface properties of mammary adenocarcinoma cell clones during growth in vitro. Int J Cancer 28: 731–738PubMedCrossRefGoogle Scholar
  25. Neri A, Ruoslathi E, Nicolson GL (1981) Distribution of fibronectin on clonal cell lines of a rat mammary adenocarcinoma growing in vitro and in vivo at primary and metastatic sites. Cancer Res 41: 5082–5095PubMedGoogle Scholar
  26. Niemczuk P, Perkins RM, Talbot IC, Critchley DR (1982) Lack of correlation between metastasis of human rectal carcinoma and the absence of stromal fibronectin. Br J Cancer 45: 500–505PubMedCrossRefGoogle Scholar
  27. Öz OK, Campbell A, Tao T (1989) Reduced cell adhesion to fibronectin and laminin is associated with altered glycosylation of ß1 integrins in a weakly metastatic glycosylation mutant. Int J Cancer 44: 343–347PubMedCrossRefGoogle Scholar
  28. Pearlstein E (1978) Substrate activation of cell adhesion factor as a prerequisite of cell attachment. Int J Cancer 22: 32–35PubMedCrossRefGoogle Scholar
  29. Pearlstein E, Gold LI (1978) High-molecular-weight glycoproteins as a mediator of cell adhesion. Ann NY Acad Sci 312: 278–292PubMedCrossRefGoogle Scholar
  30. Pouyssegur J, Willingham M, Pastan I (1977) Role of cell surface carbohydrates and proteins in cell behaviour: studies on the biochemical reversion of an N-acetyl glucosamine deficient fibroblast mutant. Proc Natl Acad Sci USA 74: 243–247PubMedCrossRefGoogle Scholar
  31. Pytela R, Pierschbacher MD, Ruoslathi E (1985) A 125/115-kDa cell surface receptor specific for vitrobectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci USA 82: 5760–5766CrossRefGoogle Scholar
  32. Reese AC, Doran JE, Callaway BD, Mansberger AR (1982) Sequestration of fibronectin at the site of an injury. Adv Shock Res 8: 118–127Google Scholar
  33. Rieber M, Castillo MA (1984) Unequal forms of 1450–110-kD glycoproteins in B 16 melanoma cells with differing detachment properties and metastatic behaviour: influence of bromodeoxyuridine. Int J Cancer 33: 765–770PubMedCrossRefGoogle Scholar
  34. Rieber M, Gross A, Rieber MS (1987) Relationship of a Mr 140 fibronectin receptor and other adhesion-related glycoprotein to tumor cell-cell interaction. Cancer Res 47: 5127–5131PubMedGoogle Scholar
  35. Ruoslathi E (1988) Fibronectin and its receptors. Ann Rev Biochem 57: 375–413CrossRefGoogle Scholar
  36. Smith HS, Riggs JL, Mosesson MW (1979) Production of fibronectin by human epithelial cells in culture. Cancer Res 39: 4138–4144PubMedGoogle Scholar
  37. Stenman S, Vaheri A (1978) Distribution of major connective tissue protein, fibronectin in normal tissue. J Exp Med 147: 1054–1064PubMedCrossRefGoogle Scholar
  38. Stenman S, Vaheri A (1981) Fibronectin in human solid tumours. Int J Cancer 27: 427–435PubMedCrossRefGoogle Scholar
  39. Tamkun JW, Schwarzbauer JE, Hynes RO (1984) A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proc Natl Acad Sci USA 81: 5140–5144PubMedCrossRefGoogle Scholar
  40. Vaheri A, Ruoslathi E, Westermak B, Ponten J (1976) A common cell type specific surface antigen in cultured human glial cells and fibroblasts: loss in malignant cells. J Exp Med 143: 64–69PubMedCrossRefGoogle Scholar
  41. Viac J, Reano A, Brochier J, Staquet M-J, Thivolet J (1983) Reactivity pattern of a monoclonal antikeratin antibody (KL 1). J Invest Dermatol 81: 351–354PubMedCrossRefGoogle Scholar
  42. Williams EC, Janmey PA, Ferry JD, Mosher DF (1979) Conformational states of fibronectin. J Biol Chem 257: 14873–14978Google Scholar
  43. Williams EC, Janmey PA, Ferry JD, Mosher DF (1982) Conformational states of fibronectin. J Biol Chem 257: 14973–14978PubMedGoogle Scholar
  44. Yang NS, Kirkland W, Jorgensen T, Furmanski P (1980) Absence of fibronectin and presence of plasminogen activator in both normal and malignant human mammary epithelial cells in culture. J Cell Biol 84: 120–130PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • N. Beck
  • D. Lorke
  • P. Möller

There are no affiliations available

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